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Precise Path Tracking with Hierarchy-Structured Dynamic Inversion Approach
Jun’ichiro Kawaguchi,Yoshikazu Miyazawa,Tetsujiro Ninomiya 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
This paper proposes an automatic flight control methodology for precise path tracking problems with hierarchy-structured dynamic inversion approach, which is based on multiple time-scale separation and multiple loop closure method. The dynamic equations for aircraft are grouped into four categories according to the time-scale of the variables and the commanded reference response for the faster variables is generated using dynamic inversion. The methodology features simple and systematic flight control design for path tracking problems since the guidance law and the attitude control law are synthesized using the complete 6DOF nonlinear aircraft dynamics. It also features that the aircraft model and the hierarchical control structure are independent from each other so that it realizes a universal design of automatic flight controllers which utilize the vehicle's 6DOF simulation data on board. This paper in the first place shows the outline of the control law development using hierarchy-structured dynamic inversion approach and its application to path tracking problems in flight control design, which is finally followed by a 6DOF nonlinear night simulation in order to ensure the validity of the methodology.
Research on and Construction of the Concrete-filled Steel Tube Column System in Japan
Shosuke Morino,Jun Kawaguchi 한국강구조학회 2005 International Journal of Steel Structures Vol.5 No.5
system. One of the main advantages is the interaction between steel tube and concrete: occurence of the local buckling of steeltube is delayed by the restraint of concrete; the strength of concrete is increased by the confing effect provided from the steeltube. Extensive research work has been done in Japan last 15 years, including “New Urban Housing Project” and “US-JapanCoperative Earthquake Research Program”, in adition to the work done by individual universities and industries, which hasedevelopment of the CFT column system in a great extent. This paper introduces the merits, the research activities and findings,the design provisions and the recent construction trends of CFT column system in Japan.
Matsuo, Kiyomi,Murata, Tomoyuki,Koga, Takanori,Kubo, Atsuko,Yoshida, Yuichi,Karakawa, Yosuke,Kawaguchi, Hiroshi,Tanaka, Toru,Masaki, Jun,Taketomi, Toshikatsu,Kitajima, Takeo Rehabilitation Engineering And Assistive Technolog 2008 재활복지공학회논문지 Vol.2 No.1
In this paper, I will report the cases of children who are able to study at kindergarten or elementary school because they learned how to move by themselves using a moving aid before school age, and I will also discuss the development of a mobility device which allows severely disabled preschoolers to practice moving around by themselves safely and easily at home and institutions.
Discovery of New Fusion Inhibitor Peptides against SARS-CoV-2 by Targeting the Spike S2 Subunit
( Mahmoud Kandeel ),( Mizuki Yamamoto ),( Hideki Tani ),( Ayako Kobayashi ),( Jin Gohda ),( Yasushi Kawaguchi ),( Byoung Kwon Park ),( Hyung-joo Kwon ),( Jun-ichiro Inoue ),( Abdallah Alkattan ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.3
A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), caused a worldwide pandemic. Our aim in this study is to produce new fusion inhibitors against SARS-CoV-2, which can be the basis for developing new antiviral drugs. The fusion core comprising the heptad repeat domains (HR1 and HR2) of SARS-CoV-2 spike (S) were used to design the peptides. A total of twelve peptides were generated, comprising a short or truncated 24-mer (peptide #1), a long 36-mer peptide (peptide #2), and ten peptide #2 analogs. In contrast to SARS-CoV, SARS-CoV-2 S-mediated cell-cell fusion cannot be inhibited with a minimal length, 24-mer peptide. Peptide #2 demonstrated potent inhibition of SARS-CoV-2 S-mediated cell-cell fusion at 1 μM concentration. Three peptide #2 analogs showed IC50 values in the low micromolar range (4.7-9.8 μM). Peptide #2 inhibited the SARSCoV- 2 pseudovirus assay at IC50=1.49 μM. Given their potent inhibition of viral activity and safety and lack of cytotoxicity, these peptides provide an attractive avenue for the development of new prophylactic and therapeutic agents against SARS-CoV-2.
Kiyomi Matsuo,Tomoyuki Murata,Takanori Koga,Atsuko Kubo,Yuichi Yoshida,Yosuke Karakawa,Hiroshi Kawaguchi,Toru Tanaka,Jun Masaki,Toshikatsu Taketomi,Takeo Kitajima 한국재활복지공학회 2008 재활복지공학회논문지 Vol.2 No.1
In this paper,I will report the cases of children who are able to study at kindergarten or elementary school because they learned how to move by themselves using a moving aid before school age, and I will also discuss the development of a mobility device which allows severely disabled preschoolers to practice moving around by themselves safely and easily at home and institutions.
Postal Addresses As An Assay of Cultural Cognition
Hiroko Nakamura,Hiroshi Yama,Gary L. Brase,Nasriah Zakaria,Yoshiko Arai,Norhayati Zakaria,Shafiz A. Mohd Yusof,Jun Kawaguchi 대한사고개발학회 2014 The International Journal of Creativity & Problem Vol.24 No.2
The present study investigate/d cultural differences in semantic processing, using a city-to-state and state-to-city priming task, in Japan, Malaysia and the United States. Prior research suggests that Easterners tend to engage in context-dependent cognition whereas Westerners tend to engage in context-independent cognition (Nisbett et al., 2001). According to this view, Japanese and Malaysians should show a greater facilitation effect when state name (context) is presented before city name (object) and/or should be more strongly affected by the prime as a contextual cue. However, if domain-specific knowledge about postal addressing order affects semantic priming, both Malaysians and Americans (who share a city-to-state postal address style) should show greater facilitation from city-to-state priming. The results showed cultural differences in the long SOA (700ms) priming task: Americans and Japanese showed significant differences between congruent pairs (e.g., Texas-Dallas) and incongruent pairs (e.g., Texas-Chicago), both in state- to-city and city-to-state priming, whereas Malaysian didn’t show such differences in state-to-city priming. On the other hand, in the short SOA (200ms) priming task, there were no differences between Easterners and Westerners in amount of priming. These results imply that when the priming order didn’t fit the domain-specific knowledge about addressing order, but was consistent with the culturally engaged cognitive tendency, this domain-general cognitive tendency facilitated the target processing via conscious use of strategies.
Kiyomi Matsuo,Tomoyuki Murata,Takanori Koga,Atsuko Kubo,Yuichi Yoshida,Yosuke Karakawa,Hiroshi Kawaguchi,Tom Tanaka,Jun Masaki,Toshikatsu Taketorni,Takeo Kitajima 한국재활복지공학회 2008 한국재활복지공학회 학술대회논문집 Vol.2008 No.11
In this paper, I will report the cases of children who are able to study at kindergarten or elementary school because they learned how to move by themselves using a moving aid before school age, and I will also discuss the development of a mobility device which allows severely disabled preschoolers to practice moving around by themselves safely and easily at home and institutions.
Yagi Kiyoshi,Goto Yuta,Kato Kenji,Suzuki Nobuyuki,Kondo Akira,Waseda Yuya,Mizutani Jun,Kawaguchi Yohei,Joyo Yuji,Waguri-Nagaya Yuko,Murakami Hideki 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.6
Study Design Human ligamentum flavum–derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose We sought to evaluate the inflammatory response of human ligamentum flavum cells to investigate hypertrophic changes occurring in the ligamentum flavum. Overview of Literature Lumbar spinal stenosis (LSS) is a disease commonly observed in the elderly. The number of patients with LSS has increased over time, yet the pathomechanisms of LSS still have not been fully elucidated. One of the clinical features of LSS is hypertrophy of the ligamentum flavum, which results in narrowing of the lumbar spinal canal. Some reports have suggested that ligamentum flavum hypertrophy is associated with inflammation and fibrosis; meanwhile, the p38 mitogen-activated protein (MAP) kinase is involved in the hypertrophy of human ligamentum flavum cells. Methods HFCs were obtained from patients with LSS who underwent surgery. HFCs were stimulated by tumor necrosis factor-α (TNF-α) and a p38 MAP kinase inhibitor, SB203580. Phosphorylation of the p38 MAP kinase was analyzed by western blotting. The concentration of interleukin-6 (IL-6) in the conditioned medium was measured by enzyme-linked immunoassay and IL-6 messenger RNA expression levels were determined by real-time polymerase chain reaction. Results TNF-α induced the phosphorylation of p38 MAP kinase in a time-dependent manner, which was suppressed by the p38 MAP kinase inhibitor, SB203580. TNF-α also stimulated IL-6 release in both a time- and dose-dependent manner. On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-α from HFCs. Conclusions This is the first report suggesting that TNF-α stimulates the gene expression and protein secretion of IL-6 via p38 MAP kinase in HFCs. A noted association between tissue hypertrophy and inflammation suggests that the p38 MAP kinase inflammatory pathway may be a therapeutic molecular target for LSS.