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정신분열병의 유전적 고위험군에서 인지, 정서 및 사회기능 연구
이경진,위휘,유소영,이애라,송지연,하태현,홍경수,김명선,권준수 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1
Objectives : Vulnerability marker in biological relatives of schizophrenia may be very useful in identifying the propensity for the development of schizophrenia. This study suggests that the relatives at risk for genetically developing schizophrenia have impairments in several domains of cognition, social function and affective function as a vulnerability marker. Methods : A neurocognitive function test, a social function test and an affective function test were administered to fifteen healthy relatives from families with two or more patients with schizophrenia (geneticallly high risk subjects). Fifteen healthy controls matched for age and gender were recruited in this study. Results : Compared to the control subject, the genetic high risk subjects performed significantly more poorly in the selective attention and recall memory of neurocognitive function. The high dsk subjects also had lower scores in independence-performance and independence-competence of the social function test and emotion control of the affective function test. Conclusion : Selective attention, recall memory, independence-performance, independence-competence and emotion control ability may be a valuable marker for genetic study of schizophrenia.
Kwon, Tae Hyuk,Lee, So Young,Lee, Ji Hye,Choi, Jae Sue,Kawabata, Shun-ichiro,Iwanaga, Sadaaki,Lee, Bok Luel 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-
Prophenoloxidase(pro-PO), a precursor of phenol oxidase(PO), was purified from the hemolymph of coleoptrean Holotrichia diomphalia larvag. The enzyme was purified to apparent homogeneity, in six steps of chromatorgraphy, using Sephadex G-100, CM-52, Dextran-sulfate Sepharose CL-6B, Phenly Sepharose CL-4B, Sephacryl S-200, and a Mono-Q column. The preparation exhibited a single band on SDS-PAGE. The proenzyme had a molecular weight of 158 kDa, as estimated by gel filtration. On SDS-PAGE under reducting. On the other hand, the purified pro-PO gave two well-separated peaks, named pro-PO-1 and pro-PO-2, on reverse-phase HPLC. Amino acid compositions of both proteins were indistinguishable, thereby suggesting the presence of an allelic variant or an isoprotein. On dextran-sulfate Sepharose CL-6B chromatorgraphy, a fraction containing pro-phenoloxidase activating enzyme(S)(PPAE fraction), free from pro-PO, was also separated. In reconstitution experimentsm, the astivation of purified pro-PO by PPAE fraction was observed in the presence of 5 mM Ca^2+, with a specific limited proteolysis. The NH_2-terminal sequence of generated PO was determined to be NH_2-Phe-Gly-Glu-Asp-Asp-. The activated PO oxidized o-diphenols but did not oxidize mono-phenol and p-diphenol substrates. The purified pro-PO was not activated by trypsin, α-chymotrypsin, and SDS.
( Sue N. Park ),( Yhun Y. Sheen ),( Ki Y. Kim ),( Ji H. Kim ),( Kyoung J. Kwon ),( Seo Y. Go ),( Kyung N. Min ),( Woo S. Lee ) 한국응용약물학회 2006 Biomolecules & Therapeutics(구 응용약물학회지) Vol.14 No.4
1,2-Dibromoethane (DBE) has been widely used as a soil fumigant, an additive to leaded gasoline and an industrial solvent. In this study, we have carried out in vitro genetic toxicity test of 1,2-dibromoethane and microarray analysis of differentially expressed genes in response to 1,2-dibromoethane. 1,2-Dibromoethane showed mutations in base substitution strain TA1535 both with and without exogenous metabolic activation. 1,2-Dibromoethane showed mutations in frame shift TA98 both with and without exogenous metabolic activation. 1,2-Dibromoethane showed DNA damage based on single cell gel/comet assay in L5178Y cells both with and without exogenous metabolic activation. 1,2-Dibromoethane increased micronuclei in CHO cells both with and without exogenous metabolic activation. Microarray analysis of gene expression profiles in L5l78Y cells in response to 1,2-dibromoethane selected differentially expressed 241 genes that would be candidate biomarkers of genetic toxic action of 1,2-dibromoethane.
Genetic Toxicity Test of Glycidol by Ames, Micronucleus, Comet Assays and Microarray Analysis
( Ji H. Kim ),( Ki Y. Kim ),( Kyoung J. Kwon ),( Seo Y. Go ),( Kyung N. Min ),( Woo S. Lee ),( Sue N. Park ),( Yhun Y. Sheen ) 한국응용약물학회 2006 Biomolecules & Therapeutics(구 응용약물학회지) Vol.14 No.4
The primary use for glycidol is as a stabilizer in the manufacture of vinylpolymers, however, it is also used as an intermediate in the production of pharmaceuticals, as an additives for oil and synthetic hydraulic fluids, and as a diluting agent is same epoxy resins. In this study, we have carried out in vitro genetic toxicity test of glycidol and microarray analysis of differentially expressed genes in response to glycidol. The result of Ames test showed mutations with glycidol treatment in base substitution strain TA1535 both with and without exogenous metabolic activation. Likewise, glycidol showed mutations in frame shift TA98 both with and without exogenous metabolic activation. The result of COMET assay in L5l78Y cells with glycidol treatment showed DNA damage both with and without exogenous metabolic activation. Glycidol increased micronuclei in CHO cells both with and without exogenous metabolic activation. 150 Genes were selected as differentially expressed genes in response to glycidol by microarray analysis and these genes would be candidate biomarkers of genetic toxic action of glycidol.
P108 : Histopathological features in psoriasis and seborrheic dermatitis of the scalp
( Ji Hye Park ),( Sue Kyung Kim ),( Ji Eun Kwon ),( You Chan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: The differential diagnosis between seborrheic dermatitis and psoriasis of the scalp can be difficult due to their similarity of clinicopathological features. Objectives: We tried to find favorable criteria for histopathological differential diagnosis of psoriasis and seborrheic dermatitis of the scalp. Methods: Eight cases of psoriasis and Twenty cases of seborrheic dermatitis of the scalp were evaluated clinically and histopathologically. Results: In the psoriasis group, 2 women and 6 men were included with an age range from 8 to 63 years. In the seborrheic dermatitis group, 8 women and 12 men were included with an age range from 16 to 79 years. The histological features showed an increased number of mitotic figures in psoriasis compared with seborrheic dermatitis (p < 0.05); follicular plugging was more common in seborrheic dermatitis than in psoriasis (p < 0.05); clubbed and even lengths of rete ridges were more common in psoriasis than in seborrheic dermatitis (p < 0.05). There were no significant differences in the amount of plasma within parakeratosis, dilatation of infundibulum, epidermal spongiosis, lymphocytic exocytosis, edema of papillary dermis, and solar elastosis. Conclusion: We suggest difference in mitotic figures would be helpful in the differential diagnosis between psoriasis and seborrheic dermatitis of the scalp: more than 5 mitotic figures in 3 high power fields favors the diagnosis of psoriasis, whereas less than 3 suggests seborrheic dermatitis.
Histopathological Differential Diagnosis of Psoriasis and Seborrheic Dermatitis of the Scalp
( Ji Hye Park ),( Young Joon Park ),( Sue Kyoung Kim ),( Ji Eun Kwon ),( Hee Young Kang ),( Eun So Lee ),( Jee Ho Choi ),( You Chan Kim ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.4
Background: The differential diagnosis of psoriasis and seborrheic dermatitis can be difficult when both conditions are localized to the scalp without the involvement of other skin sites. Objective: We aimed to evaluate the histopathological differences between psoriasis and seborrheic dermatitis on the scalp and identify favorable criteria for their differential diagnosis. Methods: We evaluated 15 cases of psoriasis and 20 cases of seborrheic dermatitis of the scalp that had been clinicopathologically diagnosed. Skin biopsy sections stained with H&E were examined. Additional immunohistochemistry was performed, including Ki-67, keratin 10, caspase- 5, and GLUT-1. Results: On histopathological examination, mounds of parakeratosis with neutrophils, spongiform micropustules of Kogoj, and clubbed and evenly elongated rete ridges were significantly more frequently observed in psoriasis. Follicular plugging, shoulder parakeratosis and prominent lymphocytic exocytosis were significantly more common in seborrheic dermatitis. Moreover, significantly higher mitotic figures were observed in psoriatic lesions than in seborrheic dermatitis. Immunohistochemistry did not show any difference between psoriasis and seborrheic dermatitis. Conclusion: Histopathological features favoring psoriasis include mounds of parakeratosis with neutrophils, spongiform micropustules of Kogoj, clubbed and evenly elongated rete ridges, and increased mitotic figures (≥ 6/high-powered field). Features indicating seborrheic dermatitis are follicular plugging, shoulder parakeratosis and prominent lymphocytic exocytosis. Immunohistochemistry was not helpful in differentiating psoriasis from seborrheic dermatitis. (Ann Dermatol 28(4) 427∼432, 2016)
Metastatic Blue Nevus-Like Melanoma Detected by Liquid-Based Catheterized Urine Cytology
( Sue Kyung Kim ),( Ji Young Yang ),( Jae Ho Han ),( Ji Eun Kwon ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.3
Primary or metastatic malignant melanoma can mimic benign blue nevus in rare cases, making the diagnosis challenging. Herein, we report an exceptionally rare case of blue nevus-like melanoma and its blue nevus-like metastasis which was detected by catheterized urine cytology. The patient presented with blue-colored papuloplaques on his temple which were diagnosed as blue nevus-like melanoma on punch biopsies. While he was admitted for administration of chemotherapy, hematuria was detected. Catheterized urine cytology revealed singly scattered oval to spindle-shaped pigmented cells with a moderate degree of variation in shape and size. Many of them had small nuclei with indiscernible to inconspicuous nucleoli while only a few cells showed nuclear enlargement and nuclear hyperchromasia, which could be diagnostic pitfalls. Most of the cells on the smear were positive for HMB45 immunostaining, which confirmed the diagnosis of metastatic blue nevus-like melanoma. To the best of our knowledge, the present case is the first report describing cytomorphologic findings of blue nevus-like metastasis of melanoma in the urine specimen. (Ann Dermatol 30(3) 356∼360, 2018)
Hur, Ji-Won,Shin, Na Young,Jang, Joon Hwan,Shim, Geumsook,Park, Hye Yoon,Hwang, Jae Yeon,Kim, Sung Nyun,Yoo, Jung Hyun,Hong, Kyung Sue,Kwon, Jun Soo SAGE Publications 2012 Australian and New Zealand journal of psychiatry Vol.46 No.2
<P>Obsessive-compulsive symptoms (OCS), which are common in psychotic-spectrum illnesses, are of clinical interest because of their association with poor prognosis or cognitive dysfunction. However, few studies on the clinical and neurocognitive implications of OCS in individuals at ultra-high risk for psychosis (UHR) have been conducted.</P>