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JungHyeHwang,MoonIlPark,YounYoungHwang,HyungJinYoo,HelenJ.Mardon 생화학분자생물학회 2002 Experimental and molecular medicine Vol.34 No.3
Integrins are heterodimeric glycoproteins that havebeen found to undergo dynamic temporal and spa-tial changes in the endometrium during the men-strual cycle and in early pregnancy. Specificity ofintegrins is known to be different in human endome-trial stromal cells and decidual cells. These shifts ofintegrins suggested to play an important role inembryo implantation and can be modulated byprogesterone, cAMP derivatives, and cytokines. Themechanisms of decidualization and its precise phys-iological role are still not clearly understood and invitro systems could provide an alternative that over-comes limitations of studying such complex biolog-ical phenomena in vivo at the time of implantation.This study was undertaken to establish an in vitromodel system for human decidualization using 8-bromo-cAMP and to investigate the characteristicsof stromal integrin expression in vitro by 8-Br-cAMP.Endometrial stromal cells were isolated and cul-tured, and then were induced to decidualize by 0.5mM 8-Br-cAMP for 15 days. Immunofluorescencestaining and flow cytometric analyses of the integrinsubunits ( a1, a4, a5, a6, b1 and avb3) were per-formed at day 9. In the presence of 8-Br-cAMP, thestaining intensity of avb3 was significantly higherthan control and measurements for a1, a4, a5, a6,and b1 were similar. Immunofluorescent localizationof the integrins reflected the diferences obtainedfrom the flow cytometric analyses described above.In summary, the expresion of avb3 integrin increasedin stromal cells in vitro decidualized by 8-Br-cAMPand this up-regulation of avb3 integrin expressionduring decidualization might influence on humanimplantation.
( Jung Hye Hwang ),( Yong Soo Kwon ),( Eun Hae Kang ),( Won Jung Koh ),( Kyeong Woo Kang ),( Ho Cheol Kim ),( Man Pyo Chung ),( Ho Joong Kim ),( O Jung Kwon ),( Gee Young Suh ) 대한내과학회 2004 The Korean Journal of Internal Medicine Vol.19 No.4
Background : Partial liquid ventilation (PLV) and prone positioning can improve the arterial oxygenation (PaO2) in acute lung injury (ALI). We evaluated the effect of prolonged prone positioning during partial liquid ventilation (PLV) in a canine model of
GG-39 : Missed abortion and fetal anomaly related with enterovirus infection in Korea
( Jung Hye Hwang ),( Jeong Wook Kim ),( Seung Sam Paik ),( Ji Young Hwang ),( Kyung Min Lee ),( Ho Sun Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Enteroviruses are a genus of positive-sense single stranded RNA viruses in a member of Picornaviridae. Coxsackievirus B is a member of human enterovirus B species and coxsackievirus B (CVB) consists with 6 serotypes of CVB1 to CVB6. Viral infections during pregnancy can provide significant effects on fetus. This study was performed to evaluate viral infection related with spontaneous abortion. A prospective study performed to 51 gravidas including missed abortion, fetal anomaly, preterm and full-tem delivery in Hanyang University Hospital. Coxsackievirus genome and protein was detected by RT-PCR and Western blot, respectively, in abortive tissues and term placenta samples. Coxsackievirus B3 (CVB3) genome was detected in 7 among 14 missed abortion cases, while 1 among 27 full term cases was positive and none of the 9 preterm cases were positive. In encephalocele anomaly case, Coxsackievirus B1 (CVB1) was detected. Herpes simplex virus type 1 (HSV 1) was found in 4 samples in full term, 3 samples in preterm, and none of the missed abortion. Prevalence of coxsackievirus in missed abortion was significantly high compare to full term or preterm delivery. Coxsackievirus B infection may be considered as important etiological agents of missed abortion.