만성 요통근로자의 능동적 운동프로그램 효과

허진강,송재철,노영만,박동식,양영애,김윤신 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.1

목적: 본 연구는 만성 요통근로자의 세 가지 능동적 운동프로그램 효과에 관한 연구로서 능동적 운동이 요추의 안정성 향상에 미치는 영향을 알아보고자 시도되었다. 방법: 3개월 이상 만성요통을 호소하는 64명의 근로자대상으로 무작위로 일반적인 물리치료그룹, 요추 운동그룹, 흉추 운동그룹, 세 그룹으로 나누었다. 능동적 운동 프로그램은 주 3회, 6개월 동안 실시하였으며, 통증강도, Oswestry 장애지수, 양손을 머리위로 최대한 올려 높이 측정, 요추부 경사각도를 평가하였다. 모든 대상자들은 연구 전, 연구 후 2주, 3개월, 6개월을 같은 측정방법으로 재평가하였다. 결과: 통증강도는 세 그룹 간에 통계적으로 유의한 차이가 없었다. Oswestry 장애지수는 연구 후 6개월에서 세 그룹 간의 유의한 차이가 있었으며, 요추운동그룹과 흉추운동그룹이 일반적인 물리치료그룹에 비하여 유의하게 감소하였다(p<0.05). 양손을 머리위로 최대한 올려 높이측정은 연구 후 3개월과 6개월에서 세 그룹 간에 유의한 차이가 있었으며, 연구 후 6개월에서는 흉추운동그룹이 일반적인 물리치료그룹과 요추운동그룹에 비하여 유의하게 증가하였다(p<0.05). 요추부 경사각도는 연구 후 2주와 3개월, 6개월에서 세 그룹 간에 유의한 차이가 있었으며, 연구 후 6개월에서는 흉추운동그룹이 일반적인 물리치료그룹과 요추운동그룹에 비하여 유의하게 감소하였다(p<0.05). 결론: 3개월 이상 만성 요통을 호소하는 근로자 대상으로 흉추의 운동성 증가를 위한 운동프로그램을 적용하여 흉추의 운동성을 증가시킨 결과에서 보면, 2주 시행하였을 때 요추의 신전 운동프로그램 보다 요추의 안정성 향상에 효과적이며, 6개월 시행하였을 때만, 요추의 심부근 근력강화 운동프로그램보다 요추의 안정성 향상에 효과적이었다. Oswestry 장애지수는 요추의 심부근 근력강화 운동프로그램과 동일하게 감소하였고, 통증강도는 세 그룹 모두 2주 시행하였을 때 감소하는 것으로 나타났다. Objective: To examine the relative efficacy of three active exercise programs for work-related, chronic low back pain, and to observe to what extent the programs affected the mechanical stability of the lumbar region. Methods: The subjects were 64 employees who were randomly divided into three groups to match the three active exercise programs which were performed 3 times a week for 6 months. All subjects were assessed with the same measurements at a pre-study examination, and then were reassessed at 2 weeks, 3 months and 6 months after the study. Results: The pain intensity didn' t show any significant difference among the three groups. However, the Oswestry Disability Index showed significant differences among the three groups at 6 months and the lumbar and thoracic exercise groups showed significant decreases compared to the general physiotherapy group (p<0.05). Maximal stretching with both hands in the overhead direction showed a significant difference among the three groups at 3 months and 6 months, and the thoracic exercise group at 6 months showed a significant increase in overhead stretching compared to the lumbar exercise and general physiotherapy groups (p<0.05). The lumbar region angle of inclination showed significant differences among the three groups at 2 weeks, 3 months and 6 months, with the thoracic exercise group being decreased significantly more than the lumbar exercise and general physiotherapy groups at 6 months (p<0.05). Conclusions: Exercise aimed at increasing thoracic mobility has an effect on lumbar stability. Furthermore, it is far more effective for lumbar stabilization than general physiotherapy and deep muscle strengthening lumbar exercise.

C6 glia 세포에서 유도성 Nitric Oxide Synthase 유전자 발현조절에 관한 연구

배진영,허강민,배소현,박지선,이충재,이재흔,석정호 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

To investigate transcriptional regulation of iNOS gene by LPS and cytokines, the production of NO, expression of iNOS mRNA and protein, binding activity of nuclear factor-kappa B(NF-kB), and promoter activity of iNOS gene were examined in rat C6 glial cells. LPS, interferon-gamma(IFN-γ), and tumor necrosis factor-alpha (TNF-α) stimulated the production of NO, which was increased synergistically by co-treatment. By the treatment of LPS, iNOS mRNA expression was initiated at 1 h, markedly increased by 3 h, and decreased gradually afterward. iNOS mRNA expression was markedly enhanced by mixture of LPS, IFN-γ and TNF-α. iNOS protein synthesis was increased by the treatment of mixture LPS and cytokine mixture. Treatment of LPS stimulated NF-kB activation, and the activation reached to the maximum level at 30 min, and the treatment of mixture of LPS and cytokines increased the activation. To determine the effect of NF-kB binding activity on iNOS promoter activation, CAT assay was performed. iNOS promoter activity was increased by the treatment with LPS for 5.5 h, and further increased by the combined treatment with LPS and cytokines. These results suggest that NF-kB activation by LPS and cytokines may play a significant role in the induction of the iNOS gene.

신경교세포 및 RAW 264.7 세포에서 Protein kinase의 활성에 의한 유도성 Nitric oxide synthase의 발현

박상철,노삼길,배소현,박지선,이충재,허강민,석정호,이재흔 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

NO(nitric oxide) plays an important role as neurotransmitter or cytokine, and pathologic factor for some diseases by the large amount production with iNOS(inducible NO synthase) expression in macrophages or glial cells. The expression of iNOS is regulated by various cytokines, protein kinases and transcription factors. In this experiment, to investigate the roles of progein kinase and NF-kB for iNOS expression, the effects of PMA(phorbol 12-myristate 13-acetate), cAMP, and various protein kinase inhibitors on LPS(lipopolysaccharide)-induced iNOS mRNAN expression and nuclear NF-kB binding complex were examined in C6 glial cells and RAW 264.7 cells. In C6 glial cells, iNOS mRNA expression by LPS was induced from 1 hour and peak at 3 hour after treatment. In RAW 264.7 cells, the mRNA was observed from 3 hour and peak at 6 hour. PMA enhanced markedly LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but did not much influence on LPS-induced iNOS mRNA expression in RAW 264.7 cells, in spite of increased LPS-induced NF-kB binding complex at 30 min. cAMP(dibutyryl cAMP) did not much influence on LPS-induced iNOS mRNA expression, by increased LPS-induced NF-kB binding complex in C6 glial cells. However, in RAW 264.7 cells, cAMP increased slightly LPS-induced iNOS mRNA expression without change of NF-kB binding complex. Staurosporine did not influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased LPS-induced iNOS mRNA expression and NF-kB binding complex. Ro-31-8220 did not much influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased significantly LPS-induced iNOS mRNA expression in spite of increased LPS-induced NF-kB binding complex for 3hours. G 6976 did not much influence on LPS-induced iNOS mRNA expression with decreased NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased iNOS mRNA expression without influence on LPS-induced NF-kB binding complex. Genistein did not influence on LPS-induced iNOS mRNA expression and NF-kB binding complex in C6 glial cells, but in RAW 264.7 cells, decreased LPS-induced iNOS mRNA expression inspite of increased NF-kB binding complex. These results suggest that LPS-induced regulation of iNOS expression or NF-kB activity in C6 glial cells, might be different from RAW 264.7 cells through various protein kinases or other factors.

골격근 근형질세망의 ATP유도 ^45Ca-uptake에 대한 Thapsigargin및 Vanillylnonanamide의 영향

황의강,배소현,홍장희,허강민,김진회,이재흔,석정호 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

To investigate the effect of thapsigargin(THP) and vanillylnonanamide(VN), derivative of capsaicin, on the ATP-induced ^45Ca-uptake in the sarcoplasmic reticulum(SR) of the skeletal muscle, the SR vesicles were prepared from the back muscle of the rabbit, and ^45Ca-uptake was carried out. The results as follows: ATP-induced ^45Ca-uptake of skeletal muscular SR was significantly increased by 1 mM ATP. It was significantly blocked by 5 μM THP, but slightly decreased by 20 μM VN. The combined effect of THP and VN on the 45Ca-uptake of the SR vesicles was much potentiated than the sum of each effect of them. The above results suggest that the action of VN, being slightly influential to ATP-induced Ca-uptake but potentiating the effect of THP on the Ca-uptake, might be related with direct perturbation of the SR membrane or exposure of the THP-binding site.

Difference of Lumbar & Lower Extremity Muscle Activity when Patients are Transferred by Physical Therapists

Jin Gang Hur,Chong Uk Park,Ju Sang Lee 대한인간공학회 2011 大韓人間工學會誌 Vol.30 No.5

Objective: The purpose of this study is to compare the muscle activities of lumbar and lower extremity muscles between left and right sides using EMG(Electromyogram) when patients are transferred by physical therapists. Background: Asymmetrical lift was recognized as a major cause of musculoskeletal disorder. Several studies show that physical therapists’ transferring patients needs caution as it could cause a lumbar pain to patients but there is not sufficient data to support. Method: Forty healthy rehabilitation hospital physical therapists joined for this study. The subjects were transferred from wheelchair to treatment mat(from left to right) by connecting the EMG device to the patients’ body both on erector spine and rectus fermoris. At the moment when subjects were being transferred, the EMG device collected data from both erector spine and rectus femoris and it was normalized as %MVC. Then the EMG data was statistically analyzed using paired t-tests. Results: The EMG data show that the left erector spinae and rectus femoris are more activated than right erector spinae and rectus femoris in all position(p<.05) in a significant degree. Conclusion: The result implies that physical therapists’ asymmetrical lifting when patients are transferred by them has a potential cause of musculoskeletal disorder of patients. Further studies will be conducted to find out a same tendency in other muscles of a body and to see if there are other factors to affect to patients during asymmetrical lifting. Application: These results can be used to provide baseline information for more understanding to asymmetrical lift loading.

정형물리치료 실기능력 향상을 위한 ADDIE(Analysis, Design, Development, Implement, Evaluation) 혼합학습 모형 개발 및 효과

허진강 ( Jin-gang Hur ),이주상 ( Ju-sang Lee ),우지혜 ( Ji-hea Woo ),남형우 ( Hyung-woo Nam ) 한국고등직업교육학회 2010 한국고등직업교육학회논문집 Vol.11 No.2·3

The purpose of this study is to see if students orthopedic physical therapy skill is improves when they use the ADDIE blended learning program that is combined with the existing instructor-led lessons which are based on e-learning and video lessons with the advantages of on and off-line courses. The instructor-led course group is organized with 24 students from March 2 to June 19 in 2008, and the ADDIE blended learning program group is organized with 27 students from March 2 to June 19 in 2009. Two groups are tested by the results of orthopedic physical therapy practical learning and course evaluation to compare the practical learning achievement and course satisfaction. The ADDIE group is significantly increased than the instructor-led group about the course preparation, the course content appropriacy, the students' understanding, the assignment quantity, the fair evaluation, and the course satisfaction in the comparative analysis of the course evaluation result differences(p <.05). According to the comparative analysis of orthopedic physical therapy practical evaluation result differences about our each body part, the ADDIE group is also significantly increased than the instructor-led group about pelvic, lumbar, thoracic, and cervical practical skills(p <.05).

발목안정화 운동이 파킨슨 환자의 정적균형능력에 미치는 효과

허진강(Hur Jin-Gang),이형진(Lee Hyung Jin),우지혜(Woo Ji-Hea) 대한치료과학회 2012 대한치료과학회지 Vol.4 No.1

Objective: In this study, unstable posture, balance disorders, gait, and looks more patients with Parkinson's disease, falls to the ankle for the prevention of static balance of the assimilation movement that affects the ability to evaluate. Method: Range of active ankle joint angles, Korean version bugs balance scale, the pressure to move the center area and the travel distance of the pre-test and 4 weeks accompanied by the movement of the fluid Mulligan dorsiflexion, plantarflexion, varus, valgus motion applied to the ankle on was once for each movements total of 5 minutes 20 minutes five times a week were conducted. Results: Range of active ankle joint angles were increased, K-BBS test before the experiment after experiment 41 points 38 points increased, the pressure to move the center area before the experiment after experiment in 2.56㎠ 0.23㎠ narrowed to 2.23㎠ move, the distance 42.19㎜ to 34.9㎜ in all experiments after experiments showed that 7.29㎜ is reduced Conclusion: The results of this study, the ankle mobilization exercises to increase the role of the muscles around the ankle joint through a static balance ability is thought to be effective in promoting.

만성 요통근로자의 흉추운동프로그램 효과

허진강 ( Jin Gang Hur ) 한국전문물리치료학회 2005 한국전문물리치료학회지 Vol.12 No.2

Association between Promoter Polymorphisms of <i>TFF1</i> , <i>TFF2</i> , and <i>TFF3</i> and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population

Jin, Eun-Heui,Lee, Sang-Il,Kim, JaeWoo,Seo, Eun Young,Lee, Su Yel,Hur, Gang Min,Shin, Sanghee,Hong, Jang Hee The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.8

Poster Session : Coordinated activation of PDK1 by tyrosine phosphorylation

( Keum Jin Yang ),( Sang Hee Shin ),( Long Zhen Piao ),( Eul Soon Shin ),( Kyung Ah Park ),( Hee Sun Byun ),( Min Ho Won ),( Gang Min Hur ),( Jeong Ho Seok ),( Brian A Hemmings ),( Jong Sun Park ) 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-