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Modeling the capacitive deionization batch mode operation for desalination
Y.A.C. Jande,김우승 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
Capacitive deionization (CDI) is an emerging desalination technology in which saline water flows through a pair of polarized/biased electrodes. The cations and anions are attracted towards the negative and positive electrodes, respectively. In CDI operation there are two possible modes: single pass and batch mode. In single pass operation, saline water passes only once through the CDI cell, whereas in batch mode operation, the fixed volume of saline water is recycled continuously until a steady state is reached. This paper presents the transient response of the CDI cell under batch mode operation. The model is developed by taking into account single pass CDI operation and the mixing phenomena that occur in the recycling tank. The developed model was successfully validated using experimental data, and the model helped to derive the equation for predicting the steady state of the CDI cell for the given operating parameters: flow rate, saline water quantity, CDI capacitance, CDI resistance, spacer volume, dead volume, applied potential, and initial concentration of the saline water.
Saleem, Muhammad Wajid,Jande, Y.A.C.,Kim, Woo-Seung Elsevier 2017 Journal of electroanalytical chemistry Vol.795 No.-
<P><B>Abstract</B></P> <P>A capacitive deionization (CDI) system is one of the emerging desalination technologies used to purify brackish water. It is an electrochemical technology that uses electrically charged porous electrodes to remove salt ions from water. In this study, we developed a process model by integrating CDI with reverse electrodialysis (RED) for the production of pure water and energy. RED is a power generation technology that uses the mixing entropy of water with high and low salt concentrations. Desalination with low energy consumption and high water recovery (WR) was a design preference for this integrated electrochemical model. CDI system was optimized with a series four pass reverse current desorption (RCD) method to achieve WR of almost 96.7% that was previously 50–80% on average. Moreover, an artificial salinity gradient was also produced for RED to generate energy through this four-pass RCD method of CDI. The concentration gain ratio (CGR), WR of CDI, and power density of RED was numerically assessed with different number of desorption passes and for CDI desorption current. WR and CGR value in CDI increased to 96% and 25, respectively, with the increase of number of desorption passes to four. Two stage RED cell system is used to get energy from salinity gradient produced through CDI. Energy consumption of 1.5kJ/l for pure water production was reduced to 0.58kJ/l with this purposed integrated four-pass CDI-RED system. This integrated electrochemical system reduced desalination energy consumption as well reducing environmental pollution with an eco-friendly, renewable power generation method and a reduction in the CDI disposal concentration.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Optimized the electrochemical desalination process for water recovery </LI> <LI> Four pass desorption method was employed to integrate the CDI-RED model. </LI> <LI> Concentration gain ratio, water recovery, and energy consumption is used for performance assessment. </LI> </UL> </P>
장평우 청주대학교 산업과학연구소 2005 産業科學硏究 Vol.22 No.3
3 dimensional FEM was used to improve dc bias current permeability of MPP core. In the simulation magnet size and magneto-motive force was varied. With increasing magnet size, bias field and permeability increased and decreased, respectively. However, increasing rate of bias field and decreasing rate of permeability decreased with magnet size. From the simulation it could be shown that a thin NdFeB magnet thinner than 1.2 mm can be effectively used for bias core. Bias core with 1.0 mm NdFeB magnet was manufactured and its properties were analyzed. As a results utility of bias MPP core suggestion could be demonstrated. However, core loss should be reduced for commercialization.
GLI1 Transcription Factor Affects Tumor Aggressiveness in Patients With Papillary Thyroid Cancers
Lee, Jandee,Jeong, Seonhyang,Lee, Cho Rok,Ku, Cheol Ryong,Kang, Sang-Wook,Jeong, Jong Ju,Nam, Kee-Hyun,Shin, Dong Yeob,Chung, Woong Youn,Lee, Eun Jig,Jo, Young Suk Williams & Wilkins Co 2015 Medicine Vol.94 No.25
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>A significant proportion of patients with papillary thyroid cancer (PTC) present with extrathyroidal extension (ETE) and lymph node metastasis (LNM). However, the molecular mechanism of tumor invasiveness in PTC remains to be elucidated.</P><P>The aim of this study is to understand the role of Hedgehog (Hh) signaling in tumor aggressiveness in patients with PTC.</P><P>Subjects were patients who underwent thyroidectomy from 2012 to 2013 in a single institution. Frozen or paraffin-embedded tumor tissues with contralateral-matched normal thyroid tissues were collected. Hh signaling activity was analyzed by quantitative RT-PCR (qRT-PCR) and immunohistochemical (IHC) staining. Datasets from Gene Expression Omnibus (GEO) (National Center for Biotechnology Information) were subjected to Gene Set Enrichment Analysis (GSEA). BRAFT1799A and telomerase reverse transcriptase promoter mutation C228T were analyzed by direct sequencing.</P><P>Among 137 patients with PTC, glioma-associated oncogene homolog 1 (<I>GLI1</I>) group III (patients in whom the ratio of <I>GLI1</I> messenger ribonucleic acid (mRNA) level in tumor tissue to <I>GLI1</I> mRNA level in matched normal tissue was in the upper third of the subject population) had elevated risk for ETE (odds ratio [OR] 4.381, 95% confidence interval [CI] 1.414–13.569, <I>P</I> = 0.01) and LNM (OR 5.627, 95% CI 1.674–18.913, <I>P</I> = 0.005). Glioma-associated oncogene homolog 2 (<I>GLI2</I>) group III also had elevated risk for ETE (OR 4.152, 95% CI 1.292–13.342, <I>P</I> = 0.017) and LNM (OR 3.924, 95% CI 1.097–14.042, <I>P</I> = 0.036). GSEA suggested that higher <I>GLI1</I> expression is associated with expression of the <I>KEGG</I> gene set related to axon guidance (<I>P</I> = 0.031, false discovery rate < 0.05), as verified by qRT-PCR and IHC staining in our subjects.</P><P><I>GLI1</I> and <I>GLI2</I> expressions were clearly related to aggressive clinicopathological features and aberrant activation of GLI1 involved in the axon guidance pathway. These results may contribute to development of new prognostic markers, as well as novel therapeutic targets.</P></▼2>
Lee, Jandee,Seol, Mi-Youn,Jeong, Seonhyang,Lee, Cho Rok,Ku, Cheol Ryong,Kang, Sang-Wook,Jeong, Jong Ju,Shin, Dong Yeob,Nam, Kee-Hyun,Lee, Eun Jig,Chung, Woong Youn,Jo, Young Suk Wolters Kluwer Health 2015 Medicine Vol.94 No.2
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Metabolic reprogramming has been regarded as an essential component of malignant transformation. However, the clinical significance of metabolic heterogeneity remains poorly characterized.</P><P>The aim of this study was to characterize metabolic heterogeneity in thyroid cancers via the analysis of the expression of mitochondrial ribosomal proteins (MRPs) and genes involved in oxidative phosphorylation (OxPhos), and investigate potential prognostic correlations.</P><P>Gene set enrichment analysis (GSEA) verified by reverse transcription polymerase chain reaction and gene network analysis was performed using public repository data. Cross-sectional observational study was conducted to classify papillary thyroid cancer (PTC) by the expression of MRP L44 (MRPL44) messenger RNA (mRNA), and to investigate the clinicopathological features.</P><P>GSEA clearly showed that the expression of OxPhos and MRP gene sets was significantly lower in primary thyroid cancer than in matched normal thyroid tissue. However, 8 of 49 primary thyroid tumors (16.3%) in the public repository did not show a reduction in OxPhos mRNA expression. Remarkably, strong positive correlations between MRPL44 expression and those of OxPhos and MRPs such as reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) 1 α subcomplex, 5; succinate dehydrogenase complex, subunit D; cytochrome c, somatic; adenosine triphosphate synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9); and MRP S5 (MRPS5) (<I>P</I> < 0.0001) were clearly denoted, suggesting that MRPL44 is a representative marker of OxPhos and MRP expressions. In laboratory experiments, metabolic heterogeneity in oxygen consumption, extracellular acidification rates (ECARs), and amounts of OxPhos complexes were consistently observed in BCPAP, TPC1, HTH-7, and XTC.UC1 cell lines. In PTCs, metabolic phenotype according to OxPhos amount defined by expression of MRPL44 mRNA was significantly related to lymph node metastasis (LNM) (<I>P</I> < 0.001). Furthermore, multivariate analysis clearly indicated that expression of MRPL44 is associated with an increased risk of lateral neck LNM (odds ratio 9.267, 95% confidence interval 1.852–46.371, <I>P</I> = 0.007).</P><P>MRPL44 expression may be a representative marker of metabolic phenotype according to OxPhos amount and a useful predictor of LNM.</P></▼2>
Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer
Lee, Jandee,Lee, Cho Rok,Ku, Cheol Ryong,Kang, Sang-Wook,Jeong, Jong Ju,Shin, Dong Yeob,Nam, Kee-Hyun,Jung, Sang Geun,Lee, Eun Jig,Chung, Woong Youn,Jo, Young Suk Springer - Society of Surgical Oncology 2015 Annals of Surgical Oncology Vol.22 No.suppl3