공황장애에서 Paroxetine 치료반응을 예측할 수 있는 생물학적 지표

박주언,유범희 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Previons studies reported altered beta-adrenergic receptor (βAR) responsiveness in panic disorder, but few studies reported to see the effect of pharmacotherapy on βAR function in panic patients. This investigation examined βAR responsiveness in patients with panic disorder before and after pharmacotherapy with paroxetine. Methods : After assessment using the Anxiety Disorder Interview Schedule for DSM-FV, 27 acute panic patients whose illness duration did not exceed 1 year were assigned to 12 weeks of paroxetine treatment. Twenty seven normal control subjects with no previous history of major medical and psychiatric illnesses were matched by age, sex, exercise, and body mass index. The Hamilton rating scaIe for anxiety (HAM-A), Hamilton rating scale for depression (HAM-D), Spielberger state-trait anxiety inventory-State (STAI-S) and Trait (STAI-T), acute panic inventory (API), anxiety sensitivity index (ASI), and Beck depression index (BDI) were performed to assess clinical states in the panic patients before and after treatment. The HAM-A, HAM-D, STAI-S and STAI-T, and BDI were also performed in the normal control subjects. We measured the βAR density (Bmax), affinity (l/Kd), and sensitivity (cyclic AMP ratio of isoproterenol-stimulated cAMP to basal cAMP)in all subjects. Results : Panic patients showed much lower scores of the HAM-A, STAI-S, STAI-T, API, ASI, HAM-D, and BDI after 12 weeks ofparoxetine treatment than those before the treatment. There was no significant difference in the means of Bmax and cAMP ratio between control subjects and panic patients before and after the treatment. However, Pretreatment Kd(R²=0.314, β=-0.876, p=0.001) and Bmax (R²=0.230, β=-0.575, P=0.019) significantly accounted for API scores after the treatment and change of Bmax according to the treatment accounted for the improvement of anxiety sensitivity (R²=0.353, β=0.594, P=0.015). The pretreatment Kd value was significantly higher in the panic patients compared with that of control subjects (78.35≥26.20 vs. 59.15≥29.33, p=0.014), which was significantly reduced after the treatment (79.43≥26.83 vs. 56.38≥28.79, p=0.002). The pretreatment Kd value significantly accounted for the improvement of API scores (R²=0.316, β=0.562, p=0.029) and the decrease in trait anxiety (R²=0.246, β=-0.513, P=0.025). Conclusion : In acute panic patients, only βAR affinity was reduced before the treatment, which was contrary to our ex-pectation. Decreased ,βAR affinity was normalized after paroxetine treatment. Decreased βAR affinity and increased βAR density before the treatment predicted good treatment response in acute panic patients. Thus, βAR affinity and density could be useful biological markers that predict the treatment response of paroxetine in panic disorder.

편두통: 정신과적 문제와 바이오피드백 치료

박주언,유범희 대한두통연구회 2004 두통 Vol.5 No.1

프리셉터 경험이 간호업무수행과 직무만족에 미치는 영향 연구

류언나,송혜숙,장은희,서효신,추연화,김인선,나명주,지성애,박경숙 중앙대학교 간호과학연구소 2001 중앙간호논문집 Vol.5 No.2

The purpose of this study was to investigate how preceptor experience has an effect upon preceptor nurses. This study was so designed that it could compare the difference between clinical performance and Job satisfaction of preceptor nurses and those of nonpreceptor nurses. Study subjects were sampled out from those nurses who worked with two university hospitals where preceptor programs were implemented. The number of subjects totaled to 134, including 69 preceptor nurses and 70 nonpreceptor nurses. The score of preceptor nurses' clinical performance and job satisfaction revealed a higher value than that of nonpreceptor nurses. A similar result was also shown in the subdomains. However these difference were not statistically significant. Among all of the preceptor nurses, the highest number of preceptor experience was just one time. Except for five times in preceptor experience, the more the number of times of preceptor experience, the higher score in clinical performance. It was manifested that the number of preceptor experience was not related to job satisfaction. The score of preceptor nurses' clinica1 performance and job satisfaction revealed a higher value than that of nonpreceptor nurses. A similar result was also shown in the subdomains. However these difference were not statistically significant. The reward that preceptor nurses wished most was a reduction of the work load assigned to them. Currently preceptor nurses are only receiving a small quantity of financial reward related with their preceptor role. Most of preceptor nurses (96.8%) were not satisfied with their existing reward. Almost half of the preceptor nurses(43.5%) did not want to play a role as preceptor again. The reason why the scores of clinical performance and job satisfaction were low might be attributed to the inadequate preceptor training program and reward system. Appropriate knowledge and clinical skill are expected to enhance the level of preceptor nurses' clinical performance and appropriate internal and external reward to elevate the level of preceptor nurses' Job satisfaction. Therefore, it is needed for us to develop more effective preceptor education program, financial reward, support of colleague nurses and nursing managers, and adjust workload for the purpose of more effective preceptor programs.

진공 승화법에 의한 금속 킬레이트 화합물의 분리 거동과 물질전달

金柱奉,孫晋彦,朴東源 동아대학교 공과대학 부설 한국자원개발연구소 1983 硏究報告 Vol.7 No.2

The heating temperature, vacuum condensing point, velocity of sublimation and distance of diffusion were measured according to the change of vacuum degree of metal acetylacetonate by vacuum sublimation method. Their corelation and separation were experimented. Mass transfer was studied with their diffusion coefficient and mass transfer coefficient. Results obtained on the sublimatographic character of metal acetylacetonate are as follows: 1) Vacuum condensing point of metal acetylacetonate at different heating temperature and vacuum degree is obtained. 2) The possibility of separation of any metal chelates will be presumable from the th-V.C.P. curve for each component in the metal chelates. 3) The vapor pressure, molar velocity of sublimation and mass transfer coefficient of metal acetylacetonate are calculated by experimental data; P_(h)/P_(s)=r r=1.12 P_(s)ⁿ=kG (n=0.97~1.01) rP_(s)ⁿ=k'G (n'=0.98~1.21) k_(Gav)=2.8325×10^(-6)

한국인 만성 긴장형두통 환자에서 바이오피드백을 활용한 자율적 이완훈련의 효과

강은호,안주연,구문선,박주언,유범희 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

Objectives : We aimed to evaluate the efficacy of biofeedback-assisted autogenic training for chronic tension-type headache, and to determine the relationship among the changes in electromyography (EMG) activity, headache activity, and mood states according to the psychophysiological treatment. Methods : Chronic tension-type headache patients aged from 20 to 40 years (n=35) were randomized to the treatment group receiving biofeedback-assisted autogenic training (8 sessions) or the monitoring-only control group. EMG activities, headache index, and various psychological variables were examined. Results : We found greater treatment response rate (≥50% reduction in headache index) in patients with biofeedback-assisted autogenic training than in the monitoring group (61% vs. 18% ; χ²=6.882, df=1, p=0.01). There were no significant changes in the mean values of the pretreatment EMG activities across the sessions m either group (all p’s>0.1). Mood states including anxiety and depression improved over time in the both groups, with the improvements being more prominent in the treatment group. Moreover, the reduction in depression level predicted treatment outcome in terms of headache index (95% confidence interval : 0.272-0.966, p=0.039). Conclusion : These results show that biofeedback-assisted autogenic training is effective for the treatment of chronic tension-type headache in a Korean population. Changes in mood states may be closely associated with the clinical outcome in the treatment of chronic tension-type headache using biofeedback-assisted autogenic training.

Prevention and Treatment of Trauma- and Stressor-Related Disorders : Focusing on Psychosocial Interventions for Adult Patients

Joo Eon Park,Hyun-Nie Ahn,Young-Eun Jung 대한신경정신의학회 2016 신경정신의학 Vol.55 No.2

Each year many people are exposed to life-threatening disaster and traumatic events that put them at risk for trauma- and stressor-related disorders such as posttraumatic stress disorder. This report reviews research on the psychosocial interventions currently employed for the prevention and treatment of trauma- and stressor-related disorders. Cognitive behavioral therapy, including cognitive therapy and prolonged exposure, has been shown to improve several outcomes. Considerable progress has also been made in the use of eye movement desensitization and reprocessing. Trauma- and stressor-related disorders are associated with complex outcomes and multiple comorbid emotional, social, and physical health difficulties. Further advances are required in the intervention for populations with complex and chronic forms and in the development of integrated and well-related systems of care.

Clinical utility of heart rate variability during Head-up tilt test in subjects with chronic posttraumatic stress disorder

Park, Joo Eon,Kang, Suk-Hoon,Lee, Ji Yeon,Won, Sung-Doo,So, Hyung Seok,Choi, Jin Hee,Kim, Chan-Hyung,Yoon, In Young Elsevier 2019 Psychiatry Research Vol.272 No.-

<P><B>Abstract</B></P> <P>Posttraumatic stress disorder (PTSD) is characterized by psychophysiological abnormalities, such as an altered baseline heart rate and hyperarousal, implying dysfunctional arousal regulation. Heart rate variabilities (HRVs) is known to reflect autonomic nervous system activity. We examined the changes of HRVs in PTSD patients with head-up tilt position to closely investigate disease-specific changes in autonomic function in PTSD patients. Sixty-seven patients with PTSD and 72 patients without PTSD were assessed using the PTSD Checklist for DSM-5 (PCL-5) and psychiatric interview. Heart rate data including standard deviation of the NN intervals, the square root of the mean squared differences of successive NN intervals, log low-frequency and log high-frequency were collected for 10 min before and after tilting. Considering interactions between groups and head-up tilting, the head-up tilting induced reduction of the high-frequency component of HRVs was significantly greater in the PTSD group [<I>F</I> (1, 272) = 4.718, <I>p</I> = 0.031]. The change of HRVs in PTSD patients suggested the presence of autonomic dysfunction in despite of the posture.</P>

Lymphocyte Subsets and Mood States in Panic Disorder Patients

Park Joo Eon,Kim Sang Wook,Park Quehn,Jeong Do Un,Yu Bum Hee 대한의학회 2005 Journal of Korean medical science Vol.20 No.2

Heart rate variability of chronic posttraumatic stress disorder in the Korean veterans

Park, Joo Eon,Lee, Ji Yeon,Kang, Suk-Hoon,Choi, Jin Hee,Kim, Tae Yong,So, Hyung Seok,Yoon, In-Young Elsevier 2017 Psychiatry Research Vol.255 No.-

<P><B>Abstract</B></P> <P>Patients with post-traumatic stress disorder (PTSD) have lower heart rate variability (HRV) than the general population, but findings in this area have been inconsistent. This study was conducted to investigate the characteristics of HRV in patients with PTSD and to evaluate associations between PTSD symptoms and HRV indices. Sixty-eight patients with PTSD and 73 controls without PTSD were evaluated. HRV was measured in all subjects after they completed self-reported questionnaires. Patients with PTSD had significantly more depressed moods, anxiety, and poorer sleep quality than individuals in the non-PTSD group. Standard deviations of NN intervals (SDNN), the square root of the mean squared differences of successive NN intervals (RMSSD), and log high-frequency (LNHF) were significantly lower in the PTSD group than in the non-PTSD group. Comparisons of HRV indices among four sub-groups according to presence/absence of PTSD and experiences of combat-related or other trauma indicated that individuals in the PTSD group who had experienced combat-related trauma had the lowest HRV indices. These indices included SDNN, RMSSD, and LNHF. Further, SDNN, RMSSD, and HF power were significantly associated with symptoms of hyperarousal. HRV measures might be useful physiological parameters in assessing and monitoring sympathovagal function in patients with PTSD.</P>

Gas Sorption and Transport in Polymer Nanocomposite Membranes Containing Porous Aromatic Frameworks (PAFs-1)

Joo-Eon Kim,Seung In Jang,Yu Jin Kim,Jong Hak Kim,You-In Park,Jaesung Park 한국막학회 2023 한국막학회 총회 및 학술발표회 Vol.2023 No.11