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Harry G. Preuss,Bobby Echard,Jia Fu,Nicholas V. Perricone,Debasis Bagchi,Mark Kaylor,Cun Zhuang 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.10
We assessed whether fraction SX derived from maitake mushroom could play a beneficial role in the treatment of a laboratory model of type-1 diabetes by decreasing circulating glucose levels and lowering blood pressure (BP). We injected 50 mg/kg body weight (BW) streptozotocin (STZ) intraperitoneally (i.p.) into 48 male Sprague-Dawley rats (SD) to produce a laboratory model of type-1 diabetes. SD were divided into four groups of 12 SD. A control group ate straight pulverized rat chow. To three treatment groups, we added into the pulverized rat chow: gliclazide (10 mg/kg), pioglitazone (10–30 mg/kg), or maitake SX (2.5 g/kg). In addition to measuring BW, circulating glucose level, and BP, the following procedures were also carried out: insulin challenge (insulin sensitivity), losartan challenge (renin–angiotensin system activity), Nw-nitro-L arginine-methyl ester hydrochloride (LNAME) challenge (nitric oxide [NO] system activity), and evaluation of serum angiotensin converting enzyme (ACE) activity. All treatments compared with control generally decreased circulating glucose levels, but only the maitake SX consistently enhanced measured insulin sensitivity. We found that maitake SX could significantly lower systolic blood pressure (SBP) in diabetic SD. In general, only SD receiving maitake SX, not the two drugs, showed decreased activity of the renin–angiotensin system and increased NO system activity compared with control under the conditions examined. Our results suggest that maitake SX may be useful for treating perturbations in glucose-insulin metabolism and elevated BP in type-1 diabetes.
Zhuang Xu,M. F. Rahman,G. Wang,Dianguo Xu 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.1
This paper presents performance evaluation of an Integrated Starter-Alternator (ISA) prototype with an Interior Permanent Magnet (IPM) synchronous machine under sensor-less operation. To attain a high starting torque at zero speed and in subsequent extremely low speed range, a hybrid signal injection method is proposed. At higher speed, an improved stator flux observer is used for the stator flux estimation. This observer is able to produce accurately-estimated stator flux linkage for high performance Direct Torque and Flux Control (DTFC) implementation. The sensor-less DTFC IPM synchronous machine drive takes full advantage of the capacity of the power converter and fulfills the control specifications for the ISA. The trajectory control algorithm responds rapidly and in a well behaved manner over a wide range of operating conditions. The experimental results verify the feasibility and advantages of the system.
Xu, Zhuang,Rahman, M.F.,Wang, G.,Xu, Dianguo The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.1
This paper presents performance evaluation of an Integrated Starter-Alternator (ISA) prototype with an Interior Permanent Magnet (IPM) synchronous machine under sensor-less operation. To attain a high starting torque at zero speed and in subsequent extremely low speed range, a hybrid signal injection method is proposed. At higher speed, an improved stator flux observer is used for the stator flux estimation. This observer is able to produce accurately-estimated stator flux linkage for high performance Direct Torque and Flux Control (DTFC) implementation. The sensor-less DTFC IPM synchronous machine drive takes full advantage of the capacity of the power converter and fulfills the control specifications for the ISA. The trajectory control algorithm responds rapidly and in a well behaved manner over a wide range of operating conditions. The experimental results verify the feasibility and advantages of the system.
The Updated Vversion of Chinese Evaluated Nuclear Data Library (CENDL-3.1)
Z. G. Ge,Z. X. Zhao,H. H. Xia,Y. X. Zhuang,T. J. Liu,J. S. Zhang,H. C. Wu 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The updated Chinese Evaluated Nuclear Data Library CENDL-3.1 is an important achievement based on the nuclear data evaluation works in recent years, at China Nuclear Data Center (CNDC) in cooperation with China Nuclear Data Coordination Network (CNDCN). CENDL-3.1 contains the evaluated data for reactions with incident neutrons on 240 nuclides (from ^1H to ^(249)Cf) in energy region of 10^(-5) eV-20MeV. All data obtained according to the evaluations of experimental data and the predictions of the nuclear reaction model calculations. For most important nuclei of this library, the benchmark testing and validations have been performed, the comparisons with other nuclear data libraries (ENDF/B, JENDL, BROND, JEF, et al.) have been done. The testing version of CENDL-3.1 is CENDL-3.0, which has been provided for China domestic users. Follow the using back feed of CENDL-3.0, a lot of improvement has been done. The CENDL3.1 is provided for all users by ENDF format and is released to the world in the end of 2009. The overview, evaluation methodology and some important results of new evaluations, benchmark testing and validations for this library will be introduced in this contribution.
Can Ficicioglu,Jacob G Dubroff,Nina Thomas,Paul R Gallagher,Jessica Burfield,Christie Hussa,Rebecca Randall,Hongming Zhuang 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.3
Background and Purpose PET scanning with fluorodeoxyglucose (FDG-PET) is a non-invasive method that measures regional glucose metabolic rate. Phenylalanine (Phe) and its metabolites appear to impair several aspects of brain energy metabolism. 1) To evaluate brain glucose metabolism with FDG-PET imaging in phenylketonuria (PKU) patients before and 4 months after sapropterin therapy; 2) to evaluate neurodevelopmental changes, blood Phe levels and dietary Phe tolerance before and after sapropterin therapy; 3) to generate pilot data to assess the feasibility of evaluating brain glucose metabolism with FDG-PET imaging and to explore potential trends resulting from the administration of sapropterin therapy. Methods We enrolled 5 subjects, ranged in age from 22 years to 51 years, with PKU. Subjects underwent FDG-PET brain imaging, blood tests for Phe and tyrosine levels, and neurocognitive evaluations before and 4 months after sapropterin therapy (20 mg/kg/day). All subjects’ Phe and tyrosine levels were monitored once a week during the study. Subjects kept 3 day diet records that allow calculation of Phe intake. Results None of the subjects responded to sapropterin therapy based on 30% decrease in blood Phe level. The data show that glucose metabolism appeared depressed in the cerebellum and left parietal cortex while it was increased in the frontal and anterior cingulate cortices in all five subjects. In response to sapropterin therapy, relative glucose metabolism showed significant increases in left Broca’s and right superior lateral temporal cortices. Interestingly, there was corresponding enhanced performance in a phonemic fluency test performed during pre- and postneurocognitive evaluation. Conclusions Further studies with a larger sample size are needed to confirm the above changesin both sapropterin non-responsive and responsive PKU patients.
Msekh, Mohammed A.,Cuong, N.H.,Zi, G.,Areias, P.,Zhuang, X.,Rabczuk, Timon Elsevier 2018 Engineering fracture mechanics Vol.188 No.-
<P><B>Abstract</B></P> <P>We predict the macroscopic tensile strength and fracture toughness of fully exfoliated nano silicate clay epoxy composites accounting for the interphase behavior between the polymeric matrix and clay reinforcement. A phase field approach is employed to model fracture in the matrix and the interphase zone of the polymeric nanocomposites (PNCs) while the stiff clay platelets are considered as linear elastic material. The effect of the interphase zones, e.g. thickness and mechanical properties (Young’s modulus and strain energy release rate) on the tensile strength, and fracture parameters of the composite is studied in detail. The dissipation energy due to fracture in the PNCs is extracted for different thicknesses and properties of the interphase zones. We show through numerical experiments that the interphase thickness has the most influence on the tensile strength while the critical strain energy release rate of the interphase zones affects the dissipation energy depending on the interphase zone thickness.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A phase field model for fracture in heterogeneous structure. </LI> <LI> A hybrid hierarchical/concurrent multiscale method for fracture in polymer-matrix composites. </LI> <LI> A phase field model for matrix and interphase fracture in polymer-matrix composites. </LI> <LI> Extraction of fracture related material properties for various input parameters, particularly for the interphase zone. </LI> </UL> </P>
Dictyostelium phenylalanine hydroxylase is activated by its substrate phenylalanine
Kim, H.L.,Park, M.B.,Kim, Y.,Yang, Y.G.,Lee, S.W.,Zhuang, N.,Lee, K.H.,Park, Y.S. North-Holland Pub ; Elsevier Science Ltd 2012 FEBS letters Vol.586 No.20
We have studied the regulatory function of Dictyostelium discoideum Ax2 phenylalanine hydroxylase (dicPAH) via characterization of domain structures. Including the full-length protein, partial proteins truncated in regulatory, tetramerization, or both, were prepared from Escherichia coli as his-tag proteins and examined for oligomeric status and catalytic parameters for phenylalanine. The proteins were also expressed extrachromosomally in the dicPAH knockout strain to examine their in vivo compatibility. The results suggest that phenylalanine activates dicPAH, which is functional in vivo as a tetramer, although cooperativity was not observed. In addition, the results of kinetic study suggest that the regulatory domain of dicPAH may play a role different from that of the domain in mammalian PAH. Structured summary of protein interactions: dicPAH and dicPAHbind by molecular sieving (View Interaction: 1, 2, 3, 4)
Zhao, K.J.,Nagashima, Y.,Li, F.M.,Shi, Yuejiang,Diamond, P.H.,Dong, J.Q.,Itoh, K.,Itoh, S.-I.,Zhuang, G.,Liu, H.,Chen, Z.P.,Cheng, J.,Nie, L.,Ding, Y.H.,Hu, Q.M.,Chen, Z.Y.,Rao, B.,Cheng, Z.F.,Gao, L. IOP 2017 Nuclear fusion Vol.57 No.12
<P>The temporal-spatial structures of plasma flows and turbulence around tearing mode islands are presented. The experiments were performed using Langmuir probe arrays in the edge plasmas of J-TEXT tokamak. The correlation analyses clearly show that the flows have similar structures of <I>m</I>/<I>n</I> = 3/1 as the magnetic island does (<I>m</I> and <I>n</I> are the poloidal and toroidal mode numbers, respectively). The sign of the potential fluctuations for the flows inverses and the powers significantly reduce at <I>q</I> = 3 surface. Approaching to the last closed flux surface for the magnetic islands, the radially elongated flow structure forms. The flows are concentrated near separatrix and show quadrupole structures. The turbulence is concentrated near X-point and partly trapped inside the magnetic islands.</P>