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The Role of Ribose on Oxidative Stress During Hypoxic Exercise: A Pilot Study
John G. Seifert,Andrew W. Subudhi,Min-Xin Fu,Karen L. Riska,Jeff C. John,Linda M. Shecterle,John A. St. Cyr 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% O2 with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7g of ribose in 250mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion (0.2±0.03nM/mg and 0.26±0.29μM, respectively) but were lower with ribose supplementation (0.04±0.03nM/mg and 0.38±0.29μM, respectively; P<.05). Uric acid levels were similar between groups (ribose vs. placebo, 4.55±0.06mg/dL vs. 4.67±0.06mg/dL). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.
The Role of Ribose on Oxidative Stress During Hypoxic Exercise: A Pilot Study
Seifert, John G.,Subudhi, Andrew W.,Fu, Min-Xin,Riska, Karen L.,John, Jeff C.,Shecterle, Linda M.,Cyr, John A. St. The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
Oxygen free radicals are produced during stress, are unstable, and potentially interact with other cellular components or molecules. This reactivity can influence cellular function, including a prolongation in tissue recovery following exercise. We tested the effect of ribose (d-ribose), a pentose carbohydrate, in a double-blinded, crossover study on markers of free radical production during hypoxic exercise. Seven healthy volunteers cycled at their lactate threshold for 25 minutes while inhaling 16% $O_2$ with a subsequent 60-minute resting period at room air. Subjects ingested either placebo or 7 g of ribose in 250mL of water before and after the exercise session. Urinary malondialdehyde (MDA) and plasma reduced glutathione levels increased significantly during placebo ingestion ($0.2\;{\pm}\;0.03\;{\mu}M/mg$ and $0.26\;{\pm}\;0.29\;{\mu}M$, respectively) but were lower with ribose supplementation ($0.04\;{\pm}\;0.03\;{\mu}M/mg$ and $0.38\;{\pm}\;0.29\;{\mu}M$, respectively; P < .05). Uric acid levels were similar between groups (ribose vs. placebo, $4.55\;{\pm}\;0.06\;mg/dL$ vs. $4.67\;{\pm}\;0.06\;mg/dL$). Ribose demonstrated a beneficial trend in lower MDA and reduced glutathione levels during hypoxic stress.
Yi Heng Seow,Ru Xin Wong,John Heng Chi Lim,Weixiang Lian,Yoon Sim Yap,Fuh Yong Wong 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: The American Joint Committee on Cancer 8th edition (AJCC8) prognostic stage (PS) was implemented January 1, 2018, but it is complex due to multiple permutations. A North American group proposed a simpler system using the anatomic stage with a risk score system (RSS) of 1 point each for grade 3 tumor and human epithelial growth factor receptor 2 (HER2) and estrogen receptor (ER) negativity. Here we aimed to evaluate this risk score system with our database of Asian breast cancer patients and compare it against the AJCC8 PS. Methods: Patients diagnosed with breast cancer stage I–IV in 2006–2012 were identified in the SingHealth Joint Breast Cancer Registry. Five-year breast cancer-specific survival (CSS) and overall survival (OS) were calculated for each anatomic stage according to the risk score and compared with the AJCC8 PS. Results: A total of 6,656 patients were analyzed. The median follow-up was 61 (interquartile range, 37–90) months. There was a high receipt of endocrine therapy (84.6% of ER+ patients), chemotherapy (84.3% of node-positive patients), and trastuzumab (86.0% of HER2+ patients). Within each anatomic stage, there were significant differences in survival in all sub-stages except IIIB. On multivariate analysis, the hazard ratio for negative ER was 1.74 (1.48–2.06), for negative HER2 was 1.49 (1.26–1.74), and for grade 3 was 1.84 (1.55–2.19). On multivariate analysis controlled for age, ethnicity, and receipt of chemotherapy, the RSS (Akaike information criterion [AIC] = 10,649.45; Harrell's Concordance Index [C] = 0.85) was not inferior to the AJCC8 PS (AIC = 10,726.65; C = 0.84) for CSS, nor was the RSS (AIC = 14,714.4; C = 0.82) inferior to the AJCC8 PS (AIC = 14,784.69; C = 0.81) for OS. Conclusion: The RSS is comparable to the AJCC8 PS for a patient population receiving chemotherapy as well as endocrine- and HER2-targeted therapy and further stratifies stage IV patients.
Umsa Jameel,Mingqiao Zhu,Xin-Zhi Chen,Hengquan Chen,Nousheen Iqbal,Zhangfa Tong,Satmon John Timayo 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.6
Selective oxidation of olefins using molecular oxygen is a great challenge. This study reports two types of novel eco-friendly heterogeneous hybrid catalysts. One comprises of a lacunary Keggin-type polyoxometalate (POM) GaW11 linked to nano-sized silica using (3-aminopropyl) triethoxysilane (APTES) to form GaW11-APTES@SiO2 . Another catalyst is Au/GaW11-APTES@SiO2 prepared by wet deposition of nano-gold on the former one. The catalysts were characterized and used for the solvent-free oxidation of cyclohexene with molecular oxygen under mild reaction conditions. Both the catalysts showed good conversion and significant selectivity towards oxidized products for cyclohexene. GaW11-APTES@SiO2 showed a high conversion of up to 62.02% with a selectivity of 59.13% towards epoxide at a mild temperature of 50°C. Au/GaW11-APTES@SiO2 showed a conversion of 69.32% with 57.34% selectivity to 2-cyclohexene-1-ol at a temperature of 80°C. The heterogeneous catalysts were reused several times with no significant loss in conversion or selectivity towards the oxidized products.
Color Prediction of Yarn-dyed Woven Fabrics-Model Evaluation-
( Young Joo Chae ),( John Xin ),( Tao Hua ) 한국의류학회 2014 한국의류학회지 Vol.38 No.3
The color appearance of a yarn-dyed woven fabric depends on the color of the yarn as well as on the weave structure. Predicting the final color appearance or formulating the recipe is a difficult task, considering the interference of colored yarns and structure variations. In a modern fabric design process, the intended color appearance is attained through a digital color methodology based on numerous color data and color mixing recipes (i.e., color prediction models, accumulated in CAD systems). For successful color reproduction, accurate color prediction models should be devised and equipped for the systems. In this study, the final colors of yarn-dyed woven fabrics were predicted using six geometric-color mixing models (i.e., simple K/S model, logK/S model, D-G model, S-N model, modified S-N model, and W-O model). The color differences between the measured and the predicted colors were calculated to evaluate the accuracy of various color models used for different weave structures. The log K/S model, D-G model, and W-O model were found to be more accurate in color prediction of the woven fabrics used. Among these three models, the W-O model was found to be the best one as it gave the least color difference between the measured and the predicted colors