http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Simple sequence repeat marker development from Codonopsis lanceolata and genetic relation analysis
Kim, Serim,Jeong, Ji Hee,Chung, Hee,Kim, Ji Hyeon,Gil, Jinsu,Yoo, Jemin,Um, Yurry,Kim, Ok Tae,Kim, Tae Dong,Kim, Yong-Yul,Lee, Dong Hoon,Kim, Ho Bang,Lee, Yi The Korean Society of Plant Biotechnology 2016 식물생명공학회지 Vol.43 No.2
In this study, we developed 15 novel polymorphic simple sequence repeat (SSR) markers by SSR-enriched genomic library construction from Codonopsis lanceolata. We obtained a total of 226 non-redundant contig sequences from the assembly process and designed primer sets. These markers were applied to 53 accessions representing the cultivated C. lanceolata in South Korea. Fifteen markers were sufficiently polymorphic, and were used to analyze the genetic relationships between the cultivated C. lanceolata. One hundred three alleles of the 15 SSR markers ranged from 3 to 19 alleles at each locus, with an average of 6.87. By cluster analysis, we detected clear genetic differences in most of the accessions, with genetic distance varying from 0.73 to 0.93. Phylogenic analysis indicated that the accessions that were collected from the same area were distributed evenly in the phylogenetic tree. These results indicate that there is no correlative genetic relationship between geographic areas. These markers will be useful in differentiating C. lanceolata genetic resources and in selecting suitable lines for a systemic breeding program.
발레 그랑 줴테 앙 투르낭(Ballet grand jete en tournant) 동작의 키네메틱 시퀀스(Kinematic sequence)에 관한 연구
김제민 ( Jemin Kim ),김종훈 ( Jong Hoon Kim ),김광진 ( Kwang Jin Kim ),서차영 ( Cha Young Suh ) 대한무용학회 2015 대한무용학회논문집 Vol.73 No.6
The purpose of this study was to identify the kinematic sequence of the “grand jete en tournant motion”, which refers to working on the ballet dancers`` body motions. Nineteen skilled female collegiate and high school ballet dancers performed the grand jete en tournant (1st arms position with left leg derrire-plie-chasse-jumping-arabesque pose; five successful trials for each participants). For the kinematic sequence, the graph lines showed a start inclination (increase acceleration) and declination (decrease acceleration) pattern of proximal and distal segments. The pelvis showed a peak angular velocity value during the grand jete en tournant motion.
( Jemin Kim ),( Jihee Kim ),( Young In Lee ),( Ju Hee Lee ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.4
En coup de sabre variant of linear morphea (LM) is a rare sclerotic skin disorder characterized by disfiguring linear depression of the frontal or frontoparietal forehead. Current attempts for cosmetic correction of atrophic lesions must be preceded by an evaluation of disease activity of LM, either by a sufficient clinical assessment or histologic evidence. Corrective procedures including corrective surgery, autologous fat grafting, hyaluronic acid filler injections were performed with varying degrees of success; still, there is a need for treatment options with non-invasive and long-term maintenance effects. Herein we report the use of micronized acellular dermal matrix filler as a novel and successful treatment for the atrophic defect of LM in a 24-year-old female. Molecular characteristics of the micronized acellular dermal matrix filler give enhanced durability and prolonged volume consistency, which results in a long-term extracellular matrix remodeling effect. (Ann Dermatol 33(4) 373∼376, 2021)
Taint Analysis Scheme using Concolic Execution to Find XSS Flaws in Legacy Java Web Applications
Jemin Kim,Joonseok Park 한국차세대컴퓨팅학회 2022 한국차세대컴퓨팅학회 학술대회 Vol.2022 No.10
Cross-site scripting(XSS) is one of the major threats in web services. Many legacy web applications, which are prevalent in industry, are vulnerable to XSS. This paper proposes dynamic taint analysis scheme by using concolic execution to prevent XSS. Our proposed scheme has no false alarm, at the same time, minimizes required dynamic taint analysis time to cover all execution path. In this manner we can find the exact input data set, which causes the XSS threat. We defined instrumentation scheme for taint analysis and concolic executions. The instrumentation phase for the Java servlet code is automated. The experimental results on test set of SecuriBench Micro, demonstrated the validity of proposed scheme. It detects 90.63% of XSS threats while showing 0% of false positive.
( Jemin Kim ),( Sooyie Choi ),( Min Young Park ),( Sang Ho Oh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Vitiligo-like depigmentation (VLD) is well known for characteristic cutaneous adverse event (AE) described in malignant melanoma (MM) patients, who are treated with immune checkpoint inhibitors. VLD has been regarded as an immunotherapy-related AE uniquely occurring in MM, but recently has also been reported to occur in patients with solid cancers except for MM. A 48-year-old woman presented with multiple variable-sized, depigmenting patches on the whole body. She was diagnosed with breast cancer 9 months prior to the visit, and after surgical resection of the breast mass in Korea, tumor stage was denoted to 1A. And she received ‘Accelerator and Brake therapy’, which is a kind of immunotherapy using activated autologous lymphocytes with the concomitant use of low-dose nivolumab and pembrolizumab in Japan. After 4 months, asymptomatic VLD patches have been developed. Blood tests including thyroid function test and anti-nuclear antibody showed normal findings. VLD was improved by phototherapy with NB-UVB combined with oral & topical corticosteroids. The mechanisms behind VLD in the context of immunotherapy are not fully understood. MM cells destroyed by immunotherapy release MM-associated antigens, which can immunologically share with normal melanocytes, leading to depigmentation. However, the development of VLD in solid tumor other than MM suggests the involvement of other unknown mechanism aside from sharing antigenicity in MM.
Multifocal aplasia cutis congenita
( Jemin Kim ),( Jihee Kim ),( Sang Ho Oh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Aplasia cutis congenita (ACC) is an uncommon congenital skin disorder which described as focal, localized absence or defects of the skin in neonates. Clinical presentation of ACC is heterogenous, but most cases of ACC are known to solitary lesion involving scalp. We report a rare presentation of ACC with multifocal, symmetric, discrete lesions on whole body. A male infant born in the 39th week of gestation was referred for multiple skin lesions right after delivery. There were multiple, symmetric, round, well demarcated, coin sized full thickness of skin defects on whole body including scalp and both extremities. no blisters or vesicle like lesions were observed and did not involve mucosa or dystrophic nails. Further investigations in search of possible anomalies showed normal results. Since there were no newly formed lesions in first few days and the lesions showed signs of spontaneous healing, we started conservative treatment with occlusive dressing. At 1 month of age, most of the lesions were healed with cicatrization. During the observation period there was no sign of infection or aggravation of the lesions and lesions remained intact up to 9 months. There have scarcely been reported that ACCs with extensive, symmetrical involvement. In addition, our case has unique clinical features showing multifocal lesions. Herein, we present the clinical presentation of atypical ACC and its clinical course.
Jemin Kim,송승용,Sang Gyu Lee,Sooyeon Choi,Young In Lee,최준용,이주희 대한의학회 2022 Journal of Korean medical science Vol.37 No.5
Background: Human immunodeficiency virus (HIV)-associated facial lipoatrophy (FLA) is a stigmatizing side effect associated with the use of highly active antiretroviral therapy. We sought to evaluate the safety and efficacy of the hyaluronic acid filler mixed with micronized cross-linked acellular dermal matrix (HA/MADM) in HIV-associated FLA. Methods: We conducted an open-label safety and efficacy study in patients with HIVassociated FLA. Fourteen patients received single injection of the HA/MADM, and 13 patients completed the 24-week follow-up evaluation. Treatment efficacy, safety, and patient and physician satisfaction were evaluated. Repeated measure analysis of variance with post-hoc analysis with the Wilcoxon signed rank test was performed to compare and incorporate parameters at each time point. Results: All 13 patients maintained a significant improvement of the Carruthers Lipoatrophy Severity Scale grade throughout the study period, along with improvement of the depressed volume due to lipoatrophy measured using a three-dimensional camera system. More than 80% of patients and physicians were satisfied with the treatment, and no treatment-related adverse events were reported, except for one case of transient subcutaneous nodule formation. Conclusion: Our study findings suggest that injectable HA/MADM is a potentially effective and safe treatment option for treating HIV-positive patients with FLA.
( Jemin Kim ),( Tunyaporn Jongudomsombat ),( Young In Lee ),( Jihee Kim ),( Ju Hee Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Tranilast, N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′), which was initially identified as an anti-allergic agent, is also known to have anti-fibrotic potential by inhibiting the proliferation of fibroblasts and collagen deposition. Previous clinical studies on the efficacy and safety of systemic treatment of tranilast on fibrotic skin diseases, such as keloid or hypertrophic scar, are limited. Objectives: To evaluate the safety and efficacy of oral tranilast in treatment of keloid scars Methods: We performed a retrospective observational study of patients with keloids who had been prescribed oral tranilast for more than 3 months. Scar improvement and patient satisfaction were assessed using the Vancouver Scar Scale (VSS) score and the 5-point patient self-assessment score. Any side effects including abnormality in routine lab tests during the treatment period were noted. Results: Of the 42 patients, 27 (64.3%) were female. The mean duration of prescription was 115 days. Significant improvement of total VSS (9.50 vs. 5.62, p<0.001) was noted, along with the subjective improvement of patient-reported symptoms. There was no specific drug-related side effect, and the laboratory tests revealed no significant change. Conclusion: Our study showed that oral tranilast is and effective and well-tolerated treatment for keloid scar. Optimization of treatment with other therapeutic modalities is necessary to develop a more standardized treatment protocol.