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종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과
노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암연구소 2005 암연구소 업적집 Vol.4 No.-
Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)
종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과
노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암공동연구소 2005 암공동연구소 업적집 Vol.4 No.
Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)
Role of Surgical Salvage for Regional Recurrence in Laryngeal Cancer
Jeong, Woo-Jin,Jung, Young Ho,Kwon, Seong Keun,Hah, J Hun,Kwon, Tack-Kyun,Sung, Myung-Whun,Kim, Kwang Hyun The American Laryngological, Rhinological Otologic 2007 The Laryngoscope Vol.117 No.1
OBJECTIVES:: The aims of this study were to analyze the pattern of regional recurrence in laryngeal cancer, evaluate the role of surgical salvage, and identify factors affecting salvage outcome. METHODS:: Retrospective analysis was conducted on medical records from a 16-year period. Of 463 patients diagnosed with laryngeal cancer, 25 patients with regional recurrence managed with salvage neck dissection were identified and subject to study. Isolated local recurrences and all distant metastases were excluded. RESULTS:: All patients were male with a median age of 61 years. The overall rate of regional recurrence was 5.4%. Median time to regional recurrence was 13 months. Isolated regional recurrence occurred in 76% of cases, whereas locoregional recurrence occurred in 24%. A 5-year survival rate for patients undergoing neck dissection as salvage management was 61.2%. Patients with recurrence in the contralateral neck were definitely associated with poor prognosis. Although standard statistical significance was not met, trends for poorer salvage result were identified in patients with a history of local recurrence before regional recurrence, recurrence in a previously dissected neck, and recurred node size of 3 cm or above. CONCLUSIONS:: Our study shows that salvage neck dissection for regional recurrence in laryngeal cancer is an acceptable approach. Surgical eradication of disease should be warranted whenever possible. Prudent planning of management is mandatory in the presence of history of local recurrence before regional recurrence, previously dissected neck, large size of recurrent node, and contralateral neck recurrence.
Ju Hun LEE,Do Yoon LEE,Hyeong Ryeol KIM,Kyung Rae KIM,Eun Jeong KIM,Chulhwan PARK,Hah Young YOO,Ho Seok KWAK,Seung Wook KIM,Ja Hyun LEE 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
In this study, extracted sugars of microalgae, which cause algal blooms and crude glycerol, which is a biodiesel industry by-product, were used simultaneously to produce 2,3-BDO. The 2,3-BDO production using only extracted algal sugars was about 4.8 g/L at 18 h, and the production of 2,3-BDO using both extracted algal sugar and crude glycerol was about 7 g/L at 18 h. It was confirmed that the main culture with crude glycerol was increased 1.5-fold compared to the case of using only extracted algal sugars. In addition, four components of the main medium (ammonium sulfate, casein hydrolysate, yeast extract and crude glycerol) were statistically optimized and the concentrations of the medium were 12 g/L, 16 g/L, 12 g/L and 13 g/L, respectively. In addition, the final 2,3-BDO production was about 11g/L, which 1.6-fold higher than before optimization process. As a result, it has been confirmed that 2,3-BDO production is possible through the simultaneous use of algal sugars and crude glycerol, which can greatly contribute to the development of zero-waste processes.
Dae-Hun Jeong,Seulki Kim,Hyun Kyung Kim,Hyun-Na Koo,Gil-Hah Kim,Soowon Cho 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10
We investigated if Pseudococcus viburni and P. longispinus, the two notorious pest species of mealybugs are foundin Korea. Our survey involved a total of 602 sites all over the country for the last three years. Pseudococcus viburniwas only once referred in Gimpel’s 1983 dissertation on P. affinis group: only one record was noted from Korea amongmany specimens from various countries. However, the species has never been reported from Korea for the last severaldecades and none was found in our thorough survey. We believe there was a misidentification, as noted by the authorregarding the species complex, and conclude that P. viburni does not occur in Korea. On the other hand, P. longispinushas been found in 36 sites, all from imported tropical houseplants in a green house or nurseries. In addition, anothersimilar species has been found from 86 sites. This unknown species was surprisingly best matched with P. orchidicola.Both species could not survive Korea’s harsh winter and they could only survive in a temperature-controlled place suchas nurseries and restaurants.
( Seong Yeol Park ),( Soo Jeong Nam ),( Bhumsuk Keam ),( Tae Min Kim ),( Yoon Kyung Jeon ),( Se Hoon Lee ),( Seong Keun Kwon ),( Hun Hah ),( Tack Kyun Kwon ),( Dong Wan Kim ),( Myung Whun Sung ),( Dae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although adenoid cystic carcinoma (ACC) is known for slow-growing tumor, once it would metastasized, it became rapidly progressive tumor. Study of molecular markers for risk stratification has been limited due to rare incidence. The purpose of this study was to evaluate potential prognostic factors in ACC. Methods: A total of 76 patients who were diagnosed as ACC at Seoul National University Hospital and available for tumor tissue were analyzed. The clinical information of these patients were reviewed and immunohistochemistry for bFGF, c-kit, FGFR2, FGFR3, MYB, PDGFR-beta, VEGF and Ki-67 were performed. Results: Among the 76 patients, primary sites were salivary gland (51%), nasal cavity or paranasal sinus (25%), oral cavity (9%), lung or trachea (8%), and others (7%). Seventy-one patients (93%) underwent curative operation, fifty-nine patients (78%) treated with radiotherapy and thirteen patients (17%) received palliative chemotherapy. fifty-four patients (71%) for bFGF, fifty-eight patients (76%) for c-kit, seven patients (9%) for FGFR2, five patients (7%) for FGFR3, forty-one patients (54%) for MYB, forty-nine patients (64%) for PDGFR-beta, sixty-nine patients (91%) for VEGF were positive and median Ki-67 value was 5.1% (range 0.3 to 32.6%). In univariate analysis, high expression of PDGFR-beta (HR = 2.76; 95% confidence interval [CI], 1.04 to 7.36; P= 0.042), VEGF (HR = 3.09; 95% CI, 1.07 to 8.94; P = 0.037) and Ki-67 (HR = 5.30; 95% CI, 1.94 to 14.49; P = 0.001) were significantly associated with poor overall survival (OS). In multivariate analysis, PDGFR-beta (P = 0.019), VEGF (P = 0.014) and Ki-67 (P= 0.001) were independently associated with poor OS. Conclusions: High expression of PDGFR-beta, VEGF and Ki-67 were independent poor prognostic factors for OS in ACC.
Neoadjuvant chemotherapy followed by limited surgery in a mouse model of head and neck cancer.
Lee, Jae Jin,Hah, Jeong-Hun,Im, Seock-Ah,Kim, Si-Young,Sung, Myung-Whun,Kim, Kwang Hyun,Heo, Dae Soeg Potamitis Press 2009 Anticancer research Vol.29 No.1
<P>BACKGROUND: This study evaluated the effect of limited surgery following neoadjuvant chemotherapy compared to radical surgery in SCC VII (squamous cell cancer) tumor-bearing syngeneic C3H/HeJ mice. MATERIALS AND METHODS: Mice showing a tumor response to cisplatin and 5-fluorouracil therapy were divided into three groups: radical surgery, with a 5 mm margin from the original tumor, group (A); limited surgery of 5 mm margin from the residual tumor, group (B); and very limited surgery with no margin from the residual tumor, group (C). The number of mice was 13 (group A), 12 (group B) and 12 (group C). RESULTS: No recurrence developed except in one mouse in group C. Three mice died in group A, one in group B and one in group C from perioperative complications. By intent-to-treat analysis, the survival was not significantly different among the three groups (p = 0.64), or between group A and B (p = 0.33). CONCLUSION: The outcome of limited surgery was comparable to radical surgery after neoadjuvant chemotherapy in the mouse model of head and neck cancer.</P>
하정훈,정은정,노동환,권성근,성명훈,김광현,Jeong-Hun Hah,M.D.,Eun-jung Jung,M.D.,Dong Hwan Roh,M.D.,Seong Keun Kwon,M.D.,Myung-Whun Sung,M.D. and Kwang Hyun Kim,M.D. 대한갑상선-내분비외과학회 2004 The Koreran journal of Endocrine Surgery Vol.4 No.2
Purpose: Well differentiated thyroid carcinomas are mostly curable diseases. Invasion of aerodigestive tract by thyroid carcinoma is rare. However, it is considered as a poor prognostic indicator of survival. Some studies showed that local invasion of thyroid carcinoma was the cause of death in many patients. Therefore, adequate local control of the tumor is critical to avoid the mortality as well as the morbidity of the disease. To find proper and adequate treatment modality of locally invasive thyroid carcinoma, we evaluated treatment modalities and outcomes in the patients with thyroid carcinoma with invasion of aerodigestive tract. Methods: Forty patients with thyroid carcinoma invading aerodigestive tract who were treated from July 1989 through July 2002 were reviewed retrospectively. Results: Direct intraluminal invasion of the thyroid carcinoma requires definitive resection of the aerodigestive tract. In case that the extent of tumor was thought to be limited to perichondrium or extraluminal invasion, tracheal shaving procedure was performed. Five-year and 10-year local control rates were 81.6% and 57.4%, respectively. Disease-specific survival rates of 5-year and 10-year were 90.1% and 81.1%, respectively. Conclusion: For the successful treatment of invasive thyroid carcinoma, the resection of the functional structures or the aerodigestive tract should be determined prudently according to the presence of the intraluminal invasion. (Korean J Endocrine Surg 2004;4:101-105)