Distinctions Between Clinicopathological Factors and Prognosis of Alpha-fetoprotein Negative and Positive Hepatocelluar Carcinoma Patients

Xu, Jia,Liu, Chang,Zhou, Lei,Tian, Feng,Tai, Ming-Hui,Wei, Ji-Chao,Qu, Kai,Meng, Fan-Di,Zhang, Ling-Qiang,Wang, Zhi-Xin,Zhang, Jing-Yao,Chang, Hu-Lin,Liu, Si-Nan,Xu, Xin-Shen,Song, Yan-Zhou,Liu, Jun,Z Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP ${\leq}$20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.

중국 유학생의 사용성 향상을 위한 부동산 UI/UX 디자인 연구

가욱휘(Xu-Hui Jia),송지성(Ji-Sung Song) 한국공공디자인학회 2024 공공디자인연구 Vol.12 No.-

최근 몇 년간 한국 유학을 선택하는 중국 유학생의 수가 지속적으로 증가하고 있으며, 유학생들은 한국 생활에서 주로 주거 문제를 직면한다. 모바일 애플리케이션은 현재 한국에서 주택 매물을 구할 때 중요한 수단으로 자리 잡은 반면, 중국 유학생의 경우 외국인 타깃 기능 부족과 언어 장벽으로 인해 사용자 경험에 대한 만족도가 상대적으로 낮았다. 본 연구는 한국 부동산 애플리케이션을 사용하는 유학생들의 문제점을 해결하고 중국 유학생의 사용 경험을 개선하는 것을 목표로 하며, 모바일 앱 데이터 분석 네트워크에서 발표한 20대의 사용 비중이 높은 부동산 애플리케이션 직방과 다방을 연구 대상으로 선정하고 관련 문헌 분석과 설문조사를 실시하였다. 설문조사 결과 분석을 통해 국내 부동산 애플리케이션의 문제점을 파악하고, 이를 바탕으로 직방의 오리지널 디자인을 기반으로 기능, 콘텐츠, 그리고 인터페이스 구성의 세 가지 측면에서 디자인 개선 방안을 제안하였다. 이에 본 연구는 한국 대표 부동산 애플리케이션이 외국인을 타깃으로 사용성을 효과적으로 향상시킬 수 있도록 새로운 관점을 제시하였다. According to the data, the choice of Chinese students to study in South Korea has shown a continuous growth trend in recent years. Housing is the primary problem to solve, and searching for suitable housing through mobile phones has become an important way to find housing. However, for Chinese overseas students, the user experience satisfaction of this group is relatively low due to the lack of targeted functions and language barrier. Therefore, the purpose of this study is to solve the pain points of using Korean real estate application software for international students and improve the usability of Chinese international students. The scope of the study selected Zigbang and Dabang, real estate applications with a high proportion of young people using real estate applications published by Mobile Application Data Analysis Network, as the analysis object. Research methods Through literature analysis and questionnaire survey, the existing problems of real estate application software in South Korea were obtained from the results of the questionnaire survey, and effective improvement ideas were put forward. Based on the original design of Zigbang, the author improved the design from the three aspects of function composition, content composition and interface composition, thus solving the pain points existing in the use of Chinese students, and further improving the user experience of South Korea real estate app.

Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-kB signaling pathway

Xiang Xu,Yu-Nan Lu,Jia-Hui Cheng,Hui-Wen Lan,Jing-Mei Lu,Guang-Nan Jin,Guang-Hua Xu,Cheng-Hua Jin,Juan Ma,Hu-Nan Piao,Xuejun Jin,Lian-Xun Piao 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1

Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated with various mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kB) signaling pathway. GRh2 also alleviated tumor-associated or lipopolysaccharide-induced depression. However, the effects and potential mechanisms of GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondii infection during pregnancy have not been investigated. Methods: We examined GRh2 effects on the depression-like behavior in mouse offspring, caused by maternal T. gondii infection during pregnancy, by measuring depression-like behaviors and assaying parameters at the neuronal and molecular level. Results: We showed that GRh2 significantly improved behavioral measures: sucrose consumption, forced swim time and tail suspended immobility time of their offspring. These corresponded with increased tissue concentrations of 5-hydroxytryptamine and dopamine, and attenuated indoleamine 2,3-dioxygenase or enhanced tyrosine hydroxylase expression in the prefrontal cortex. GRh2 ameliorated neuronal damage in the prefrontal cortex. Molecular docking results revealed that GRh2 binds strongly to both TLR4 and high mobility group box 1 (HMGB1). Conclusion: This study demonstrated that GRh2 ameliorated the depression-like behavior in mouse offspring of maternal T. gondii infection during pregnancy by attenuating the excessive activation of microglia and neuroinflammation through the HMGB1/TLR4/NF-kB signaling pathway. It suggests that GRh2 could be considered a potential therapy in preventing and treating psychiatric disorders in the offspring mice of mothers with prenatal exposure to T. gondii infection.

Characteristics of SiC inverter powertrains on common-mode EMI noise

Jia, Xiaoyu,Dong, Bitao,Wang, Hui,Hu, Changsheng,Xu, Dehong The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.2

This paper studies the characteristics of SiC inverter powertrains on common-mode (CM) EMI emission. First, a CM noise source model of an EV powertrain is built. Then, the factors of switching frequency, switching speed, and switching ringing on the CM noise source are analyzed. Finally, experiments on a conducted EMI test-bed are carried out to verify the influence of SiC inverters on conducted CM EMI emission in EV powertrains.

Metabolic dynamics across prolonged diapause development in larvae of the sawfly, Cephalcia chuxiongica (Hymenoptera: Pamphiliidae)

Xu Rong,Chen Yu-Hui,Xia Ju-Fei,Zeng Ting-Xiao,Li Yong-He,Zhu Jia-Ying 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.2

Nutrient metabolism is crucial for the survival of insects through the diapause. However, little is known about the metabolic mechanism of prolonged diapause. The sawfly, Cephalcia chuxiongica (Hymenoptera: Pamphilii�dae), is a notorious defoliator of pine trees in southwest China. One of the distinguishing biological character�istics of this pest is the prolonged diapause of about 1.5 years. In this study, the body lipid, carbohydrate (total body sugar, glycogen, trehalose, and glucose), protein, and glycerol contents were measured in diapausing larvae of C. chuxiongica. The results showed that the changes of biochemical composition in C. chuxiongica are asso�ciated with the diapause initiation, maintenance, and termination phases. During the initiation phase, trehalose, glucose, and glycerol increased significantly, but glycogen decreased sharply. In general, the lipid, carbohydrate, and glycerol levels decreased gradually across the maintenance phase. At termination phase, the contents of glycogen and lipid persistently decreased, while an increase of trehalose, glucose, and glycerol contents were detected. The protein level was significantly higher at maintenance phase than at initiation and termination phases. It was also found that elevation of trehalose, glucose, and glycerol contents occurred in winter. These implies that the metabolites with altered levels in diapausing larvae of C. chuxiongica are responsible for maintaining a prolonged development and overwintering.

Optimal SVM learning method based on adaptive sparse sampling and granularity shift factor

Hui Wen,Dongshun Jia,Zhiqiang Liu,Hang Xu,Guangtao Hao 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.4

To improve the training efficiency and generalization performance of a support vector machine (SVM) in a large-scale set, an optimal SVM learning method based on adaptive sparse sampling and the granularity shift factor is presented. The proposed method combines sampling optimization with learner optimization. First, an adaptive sparse sampling method based on the potential function density clustering is designed to adaptively obtain sparse sampling samples, which can achieve a reduction in the training sample set and effectively approximate the spatial structure distribution of the original sample set. A granularity shift factor method is then constructed to optimize the SVM decision hyperplane, which fully considers the neighborhood information of each granularity region in the sparse sampling set. Experiments on an artificial dataset and three benchmark datasets show that the proposed method can achieve a relatively higher training efficiency, as well as ensure a good generalization performance of the learner. Finally, the effectiveness of the proposed method is verified.

Betulin Targets Lipin1/2-Meidated P2X7 Receptor as a Therapeutic Approach to Attenuate Lipid Accumulation and Metaflammation

( Jia-yi Dou ),( Yu-chen Jiang ),( Zhong-he Hu ),( Kun-chen Yao ),( Ming-hui Yuan ),( Xiao-xue Bao ),( Mei-jie Zhou ),( Yue Liu ),( Zhao-xu Li ),( Li-hua Lian ),( Ji-xing Nan ),( Yan-ling Wu ) 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.3

The present study focused on the potential mechanism of betulin (BT), a pentacyclic triterpenoid isolated from the bark of white birch (Betula pubescens), against chronic alcohol-induced lipid accumulation and metaflammation. AML-12 and RAW 264.7 cells were administered ethanol (EtOH), lipopolysaccharide (LPS) or BT. Male C57BL/6 mice were fed Lieber-DeCarli liquid diets containing 5% EtOH for 4 weeks, followed by single EtOH gavage on the last day and simultaneous treatment with BT (20 or 50 mg/kg) by oral gavage once per day. In vitro, MTT showed that 0-25 mM EtOH and 0-25 μM BT had no toxic effect on AML-12 cells. BT could regulate sterolregulatory-element-binding protein 1 (SREBP1), lipin1/2, P2X7 receptor (P2X7r) and NOD-like receptor family, pyrin domains-containing protein 3 (NLRP3) expressions again EtOH-stimulation. Oil Red O staining also indicated that BT significantly reduced lipid accumulation in EtOH-stimulated AML-12 cells. Lipin1/2 deficiency indicated that BT might mediate lipin1/2 to regulate SREBP1 and P2X7r expression and further alleviate lipid accumulation and inflammation. In vivo, BT significantly alleviated histopathological changes, reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and triglyceride (TG) levels, and regulated lipin1/2, SREBP1, peroxisome proliferator activated receptor α/γ (PPARα/γ) and PGC-1α expression compared with the EtOH group. BT reduced the secretion of inflammatory factors and blocked the P2X7r-NLRP3 signaling pathway. Collectively, BT attenuated lipid accumulation and metaflammation by regulating the lipin1/2-mediated P2X7r signaling pathway.

Discovering Station Patterns of Urban Transit Network with Multisource Data: Empirical Evidence in Jinan, China

Hui Zhang,Xu Li,Lele Zhang,Wei Wang,Jianmin Jia,Baiying Shi 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.2

The various performances of buses at stations bring lots of difficulties for operators to manage them to improve the service quality. This paper proposes a data-driven framework to analyze the patterns of stations with network structure data, points of interest (POI) data and vehicle global positioning system (GPS) trajectory data. First, we build six indicators based on these data to measure the performance from station perspective. The results show that the number of POI around stations within 1 kilometer follows an exponential distribution. Moreover, the average headway and headway deviation of stations follow lognormal distributions. Second, we use agglomerative hierarchical clustering method to divided bus stations into different groups. Results indicate that the bus stations of Jinan could be divided into four groups with obvious characteristics. The findings could help operators to make exclusive strategies to manage bus systems.

Lightweight and Ultrastrong Polymer Foams with Unusually Superior Flame Retardancy

Xu, Linli,Xiao, Linhong,Jia, Pan,Goossens, Karel,Liu, Peng,Li, Hui,Cheng, Chungui,Huang, Yong,Bielawski, Christopher W.,Geng, Jianxin American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.31

<P>High-performance flame-retardant materials are urgently needed to address outstanding issues that pertain to safety. Traditional flame retardants are toxic to the environment and/or lack the physical properties required for use in many contemporary applications. Here, we show that isocyanate-based polyimide (PI) foam, a flammable material, can exhibit unusually superior flame retardancy as well as, other excellent properties, such as being lightweight and displaying high mechanical strength, by incorporating red phosphorus (RP)-hybridized graphene. The covalent bonds formed between the graphene platelets and the PI matrix provide the resultant PI foam with a specific Young's modulus (83 kNm kg(-1)) that is comparable to or even higher than those displayed by state-of-the-art foams, including silica aerogels, polystyrene foams, and polyurethane foams. In addition, even a low content of the RP -hybridized graphene (2.2 wt %) results in an exceptionally higher limiting oxygen index (39.4) than those of traditional flame-retardant polymer-based materials (typically 20-30). The resultant PI foam also exhibits thermal insulation properties that are similar to that of air. Moreover, the RP -hybridized graphene is prepared using a one-step ball milling process in 100% yield, and does not require solvent or produce waste. The preparation of the flame-retardant PI foams can be scaled as the starting materials are commercially available and the techniques employed are industrially compatible.</P>

Simultaneous Information and Power Transfer for Multi-antenna Primary-Secondary Cooperation in Cognitive Radio Networks

Zhi Hui Liu,Wen Jun Xu,Sheng Yu Li,Cheng Zhi Long,Jia Ru Lin 한국전자통신연구원 2016 ETRI Journal Vol.38 No.5

In this paper, cognitive radio and simultaneous wireless information and power transfer (SWIPT) are effectively combined to design a spectrum-efficient and energy-efficient transmission paradigm. Specifically, a novel SWIPT-based primary-secondary cooperation model is proposed to increase the transmission rate of energy/spectrum constrained users. In the proposed model, a multi-antenna secondary user conducts simultaneous energy harvesting and information forwarding by means of power splitting (PS), and tries to maximize its own transmission rate under the premise of successfully assisting the data delivery of the primary user. After the problem formulation, joint power splitting and beamforming optimization algorithms for decode-and-forward and amplify-and-forward modes are presented, in which we obtain the optimal PS factor and beamforming vectors using a golden search method and dual methods. Simulation results show that the proposed SWIPTbased primary-secondary cooperation schemes can obtain a much higher level of performance than that of non-SWIPT cooperation and non-cooperation schemes.