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VPL-DBS on neuropathic pain rat model is effective in mechanical allodynia than cold allodynia.
Kim, Jaehyung,Kim, Jinhyung,Min, Kyou Sik,Lee, Sung Eun,Kim, Sung June,Chang, Jin Woo Springer-Verlag Italia 2012 Neurological sciences Vol.33 No.6
<P>Recently, deep brain stimulation (DBS) is widely used in various types of neurodegenerative disorders for minimal invasiveness and safety of the procedure. Deep brain stimulation is consistently applied for the treatment of patients with neuropathic pain even though the success rate is not as high as other neurodegenerative disorders. Furthermore, it is also unclear how DBS improves neuropathic pain. In this study, we investigated the role of DBS following the stimulation parameter for analgesic effect on mechanical allodynia and cold allodynia in neuropathic pain rats. We used a sciatic nerve injury model to induce neuropathic pain, and observed responses to mechanical and cold stimulation by the von Frey test and acetone test, respectively. We classified the rats into four groups: na?ve (na?ve, n = 10), na?ve + DBS (N + DBS, n = 10), neuropathic pain (NP, n = 10), and neuropathic pain + DBS (NP + DBS, n = 10). We inserted the DBS electrode into the ventral posterolateral nucleus (VPL) into the rats (VPL-DBS). The score for mechanical allodynia was significantly decreased in NP + DBS group (p < 0.01). However, the score for cold allodynia did not significantly drop in any groups including NP + DBS group (p > 0.05). In this study, we found that the electrical stimulation of the VPL works more effectively with mechanical allodynia than cold one, and pain signal induced by mechanical stimulus and cold stimulus may be processed through different pathways in the brain.</P>
Gallotannin-Capped Gold Nanoparticles: Green Synthesis and Enhanced Morphology of AFM Images
Kim, Jaehyung,Yhim, Won Been,Park, Jong-Won,Lee, Sang-Hyeon,Kim, Tae Yoon,Cha, Song-Hyun,Kim, Hyun-Seok,Jang, Hong-Lae,Cho, Miyeon,Park, Youmie American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.6
<P>Gold nanoparticles (AuNPs) were synthesized by a green method using a plant secondary metabolite, gallotannin. Gallotannin was used as a reducing and capping agent to convert gold ions into AuNPs for the generation of gallotannin-capped AuNPs (GT-AuNPs). This synthetic route is ecofriendly and eliminates the use of toxic chemical reducing agents. The characteristic surface plasmon resonance of the GT-AuNPs was observed at 536 nm in the UV-visible spectra. The face-centered cubic structure of GT-AuNPs was verified by X-ray diffraction analysis. The majority of the GT-AuNPs had a spherical shape with an average diameter of 15.93 +/- 8.60 nm. Fourier transform infrared spectra suggested that the hydroxyl functional groups of gallotannin were involved in the synthesis of GT-AuNPs. The size and shape of nanoparticles can have a crucial impact on their biological, mechanical, and structural properties. Herein, we developed a modified anisotropic diffusion equation to selectively remove nanoscale experimental noise while preserving nanoscale intrinsic geometry information. To demonstrate the performance of the developed method, the ridge and valley lines were plotted by utilizing the principle curvatures. Compared to the original anisotropic diffusion and raw atomic force microscopy (AFM) experimental data, the developed modified anisotropic diffusion shows excellent performance in nanoscale noise removal while preserving the intrinsic geometry of the nanoparticles.</P>
Eunsol Kim,Yong Ha Kim,Ik-Seon Hong,Jaehyung Yu,Eungseok Lee,Kyoungja Kim 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.2
At the suggestion of the NASA Meteoroid Environment Office (NASA/MEO), which promotes lunar impact monitoring worldwide during NASA’s Lunar Atmosphere and Dust Environment Explorer (LADEE) mission period (launched Sept. 2013), we set up a video observation system for lunar impact flashes using a 16-inch educational telescope at Chungnam National University. From Oct. 2013 through Apr. 2014, we recorded 80 hours of video observation of the unilluminated part of the crescent moon in the evening hours. We found a plausible candidate impact flash on Feb. 3, 2014 at selenographic longitude 2.1° and latitude 25.4°. The flash lasted for 0.2 s and the light curve was asymmetric with a slow decrease after a peak brightness of 8.7 ± 0.3 mag. Based on a star-like distribution of pixel brightness and asymmetric light curve, we conclude that the observed flash was due to a meteoroid impact on the lunar surface. Since unequivocal detection of an impact flash requires simultaneous observation from at least two sites, we strongly recommend that other institutes and universities in Korea set up similar inexpensive monitoring systems involving educational or amateur telescopes, and that they collaborate in the near future.
Kim, Jaehyung,Shin, Beumjoo,Jeon, Gyerok The Korea Institute of Information and Commucation 2017 Journal of information and communication convergen Vol.15 No.2
The early detection of intravenous (IV) infiltration is necessary to minimize the injury caused by the infiltration, which is one of the most important tasks for nurses. For detecting early infiltration in patients receiving invasive vein treatment, bioelectrical impedance was measured using multi-frequency bioelectrical impedance. The impedance decreased significantly at infiltration, and then decreased gradually over time after infiltration. The relative impedance at 20 kHz decreased remarkably at infiltration, and then gradually decreased thereafter. In addition, the impedance ratio increased temporarily at infiltration and then gradually decreased over time. Furthermore, the impedance at each frequency decreased quantitatively over time. This indicates that IV solution leaking from the vein due to infiltration accumulates in the subcutaneous tissues. Moreover, slopes of log Z vs. log f differently decreased with increasing log f, indicating that the impedance exhibits different responses depending on the frequency.
Kim, Chinkyo,Yang, Min,Lee, Wonsang,Yi, Jaehyung,Kim, Sungwoo,Choi, Yoonho,Yoo, Tae-Kyung,Kim, Seon Tai 대전산업대학교 반도체기술연구소 2000 半導體技術硏究所報 Vol.2 No.-
Heteroepitaxial GaN film was grown on sapphire (0001) substrate by hydride vapor-phase epitaxy and it was observed employing scanning electron microscopy and cathodoluminescence that there were microstructural inhomogeneous areas showing suppressed luminescence characteristics compared with the surrounding matrix. They were presumed to be induced by polarity-inverted domains identified on the basis of the chemical inertness and heavily doped characteristics manifested in cathodoluminescence spectra.
Kim, Hyerin,Kang, NaNa,An, KyuHyeon,Koo, JaeHyung,Kim, Min-Soo Oxford University Press 2016 Nucleic acids research Vol.44 No.w1
<P>Design of high-quality primers for multiple target sequences is essential for qPCR experiments, but is challenging due to the need to consider both homology tests on off-target sequences and the same stringent filtering constraints on the primers. Existing web servers for primer design have major drawbacks, including requiring the use of BLAST-like tools for homology tests, lack of support for ranking of primers, TaqMan probes and simultaneous design of primers against multiple targets. Due to the large-scale computational overhead, the few web servers supporting homology tests use heuristic approaches or perform homology tests within a limited scope. Here, we describe the MRPrimerW, which performs complete homology testing, supports batch design of primers for multi-target qPCR experiments, supports design of TaqMan probes and ranks the resulting primers to return the top-1 best primers to the user. To ensure high accuracy, we adopted the core algorithm of a previously reported MapReduce-based method, MRPrimer, but completely redesigned it to allow users to receive query results quickly in a web interface, without requiring a MapReduce cluster or a long computation. MRPrimerW provides primer design services and a complete set of 341 963 135 <I>in silico</I> validated primers covering 99% of human and mouse genes. Free access: http://MRPrimerW.com.</P>