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( Jee-hyun Hwang ),( Haengdueng Jeong ),( Nahyun Lee ),( Sumin Hur ),( Nakyum Lee ),( Jeong Jun Han ),( Hye Won Jang ),( Wang Keun Choi ),( Ki Taek Nam ),( Kyung-min Lim ) 한국피부장벽학회 2021 한국피부장벽학회지 Vol.23 No.2
Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited. Here, we investigated whether an ex vivo live porcine skin model can be employed to study the safety and skin barrier-improving effects of hydroxyacids widely used in cosmetics for keratolytic peels. Glycolic acid (1-10%), salicylic acid (0.2-2%), and lactobionic acid (1.2-12%) were used as representative substances for α-hydroxyacid (AHA), β-hydroxyacid (BHA), and polyhydroxyacid (PHA), respectively. When hydroxyacids were applied at high concentrations on the porcine skin every other day for 6 days, tissue viability was reduced to 50-80%, suggesting that the toxicity of cosmetic ingredients can be evaluated with this model. Based on tissue viability, the treatment scheme was changed to a single exposure for 20 min. The protective effects of a single exposure of hydroxyacids on skin barrier function were evaluated by examining rhodamine permeability and epidermal structural components of barrier function using immunohistochemistry (IHC) and immunofluorescence (IF) staining. Lactobionic acid (PHAs) improved skin barrier function most compared to other AHAs and BHAs. Most importantly, trans-epidermal water loss (TEWL), an important functional marker of skin barrier function, could be measured with this model, which confirmed the significant skin barrier-protective effects of PHAs. Collectively, we demonstrated that the ex vivo live full-thickness porcine skin model can be an excellent alternative to animal experiments for skin studies on the safety and efficacy of cosmetic ingredients. Funding: This study was funded by the Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. HP20C0061).
Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and PB-22
( Kwang-hyun Hur ),( Shi-xun Ma ),( Bo-ram Lee ),( Yong-hyun Ko ),( Jee-yeon Seo ),( Hye Won Ryu ),( Hye Jin Kim ),( Seolmin Yoon ),( Yong-sup Lee ),( Seok-yong Lee ),( Choon-gon Jang ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.4
Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. However, because of the lack of scientific evidence to elucidate their dangerous pharmacological effects, SCBs are weakly regulated and continue to circulate in illegal drug markets. In the present study, the intravenous self-administration (IVSA) paradigm was used to evaluate the abuse potential of three SCBs (AM-1248, CB-13, and PB-22) in rats. All three SCBs maintained IVSA with a large number of infusions and active lever presses, demonstrating their reinforcing effects. The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcementenhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demonstrated that SCBs have distinct pharmacological properties and abuse potential.
( Jung Won Yoon ),( Hye Young Hur ),( Hye Mi Jee ),( Ji Hyeon Baek ),( Hyeong Yoon Kim ),( Youn Ho Shin ),( Man Yong Han ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4
Purpose: Little data is currently available on the use of the impulse oscillometry system (IOS) parameter in analyzing the lung func-tion of young children with cough-variant asthma (CVA) and classic asthma. The aims of this study were to evaluate the bronchial responsiveness between patients with CVA and those with classic asthma using dose-response slope and various cutoff values. Methods: A methacholine challenge test and a pulmonary function test were performed in 43 children with classic asthma and 26 children with CVA using IOS, and the respiratory resistance (Rrs) and reactance (Xrs) were obtained. The bronchial responsiveness were assessed by provocative concentration causing an 80% fall from baseline in reactance at 5 Hz (PC80_Xrs5) and a 40% increase in resistance at 5 Hz (PC40_Rrs5) and calculating from the degree of dose-response slope (DRS) for airway resistance and reactance. Results: There was no significant difference in base lung function between the two groups. However, the mean DRS_Xrs5 and the number who showed more than an 80% fall in reactance were significantly higher in classic asthma group than those in CVA group (P=0.040 and P=0.040, respectively).Conclusion: The use of DRS in oscillatory reactance at 5 Hz is useful for the differential diagnosis of classic asthma and CVA based on bronchial hyperresponsiveness. (Allergy Asthma Respir Dis 2013;1:309-313)
( Jung Won Yoon ),( Hye Young Hur ),( Hye Mi Jee ),( Ji Hyeon Baek ),( Hyeong Yoon Kim ),( Youn Ho Shin ),( Man Yong Han ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Purpose: Little data is currently available on the use of the impulse oscillometry system (IOS) parameter in analyzing the lung func-tion of young children with cough-variant asthma (CVA) and classic asthma. The aims of this study were to evaluate the bronchial responsiveness between patients with CVA and those with classic asthma using dose-response slope and various cutoff values. Methods: A methacholine challenge test and a pulmonary function test were performed in 43 children with classic asthma and 26 children with CVA using IOS, and the respiratory resistance (Rrs) and reactance (Xrs) were obtained. The bronchial responsiveness were assessed by provocative concentration causing an 80% fall from baseline in reactance at 5 Hz (PC80_Xrs5) and a 40% increase in resistance at 5 Hz (PC40_Rrs5) and calculating from the degree of dose-response slope (DRS) for airway resistance and reactance.Results: There was no significant difference in base lung function between the two groups. However, the mean DRS_Xrs5 and the number who showed more than an 80% fall in reactance were significantly higher in classic asthma group than those in CVA group (P=0.040 and P=0.040, respectively).Conclusion: The use of DRS in oscillatory reactance at 5 Hz is useful for the differential diagnosis of classic asthma and CVA based on bronchial hyperresponsiveness.
Jae Wook Lee,Jee Hye Hur,Dong Hyun Yang,Bae Young Lee,임동진,Su Jin Hong,Eun Young Kim,Eun-Ah Park,Yeseul Jo,Jeongjae Kim,Chul Hwan Park,용환석 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.11
Cardiovascular magnetic resonance imaging (CMR) is expected to be increasingly used in Korea due to technological advances and the expanded national insurance coverage of CMR assessments. For improved patient care, proper acquisition of CMR images as well as their accurate interpretation by well-trained personnel are equally important. In response to the increased demand for CMR, the Korean Society of Cardiovascular Imaging (KOSCI) has issued interpretation guidelines in conjunction with the Korean Society of Radiology. KOSCI has also created a formal Committee on CMR guidelines to create updated practices. The members of this committee review previously published interpretation guidelines and discuss the patterns of CMR use in Korea.
Lee Jae Wook,Hur Jee Hye,Yang Dong Hyun,Lee Bae Young,Im Dong Jin,Hong Su Jin,Kim Eun Young,Park Eun-Ah,Jo Yeseul,Kim Jeong Jae,Park Chul Hwan,Yong Hwan Seok 아시아심장혈관영상의학회 2019 Cardiovascular Imaging Asia Vol.3 No.4
Cardiovascular magnetic resonance imaging (CMR) is expected to be increasingly used in Korea due to technological advances and the expanded national insurance coverage of CMR assessments. For improved patient care, proper acquisition of CMR images as well as their accurate interpretation by well-trained personnel are equally important. In response to the increased demand for CMR, the Korean Society of Cardiovascular Imaging (KOSCI) has issued interpretation guidelines in conjunction with the Korean Society of Radiology. KOSCI has also created a formal Committee on CMR guidelines to create updated practices. The members of this committee review previously published interpretation guidelines and discuss the patterns of CMR use in Korea.
Lee, Jae Wook,Hur, Jee Hye,Yang, Dong Hyun,Lee, Bae Young,Im, Dong Jin,Hong, Su Jin,Kim, Eun Young,Park, Eun-Ah,Jo, Yeseul,Kim, Jeong Jae,Park, Chul Hwan,Yong, Hwan Seok Korean Society of Magnetic Resonance in Medicine 2019 Investigative Magnetic Resonance Imaging Vol.23 No.4
Cardiovascular magnetic resonance imaging (CMR) is expected to be increasingly used in Korea due to technology advances and the expanded national insurance coverage of these tests. For improved patient care, it is crucial not only that CMR images are properly acquired but that they are accurately interpreted by well-trained personnel. In response to the increased demand for CMR, the Korean Society of Cardiovascular Imaging (KOSCI) has issued interpretation guidelines in conjunction with the Korean Society of Radiology (KSR). KOSCI has also created a formal Committee on CMR Guidelines to write updated practices. The members of this Committee review previously published interpretation guidelines and discuss the patterns of CMR use in Korea.
( Hyon Sob Han ),( Bo Hye Nam ),( Jung Ha Kang ),( Yi Kyoung Kim ),( Young Ju Jee ),( Young Baek Hur ),( Moon Geun Yoon ) 한국수산과학회(구 한국수산학회) 2012 Fisheries and Aquatic Sciences Vol.15 No.2
We used nine microsatellite DNA markers to estimate genetic variation among wild and cultured populations of the sea squirt Halocynthia roretzi. The loci were polymorphic, with 6-32 alleles, and allelic richness ranged from 6.0 to 26.1 in each population. The wild and the cultured populations had similar mean heterozygosities (HO and HE), allele numbers, and allelic richness. One cultured population with softness syndrome had a lower mean in the observed heterozygosity (HO = 0.57) and higher mean inbreeding coefficient (FIS = 0.261) than any other populations. This suggests that the loss of genetic variation in the diseased population might be due to increased inbreeding. A neighbor-joining tree and pairwise population estimates of FST showed moderate genetic differentiation between the wild and the cultured populations. Additionally, the softness syndrome population was genetically divergent from wild populations, but it was genetically close to the cultured populations.