발사체 공력해석 프로그램 RocketAeroMaster2005 개발

김재수,김종록,우철훈,김태훈,임오택,박정주,오범석,옥호남 朝鮮大學校 機械技術硏究所 2005 機械技術硏究 Vol.8 No.1

예비설계 단계에서 외형설계, 구조설계를 위한 하중분포 계산, 발사체의 안정성 및 성능분석을 위하여 데이터베이스형 발사체 공력코드를 개발하였다. 분석방법으로는 동체, 스트랩온 부스터의 공력계수와 동체와 스트랩온 부스터의 간섭 동의 분석을 거쳐 전체 발사체에 대한 분석이 이루어졌다. 발사체 공력코드의 데이터베이스구성은 기존의 DATCOM의 데이터베이스를 기반으로 발사체 형상에 대한 실험데이터(MD)를 추가 구성함으로서 발사체 공력코드의 신뢰성을 증대시켰다. 또한, 기존의 발사체 공력설계코드와 비교 분석을 수행하여 발사체 공력코드를 검증하였다. For the development of launch vehicle, the aerodynamic characteristics have to be performed for the configuration design in the preliminary design, the load distribution in the detail design, and the performance analysis. The static and dynamic coefficients are analyzed for strap on booster, body and strap on booster-body interface characteristics. A detail analysis is required during the detail design phase, but a rapid analysis is better in the preliminary design. Therefore, the database code, based on the theory and experimental datum, is useful to analyze the variety of models during the preliminary design phase, and the computational aerodynamic code is required to calculate the detail load distribution during the detail design phase. In this computational aerodynamic code, based on the database of theoretical and experimental datum, have been developed.

Crystal structure of Rv2258c from Mycobacterium tuberculosis H37Rv, an S-adenosyl-l-methionine-dependent methyltransferase

Im, H.N.,Kim, H.S.,An, D.R.,Jang, J.Y.,Kim, J.,Yoon, H.J.,Yang, J.K.,Suh, S.W. Academic Press 2016 Journal of structural biology Vol.193 No.3

<P>The Mycobacterium tuberculosis Rv2258c protein is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase). Here, we have determined its crystal structure in three forms: a ligand-unbound form, a binary complex with sinefungin (SFG), and a binary complex with S-adenosyl-L-homocysteine (SAH). The monomer structure of Rv2258c consists of two domains which are linked by a long alpha-helix. The N-terminal domain is essential for dimerization and the C-terminal domain has the Class I MTase fold. Rv2258c forms a homodimer in the crystal, with the N-terminal domains facing each other. It also exists as a homodimer in solution. A DALI structural similarity search with Rv2258c reveals that the overall structure of Rv2258c is very similar to small-molecule SAM -dependent MTases. Rv2258c interacts with the bound SFG (or SAH) in an extended conformation maintained by a network of hydrogen bonds and stacking interactions. Rv2258c has a relatively large hydrophobic cavity for binding of the methyl-accepting substrate, suggesting that bulky nonpolar molecules with aromatic rings might be targeted for methylation by Rv2258c in M. tuberculosis. However, the ligand-binding specificity and the biological role of Rv2258c remain to be elucidated due to high variability of the amino acid residues defining the substrate-binding site. (C) 2016 Elsevier Inc. All rights reserved.</P>

Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas

Kim, J.H.,Hur, J.H.,Lee, S.M.,Im, K.S.,Kim, N.H.,Sur, J.H. Ballière Tindall ; W.B. Saunders 2012 The veterinary journal Vol.193 No.1

Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n=37). Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.

Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer

Shin, S.J.,Kim, N.K.,Keum, K.C.,Kim, H.G.,Im, J.S.,Choi, H.J.,Baik, S.H.,Choen, J.H.,Jeung, H.C.,Rha, S.Y.,Roh, J.K.,Chung, H.C.,Ahn, J.B. Elsevier Science Publishers 2010 Radiotherapy and oncology Vol.95 No.3

Background and purpose: The aim of this study is to evaluate the efficacy and safety of preoperative radiation therapy combined with S-1 and irinotecan (SI) in LARC. Materials and methods: Patients were considered LARC if they had a T3/T4 lesion or node positive. Weekly doses of 40mg/m<SUP>2</SUP> irinotecan were intravenously administered once per week during weeks 1-5 of radiotherapy. S-1 (70mg/m<SUP>2</SUP>) was given from Monday to Friday in all weeks of radiotherapy. 3-D conformal radiotherapy was given at daily fractions of 1.8Gy for 5days for a total dose of 50.4 (45+5.4)Gy. Surgery was performed 4-6weeks following the completion of chemoradiation. Results: Between June 2006 and November 2007, 43 pts were enrolled. The stage was: cT3 24 patients, cT4 6 patients; 28 patients were cN+. Forty-one patients completed the chemoradiation and 42 patients underwent operation: a low anterior resection was performed in 36 patients, a total colectomy in 1 patient, and an abdominal perineal resection in 5 patients. T downstaging was observed in 50%; 23 N+ patients became N- (55%). The complete pathological response was observed in 9 patients (21%). The 3-year locoregional failure rate, distant failure rate, disease-free survival, and overall survival were 9.5%, 18.6%, 72.1%, and 94.3%, respectively. Only three patients experienced G3 diarrhea; one had G3 sepsis and two had septic shock. Hematological toxicity (G3-G4) was observed in five patients. Conclusions: This study demonstrated the efficacy of preoperative CRT with S-1 and irinotecan with 21% of complete response. However, prompt recognition and management of infection is needed to use it in patients with locally advanced rectal cancer.

Detection of mechanical complications related to the potential risk of sudden cardiac death in patients with pulmonary arterial hypertension by computed tomography

Lee, S.E.,Im, J.H.,Sung, J.M.,Cho, I.J.,Shim, C.Y.,Hong, G.R.,Chung, N.,Jung, J.W.,Chang, H.J. Elsevier/North-Holland Biomedical Press 2017 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.243 No.-

Background: We explored the value of cardiac computed tomography (CT) for the detection and prediction of mechanical complications related to the risk of sudden cardiac death (SCD) in pulmonary arterial hypertension (PAH) patients. Methods: PAH patients (n=60, mean age 47+/-15, 31.7% male) with pulmonary artery (PA) enlargement (≥40mm) by echocardiography were studied with cardiac CT. Complications explored were the presence of left main coronary artery (LM) compression, airway compression, PA dissection and PA thrombosis in relation to diameters of main PA (MPA) which were measured in (1) axial plane (MPA<SUB>Ax</SUB>) and (2) LM oblique view (MPA<SUB>LMobq</SUB>). Results: Mechanical complications were found in 21 patients (35.0%): LM compression in 20 patients; airway compression in 3 patients; and PA thrombosis in 4 patients. Patients with complications had more dilated MPA<SUB>LMobq</SUB> than patients without complication (59.4+/-13.0mm vs. 42.4+/-7.0mm, p<0.001). The area under the receiver operating characteristic curve for MPA<SUB>LMobq</SUB> was 0.889 (95% confidence interval: 0.795 to 0.983, p<0.001) with the highest discriminating sensitivity and specificity being 90.5% and 69.2%, respectively at MPA<SUB>LMobq</SUB> of 45mm. MPA<SUB>Ax</SUB> failed to predict the presence of mechanical complications (p>0.05). Conclusion: MPA<SUB>LMobq</SUB>≥45mm was significantly associated with the presence of mechanical complications of PAH. Evaluation with CT should be considered in PAH patients with dilated MPA.

Effects of cloned-cattle meat on reproductive physiology in rats.

Hwang, S,Lee, N-J,Hwang, J-S,Yang, B-C,Im, G-S,Ko, Y-G,Park, E-W,Park, S-B,Kang, J-K,Seong, H-H Cambridge University Press 2010 Animal Vol.4 No.2

<P>The influence of the cloned-cattle meat diets upon reproduction in mammals was rarely studied. This study was performed to analyze the effects of the diets containing cloned-cattle (Korean native beef, Hanwoo) meat on the reproductive physiology in rats. The male and female rats were fed with the diets containing 5% or 10% of normal- (N-5 or N-10) or cloned- (C-5 or C-10) cattle meat during test periods. The rats fed with commercial pellets were used as control. Lower food consumption in normal- and cloned-cattle meat diet groups is detected in both male and female rats compared with that of control (P < 0.05, 0.01 and 0.001). No signs of cloned-cattle meat diets on male reproductive parameters are found in all groups, except for lower sperm deformity in C-5 group (P < 0.05) and higher testosterone concentration in C-10 group (P < 0.05), respectively. There are no significant test substance-related differences of Caesarean section and delivery in dams and external examination and physiological development test in neonate compared with control and normal meat groups. Based on these results, it can be postulated that there are no obvious negative effects on the reproductive physiology in rats fed with cloned-cattle meat diets compared to their comparators.</P>

INFLUENCE OF CHOLERA ON THE WATER CONTENT IN BLOOD

Lee, K.Y.,Im, J.S.,Sung, N.U. 서울대학교 1957 서울대학교 論文集 Vol.6 No.-

1946年 9月에 南韓에서 發生한 虎列剌患者 7名에 對하여 그 臨床經過와 아울러 血液水分量의 變動을 調査하여 다음과 같은 結果를 얻어 여기 發表하는 바이다. (1) 虎列剌患者에 있어서는 血水量이 우리가 調査한 各種疾患中에서 最低値를 보여 주고 있다. (70.1%-75.3%) 이것은 標準正常穴深水分量보다 各各 8.7%-5.1%나 적은 것을 意味한다. (2) 臨床增勢가 良好하여짐에 따라 血水量은 迅速히 增加되며 大槪 4-5日間 內에 正常値에 지 到達한다. (3) 死亡한 例에 있어서는 血水量은 72%에 不過하고 入院後 곧 死亡한 故로 그後 調査는 不能하였다. (4) 一般으로 血水量이 적은 患者일수록 脫水狀態는 甚하다.

Deoxycorticosterone acetate가 흰 생쥐의 신사구방세포에 미치는 영향

심현,오영,원경희,임정남,홍기숙 이화여자대학교 의과대학 1977 梨花醫學誌 Vol.- No.9

정상 및 부신을 적출한 숫 흰생쥐를 소정의 사료로 사육하면서 deoxycorticosterone acetate (DCA)를 1주간 투여하였다. 신장을 절취하여 Helly씨 용액으로 고정한 후 Wilson씨 방법으로 염색하여 사구방과립세포를 관찰하였으며 동시에 과립세포지수(GCI) 및 과립지수(JGI)를 조사하여 각 실험군을 비교하였다. 1. 정상군에 DCA를 투여한 결과 GCI 및 JGI의 수치는 의의있는 감소를 인정할 수 없었으며 또한 과립세포형의 출현빈도도 제 1형, 제2형, 제3형의 순으로 변화가 없었다. 2. 부신을 적출하면 GCI는 약간의 증가를 하고, JGI는 현저한 증가를 보이고 있었으며 각 세포형의 출현빈도는 제3형, 제2형, 제1형의 순으로 반전되었음을 보여주었다. 3. 부신을 적출한 흰생쥐에 DCA를 투여한 결과는 정상군에 DCA를 투여한 결과와 같이 GCI 및 JGI 양자 모두, 의의있는 감소를 보여주고 있지 않으며 각 과립세포형의 출현빈도에도 변화를 주고 있지 않다. 4. 이상의 결과는 사구방과립세포가 정상상태에 있건 부신을 적출하여 초래된 기능항진된 상태에 있건 간에 DCA 투여는 큰 영향을 주지 않는 것 같다. For the study of the juxtaglomerular granular cells deoxycorticosterone acetate(DCA), 2.5mg/day was administered to the normal and adrenalectomized mice for one week. The sections of renal tissues of all the experimental groups were stained by Wilson's method after the fixation with Helly's fluid, and the juxtaglomerular granular cell index (GCI) and juxtaglomerular granular index (JGI) were calculated at the magnification of 480 under the light microscope. And compared each other. The results observed were as follows. 1. There were not any significant decrease in both the GCI and JGI following the administration of DCA to normal animals, and the frequency of appearance of the various granular cell types in DCA-treated groups was in the order of Type1, Type 2, and type 3 as in the normal. 2. After adrenalectomy, significant increase in JGI was found and the order of the frequency of appearance of the various granular cell types was reversed. The GCI however, showed slight increase in number but is not significant. 3. The administration of DCA to adrenalectomized mice seemed not to show any significant decrease in GCI and JGI as in the DCA-treated normal group and the frequency of appearance of cell types was as same as in the DCA-treated adrenalectomized group. 4. The above results could show that the administration of DCA would not affect to decrease the granulation of juxtaglomerular granular cells in both the normal and adrenalectomized groups.

糖尿病性 昏睡 1例

任南宰,洪仁玉,高光昱 대한소아과학회 1966 小兒科 Vol.9 No.3

Air-Water 모델에서 가시화를 통한 유동특성에 관한 연구

임태훈,박근욱,서동표,정낙규,김진흥,오율권 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.2

In the air-water model, the characteristics of flow parameters were experimentally investigated. An electro-conductivity probe was used for measuring flow parameters such as local volume fraction and bubbles frequency. The flow parameters were very high at the near nozzle. For visualization of flow characteristics, a camera technique method and a thermo vision camera were adopted in the present study. The experimental results shows that the heat transfer from bubble surface to water is almost achieved within z=10[mm〕 from the nozzle. Then the temperature of bubble surface teaches to the water temperature in a short time. The camera and argon illumination laser were applied to the water circulation zone for flow visualization. The flow was more developed near the wall than at bubble-water plume. Voltex flow in the bottom region was relatively weaker than in the upper region.