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Seo, Mi-Ran,Kim, Seong-Jong,Kim, Yeonjae,Kim, Jieun,Choi, Tae Yeal,Kang, Jung Oak,Wie, Seong-Heon,Ki, Moran,Cho, Young Kyun,Lim, Seung-Kwan,Lee, Jin Seo,Kwon, Ki Tae,Lee, Hyuck,Cheong, Hee Jin,Park, D The Korean Academy of Medical Sciences 2014 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.29 No.8
<P>With increase of multi-drug resistant <I>Escherichia coli</I> in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of <I>E. coli</I> isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 <I>E. coli</I> collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.</P><P><B>Graphical Abstract</B></P><P/>
Hydroxyl Groups in Demineralized Bone Matrix
Seo, Seog Jin,Song, Seok Beom,Chae, Ji Hwa,Kim, Jin Young,Ahn, Jae Hyoung,Kim, Tae Woon,Hwang, Ho Chan,Kim, Jin,Lee, Kwang Won,Kang, Nak Heon,Cho, Chong Su,Kang, Ke Won Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342-343 No.-
<P>Human demineralized bone matrix (DBM) containing bone morphogenetic proteins (BMPs) is naturally biocompatible and can be remodeled by patients’ own bone. The major shortcoming of many of the currently used DBM gel formulations is that they have a tendency to flow, particularly if there is continuous bleeding at the application site. In this study, the physicochemical properties of human DBM were examined to improve the efficiency of DBM formulations. DBM remarkably showed higher water absorption than nondemineralized bone powder after 150 min. Hydroxyl groups in DBM appeared in fourier transform infrared analysis, although hydroxyl band in nondemineralized bone powder was not observed. The results suggested that hydrogels such as CMC, hyaluronic acid, or poloxamer as carriers can be applied for injectable DBM products, such as gel or putty types.</P>
Seo, Hyeon Jin,Jeong, Rak Hyun,Boo, Jang-Heon,Song, Jimin,Boo, Jin-Hyo The Korean Vacuum Society 2017 Applied Science and Convergence Technology Vol.26 No.6
This study was conducted to remove $NO_x$, which is the main cause of fine dust and air pollution as well as acid rain. $NO_x$ was tested using 3% NO (diluted in He) as a simulated gas. Experiments were sequentially carried out by oxidizing NO to $NO_2$ and absorbing $NO_2$. Especially, we focused on the changes of NO oxidation according to both oxidant ($NaClO_2$) concentration change (1~10 M) and oxidant pH change (pH = 1~5) by adding HCl. In addition, we tried to suggest a method to improve $NO_2$ absorption by conducting $NO_2$ reduction reaction with reducing agent (NaOH) concentration (40~60%). It was found that NO removal efficiency increased as both concentration of oxidant and flow rate of NO gas increased, and NO decreased more effectively as the pH of hydrochloric acid added to the oxidant was lower. The $NO_2$ adsorption was also better with increasing NaOH concentration, but the NO removal efficiency was ~20% lower than that of the selective NO reduction. Indeed, this experimental method is expected to be a new method that can be applied to the capture and removal of fine dust caused by air pollution because it is a method that can easily remove NO gas by a simple device without expensive giant equipment.
Photocatalytic activity enhancement of TiO<sub>2</sub> with adding Zn particles
Seo, Hyeon Jin,Boo, Jang Heon,Jang, Hyun Woo,Kim, Mi Jeong,Boo, Jin-Hyo The Korean Vacuum Society 2016 Applied Science and Convergence Technology Vol.25 No.6
APhotocatalysis process uses ambient oxygen from air and irradiation, fundamentally UV light, to generate oxidation and reduction which can degrade almost all harmful organic and inorganic compounds to nontoxic substances. This study was focused on enhancement of photocatalytic activity which improves the photocatlytic efficiency with $TiO_2$ particle by mixing of certain amounts of Zn particles. We analyzed degradation of organic pollutant materials such as toluene and phenol with the mixed photocatalysis by using UV-visible spectrophotometer and obtained a result that photocatalytic activity is increased with increasing amount of Zn particle. Especially, in the case of $TiO_2$ (1 mmol) and Zn (0.1 mmol) mixture photocatalyst, we obtained at least 2 times higher photocatalytic activity compared with the commercially available $TiO_2$ photocatalyst (Degussa P-25), indicating that our mixed photocatalyts (Zn-doped $TiO_2$) is very effective of removing both organic dye and pollutants and the conversion rate of toluene is much faster than that of phenol.
Osteogenic Effects on Athymic Rat Calvarial Defects by Human Originated Cortical Bone
( Seog Jin Seo ),( Jae Won Heo ),( Ji Hwa Chae ),( Seong Hyun Jeon ),( Jin Kim ),( Nak Heon Kang ),( Kwang Won Lee ),( Ke Won Kang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
The purpose of this study was to evaluate effects of bone regeneration by the external sources of human bone substitutes which were developed for the transplantation. There are many different forms of bone based substitute materials. This study is focused on transplantable bone products developed by HansBiomed Inc. and some selected products, namely, human cortical bone powder, demineralized bone matrix(DBM), and bovine bone powders. SureOss and SureFuse are freeze-dried form of human cortical bone powder and DBM combined products, available from HansBiomed Corp, Korea, and Bio-Oss is the granule form of bovine bone powder by Geistlich- Pharma, Switzerland. The 4-mm critical size skull defects in athymic rats were prepared, and the defects were filled with the materials to be tested. The animals were sacrificed at 12 weeks. New bone formation was assessed by optical, radiographic and histological analyses. In our results, photographical density showed that SureOss-graft model induced the best bone formation occurring from defect edges. In summary, our findings indicate that human cortical bone powder enhances bone formation in rat model and the new products based human cortical bone powder may be a good bone substitute material for allografts.
Photocatalytic activity enhancement of TiO₂ with adding Zn particles
Hyeon Jin Seo,Jang Heon Boo,Hyun Woo Jang,Mi Jeong Kim,Jin-Hyo Boo 한국진공학회(ASCT) 2016 Applied Science and Convergence Technology Vol.25 No.6
APhotocatalysis process uses ambient oxygen from air and irradiation, fundamentally UV light, to generate oxidation and reduction which can degrade almost all harmful organic and inorganic compounds to nontoxic substances. This study was focused on enhancement of photocatalytic activity which improves the photocatlytic efficiency with TiO₂ particle by mixing of certain amounts of Zn particles. We analyzed degradation of organic pollutant materials such as toluene and phenol with the mixed photocatalysis by using UV-visible spectrophotometer and obtained a result that photocatalytic activity is increased with increasing amount of Zn particle. Especially, in the case of TiO₂ (1 mmol) and Zn (0.1 mmol) mixture photocatalyst, we obtained at least 2 times higher photocatalytic activity compared with the commercially available TiO₂ photocatalyst (Degussa P-25), indicating that our mixed photocatalyts (Zn-doped TiO₂) is very effective of removing both organic dye and pollutants and the conversion rate of toluene is much faster than that of phenol.