Envelope Proteins Pertain with Evolution and Adaptive Mechanism of the Novel Influenza A/H1N1 in Humans

( Mondal,Shakhinur Islam ),( Abdullah Zubaer ),( Simrika Thapa ),( Chinmoy Saha ),( Md. Asraful Alum ),( Md. Salman Reza ),( Arzuba Akter ),( Abul Kalam Azad ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.11

The novel swine-origin influenza A/H1N1 virus (S-OIV) first detected in April 2009 has been identified to transmit from humans to humans directly and is the cause of the currently emerged pandemic. In this study, nucleotide and deduced amino acid sequences of the hemagglutinin (HA) and neuraminidase (NA) of the S-OIV and other influenza A viruses were analyzed through bioinformatic tools for phylogenetic analysis, genetic recombination, and point mutation to investigate the emergence and adaptation of the S-OIV in humans. The phylogenetic analysis showed that the HA comes from triple reassortant influenza A/ H1N2 and the NA from Eurasian swine influenza A/H1N1, indicating that HA and NA descend from different lineages during the genesis of the S-OIV. Recombination analysis nullified the possibility of occurrence of recombination in HA and NA, denoting the role of reassortment in the outbreak. Several conservative mutations were observed in the amino acid sequences of the HA and NA, and these mutated residues were identical in the S-OIV. The results reported herein suggest the notion that the recent pandemic is the result of reassortment of different genes from different lineages of two envelope proteins, HA and NA, which are responsible for the antigenic activity of the virus. This study further suggests that the adaptive capability of the S-OIV in humans is acquired by the unique mutations generated during emergence.

Rapid Hydrogen Peroxide Detectable Multifunctional Synthetic Nanoenzyme Embedded Colorimetric Paper Biosensor

( Mondal ),안정만,최원호,이용규 한국공업화학회 2023 한국공업화학회 연구논문 초록집 Vol.2023 No.0

Room-temperature synthesis of cobalt nanoparticles and their use as catalysts for Methylene Blue and Rhodamine-B dye degradation

Mondal, Arijit,Mondal, Asish,Mukherjee, Debkumar Techno-Press 2015 Advances in nano research Vol.3 No.2

Air stable nanoparticles were prepared from cobalt sulphate using tetra butyl ammonium bromide as surfactant and sodium borohydride as reductant at room temperature. The cobalt nanocolloids in aqueous medium were found to be efficient catalysts for the degradation of toxic organic dyes. Our present study involves degradation of Methylene Blue and Rhodamine-B using cobalt nanoparticles and easy recovery of the catalyst from the system. The recovered nanoparticles could be recycled several times without loss of catalytic activity. Palladium nanoparticles prepared from palladium chloride and the same surfactant were found to degrade the organic dyes effectively but lose their catalytic activity after recovery. The cause of dye colour discharge by nanocolloids has been assigned based on our experimental findings.

Free radical scavenging property of Annona reticulata leaves

Mondal, Susanta Kumar,Saha, Prerona,Mondal, NB,Mazumder, UK Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.3

Annona reticulata belonging to the family Annonaceae is traditionally used as anthelmintic and it is reported to have anticancer activity. Free radicals are known to be involved in various types of diseases like cancer, diabetes, neurological disorders etc. The present study was aimed to evaluate free radical scavenging property of methanol extract of the leaves of Annona reticulata in some in vitro models e.g. DPPH, nitric oxide, superoxide and lipid peroxide radical model. The extract showed good dose-dependent free radical scavenging property in all the models. $IC_{50}$ values were found to be 3.22, 170.01, 25.12 and $140.12\;{\mu}g/ml$ respectively in DPPH, nitric oxide, superoxide and lipid peroxidation inhibition assays. Reductive ability of the extract was also tested based on potassium ferricyanide reduction where dose dependant reducing capability was observed. Measurement of total phenolic compounds by Folin-Ciocalteu's phenol reagent indicated that 1mg of the extract contained $146.20\;{\mu}g$ equivalent of pyrocatechol. The findings ascertain promising free radical scavenging property of the extract and the antioxidant property of the extract may be due to the high content of phenolic compounds.

Precursor-driven selective synthesis of hexagonal chalcocite (Cu₂S) nanocrystals: structural, optical, electrical and photocatalytic properties

Mondal, Gopinath,Bera, Pradip,Santra, Ananyakumari,Jana, Sumanta,Mandal, Tarak Nath,Mondal, Anup,Seok, Sang Il,Bera, Pulakesh The Royal Society of Chemistry 2014 NEW JOURNAL OF CHEMISTRY Vol.38 No.10

<P>The reaction of CuCl<SUB>2</SUB>·2H<SUB>2</SUB>O with the methyl ester of 3,5-dimethyl pyrazole-1-dithioic acid (mdpa) yields a blackish brown complex of composition, [Cu(mdpa)<SUB>2</SUB>][CuCl<SUB>2</SUB>]. The complex formed a well-defined crystal and is characterized by single-crystal X-ray diffraction, thermogravimetry (TG), and spectroscopic studies. The molecule possesses a distorted tetrahedral configuration with a CuN<SUB>2</SUB>S<SUB>2</SUB> chromophore with +1 oxidation state of copper. The TG study reveals that the molecule is a suitable precursor for copper sulfide nanoparticles. The low temperature thermal decomposition of the single-source precursor produces hexagonal chalcocite (Cu<SUB>2</SUB>S) nanostructures in ethylene diamine and ethylene glycol. A selective synthesis of copper-rich high chalcocite was obtained using the new precursor. The size and morphology of the synthesized Cu<SUB>2</SUB>S nanoparticles are guided by the precursor and likely to be less dependent on the solvent used in the experiment. The nanoparticles were characterized by X-ray diffraction, scanning electronic microscope, and UV-Vis spectroscopic studies. The optical band gap of the as-synthesized Cu<SUB>2</SUB>S nanoparticles is measured to be 1.80–2.40 eV. The Cu<SUB>2</SUB>S nanoparticles are found to be good catalysts in UV photo catalytic decomposition (90%) of Congo red (CR) dye following first-order reaction kinetics, and the reusability study of the Cu<SUB>2</SUB>S catalyst also shows excellent catalytic performance (80%).</P> <P>Graphic Abstract</P><P>A new single-source precursor, [Cu(mdpa)<SUB>2</SUB>][CuCl<SUB>2</SUB>], is used to prepare selectively high chalcocite (Cu<SUB>2</SUB>S) with excellent photodegradation of Congo red (CR). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4nj00584h'> </P>

Free radical scavenging property of Annona reticulata leaves

Susanta Kumar Mondal,Prerona Saha,NB Mondal,UK Mazumder 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.3

Annona reticulata belonging to the family Annonaceae is traditionally used as anthelmintic and it is reported to have anticancer activity. Free radicals are known to be involved in various types of diseases like cancer, diabetes, neurological disorders etc. The present study was aimed to evaluate free radical scavenging property of methanol extract of the leaves of Annona reticulata in some in vitro models e.g. DPPH, nitric oxide, superoxide and lipid peroxide radical model. The extract showed good dose-dependent free radical scavenging property in all the models. IC50 values were found to be 3.22, 170.01, 25.12 and 140.12 μg/ml respectively in DPPH, nitric oxide, superoxide and lipid peroxidation inhibition assays. Reductive ability of the extract was also tested based on potassium ferricyanide reduction where dose dependant reducing capability was observed. Measurement of total phenolic compounds by Folin-Ciocalteu’s phenol reagent indicated that 1mg of the extract contained 146.20 μg equivalent of pyrocatechol. The findings ascertain promising free radical scavenging property of the extract and the antioxidant property of the extract may be due to the high content of phenolic compounds. Annona reticulata belonging to the family Annonaceae is traditionally used as anthelmintic and it is reported to have anticancer activity. Free radicals are known to be involved in various types of diseases like cancer, diabetes, neurological disorders etc. The present study was aimed to evaluate free radical scavenging property of methanol extract of the leaves of Annona reticulata in some in vitro models e.g. DPPH, nitric oxide, superoxide and lipid peroxide radical model. The extract showed good dose-dependent free radical scavenging property in all the models. IC50 values were found to be 3.22, 170.01, 25.12 and 140.12 μg/ml respectively in DPPH, nitric oxide, superoxide and lipid peroxidation inhibition assays. Reductive ability of the extract was also tested based on potassium ferricyanide reduction where dose dependant reducing capability was observed. Measurement of total phenolic compounds by Folin-Ciocalteu’s phenol reagent indicated that 1mg of the extract contained 146.20 μg equivalent of pyrocatechol. The findings ascertain promising free radical scavenging property of the extract and the antioxidant property of the extract may be due to the high content of phenolic compounds.

Advances in Floating Aerogenerators: Present Status and Future

Amit Kumar Mondal,Surajit Mondal,Vindhya Devalla,Paawan Sharma,Mukul Kumar Gupta 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.11

High altitude winds are considered to be the most favorable source of renewable energy in the future. In this paper, review has been conducted on harnessing of high altitude wind energy via floating type aero-generators. This new generation of systems employs tethered wings, aircrafts, multi-copters, balloons in order to harness the higher atmospheric winds. A number of systems based on different concepts have been analyzed and tested from mid-seventies, with a rapid acceleration in last couple of years. This paper presents a comprehensive overview of different technologies that have been designed/ built to harvest the energy of high altitude winds, highlighting the accomplished results, technological issues and classification of such systems have been proposed on the basis of their working and design. Apart from the Airborne Wind Energy or High-Altitude Wind Energy based systems, a brief overview on offshore floating wind turbines have also been provided.

Nanostructured hollow hydroxyapatite fabrication by carbon templating for enhanced drug delivery and biomedical applications

Mondal, Sudip,Hoang, Giang,Manivasagan, Panchanathan,Kim, Hyehyun,Oh, Junghwan Elsevier 2019 Ceramics international Vol.45 No.14

<P><B>Abstract</B></P> <P>Fabrication of nanostructured materials with multifunctional properties and improved biocompatibility have immense potential for biomedical applications. The novelty of this research is to synthesize nanostructured hollow hydroxyapatite (H-HAp) for enhanced drug delivery applications. The nano hollow structure synthesis mechanism involves the controlled precipitation of calcium and phosphate ions over a pre-synthesized nano carbon template, followed by calcination to eliminate the core carbon structure. The synthesized nano-structured H-HAp was analyzed to determine its chemical, elemental, structural, and morphological characteristics by different spectroscopic, gravimetric, and electron microscopy techniques. The potential advances of H-HAp nanoparticles in biological applications were studied by using MDA-MB-231 breast cancer cell lines, and drug kinetics experiments. The cytotoxicity and the efficacy of H-HAp as a drug carrier agent were studied by MTT and fluorescence staining assay. The comparative drug loading/releasing kinetics were studied using nanostructured H-HAp and HAp with the model drug doxorubicin (DOX) and bovine serum albumin (BSA) protein. The synthesized nanostructured materials show relatively enhanced drug (DOX = ∼53.33%) and protein (BSA = ∼43.06%) loading capacities compared to conventional HAp (DOX = ∼46% and BSA = ∼23.62%). The H-HAp nanostructured system shows a pH-dependent sustained <I>in vitro</I> release behavior of model drug molecules. The novelty of this study relies on its facile synthesis mechanism to fabricate a hollow nano HAp structure, which differs from limited reported articles based mostly on microstructure H-HAp for biomedical applications.</P>

BOUNDS AND INEQUALITIES OF THE MODIFIED LOMMEL FUNCTIONS

Mondal, Saiful R. Korean Mathematical Society 2019 대한수학회논문집 Vol.34 No.2

This article studies the monotonicity, log-convexity of the modified Lommel functions by using its power series and infinite product representation. Some properties for the ratio of the modified Lommel functions with the Lommel function, sinh and cosh are also discussed. As a consequence, $Tur{\acute{a}}n$ type and reverse $Tur{\acute{a}}n$ type inequalities are given. A Rayleigh type function for the Lommel functions are derived and as an application, we obtain the Redheffer-type inequality.

Effect of tension stiffening on the behaviour of square RC column under torsion

Mondal, T. Ghosh,Prakash, S. Suriya Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.54 No.3

Presence of torsional loadings can significantly affect the flow of internal forces and deformation capacity of reinforced concrete (RC) columns. It increases the possibility of brittle shear failure leading to catastrophic collapse of structural members. This necessitates accurate prediction of the torsional behaviour of RC members for their safe design. However, a review of previously published studies indicates that the torsional behaviour of RC members has not been studied in as much depth as the behaviour under flexure and shear in spite of its frequent occurrence in bridge columns. Very few analytical models are available to predict the response of RC members under torsional loads. Softened truss model (STM) developed in the University of Houston is one of them, which is widely used for this purpose. The present study shows that STM prediction is not sufficiently accurate particularly in the post cracking region when compared to test results. An improved analytical model for RC square columns subjected to torsion with and without axial compression is developed. Since concrete is weak in tension, its contribution to torsional capacity of RC members was neglected in the original STM. The present investigation revealed that, disregard to tensile strength of concrete is the main reason behind the discrepancies in the STM predictions. The existing STM is extended in this paper to include the effect of tension stiffening for better prediction of behaviour of square RC columns under torsion. Three different tension stiffening models comprising a linear, a quadratic and an exponential relationship have been considered in this study. The predictions of these models are validated through comparison with test data on local and global behaviour. It was observed that tension stiffening has significant influence on torsional behaviour of square RC members. The exponential and parabolic tension stiffening models were found to yield the most accurate predictions.