은행원의 VDT작업에 따른 안자각종상

구정완,이승환,이자영 가톨릭대학산업의학쎈타 산업의학연구소 1991 韓國의 産業醫學 Vol.30 No.5

In order to investigate the effects due to visual display terminal(VDT) work of banking operations, the questionnaire survey for subjective eye symptoms was carried out on 378 bank clerks who had been engaged in VDT work for various length of work hours. The results were as follows: 1. Of the 17 items of questionnaire, the highest percentage was accounted for by 'eye strain' (61.1%),follwed by 'feel pressure in eyes'(33.3%),'eyes feel ache' (26.7%),'eyes feel heavy'(21.4%) and 'blurred vision of objectl'(16.7%) in the order of sequence. 2. The average weighetd score of subjictive eye symptoms was 13.75, 14.39, 16.78 and 13.13 in the age groups of less than 25,25-29, 30-34, and 35-44 years, respectively, it was significantly increased from the age group of less than 25 years to 30-34 years. Also, it was significantly increased according to increasing with work duration. 3. The average weighted score of female was larger than that of male and the score of green color was larger than that of black-white color by the color of cathode ray tube display. 4. Aggravating time of subuective symptioms was during the end of month in period of a month, a monday in a day of week and on duty (P.M.) in a daily work.

韓國의 藥膳 食文化

具成子 동아시아식생활학회 2000 동아시아식생활학회지 Vol.10 No.6

자기공명영상을 이용한 정신분열병 환자의 뇌량크기 측정

성상율,구자섭,조근호,원승희,이종훈,박종한 대한생물치료정신의학회 2004 생물치료정신의학 Vol.10 No.1

Objectives : Nowadays many studies with MRI have reported structurai abnormalltles of corpus callosum of schizophrenic patients. However, the results are various and inconstant. In this study, we attempted to identify structural change of C O ~ U S cailosurn. Method : We measured the size of corpus callosum of the 24 schizophrenia patients (male 11, female 18) who were diagnosed by DSM-IV (19943, visited at department of psychiatry, catholic university hospital of Daegu from January 2002 to December 2003, by using midline sagittal slice of MRI. These results were compared with the size of corpus callosum of 25 controls (male 7, female 78). We divided corpus callosurn into 7 areas. We calculated and compared the areas of each subregion, mid-sagittal cerebral area, and entire corpus callosum. The results were analyzed by independent t-test. Result :When we compared subregion to corpus callosum adjusted wth mid-sagittal cerebral area, schlzoph-renia patients had significantly smaller genu (1.64k0.32 vs. 1.43k0.26 p<O.O5) and splenium (2.16f0.27 VS. 1.96+0.30 ; ~(0.05). Similarly, the ratio of total corpus callosum to midline sagittal cerebral area (%)(7.50*0.72 vs. 6.90t0.82 ~(0.05) was significantly smaller In schizophrenia than control group. Conclusion : In this study, we found significant differences in corpus callosum between schizophrenic patients and normal control group.

말초전정병증에서 빙수자극에 의한 안진의 두위의존성

최병윤,구자원,오승하,장선오,김종선 대한평형의학회 2003 Research in Vestibular Science Vol.2 No.2

하루 콩단백질 25g 섭취를 위한 메뉴작성 및 영양성분 분석

한재숙,김정애,서봉순,이연정,서향순,조연숙,한경필,이신정,오옥희,우경자,조은자,구성자,김수진,李承彦,南出隆久 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.2

The purpose of this study was to develop menus for daily intake of 25g soybean protein and to analyse nutrients of these foods. Analytical values were compared to the theoretical one using the food composition table and recommended dietary allowances for Koreans (7th revision). The results are as follows. 1. Soybean curd residue stew, Soybean curd, Kimchi saute, and hard boiled soybean and lotus root were selected for the menu for January, of which the content of soy bean protein(SBP) was 33.1g, soybean stew, soybean curd and soybean sprout saute, and Italian deep fried soybean curd were for February, of which the content of SBP was 35.0g. The content of SBP in soybean paste soup with soybean curd, fried soybean curd and fried soybean curd roll, the menu for March, was 24.9g. That of April were soybean curd gratin with soymilk, soybean curd and ham with garlic dressing and the content of SBP was 26.3g. That of May were soybean porridge, soybean flour cake with honey (Dasik), soybean sprout soup and the content of SBP was 26.7g. That of June were soymilk, pan-fried soybean curd, steamed soybean curd with chicken and the content of SBP was 28.4g. That of July were noodle with soymilk, mapatofu, soybean curd salad and the content of SBP was 24.7g. That of August were soybean sprout with mustard dressing, Tossed green pepper with raw soybean flour, Tofu and Kimchi stew, soybean curd steak and the content of SBP was 26.2g. That of September were Chinese cabbage soup with raw soybean flour, sweet and sour tofu and the content of SBP was 23.2g. That of Oct. were Fermented soybean stew, soybean pan cake and the content of SBP was 24.3g. That of November were not-pressed soybean curd casserole, pan-fried mashed soybean curd with egg, stir frying deep-fried soybean curd with vegetables and the content of SBP was 22.4g. That of December were soybean curd and mushroom casserole, fried soybean curd and vegetables, hard boiled soybean curd and the content of SBP was 28.9g. 2. The ratio of the analytical value over theoretical value (A/B%) of one serving in kcal, carbohydrate, protein, fat, ash and dietary fiber were 57.7~107.7%, 42.9~131.9%, 79.2~118.3%, 54.5~100%, 40.7~80.8% and 42.1~113.2%, respectively. 3. The ratio of A/B% of one serving in Ca, K, Na, P and Fe were 44.1~93.6%, 59.0~153.1%, 53.1~117.7% 64.6%~138.8 and 33.8~77.3%, respectively. That in Fe was the lowest among minerals. 4. The ratio of analytical value over Korean R.D.A(A/C%) in Ca was relatively higher (22.0~85.9%) than that in kcal(18~63%). 5. The ratio of A/C% in Fe was 25.1~64.3% and lower than that in Ca and protein in general.

Expression of Metabolism-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma

Koo, Ja Seung,Yoon, Jin Sook American Society for Clinical Pathology 2015 American journal of clinical pathology Vol.143 No.4

<P><B>Objectives:</B></P><P>To investigate the expression and the clinical implications of metabolism-related proteins in lacrimal gland adenoid cystic carcinoma (ACC) in comparison with salivary gland ACC.</P><P><B>Methods:</B></P><P>Human tissue samples of lacrimal gland ACC (n = 11) and salivary gland ACC (n = 64) were analyzed. Immunochemistry was used to measure expression of proteins related to glycolysis (glucose transporter 1, hexokinase II, carbonic anhydrase IX, and monocarboxylate transporter 4 [MCT4]), glutaminolysis (glutaminase 1 [GLS1], glutamate dehydrogenase [GDH], and amino acid transporter 2 [ASCT2]), mitochondria (adenosine triphosphate [ATP] synthase, succinate dehydrogenase A [SDHA], and succinate dehydrogenase B), and glycolytic intermediate metabolism (phosphoserine phosphatase [PSPH], serine hydroxymethyl transferase 1 [SHMT1]).</P><P><B>Results:</B></P><P>GLS1 and ASCT2 were more highly expressed, and GDH, ATP synthase, and SDHA were expressed to a lesser degree in lacrimal gland ACC than in salivary gland ACC (<I>P</I> < .05). Lacrimal gland ACC showed less of a mitochondrial phenotype than did salivary gland ACC (<I>P</I> = .001). Positivity of MCT4 and PSPH was related to shorter disease-free survival, and SHMT1 was related to shorter overall survival (<I>P</I> < .05).</P><P><B>Conclusions:</B></P><P>Lacrimal gland ACC exhibited higher expression of GLS1 and ASCT2, compared with salivary gland ACC. Overexpression of MCT4, PSPH, and SHMT1 was associated with poorer prognosis.</P>

Thyroid Papillary Carcinomas with Extensive Calcification and Bone Metaplasia: A Clinicopathological Analysis of 41 Carcinoma Cases and Comparison with 30 Benign Cases with Extensive Calcification and Bone Metaplasia

( Ja Seung Koo ),( Soonwon Hong ) 대한갑상선학회 2010 International Journal of Thyroidology Vol.3 No.1

Background and Objectives: The aim of the present study was to investigate the clinicopathological characteristics and implications of papillary carcinoma with extensive calcification and bone metaplasia (PTCECB), and to determine the differences between PTCECB and benign nodules with calcification and bone metaplasia (BNECB). Materials and Methods: We retrospectively reviewed the slides of 41 PTCECB cases and 30 BNECB cases. Results: Only four (9.8%) cases of PTCECB demonstrated psammoma bodies. Twenty eight (68.3%) cases of PTCECB showed prominent follicular architectures with occasional bland-appearing thyrocytes showing diffuse immunohistochemical expression for CK19 and galectin-3. All BNECBs revealed expanding tumor margins and were intrathyroidally located. In contrast, PTCECB showed expanding tumor margins in 26 (63.4%) cases (p=0.001) and extrathyroidal extension in 20 (48.8%) cases (p=0.000). Conclusion: PTCECB showed characteristics of prominent follicular architecture and an absence of psammoma bodies and should be differentiated from BNECB by histological features such as extrathyroidal extension and characteristic nuclear features of papillary thyroid carcinoma combined with immunohistochemical study such as CK19 and galectin-3.

How Do Advisors Influence Mergers and Acquisitions?: An Analysis of Acquisitions in Japan

KOO, Ja Seung Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.7

The objective of this study is to examine the differentiated influence of sell-side advisors and buy-side advisors on mergers and acquisitions (M&A). Unlike prior studies on M&A advisors, the study addresses different roles of target and acquirer advisors, and explores their influences on the cumulative abnormal returns (CAR) and acquisition premiums with an empirical analysis of longitudinal data of M&As conducted by Japanese listed firms except financial companies from 1995 to 2012. M&A data were obtained from the Securities Data Corporation's (SDC) database, and the individual firm data were collected from the Nikkei Economic Electronic Databank System (NEEDS), which provides a wide range of corporate information including financial status, operational performance, and strategy. Using a sample of 452 cases for the CAR and 498 cases for the analysis of acquisition premiums, the empirical results support the hypotheses of the target advisor's positive association with CAR and acquirer advisor's positive association with acquisition premiums. The findings of this study indicate the target advisor's positive contribution to the success of acquisition process and performance, and acquirer advisor's negative influence on the deal progress. The study provides theoretical implications on M&A research and practical insights into the investment banking industry.

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

Koo, Gi-Bang,Morgan, Michael J,Lee, Da-Gyum,Kim, Woo-Jung,Yoon, Jung-Ho,Koo, Ja Seung,Kim, Seung Il,Kim, Soo Jung,Son, Mi Kwon,Hong, Soon Sun,Levy, Jean M Mulcahy,Pollyea, Daniel A,Jordan, Craig T,Yan Springer Science and Business Media LLC 2015 Cell research Vol.25 No.6

<P>Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the cellular machinery that executes 'programmed' or 'regulated' necrosis. Here we show that programmed necrosis is activated in response to many chemotherapeutic agents and contributes to chemotherapy-induced cell death. However, we show that RIP3 expression is often silenced in cancer cells due to genomic methylation near its transcriptional start site, thus RIP3-dependent activation of MLKL and downstream programmed necrosis during chemotherapeutic death is largely repressed. Nevertheless, treatment with hypomethylating agents restores RIP3 expression, and thereby promotes sensitivity to chemotherapeutics in a RIP3-dependent manner. RIP3 expression is reduced in tumors compared to normal tissue in 85% of breast cancer patients, suggesting that RIP3 deficiency is positively selected during tumor growth/development. Since hypomethylating agents are reasonably well-tolerated in patients, we propose that RIP3-deficient cancer patients may benefit from receiving hypomethylating agents to induce RIP3 expression prior to treatment with conventional chemotherapeutics.</P>

How the Lender–Borrower Relationship Influences M&As: an Analysis of a Strategic Action in Japan

Ja-Seung Koo 한국유통과학회 2016 유통과학연구 Vol.14 No.8

Purpose - This study examines lenders’ reactions to M&A, based on the strength of the lender–borrower relationship and the lender’s expectations of the potential benefits or risks of the deal. Research design, data, and methodology – This research addresses the lender’s influence on the implementation stage of a large-scale strategic action such as M&A to understand the motivation and dynamics of lenders’ responses and empirically examines how the lender–borrower relationship influences the focal firm’s merger and acquisition (M&A) transactions, using data on 501 M&A deals in Japan from 1990 to 2010. Results - The presented analysis found that lenders that have a strong lender–borrower relationship, especially those showing a high debt equity ratio, support borrowers’ M&A progress and the target firm’s lenders resist the deal progressing and may raise the acquisition premium if their current power relative to borrowers is weak. Conclusions - Stakeholders including lenders do not favor strategies of focal firms that threaten their future benefits, while they also tend to estimate the potential benefits and losses by comparing their current circumstances with those of other stakeholders. The empirical results of the presented analysis help explain the mechanism of lenders’ reactions and offer insights into the power of a closer and stronger lender–borrower relationship.