Electron-Electron Interactions in a Two-Dimensional Electron Systemin an Al0.15Ga0.85N/GaN Heterostructure Grown on p-Type Si

Jian-Zhe Huang,Li-Hung Lin,Chin-An Chang,Chi-Te Liang,Kuang Yao Chen,Kui-Ming Chen,N. C. Chen,P. H. Chang,Shiou-Shian Han,Zhi-Hao Sun 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.3

We report on experimental studies of an Al$_{0.15}$Ga$_{0.85}$N/GaN high-electron-mobility transistor structure grown on a $p$-type Si (111) substrate. This structure is compatible with complementary metal-oxide-semiconductor (CMOS) technology and, thus, has great potential device applications. The low-temperature magnetoresistivity shows a parabolic dependence on the applied perpendicular magnetic field. This effect is ascribed to electron-electron interaction (EEI) effects in a weakly-disordered two-dimensional system. Our experimental results agree with the EEI theory when the correction term in the ballistic region has been subtracted.

Structural dynamic optimization with probability constraints of frequency and mode

Jian-jun Chen,Jian-wenChe,Huai-anSun,Hong-boMa,Ming-taoCui 국제구조공학회 2002 Structural Engineering and Mechanics, An Int'l Jou Vol.14 No.6

Listeria monocytogenes Serovar 4a is a Possible Evolutionary Intermediate Between L. monocytogenes Serovars 1/2a and 4b and L. innocua

Jian Shun Chen,Ling Li Jiang,Xue Yan Chen,Xiao Kai Luo,Yang Chen,Ying Yu,Guo Ming Tian,Dong You Liu,Wei Huan Fang 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.3

Analysis of Small Fragment Deletions of the APC gene in Chinese Patients with Familial Adenomatous Polyposis, a Precancerous Condition

Chen, Qing-Wei,Zhang, Xiao-Mei,Zhou, Jian-Nong,Zhou, Xin,Ma, Guo-Jian,Zhu, Ming,Zhang, Yuan-Ying,Yu, Jun,Feng, Ji-Feng,Chen, Sen-Qing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: : Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease mainly caused by mutations of the adenomatous polyposis coli (APC) gene with almost complete penetrance. These colorectal polyps are precancerous lesions that will inevitable develop into colorectal cancer at the median age of 40-year old if total proctocolectomy is not performed. So identification of APC germline mutations has great implications for genetic counseling and management of FAP patients. In this study, we screened APC germline mutations in Chinese FAP patients, in order to find novel mutations and the APC gene germline mutation characteristics of Chinese FAP patients. Materials and Methods: The FAP patients were diagnosed by clinical manifestations, family histories, endoscope and biopsy. Then patients peripheral blood samples were collected, afterwards, genomic DNA was extracted. The mutation analysis of the APC gene was conducted by direct polymerase chain reaction (PCR) sequencing for micromutations and multiplex ligation-dependent probe amplification (MLPA) for large duplications and/or deletions. Results: We found 6 micromutations out of 14 FAP pedigrees, while there were no large duplications and/or deletions found. These germline mutations are c.5432C>T(p. Ser1811Leu), two c.3926_3930delAAAAG (p.Glu1309AspfsX4), c.3921_3924delAAAA (p.Ile1307MetfsX13), c3184_3187delCAAA(p.Gln1061AspfsX59) and c4127_4126delAT (p.Tyr1376LysfsX9), respectively, and all deletion mutations resulted in a premature stop codon. At the same time, we found c.3921_3924delAAAA and two c.3926_3930delAAAAG are located in AAAAG short tandem repeats, c3184_3187delCAAA is located in the CAAA interrupted direct repeats, and c4127_4128 del AT is located in the 5'-CCTGAACA-3', 3'-ACAAGTCC-5 palindromes (inverted repeats) of the APC gene. Furthermore, deletion mutations are mostly located at condon 1309. Conclusions: Though there were no novel mutations found as the pathogenic gene of FAP in this study, we found nucleotide sequence containing short tandem repeats and palindromes (inverted repeats), especially the 5 bp base deletion at codon 1309, are mutations in high incidence area in APC gene,.

Structural dynamic optimization with probability constraints of frequency and mode

Chen, Jian-Jun,Che, Jian-Wen,Sun, Huai-An,Ma, Hong-Bo,Cui, Ming-Tao Techno-Press 2002 Structural Engineering and Mechanics, An Int'l Jou Vol.13 No.5

The structural dynamic optimization problem based on probability is studied. Considering the randomness of structural physical parameters and the given constraint values, we develop a dynamic optimization mathematical model of engineering structures with the probability constraints of frequency, forbidden frequency domain and the vibration mode. The sensitivity of structural dynamic characteristics based on probability is derived. Two examples illustrate that the optimization model and the method applied are rational and efficient.

Experimental study on cold-formed lipped channel stub columns reinforced by steel bars or steel strips

Jian-Feng Chen,Ming-Qi Chen,Yong-Kang Shen,Jian-Hua Shao,Xin-Xin Yang 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.3

In this paper, the axial compressive properties of cold-formed steel lipped channel stub columns strengthened by rebars or steel strips are experimentally studied. The experiment included two sections. A kind of columns with local buckling is reinforced longitudinally by steel strips at the web. The other is the columns with distorted buckling, which is reinforced longitudinally by steel bars at the curling edge. The failure mode, deformation characteristics, ultimate bearing capacity and load displacement curve of the specimen are obtained through the experiment. On the basis of the experiment, the calculation results of theoretical axial bearing capacity of cold-formed steel lipped channel stub columns in Chinese, North American and Australian code are compared and analyzed. Research indicates: First, the cold-formed steel lipped channel stub columns strengthened by steel bars or steel strips can effectively improve the compressive bearing capacity of the specimen. Secondly, when the initial stress ratio of specimen is less than 0.3, the reinforcement effect is ideal. Thirdly, the three standards don’t stipulate the calculation of theoretical bearing capacity of the specimen strengthened after loading, so there is a large deviation between the theoretical calculation value and the test value.

Microwave-assisted synthesis of organic/inorganic hybrid composites with gas barrier and heat-dissipating capability and their application for the encapsulation of top-emitting organic light emitting diodes (TEOLEDs)

Jian-Shian Lin,Ming-Hua Chung,Chen-Ming Chen,Fuh-Shyang Juang,Yu-Sheng Tsai,Shu-Wei Chang,Shun-Hsi Wang,Teh-Chao Liao,Lung-Chang Liu 한국물리학회 2010 Current Applied Physics Vol.10 No.5

UV-curable organic/inorganic hybrid composites with gas barrier and heat-dissipating capability have been successfully fast synthesized with microwave irradiation and utilized for the encapsulation of top-emitting organic light-emitting diodes (TEOLEDs). Experimental results manifest that lab-made organic/inorganic hybrid composites can effectively not only obstruct the invasion of moisture as well as oxygen in the atmosphere into the device but also lower the temperature of device. Therefore, the lifetimes of TEOLEDs with their encapsulation are 2.2 folds longer than those without encapsulation.

Long Term Outcomes and Prognostic Factors of N₀ Stage Nasopharyngeal Carcinoma: a Single Institutional Experience with 610 Patients

Sun, Jian-Da,Chen, Chuang-Zhen,Chen, Jian-Zhou,Li, Dong-Sheng,Chen, Zhi-Jian,Zhou, Ming-Zhen,Li, De-Rui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Treatment responses of $N_0$ stage nasopharyngeal carcinoma were firstly analyzed comprehensively to evaluate long term outcomes of patients and identify prognostic factors. A total of 610 patients with $N_0$ NPC, undergoing definitive radiotherapy to their primary lesion and prophylactic radiation to upper neck, were reviewed retrospectively. Concomitant chemotherapy was administrated to 65 out of the 610. Survival rates of the patients were calculated using the Kaplan-Meier method and compared by log-rank test. Prognostic factors were identified by the Cox regression model. The study revealed the 5-year and 10-year overall, disease-free, disease-specific, local failure-free, regional failure-free, locoregional failure-free and distant metastasis-free survival rates to be 78.7% and 66.8%, 68.8% and 55.8%, 79.9% and 70.4%, 81.2% and 72.5%, 95.8% and 91.8%, 78.3% and 68.5%, 88.5% and 85.5%, respectively. There were 192 patients experiencing failure (31.5%) after radiotherapy or chemoradiotherapy. Of these, local recurrence, regional relapse and distant metastases as the first event of failure occurred in 100 (100/610, 16.4%), 15(15/610, 2.5%) and 52 (52/610, 8.5%), respectively. Multivariate analysis showed that T stage was the only independent prognostic factor for patients with $N_0$ NPC (P=0.000). Late T stage (P=0.000), male (P=0.039) and anemia (P=0.007) were independently unfavorable factors predicting disease-free survival. After treatment, satisfactory outcome wasgenerally achieved in patients with $N_0$ NPC. Local recurrence represented the predominant mode of treatment failure, while T stage was the only independent prognostic factor for overall survival. Late T stage, male gender, and anemia independently predicted lower possibility of the disease-free survival.

포스트모던 도예의 하이브리드적 유형 분석

천지엔명(Chen Jian ming),이명순(Lee Myung soon) 한국조형디자인학회 2018 조형디자인연구 Vol.21 No.3

하이브리드 기법은 20세기 이후로 포스트모던 도예에서 탈 중심지향성, 상호텍스트성, 파편화 등의 의미로 해석되던 것이 21세기에 와서는 근본적으로 서로 다른 사물들의 결합, 융합 등 그 의미상 확대와 심화가 동시에 일어나고 있다. 그 기법은 제작과정인 태토, 성형, 시유 및 소성에서 이질적인 요소들이 상호 결합해서 다양한 유형을 창출하고 있는데, 본 연구자는 그것을 네 가지로 구분, 분석하였다. 첫째 유형은 인체, 동물, 사물 간의 이종 형태들의 결합으로서 그리스, 로마 신화에서 동물 머리와 인간 신체, 혹은 동물 얼굴과 인간 다리 등의 결합이 대표적이다. 중국의『산해경』에서도 인간과 짐승의 결합형, 짐승과 짐승의 결합형 등의 반인반승을 언급했으며, 민경익, 성동훈, 권나리와 노트킨의 작품들도 논하였다. 둘째 유형은 재료 결합형 하이브리드 도예로서 고전적인 그릇의 형태와 현대적 색감의 시유, 하이브리드 몽타주 기법, 현대사회 아이콘의 차용, 성적임 등의 페미니즘, 제 예술 영역 사이의 교류와 융합, 다국적인 문화의 융합 등을 주제나 표현소재로 다루었다. 그리고 이와 관련된 신미경, 한, 윤영수, 오펜하임, 이수경, 탕의 작품을 제시, 분석하였다. 셋째 유형은 매체 결합형 하이브리드 도예로서 미디어의 활용을 통한 과학과 예술의 접목, 도자와 직조의 결합, 도예와 음악의 만남, 순수미술과 디자인의 만남 등 제 예술의 영역에서 판이한 특성을 가진 매체들의 결합이나 융합을 시도한 것이다. 그리고 이와 관련된 양민하, 이은주, 치마티의 작품을 제시, 분석하였다. 넷째 유형은 행위 예술형 하이브리드 도예로서 작품의 제작과정 중에서 특히 성형이나 시유과정을 순수미술의 입장에서나 아니면 사회문화적 현상을 융합하여 클로즈업시키는 등의 콘텐츠를 작가가 행위예술로 시연하고, 거기에 음악 등 다른 예술 영역을 가미함으로써 색다른 융합으로서의 하이브리드 기법을 선보였다. 그리고 이와 관련된 이강효, 맥크라켄, 호울레, 브라운스워드, 케리트 랭리쉬-스미스의 작품을 제시, 분석하였다. Hybrid, from the 21st century, became to be interpreted as being meant of de-centeredness, inter-textuality, fragmentarizaton, etc., and simultaneously brought about the expansion and deepening in their significance like a fundamental combination, integrity, etc. of mutually different objects. Its technique of this kind creates various types by dint of a mutual combination of different elements of Postmodern ceramics in their making processes, that is, clay, formation, glazing, and firing, which I divided it into four, and analyzed them. First type is related with a combination of hybridization among man, animal, and object, frequently appearing as examples combining animal’s head with man’s body, or animal’s face with man’s legs, etc. as in Greek, Rome mythology. There are also several examples from Shan Hai Jing containing many Chinese myths, indicating a semi-animal or a semi-man type, a combined form of man with animal, of animal with animal, etc. Additionally, I attempted to prove it with the artworks by Min Gyeong-ik, Seong Dong-hoon, Kwon Na-ri and R. Notkin. Second type is a material-combined type of hybrid ceramics, and I treated the form of classical vessels and glazing of modern colors, hybrid montage technique, borrowing of icons of contemporary society, Feminism of sexuality, exchange and integrity between the disciplines, integrity of multinational cultures as theme or subject-matters. And I suggested and analyzed the ceramics by Shin Mi-kyung, D. Han, Yoon Young-soo, M. Oppenheim, Lee Su-kyung, and B. L. S. Tang. Third type is a medium-combined type of hybrid ceramics, and I analyzed the artworks that proceeded to a combination or integrity of media with different characters in the field of art genre such as an implantation of science with art, a unification of ceramic art with weaving, a meeting of ceramics with music, an encounter of fine art with design, etc. through the usage of the media. And I suggested and analyzed the ceramics by Yang Min-ha, Lee Eun-ju, and A. Cimatti. Fourth type is a performance-typed hybrid ceramics, and the artists displayed the contents to close-up the formation or glazing especially among the making processes of ceramics either from the standpoint of fine art or from a combination with sociocultural phenomenon, to which they represented a hybrid technique as a unique integrity by adding other art genre such as music, etc. I suggested and analyzed the ceramics by Lee Kang-hyo, J. J. McCraken, N. Hole, N. Brownsword, and Kate Langrish-Smith.

The Prognostic Value of Treatment-Related Lymphopenia in Nasopharyngeal Carcinoma Patients

Li-Ting Liu,Qiu-Yan Chen,Lin-Quan Tang,Shan-Shan Guo,Ling Guo,Hao-Yuan Mo,Ming-Yuan Chen,Chong Zhao,Xiang Guo,Chao-Nan Qian,Mu-Sheng Zeng,Jin-Xin Bei,Jing Tan,Shuai Chen,Ming-Huang Hong,Jian-Yong Shao 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1

Purpose This study was conducted to evaluate the prognostic value of treatment-related lymphopenia in patients with nasopharyngeal carcinoma (NPC). Materials and Methods A total of 413 consecutive stage II-IVb NPC patients treated with concurrent chemoradiotherapy (CCRT) were enrolled. The overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) were calculated with the Kaplan-Meier method, and differences were compared using the log-rank test. Results A minimum (mini)–absolute lymphocyte counts (ALC) of < 390 cells/μL or ALC after 3 months of CCRT (post3m-ALC) < 705 cells/μL was significantly associated with worse outcome than mini-ALC ! 390 cells/μL (OS, p=0.002; PFS, p=0.005; DMFS, p=0.004) or post3m-ALC ! 705 cells/μL (OS, p < 0.001; PFS, p < 0.001; DMFS, p=0.001). Patients with lymphopenia (mini-ALC < 390 cells/μL and post3m-ALC < 705 cells/μL) had a worse prognosis than those without lymphopenia (mini-ALC ! 390 cells/μL and post3m-ALC ! 705 cells/μL) (OS, p < 0.001; PFS, p < 0.001; DMFS, p < 0.001). Multivariate analysis revealed that post3m-ALC was an independent prognostic factor for OS (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.12 to 2.78; p=0.015), PFS (HR, 1.86; 95% CI, 1.23 to 2.82; p=0.003), and DMFS (HR, 1.87; 95% CI, 1.13 to 3.08; p=0.014). Multivariate analysis also revealed that patients with lymphopenia had a high risk of death (HR, 3.79; 95% CI, 1.75 to 8.19; p=0.001), disease progression (HR, 2.93; 95% CI, 1.59 to 5.41; p=0.001), and distant metastasis (HR, 3.89; 95% CI, 1.67 to 9.10; p=0.002). Multivariate analysis performed with time dependent Cox regression demonstrated ALC was an independent prognostic factor for OS (HR, 0.995; 95% CI, 0.991 to 0.999; p=0.025) and PFS (HR, 0.993; 95% CI, 0.988 to 0.998; p=0.006). Conclusion Treatment-related lymphopenia was a poor prognostic factor in NPC patients.