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일개 철강 사업장에서 대사증후군의 위험요인과 γ-GTP와의 관련성
문제혁,이상준,박정덕 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1
목적: 대사증후군은 심혈관계 질환의 이환과 이로 인한 사망률을 증가시키는 것으로 알려져 있으며, 비만, 고 중성지방혈증, 저 HDL-콜레스테롤혈증, 고혈압, 공복 시 고혈당 등에서 3개 항목 이상을 만족한 경우로 정의된다. 간기능 검사 중 γ-GTP는 간세포 손상에 대한 생체지표로 흔히 사용되는 검사이며, 고혈압, 제 2형 당뇨 및 뇌졸중과도 관련이 있음이 밝혀져 있다. 이번 연구에서는 일개 철강 사업장내 근로자들의 대사증후군의 유병률과 위험요인 및 대사증후군과 γ-GTP와의 관련성을 알아보았다. 방법: 수도권 소재 일개 철강 사업장 남자 근로자 1,604명을 대상으로 대사증후군의 구성요소(체질량지수, 중성지방, HDL-콜레스테롤, 수축기와 이완기 혈압, 공 복 시 혈당)와 γ-GTP, 교대근무 여부, 음주력, 흡연력, 운동 여부 및 가족병력 등을 조사하여 분석하였다. 결과: 일개 철강사업장근로자에 있어서 대사증후군의 유병률은 21.3%, 연령 보정 유병률은 15.5%이었다. 대사증후군에 영향을 미치는 역학적 요인은 연령(OR: 1.063, 95% CI: 1.033-1.094), 음주(OR: 1.657, 95% CI: 1.175. 2.337) 및 흡연(OR: 1.359, 95% CI: 1.017. 1.816) 등 이었고, 교대근무는 고혈압(OR: 1.329, 95% CI: 1.038-1.700)에만 영향을 주었다. 고 γ-GTP 혈증군에서 대사증후군의 구성인자인 비만, 고 중성지방혈증, 고혈압 및 공복시 고혈당의 위험도는 각각 2.625, 3.384, 1.887, 2.406이었고, 대사증후군의 위험도는 3.345이었다. 결론: 이번 연구결과로 볼 때, 철강 사업장에서 대사증후군에 대한 적극적인 관리를 위하여 금주와 금연 등 생활행태 개선을 위한 보건교육이 요구되었고, γ-GTP가 대사증후군의 조기 색출지표로서의 가능성이 제기되었다. Objectives: This study was performed to estimate the prevalence and possible risk factors of the metabolic syndrome in steel-mill workers, and to evaluate the relation between γ-glutamyltransferase (γ-GTP) and the metabolic syndrome. Methods: The study subjects comprised 1,604 male steel-mill workers. The indices of metabolic syndrome, such as BMI, triglyceride, HDL-cholesterol, blood pressure, fasting glucose, and γ-GTP were analyzed in each subject. We collected information about demographic characteristics, behavioral patterns, such as alcohol drinking, smoking, and exercise, and family medical history through a self-administered questionnaire. Statistical analysis was done by using the chi-square test, Mantel-Haenszel trend test and logistic regression model. Results: The crude and age-adjusted prevalences of the metabolic syndrome were 21.3% and 15.5%, respectively, in the steel-mill workers. Age (OR: 1.063, 95% CI: 1.033-1.094), alcohol drinking (OR: 1.657, 95% CI: 1.175-2.337) and smoking (OR: 1.359, 95% CI: 1.017-1.816) were risk factors for the metabolic syndrome. Meanwhile, shift work showed a significant relation with hypertension (OR: 1.329, 95% CI: 1.038-1.700), but not with other metabolic syndrome components. However, tenure, exercise and family medical history were not significant factors for the metabolic syndrome in this study. The risk ratio of the metabolic syndrome (OR: 3.345, 95 % CI: 2.534-4.416) and its components, such as obesity, hypertriglyceridemia, hypertension and hyperglycemia, were higher in the high γ-GTP group (≥63 IU/Ɩ ) than in the controls (<63 IU/Ɩ ). Conclusions: These results confirm the need for health education to control the metabolic syndrome by improving behavioral patterns, such as alcohol drinking and smoking, in factory workers. In addition, it is suggested that γ-GTP might be a useful candidate in screening for the metabolic syndrome.
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다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과
류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-
Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.
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Effect of exercise program using mirrors for stroke patients
Lee, Je-Hyeok,Kim, Hyun-Joo The Korea Contents Association 2013 International Journal of Contents Vol.9 No.1
This study was performed for two of specific reasons, one is for exercise development for improving stroke patient's muscle power, balance and gait and, after verifying the effect of the exercise, the other is for showing that the appling this exercise was more effective on hemi-plegic stroke patients into the clinical trial. The subjects of this study were hemi-plegic patients by stroke, 51 patients were picked up, who were agreed with this research. Close kinetic chain leg exercise using mirrors was applied to study group I, Close kinetic chain leg exercise without mirrors was applied to study group II and general physical therapy was applied to comparison group. The results of this study are as follows. The difference of the groups, study group I showed more effective than study group II on checking rectus femoris, vastus lateralis, biceps femoris, Korean version of Berg Balance Scale, Center of pressure, Functional gait assessment. In this study, Close kinetic chain leg exercise showed more effective and significant on improving for muscle power, balance and gait on stroke patients. Especially, doing exercise using mirrors is considered as more effective method than without mirrors.
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Lee, Eun Je,Lee, Hyeok Moo,Li, Yue,Hong, Lan Young,Kim, Dong Pyo,Cho, Sung Oh WILEY-VCH Verlag 2007 Macromolecular Rapid Communications Vol.28 No.3
<P>Unique hierarchical pore structures were fabricated by simply irradiating an electron beam onto silicone grease films. The hierarchical pore structures consisted of micrometer-sized pores and macroporous walls. Due to the high surface roughness, the hierarchical pore structures exhibited both superhydrophobicity with a water contact angle (CA) of 170° and superhydrophilicity with an extremely low water CA of 3° after the chemical treatment of the surfaces. In addition to the hierarchical pore structures, sponge-like pore structures were also fabricated by the electron irradiation of silicone grease films.</P><P> <img src='wiley_img/10221336-2007-28-3-MARC200600746-gra001.gif' alt='wiley_img/10221336-2007-28-3-MARC200600746-gra001'> </P>
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( Je-hyeok Lee ),( Jong-duk Choi ) 대한물리의학회 2016 대한물리의학회지 Vol.11 No.4
PURPOSE: The purpose of this study was to investigate the effects of differences in exercise time arrangement on the functional recovery of the lower limbs and balance of stroke patients. METHODS: The subjects of this study were 100 patients who were hospitalized in two hospitals located in Gyeonggi-do. Before the experiment, 60 of these patients who met the inclusion criteria and did not meet the exclusion criteria were randomly divided into an experimental group (n = 30), whose exercise time was concentrated, and a control group (n = 30), whose exercise time was diffuse. The two groups underwent six weeks of physical and occupational therapy four times a day for five days a week. One session of therapy took 30 minutes, including three sets of physical therapy and one set of occupational therapy. The rest time between the sessions was different for each group. The experimental group had five minutes of rest between each therapy session, and the control group had two hours of rest time between each session. The Fugl-Meyer assessment (FMA), an assessment of each patient`s limit of stability (LOS), and a timed up and go test (TUG) were used as test tools. RESULTS: Both groups showed statistically significant increases in their FMA results, LOS measurements, and TUG results. The FMA results of the experimental group were significantly higher than those of the control group. CONCLUSION: Thus, concentrated exercise time was more effective than diffuse exercise time for the recovery of motor function.
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배호흡운동을 동반한 닫힌 사슬 하지운동이 뇌졸중 환자의 체간조절 및 균형에 미치는 영향
이제혁(Lee Je-Hyeok),김성호(Kim Seong-Ho) 대한치료과학회 2019 대한치료과학회지 Vol.10 No.2
Objective: The purpose of this study was to evaluate the effects of closed chain lower limb exercise with abdominal breathing exercise on stroke patients and their effects on trunk control ability and balance. Method: The subjects were 40 stroke patients, 19 patients in the experimental group and 18 patients in the control group. The period was 5 weeks, 5 times a week, 30 minutes per session. The experimental group was subjected to a closed chain lower limb exercise with abdominal breathing exercise and the control group was subjected to a closed chain lower limb exercise. The posture assessment scale for stroke(PASS), trunk impairment scale(TIS) were used for trunk adjustment ability, and the balance ability was measured as center of pressure(COP) and limit of stability(LOS). Results: Results of this study showed that the PASS and TIS test significantly increased the experimental group compared to the control group. As a result of comparing the changes of pre and post intervention intervals between the two groups, the TIS test was significantly lower in the experimental group than in the control group, but the LOS test was not significantly increased in the experimental group. Conclusion: Closed chain lower limb exercise with abdominal breathing exercise showed a significant improvement in the trunk control and balance ability of the stroke patients compared to the closed chain lower limb exercise without the abdominal breathing exercise.
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