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      • New teleomorph combinations in the entomopathogenic genus <i>Metacordyceps</i>

        Kepler, R.M.,Sung, G.-H.,Ban, S.,Nakagiri, A.,Chen, M.-J.,Huang, B.,Li, Z.,Spatafora, J.W. Informa UK (TaylorFrancis) 2012 Mycologia Vol.104 No.1

        <P>The genus Metacordyceps contains arthropod pathogens in Clavicipitaceae (Hypocreales) that formerly were classified in Cordyceps sensu Kobayasi et Mains. Of the current arthropod pathogenic genera of Hypocreales, the genus Metacordyceps remains one of the most poorly understood and contains a number of teleomorphic morphologies convergent with species of Cordyceps s.s. (Cordycipitaceae) and Ophiocordyceps (Ophiocordycipitaceae). Of note, the anamorph genera Metarhizium and Pochonia were found to be associated only with Metacordyceps and demonstrated to be phylogenetically informative for the clade. Several species of Cordyceps considered to have uncertain placements (incertae sedis) in the current taxonomic framework of clavicipitoid fungi were collected during field expeditions mostly in eastern Asia. Species reclassified here in Metacordyceps include Cordyceps atrovirens Kobayasi & Shimizu, Cordyceps indigotica Kobayasi & Shimizu, Cordyceps khaoyaiensis Hywel-Jones, Cordyceps kusanagiensis Kobayasi & Shimizu, Cordyceps martialis Speg., Ophiocordyceps owariensis Kobayasi, Cordyceps pseudoatrovirens Kobayasi & Shimizu and Ophicordyceps owariensis f. viridescens (Uchiy. & Udagawa) G.H. Sung, J.M. Sung, Hywel-Jones & Spatafora. Incorporation of these species in a multigene phylogenetic framework of the major clades of clavicipitoid fungi more than doubled the number of species in Metacordyceps and allowed for refinement of morphological concepts for the genus consistent with the phylogenetic structure. Based on these findings we then discuss evolution of this genus, subgeneric relationships, anamorph connections, and suggest additional species that should be confirmed for possible inclusion in Metacordyceps.</P>

      • Response of plasma rotation to resonant magnetic perturbations in J-TEXT tokamak

        Yan, W,Chen, Z Y,Huang, D W,Hu, Q M,Shi, Y J,Ding, Y H,Cheng, Z F,Yang, Z J,Pan, X M,Lee, S G,Tong, R H,Wei, Y N,Dong, Y B IOP 2018 Plasma physics and controlled fusion Vol.60 No.3

        <P>The response of plasma toroidal rotation to the external resonant magnetic perturbations (RMP) has been investigated in Joint Texas Experimental Tokamak (J-TEXT) ohmic heating plasmas. For the J-TEXT’s plasmas without the application of RMP, the core toroidal rotation is in the counter-current direction while the edge rotation is near zero or slightly in the co-current direction. Both static RMP experiments and rotating RMP experiments have been applied to investigate the plasma toroidal rotation. The core toroidal rotation decreases to lower level with static RMP. At the same time, the edge rotation can spin to more than 20 km s<SUP>−1</SUP> in co-current direction. On the other hand, the core plasma rotation can be slowed down or be accelerated with the rotating RMP. When the rotating RMP frequency is higher than mode frequency, the plasma rotation can be accelerated to the rotating RMP frequency. The plasma confinement is improved with high frequency rotating RMP. The plasma rotation is decelerated to the rotating RMP frequency when the rotating RMP frequency is lower than the mode frequency. The plasma confinement also degrades with low frequency rotating RMP.</P>

      • SCISCIESCOPUS

        THE TAIWANESE-AMERICAN OCCULTATION SURVEY PROJECT STELLAR VARIABILITY. II. DETECTION OF 15 VARIABLE STARS

        Mondal, S.,Lin, C. C.,Chen, W. P.,Zhang, Z.-W.,Alcock, C.,Axelrod, T.,Bianco, F. B.,Byun, Y.-I.,Coehlo, N. K.,Cook, K. H.,Dave, R.,Kim, D.-W.,King, S.-K.,Lee, T.,Lehner, M. J.,Lin, H.-C.,Marshall, S. American Institute of Physics 2010 The Astronomical journal Vol.139 No.5

        <P>The Taiwanese-American Occultation Survey (TAOS) project has collected more than a billion photometric measurements since 2005 January. These sky survey data—covering timescales from a fraction of a second to a few hundred days—are a useful source to study stellar variability. A total of 167 star fields, mostly along the ecliptic plane, have been selected for photometric monitoring with the TAOS telescopes. This paper presents our initial analysis of a search for periodic variable stars from the time-series TAOS data on one particular TAOS field, No. 151 (R.A. = 17<SUP>h</SUP>30<SUP>m</SUP>6<img entity='fs' SRC='http://ej.iop.org/icons/Entities/fs.gif' ALT='fs' ALIGN='BASELINE' />7, decl. = 27°17'30'', J2000), which had been observed over 47 epochs in 2005. A total of 81 candidate variables are identified in the 3 deg<SUP>2</SUP> field, with magnitudes in the range 8 < R < 16. On the basis of the periodicity and shape of the light curves, 29 variables, 15 of which were previously unknown, are classified as RR Lyrae, Cepheid, δ Scuti, SX Phonencis, semi-regular, and eclipsing binaries.</P>

      • SCIESCOPUSKCI등재

        True Digestibility of Phosphorus in Different Resources of Feed Ingredients in Growing Pigs

        Wu, X.,Ruan, Z.,Zhang, Y.G.,Hou, Y.Q.,Yin, Y.L.,Li, T.J.,Huang, R.L.,Chu, W.Y.,Kong, X.F.,Gao, B.,Chen, L.X. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.1

        To determine the true digestible phosphorus (TDP) requirement of growing pigs, two experiments were designed with the experimental diets containing five true digestible P levels (0.16%, 0.20%, 0.23%, 0.26% and 0.39%) and the ratio of total calcium to true digestible P (TDP) kept at 2:1. In Experiment 1, five barrows (Duroc${\times}$Landrace${\times}$Yorkshire) with an average initial body weight of 27.9 kg were used in a $5{\times}5$ Latin-square design to evaluate the effect of different dietary P levels on the digestibility and output of P and nitrogen. In Experiment 2, sixty healthy growing pigs (Duroc${\times}$Landrace${\times}$Yorkshire) with an average body weight (BW) of 21.4 kg were assigned randomly to one of the five dietary treatments (12 pigs/diet), and were used to determine the true digestible phosphorus (TDP) requirement of growing pigs on the basis of growth performance and serum biochemical indices. The results indicated that the true digestibility of P increased (p<0.05) linearly with increasing dietary TDP level below 0.26%. The true P digestibility was highest (56.6%) when dietary TDP was 0.34%. Expressed as g/kg dry matter intake (DMI), fecal P output increased (p<0.05) linearly with increasing P input. On the basis of g/kg fecal dry matter (DM), fecal P output was lowest for Diet 4 and highest (p<0.05) for Diet 5. The apparent digestibility of crude protein (CP) did not differ (p>0.05) among the five diets, with the average nitrogen output of 12.14 g/d and nitrogen retention of 66% to 74% (p>0.05), which suggested that there was no interaction between dietary P and CP protein levels. During the 28-d experimental period of Experiment 2, the average daily gain (ADG) of pigs was affected by dietary TDP levels as described by Eq. (1): $y=-809,532x^4+788,079x^3-276,250x^2+42,114x-1,759$; ($R^2=0.99$; p<0.01; y = ADG, g/d; x = dietary TDP, %), F/G for pigs by Eq. (2): $y=3,651.1x^4-3,480.4x^3+1,183.8x^2-172.5x+10.9$ ($R^2=0.99$; p<0.01; y = F/G; x = dietary TDP, %), and Total P concentrations in serum by Eq. (3): $y=-3,311.7x^4+3,342.7x^3-1,224.6x^2+195.6x-8.7$ (R2 = 0.99; p<0.01; y = total serum P concentration and x = dietary TDP, %). The highest ADG (782 g/d), the lowest F/G (1.07) and the highest total serum P concentration (3.1 mmol/L) were obtained when dietary TDP level was 0.34%. Collectively, these results indicate that the optimal TDP requirement of growing pigs is 0.34% of the diet at a total Ca to TDP ratio of 2:1.

      • SCISCIESCOPUS
      • KCI등재

        Experimental Study of the Runaway Current in the J-TEXT Tokamak

        Y. H. Luo,Z. Y. Chen,X. Q. Zhang,D. W. Huang,W. Jin,Y. H. Huang,Y. Tang,J. C. Li,R. H. Tong,W. Yan,G. Zhuang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.3

        Major plasma disruptions in tokamaks often generate runaway currents, which contain electronswith energies of several tens of megaelectron-volts (MeV). These currents can cause substantialdamage when control is lost and the current hits the limiters or the vessel wall. The interactionbetween the runaway electrons and the impurities inside the plasma results in soft X-ray emission,which can provide detailed information about the runaway generation process and the confinementof runaway electrons. A vertical soft X-ray array at the top of Joint Texas Experimental Tokamak(J-TEXT) was used to study the runaway beams resulting from major disruptions. Runawayelectron production and confinement of runaway current were observed by using soft X-ray images.

      • SCISCIESCOPUS

        Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function

        Tai, Yu-Tzu,Horton, Holly M.,Kong, Sun-Young,Pong, Erik,Chen, Hsing,Cemerski, Saso,Bernett, Matthew J.,Nguyen, Duc-Hanh T.,Karki, Sher,Chu, Seung Y.,Lazar, Greg A.,Munshi, Nikhil C.,Desjarlais, John R American Society of Hematology 2012 Blood Vol.119 No.9

        <B>Abstract</B><P>HM1.24, an immunologic target for multiple myeloma (MM) cells, has not been effectively targeted with therapeutic monoclonal antibodies (mAbs). In this study, we investigated in vitro and in vivo anti-MM activities of XmAb5592, a humanized anti-HM1.24 mAb with Fc-domain engineered to significantly enhance FcγR binding and associated immune effector functions. XmAb5592 increased antibody-dependent cellular cytotoxicity (ADCC) several fold relative to the anti-HM1.24 IgG1 analog against both MM cell lines and primary patient myeloma cells. XmAb5592 also augmented antibody dependent cellular phagocytosis (ADCP) by macrophages. Natural killer (NK) cells became more activated by XmAb5592 than the IgG1 analog, evidenced by increased cell surface expression of granzyme B-dependent CD107a and MM cell lysis, even in the presence of bone marrow stromal cells. XmAb5592 potently inhibited tumor growth in mice bearing human MM xenografts via FcγR-dependent mechanisms, and was significantly more effective than the IgG1 analog. Lenalidomide synergistically enhanced in vitro ADCC against MM cells and in vivo tumor inhibition induced by XmAb5592. A single dose of 20 mg/kg XmAb5592 effectively depleted both blood and bone marrow plasma cells in cynomolgus monkeys. These results support clinical development of XmAb5592, both as a monotherapy and in combination with lenalidomide, to improve patient outcome of MM.</P>

      • SCIESCOPUSKCI등재

        New Evidences of Effect of Melanocortin-4 Receptor and Insulin-like Growth Factor 2 Genes on Fat Deposition and Carcass Traits in Different Pig Populations

        Chen, J.F.,Xiong, Y.Z.,Zuo, B.,Zheng, R.,Li, F.E.,Lei, M.G.,Li, J.L.,Deng, C.Y.,Jiang, S.W. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.11

        The Melanocortin-4 Receptor (MC4R) and Insulin-like Growth Factor 2 (IGF2) are two important candidate genes related to fat deposition and carcass traits. MC4R was found on study on human obesity and then was studied as candidate gene affecting food intake and fat deposition traits in mice and pigs. Insulin-like Growth Factor 2 (IGF2) gene plays an important role on tumor cell proliferation and muscle growth. It also affects fat traits and live weight in pigs. In this paper, MC4R and IGF2 were studied as two candidate genes associated with important economic traits such as fat deposition and carcass traits in five different pig populations. Taq I-PCR-RFLP and Bcn I-PCR-RFLP were respectively used to detect the polymorphism of genotypes of MC4R and IGF2 genes. Different MC4R genotype frequencies were observed in four populations. IGF2 genotype frequencies were also different in two populations. The results of association analysis show both MC4R and IGF2 genes were significantly associated with fat deposition and carcass traits in about 300 pigs. This work will add new evidence of MC4R and IGF2 affecting fat deposition and carcass traits in pigs and show that two genes can be used as important candidate genes for marker assistant selection (MAS) of growth and lean meat percentage in pigs.

      • KCI등재

        RESEARCH ON THE ELECTRO-HYDRAULIC VARIABLE VALVE ACTUATION SYSTEM BASED ON A THREE-WAY PROPORTIONAL REDUCING VALVE

        J.-R. LIU,B. JIN,Y.-J. XIE,Y. CHEN,Z.-T. WENG 한국자동차공학회 2009 International journal of automotive technology Vol.10 No.1

        As the internal combustion engine moves into the 21st century, fully flexible valve actuation systems are being proposed as an enabling technology for advanced internal combustion engine concepts. Electro-hydraulic valve actuator systems are being considered as a potential variable valve technology. Compared to the servo control system, the system using a proportional valve has the advantages of low price, high anti-pollution ability and high reliability. Our research focuses on exploring the dynamic characteristic of the electro-hydraulic variable valve system, which is based on three-way proportional reducing valve. In this paper, the structure and working principles of the system are described. The dynamic mathematical model of the system is derived. From the analysis of a linearized model and dynamic simulation, it is demonstrated that the system will be stable only if the proportional reducing valve has a positive opening. Some structural factors that affect the system’s dynamic characteristics, such as input signal, the stiffness of the return spring and the pre-tightening force of the return spring, are studied using AMESim. The experimental results coincide with the theoretical and simulated analyses. Further study shows that the dynamic response can be improved effectively by adopting closed-loop control of valve lift. As the internal combustion engine moves into the 21st century, fully flexible valve actuation systems are being proposed as an enabling technology for advanced internal combustion engine concepts. Electro-hydraulic valve actuator systems are being considered as a potential variable valve technology. Compared to the servo control system, the system using a proportional valve has the advantages of low price, high anti-pollution ability and high reliability. Our research focuses on exploring the dynamic characteristic of the electro-hydraulic variable valve system, which is based on three-way proportional reducing valve. In this paper, the structure and working principles of the system are described. The dynamic mathematical model of the system is derived. From the analysis of a linearized model and dynamic simulation, it is demonstrated that the system will be stable only if the proportional reducing valve has a positive opening. Some structural factors that affect the system’s dynamic characteristics, such as input signal, the stiffness of the return spring and the pre-tightening force of the return spring, are studied using AMESim. The experimental results coincide with the theoretical and simulated analyses. Further study shows that the dynamic response can be improved effectively by adopting closed-loop control of valve lift.

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