Identification of quantitative trait loci for the fatty acid composition in Korean native chicken

Jin, Shil,Park, Hee Bok,Seo, Dongwon,Choi, Nu Ri,Manjula, Prabuddha,Cahyadi, Muhammad,Jung, Samooel,Jo, Cheorun,Lee, Jun Heon Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.8

Objective: Fatty acid composition is one of the most important meat quality traits because it can contribute to functional, sensorial, and nutritional factors. In this study, quantitative trait locus (QTL) analyses for fatty acid composition traits were investigated in thigh and breast meat of Korean native chicken (KNC). Methods: In total, 18 fatty acid composition traits were investigated from each meat sample using 83 parents, and 595 $F_1$ chicks of 20 week old. Genotype assessment was performed using 171 informative DNA markers on 26 autosomes. The KNC linkage map was constructed by CRI-MAP software, which calculated genetic distances, with map orders between markers. The half-sib and full-sib QTL analyses were performed using GridQTL and SOLAR programs, respectively. Results: In total, 30 QTLs (12 in the thigh and 18 in the breast meat) were detected by the half-sib analysis and 7 QTLs (3 in the thigh and 4 in the breast meat) were identified by the full-sib analysis. Conclusion: With further verification of the QTL regions using additional markers and positional candidate gene studies, these results can provide valuable information for determining causative mutations affecting the fatty acid composition of KNC meat. Moreover, these findings may aid in the selection of birds with favorable fatty acid composition traits.

Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study

JinShil Kim,Minjeong An,Seongkum Heo,Mi-Seung Shin 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.1

Background/Aims: Advance directives (ADs) in Korean patients with heart failure (HF) and the associations of attitude towards ADs and HF prognosis with ADs were initially assessed using the model of the Korean-Advance Directive (K-AD). Methods: Twenty-four patients with HF (age, 67.1 years; men, 58.3%; ejection fraction, 35.9%) participated. A pilot test to evaluate the feasibility of ADs and the possible associations of attitudes towards ADs and prognosis with end-of-life treatment preferences among patients with HF was conducted. Results: Fifteen patients (62.5%) completed the K-ADs. The major reason for incomplete K-AD was knowledge deficit. Patients valued “comfortable death” the most (45.4%), followed by “giving no burden to the family” (13.6%). Among treatment preferences, hospice care was preferred by the majority (66.7%), while cardiopulmonary resuscitation (CPR) was preferred by the minority (31.8%). Children (50.0%) were mostly appointed as a proxy, followed by the spouse (33.3%). More patients with moderately positive attitudes completed the K-ADs than their counterparts (70.0% vs. 57.1%). The 5-year survival rate was 69.2%; the patients who preferred CPR had a higher survival rate (70.6% vs. 68.5%) whereas those who preferred hospice care had a lower survival rate than their counterparts (70.7% vs. 75.2%). Conclusions: The findings support the feasibility of the K-AD model, with a high acceptance rate in two-thirds of the sample. Further studies are warranted to investigate whether treatment preferences are associated with attitude towards ADs and/or HF prognosis using larger sample size.

Compare Advance Directive Perspectives and Desired Life-Sustaining Treatments Between Implantable Cardioverter-Defibrillator Recipients for Secondary Prevention and Patients with Heart Failure

JinShil Kim,Hyung Wook Park,Seongkum Heo,KyungAh Cho,Taehun Kim,Minjeong An 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aims: It remains unknown whether life-sustaining treatment (LST) preferences and perspectives regarding advance directives (AD) vary by the diagnostic contexts, implantable cardioverter-defibrillator (ICD) therapy and heart failure (HF). Therefore, this study aimed to compare AD perspectives (attitudes, and perceived barriers and benefits) between the diagnostic groups (ICD vs. HF) and examine the diagnostic contexts and these factors associated with preferred LSTs (cardiopulmonary resuscitation [CPR], ventilation support, and hemodialysis) and hospice care. Methods: Using secondary analysis, data on the perspectives and preferences for LSTs and hospice care from ICD recipients and patients with HF prior to or after the planned visits for routine care at the outpatient areas. Results: Forty-two secondary ICD recipients (mean age, 50.13 years; male, 85.4%) and 36 HF patients (mean age, 65.44 years; male, 69.4%) provided data. LST preferences were not significantly different, while hospice care preference in HF patients was higher than in ICD recipients (40.5% vs. 69.4%; p=.010). HF diagnosis decreased the odds of preferences for CPR (odds ratio [OR] = 0.125, confidence interval [CI] = 0.020, 0.771) and hemodialysis (OR = 0.189, CI = 0.043, 0.827). CPR preference increased with barriers (OR = 1.062, CI = 1.014, 1.112); hemodialysis increased with positive attitudes (OR = 1.128, CI = 1.026, 1.240) and barriers (OR = 1.057, CI = 1.006, 1.106). Hospice care preference increased with positive attitudes (OR = 1.183, CI = 1.049, 1.334). Conclusions: Preferences for LSTs were somewhat high, but were not different between the two groups. HF diagnosis was associated with less preference for LSTs, and less positive attitudes and/or higher barriers were associated with more preferences for LSTs and less for hospice care. These initial insights imply that informed decision-making for end-of-life care can be facilitated through early discussion about ADs, with consideration of the diagnostic contexts and some modifiable factors.

The Cognitive Impact of Chronic Diseases on Functional Capacity in Community-Dwelling Adults

KIM, JinShil,PARK, Eunok,AN, Minjeong Lippincott WilliamsWilkins 2019 The journal of nursing research Vol.27 No.1

<P><B>ABSTRACT</B></P><P><B>Background:</B></P><P>People with chronic diseases may experience poor cognitive functioning associated with advanced age, progression of disease, or other comorbid chronic conditions. Empirical evidence of this phenomenon is limited despite the clinical relevance of cognitive decline and associated adverse outcomes such as poor physical functioning.</P><P><B>Purpose:</B></P><P>The purpose of this study was to examine cognitive functioning in the domains of memory, attention, and executive function and its association with functional capacity in a sample of community-dwelling adults with a spectrum of chronic diseases.</P><P><B>Methods:</B></P><P>An exploratory cross-sectional study was conducted in a sample of community-dwelling adults with chronic diseases, including hypertension (58.9%), diabetes mellitus (DM; 20.0%), and dyslipidemia (14.4%). Participants’ mean age was 64.1 ± 11.2 years, and 48.9% were male. Ninety persons completed the face-to-face interviews, which evaluated cognitive functioning in the domains of memory, attention, and executive function using neuropsychological tests and the physical well-being test, which measured functional capacity using the Duke Activity Status Index.</P><P><B>Results:</B></P><P>Compared with those with other chronic diseases, our sample with hypertension and DM had significantly more memory loss and poorer executive function. These significant differences were nullified when adjusting for age, gender, and education. Approximately one third had functional limitations (<I>n</I> = 29, 32.2%), using a cutoff point of 35 or less (Duke Activity Status Index). Memory loss (delayed recall, <I>b</I> = 1.5, <I>p</I> = .016) and poor executive function (Trail Making Test Part A, <I>b =</I> −0.2, <I>p</I> < .001) were predicting factors of functional decline, independent of age, gender, education, and comorbidity.</P><P><B>Conclusions/Implications for Practice:</B></P><P>Cognitive function, particularly memory and executive function, was poorer among chronically ill Korean adults in the community with hypertension or DM than their counterparts. Functional decline was worse in the presence of memory loss and poor executive function. Studies examining the mechanism by which overall functioning is impacted by cognitive decline and its relevance to functional declines in a larger representative sample are warranted.</P>

A Context-oriented Communication Algorithm for Advance Care Planning : A Model to Assist Palliative Care in Heart Failure

Kim, JinShil,Kim, Shinmi,Shin, Mi-Seung,Jin, Jae Ok,Kim, Yunmi,Lee, Mee-Ok Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2018 The Journal of cardiovascular nursing Vol.33 No.5

Life Transition Process Effects on Depressive Symptoms in Parents of Children with Autism Spectrum Disorder

Sun Woo Hong,JinShil Kim,Ae Ran Lee,Jeong Sil Choi 한국아동간호학회 2018 Child Health Nursing Research Vol.24 No.3

Purpose: The purpose of this study is to examine the association between each phase of the Life Transition Process (LTP) and depressive symptoms among parents of children with Autism Spectrum Disorder (ASD). Methods: Using a cross-sectional study design, data pertaining to LTP and depressive symptoms were collected from 285 parents of children with ASD (101 fathers and 184 mothers). Participants were recruited through the Autism Society of Korea and a counseling center for families of children with ASD. Results: Using a cut-off point of 5 or higher on the Beck Depression Inventory-Short Form, more than half of the parents (53.4%) were deemed depressed; these parents experienced moderate (27.4%) to severe (11.6%) levels of depressive symptoms. A hierarchical multiple regression using the socio-demographic characteristics of children and parents and each phase of the LTP as predictors, found that lower income (β=-.14, p=.007) and greater scores for the wandering phase (β=.59, p<.001) were significant predictors of greater levels of depressive symptoms. Conclusion: These findings confirm the association between LTP and depressive symptoms for parents of children with ASD, who were found to have a greater risk of depressive symptoms during wandering phase.

Validity and Reliability of the Life Transition Scale in Parents of Disabled Children Across the Life Transition Process

Hong, Sun Woo,Kim, JinShil,Bang, Hwal Lan Korean Academy of Child Health Nursing 2020 Child Health Nursing Research Vol.26 No.3

Purpose: The Life Transition Scale (LTS) consists of 24 items that assess the life transition process of parents of autistic children. This study aimed to examine the validity and reliability of the LTS in parents of children with a wide spectrum of disabilities. Methods: Data were collected from 260 parents of children with disabilities through self-report questionnaires. Validity was examined using exploratory and confirmative factor analysis to determine the factor structures of the LTS; socio-demographic differences in LTS scores were examined using the t-test or ANOVA. Reliability was examined using Cronbach's α coefficient. Results: A four-factor structure was validated (χ²=640.0, p<.001, GFI=.81, RMSEA=.07, NNFI=.89, CFI=.89, PNFI=.74, Q [χ²/df]=2.60). The validity of the LTS was verified by exploratory factor analysis, with factor loading ranging from .30 to .80. There were significant differences in the accepting phase according to children's and parents' age and the type of disability, and in the wandering phase according to parental gender, educational level, job, and socioeconomic status. The Cronbach's αs for the reliability of each of the four structures were acceptable, within a range of .80~.90. Conclusion: The LTS is a valid and reliable measurement to assess the life transition process of parents with disabled children.

햅틱을 이용한 자동차 네비게이션 지원 시스템과 UI 개발 및 평가

정경미(Kyungmi Chung),현진실(Jinshil Hyun),황중식(Jungsik Hwang),조광수(Kwangsu Cho) 한국HCI학회 2012 한국HCI학회 학술대회 Vol.2012 No.1

이 연구에서는 운전자의 주의 집중을 저해할 수 있는 위험한 상황에서 진동 촉각 단서의 제시 간격과 시각적 표적의 제시 위치 일치 여부에 따라 나타날 수 있는 촉진효과와 억제효과의 가능성과 함께 회귀억제 현상이 일어날 경우 눈의 움직임엔 어떠한 변화가 있는지를 살펴보고자 하였다. 운전 중 촉각으로 공간정보를 전달하기 위해 5×5 배열의 진동단자로 구성한 진동시스템을 운전자 시트의 등에 부착하였으며, Flicker paradigm 을 사용하여 시각적 변화를 탐색하는 실험을 실시하였다. 두 독립변인으로는 유효성(유효, 비유효, 통제조건)과 자극제시간격(pre 1440ms, pre 2160ms, pre 2880ms)을 설정하였고, 바뀐 시각자극을 찾는데 걸린 시간과 4 분면 안에서 바뀐 물체의 위치를 올바르게 찾을 수 있는지의 여부를 종속변인으로 측정하였다. This study investigated that the possibility of the facilitation and inhibition effects resulting from the SOAs of the vibrotactile cue and whether the location of the presented visual target corresponds to that of the cue, observing the changes in eye movement when IOR appears. To convey spatial haptic cue-based information while driving, we installed the haptic interface using vibrotactile signals with 5-by-5 tactor array on the back of the driver's seat and conducted a visual search experiment based on flicker paradigm. The two independent variables were validity (valid, invalid, no cueing) and the interval between the onset of the cue and onset of the target (pre 1440ms, pre 2160ms, pre 2880ms), and reaction times (RTs) for correct responded trials were measured as dependent variables.

Patient-Tailored Self-Management Intervention for Older Adults with Hypertension in Nursing Home

Yeon-Hwan Park,Jinshil Kim,Heekyung Chang,Jin Sang Kwark 한국간호과학회 2011 한국간호과학회 학술대회 Vol.2011 No.10

자외선 흡광도를 이용한 유전자재조합의약품 함량 결정과정 분석

강소영(Soyeong Kang),최진실(JinShil Choi),엄준호(Joon Ho Eom) 대한약학회 2020 약학회지 Vol.64 No.2

This study summarizes the theoretical background of the protein concentration determination process using UV absorbance and proposes the standard calculation formular. We analyzed the protein concentration determination process of recombinant DNA-derived biologics that is inspected by the Ministry of Food and Drug Safety for the last three years (2017-2019) and we found some errors in calculation formular. In addition, we analyzed parameters and acceptance criteria of system suitability test (SST), and we proposed the direction for setting the SST. If the results of this study are widely understood and utilized by product manufacturers and research developers, the calculation of protein concentration using UV absorbance for each product would be simplified and standardized, and contribute to efficient communication between product manufacturers and regulatory authority.