http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jia Guo Geng (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Extraction of parishin B and parishin C from Gastrodiae Rhizoma by subcritical water technology
Guozhen Wu,Hongjing Dong,Jia Li,Lanping Guo,Yan Cheng,Yanling Geng,Xiao Wang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
Subcritical water extraction (SWE) was used to extract bioactive parishin B (PB) and parishin C (PC) fromGastrodiae Rhizoma. Extraction conditions were optimized by Box-Behnken design (BBD) of responsesurface methodology (RSM). The highest yield of PB was 7.46 ± 0.18 mg/g when the solid/liquid ratio(SLR) was 4.5 mg/mL at an extraction temperature of 118 C and extraction time of 50 min, and the highestyield of PC was 5.27 ± 0.07 mg/g when the SLR was 22 mg/mL at an extraction temperature of 145 Cand extraction time of 23 min. Compared with heating reflux extraction the yield of PB was about 1.3times higher, and that of PC about 2.6 times higher; Compared with ultrasound assisted extraction theyield of PB was about 3 times higher, and that of PC about 6 times higher. Degradation of parishin Aby SWE showed that the increasing mechanism of PB and PC mainly attributed to the conversion of PAinto PB and PC. This study suggests that SWE was an efficient and green way to extract natural productswith greater values.
-
Li-jun Liang,Chen-xi Hu,Yi-xuan Wen,Xiao-wei Geng,Ting Chen,Guo-qing Gu,Lei Wang,You-you Xia,Yong Liu,Jia-yan Fei,Jie Dong,Feng-hua Zhao,Yiliyar Ahongjiang,Kai-yuan Hui,Xiao-dong Jiang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma. Materials and Methods Lewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed. Results For the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved. Conclusion Our results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR.
-
CCDC26 Gene Polymorphism and Glioblastoma Risk in the Han Chinese Population
Wei, Xiao-Bing,Jin, Tian-Bo,Li, Gang,Geng, Ting-Ting,Zhang, Jia-Yi,Chen, Cui-Ping,Gao, Guo-Dong,Chen, Chao,Gong, Yong-Kuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: Glioblastoma (GBM) is an immunosuppressive tumor whose median survival time is only 12-15 months, and patients with GBM have a uniformly poor prognosis. It is known that heredity contributes to formation of glioma, but there are few genetic studies concerning GBM. Materials and Methods: We genotyped six tagging SNPs (tSNP) in Han Chinese GBM and control patients. We used Microsoft Excel and SPSS 16.0 statistical package for statistical analysis and SNP Stats to test for associations between certain tSNPs and risk of GBM in five different models. ORs and 95%CIs were calculated for unconditional logistic-regression analysis with adjustment for age and gender. The SHEsis software platform was applied for analysis of linkage disequilibrium, haplotype construction, and genetic associations at polymorphism loci. Results: We found rs891835 in CCDC26 to be associated with GBM susceptibility at a level of p=0.009. The following genotypes of rs891835 were found to be associated with GBM risk in four different models of gene action: i) genotype GT (OR=2.26; 95%CI, 1.29-3.97; p=0.019) or GG (OR=1.33; 95%CI, 0.23-7.81; p=0.019) in the codominant model; ii) genotypes GT and GG (OR=2.18; 95%CI, 1.26-3.78; p=0.0061) in the dominant model; iii) GT (OR=2.24; 95%CI, 1.28-3.92; p=0.0053) in the overdominant model; iv) the allele G of rs891835 (OR=1.85; 95%CI, 1.14-3.00; p=0.015) in the additive model. In addition, "CG" and "CGGAG" were found by haplotype analysis to be associated with increased GBM risk. In contrast, genotype GG of CCDC26 rs6470745 was associated with decreased GBM risk (OR=0.34; 95%CI, 0.12-1.01; p=0.029) in the recessive model. Conclusions: Our results, combined with those from previous studies, suggest a potential genetic contribution of CCDC26 to GBM progression among Han Chinese.
-
Hyun A Jang,May Moe Oo,Dae-Gyu Kim,Ha-Yeon Yoon,Mi-Reu Kim,Kyo-Sang Lee,Khaing Shwe Zin Thinn,Saima Arif,Jia Guo Geng,Ji-Young Min,Dong Jun Lim,허윤영,오상근 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.5
Grape ripe rot is a fungal disease, which is almost inextinguishable particularly before and after harvest in most vineyards. The management of this disease largely depends on the breeding of resistant varieties. Thus, the search for resistant varietiesshould parallel the molecular analysis of the markers associated with disease resistance. Here, we tested the leaf inoculationassay of Colletotrichum acutatum and C. gloeosporioides by inoculating them into 350 grapevine varieties. As a resultof the phenotypes common to both species, 119 varieties (34%) were classifi ed as resistant. Consequently, we discoveredthe locus with nucleotide-binding sites and carboxyterminal leucine-rich repeat regions ( NBS-LRR ) associated with graperipe rot resistance through genotyping-by-sequencing and genome-wide association study. Ultimately, we identifi ed theVitis vinifera Colletotrichum resistance protein ( VvCRP ) markers from chromosome 3, which belongs to the CC-NBS-LRRtype, as disease-resistant proteins. These markers were verifi ed as the melting peak, and their chromatograms of nucleotidesequences were visualized in each single nucleotide polymorphism (SNP) loci. All the SNP markers diff erentiated successfullythe resistant from the susceptible cultivars. Interestingly, we also found that a resistant cultivar named Bailey AlicanteA has a heterozygous genotype, substantiating its potential usefulness for crops such as grapevine with many hybrids. Altogether,our results indicate that VvCRP markers can be utilized to distinguish grape ripe rot-resistant cultivars, particularlyin crossbreeding populations.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
