인천 인현동 호프집 화재 피해자 분석

최정태,안무업,안희철,최영미,정재봉,서정열,유기철,이삼우,박석현,조준휘,김성환,김아진,송근정 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Purpose : This study was conducted to develop field triage, transportation, distribution, and prehospital care at a fire disaster by analyzing the victims of the fore that broke out at a bar in Incheon. Method : We analyzed the cases of the victims of a fire in Incheon in Oct. 1999. We determined the primary care hospital, the arrival time, the burn size, the outcome, and the injury type from the medical records, the concerned organ records, and interviews with concerned persons. Result : The total number of victims was 137: 56 prehospital deaths, 1 hospital death, and 80 survivals. The Pearson correlation coefficient between the burn size and the severity was -0.175. There were 121(89.6%) cases of inhalation injury, 59 (43.7%) cases of flame burns, 66 (48.9%) cases of hypoxic brain damage, and 16 (11.9%) cases involving other types of injury. Conclusion : The causes of death of the fire victims were inhalation injury and hypoxic brain damage due to CO poisoning and other toxic inhalants. We propose the use of a simple triage and rapid treatment(START) system and a reassessment the delayed category in fire disasters.

Comorbid Benign Paroxysmal Positional Vertigo in Idiopathic Sudden Sensorineural Hearing Loss: An Ominous Sign for Hearing Recovery

Song, Jae-Jin,Yoo, Young-Tae,An, Yong-Hwi,Yoo, Jae Chul,Kim, Ji Soo,Koo, Ja-Won Otology Neurotology, Inc. 2012 Otology & Neurotology Vol.33 No.2

OBJECTIVE: To determine characteristics and their prognostic value in idiopathic sudden sensorineural hearing loss (ISSNHL) with comorbid ipsilateral benign paroxysmal positional vertigo (BPPV). STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: Of the 374 patients with a diagnosis of ISSNHL at Seoul National University Bundang Hospital from January 2004 to December 2009, 32 patients (8.6%) with comorbid BPPV were recruited and compared with matched ISSNHL patients without BPPV. INTERVENTIONS: Otologic and neurotologic examinations, pure-tone audiometry (PTA), vestibular function tests, and brain magnetic resonance imagings. MAIN OUTCOME MEASURES: Comparison of the findings of serial audiograms for 6 months and vestibular function tests in patients with ISSNHL and concurrent BPPV with those in age-matched ISSNHL patients without BPPV. RESULTS: Patients with BPPV showed higher PTA averages than those without BPPV on initial and follow-up audiograms. Moreover, the improvement in PTA was less in the BPPV group than in the control. BPPV most commonly involved the posterior canal (17/32, 53.1%), followed by the horizontal canal (8/32, 25%), both the posterior and horizontal canals (6/32, 18.8%), and the anterior canal (1/32, 3.1%). Thirteen (40.6%) of 32 patients had recurrences of BPPV, 9 within a week and another 2 within 3 months. CONCLUSION: Comorbid BPPV is a negative prognostic indicator of auditory function in ISSNHL. Concurrent BPPV in ISSNHL suggests combined damage to the utricle and may indicate severe and widespread labyrinthine damage, leading to the poor prognosis.

Somatic Mutations of the ENPP2 (Autotaxin/lysoPLD) Gene in Breast Cancer

Song, Jae-Hwi,Kim, Jeong-Kyu,Noh, Ji-Heon,Jung, Kwang-Hwa,Eun, Jung-Woo,Kim, Chang-Jae,Bae, Hyun-Jin,Xie, Hong-Jian,Ahn, Young-Min,Lee, Sug-Hyung,Yoo, Nam-Jin,Lee, Jung-Young,Park, Won-Sang,Nam, Suk-W The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.4

ENPP2, a 125 kDa secreted lysophopholipase D which originally identified as a tumor-motogen, Autotaxin, enhances cellular locomotion, cell proliferation, angiogenesis and cell survival by generating the signal molecule lysophosphatic acid or sphingosine-1-phosphate. Previous studies have suggested that expression of Autotaxin is associated with invasive phenotype in advanced breast carcinomas. Thus, to determine whether genetic alterations of ENPP2 gene are involved in the development or progression of breast cancer, we analyzed its somatic mutation in 85 breast carcinomas by single-stranded conformational polymorphism and sequencing. Overall, six ENPP2 mutations were found (7.0%), comprising five missense and one nonsense mutation (s). To our knowledge, this is the first report on ENPP2 mutation in breast carcinoma, and the data indicate that ENPP2 is occasionally mutated in breast carcinomas, and suggest that ENPP2 mutation may contribute to the tumor development in some breast carcinomas.

Immunohistochemical Analysis of TBX3 and $\beta$-catenin in Gastric Cancers

Song, Jae-Hwi,Yoon, Jung-Hwan,Kang, Young-Hwi,Cao, Zhang,Nam, Suk-Woo,Lee, Jung-Young,Park, Won-Sang The Korean Society of Toxicogenomics and Toxicopro 2009 Molecular & cellular toxicology Vol.5 No.4

TBX3 has demonstrated oncogenic activity as a downstream target of the Wnt/$\beta$-catenin signaling pathway. In this study, the aim was to determine whether overexpression of the TBX3 protein is involved in the development and/or progression of gastric cancers. We analyzed the expression pattern of the TBX3 and $\beta$-catenin proteins in a series of 186 sporadic gastric cancers. Altered expression of the TBX3 and $\beta$-catenin proteins was observed in 54 (29.0%) and 48 (25.8%) of the 186 gastric cancers. Statistically, overexpression of the TBX3 and $\beta$-catenin proteins was not associated with the clinical and pathological parameters studied including: histological type, tumor location, tumor size, and the 5-year survival (P>0.05). However, TBX3 overexpression was closely associated with lymph node metastasis and aberrant $\beta$-catenin expression (P<0.05). In addition, overexpression of the TBX3 protein was confirmed by Western blot analysis of primary gastric cancer tissues and cell lines. These data suggest that TBX3 overexpression may play a role in the development and progression of sporadic gastric cancers.

Case Report : Spontaneous Healing of a Displaced Bucket-Handle Tear of the Lateral Meniscus in a Child

( Jae Hwi Han ),( Jae Gwang Song ),( Jae Ho Kwon ),( Kyung Woon Kang ),( Daviesh Shah ),( Kyung Wook Nha ) 대한슬관절학회 2015 대한슬관절학회지 Vol.27 No.1

Bucket-handle tears less frequently occur in the lateral meniscus than in the medial meniscus. An 11-year-old male patient complained of painful swelling and locking due to a displaced bucket-handle tear of the lateral meniscus. We recommended an arthroscopic surgery; however, the patient left the hospital without surgical treatment. Six weeks afterwards, he returned without any complain of pain and he regained full range of motion. The final follow-up magnetic resonance imaging showed reduction of the torn meniscal fragment without any signal changes suggestive of a meniscal tear. We report a rare case of an isolated displaced bucket-handle tear of the lateral meniscus in an 11-year-old patient that healed spontaneously without surgical intervention.

Is Bone Grafting Necessary in Opening Wedge High Tibial Osteotomy? A Meta-Analysis of Radiological Outcomes

( Jae Hwi Han ),( Hyun Jung Kim ),( Jae Gwang Song ),( Jae Hyuk Yang ),( Nikhl N Bhandare ),( Aldrich Raymund Fernandez ),( Hyung Jun Park ),( Kyung Wook Nha ) 대한슬관절학회 2015 대한슬관절학회지 Vol.27 No.4

Purpose: Bone grafting in opening wedge high tibial osteotomy (OWHTO) is still controversial. The purpose of this study is to compare the radiological outcomes of OWHTO with bone graft (autogenous, allogenous, and synthetic bone graft) and those without bone graft. Materials and Methods: PubMed, MEDLINE, EMBASE and Cochrane Register of Studies databases were searched using specific inclusion and exclusion criteria for radiological studies involving OWHTO with bone graft and without bone graft groups. All reported delayed union, nonunion and correction loss were analyzed. Data were searched from the time period of January 2000 through July 2014. In addition, a modified Coleman methodology score (CMS) system was used to assess the methodological quality of the included studies. Results: Twenty-five studies with a mean CMS value of 77 (range, 61 to 85 score) were included. In total, 1,841 patients underwent OWHTO using 4 different procedures for bone graft: autobone graft (n=352), allobone graft (n=547), synthetic bone graft (n=541) and no bone graft (n=401). There was a similar tendency for delayed union, nonunion and correction loss rate among the osteotomy space filling methods. Conclusions: The meta-analysis showed there was a similar tendency for radiological union and correction maintenance among patients undergoing OWHTO regardless of the type of bone in all of the studies. However, the currently available evidence is not sufficient to strongly support the superiority of OWHTO with bone graft to OWHTO without bone graft.

TGFBR2 frameshift mutation in gastric tumors with microsatellite instability

Song, Jae-Hwi,Lee, Hwa-Sung,Yoon, Jung-Hwan,Kang, Young-Hwi,Nam, Suk-Woo,Lee, Jung-Young,Park, Won-Sang The Korean Society of Toxicogenomics and Toxicopro 2010 Molecular & cellular toxicology Vol.6 No.3

Microsatellite instability (MSI) is a form of genetic instability present in virtually all tumors from patients with hereditary nonpolyposis colon cancer and a subset of various sporadic tumors, including colorectal and gastric cancers. Transforming growth factor-beta receptor 2 (TGFBR2) mutations in MSI-positive cancer cell lines may partially inactivate TGF-$\beta$-induced growth inhibition. The aim of this study was to investigate whether MSI and TGFBR2 gene mutations contribute to the progression from gastric adenoma to cancer in multi step gastric carcinogenesis. MSIs were analyzed using 5 micro satellite markers and a frame shift mutation in poly(A)10 within the TGFBR2 gene in 50 gastric adenomas and 88 gastric cancer specimens. One (2.0%) of 50 gastric adenomas and 22 (25.0%) of 88 gastric cancers were MSI-positive. TGFBR2 frame shift mutations were found in 9 gastric cancers, but not in adenoma. All cases with the TGFBR2 frameshift mutation showed high-frequency MSIs. These results suggest that MSIs may occur in the development of gastric cancers, but not in adenomas less than 2 cm, and the TGFBR2 gene may be a target of genomic instability in MSI gastric carcinogenesis.

Genetic alterations of the CHOP gene in gastric cancers

Jae Hwi Song,박종경,윤정환,남석우,이정용,박원상 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.1

CHOP, a member of the C/EBP family of the transcriptional factor, showed a tumor suppressor activity by binding to TCF and inhibiting the Wnt signaling pathway. In this study, to determine whether genetic alterations of CHOP gene are involved in the development and/or progression of the gastric cancers, we have screened a set of 47 gastric adenoma and 81 sporadic gastric cancers for mutations and allelic loss. In mutation analysis, we found one and five somatic missense mutations, P41T, E69K, S79N, P80S, P80L and G36S, in gastric adenoma and cancer, respectively. All of the mutations were detected in transactivation domain of the CHOP gene. An allelic loss was found in 19 (38.8%) of forty-nine informative cases at one or both microsatellite markers, D12S305 and D12S1691. Clinically, five cancer cases with mutations were of intestinal-type gastric cancers and three mutations were found in the cases with surrounding lymph node metastasis. These data suggest that genetic alterations of the CHOP gene may play an important role in the development of sporadic gastric cancers.

Genetic and epigenetic analysis of the <i>EPHB2</i> gene in gastric cancers

SONG, JAE HWI,KIM, CHANG JAE,CHO, YONG GU,KWAK, HYUN JUNG,NAM, SUK WOO,YOO, NAM JIN,LEE, JUNG YOUNG,PARK, WON SANG Wiley-Blackwell Munksgaard 2007 APMIS Vol. No.

<P>EPHB2 is a member of the Eph receptor tyrosine kinase family and a direct transcriptional target of &bgr;-catenin/TCF. EPHB2 plays an important role in maintaining the correct positioning of the proliferative compartment in the crypt-villous axis. A loss of EPHB2 expression has been observed in human tumors, particularly in colonic adenomas and carcinomas. A search was made for mutations at the A9 tract in exon 17, an allelic loss at the <I>EPHB2</I> gene locus, and promoter hypermethylation of the <I>EPHB2</I> gene in 81 sporadic gastric cancers in order to determine if genetic or epigenetic alterations of the <I>EPHB2</I> gene are involved in the development and/or progression of gastric cancer. Unexpectedly, no frameshift mutation was found and there was a low frequency (20.8%) of allelic loss. In addition, promoter hypermethylation was detected in only one gastric cancer tissue sample. Therefore, genetic or epigenetic alterations of the <I>EPHB2</I> gene might be an uncommon event in the development or progression of gastric cancers.</P>

Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease

( Jae-hwi Song ),( Goon-tae Kim ),( Kyung-ho Park ),( Woo-jae Park ),( Tae-sik Park ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.4

Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory condition involving the accumulation of macrophages and various lipids (low-density lipoprotein [LDL] cholesterol, ceramide, S1P). Moreover, endothelial cells, macrophages, leukocytes, and smooth muscle cells are the major players in the atherogenic process. Sphingolipids are now emerging as important regulators in various pathophysiological processes, including the atherogenic process. Various sphingolipids exist, such as the ceramides, ceramide-1-phosphate, sphingosine, sphinganine, sphingosine-1-phosphate (S1P), sphingomyelin, and hundreds of glycosphingolipids. Among these, ceramides, glycosphingolipids, and S1P play important roles in the atherogenic processes. The atherosclerotic plaque consists of higher amounts of ceramide, glycosphingolipids, and sphingomyelin. The inhibition of the de novo ceramide biosynthesis reduces the development of atherosclerosis. S1P regulates atherogenesis via binding to the S1P receptor (S1PR). Among the five S1PRs (S1PR1-5), S1PR1 and S1PR3 mainly exert anti-atherosclerotic properties. This review mainly focuses on the effects of ceramide and S1P via the S1PR in the development of atherosclerosis. Moreover, it discusses the recent findings and potential therapeutic implications in atherosclerosis.