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Impact and challenges of the COVID-19 pandemic on patients requiring botulinum toxin A treatment
Azalea Tenerife Pajo,Adrian Isidoro Espiritu,Roland Dominic Go Jamora 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
In late December 2019, an initial outbreak of a mysterious pneumonia characterized by fever, dry cough, fatigue, and occasional gastrointestinal symptoms was reported in a seafood wholesale wet market in Wuhan involving approximately 66% of the staff.1 Over the next few months, the outbreak resulted in the spread to 213 countries, affecting 11.5 million people with an estimated mortality rate of 3.4%.2 It is the largest and most severe pandemic since the 1918 influenza pandemic.3 The first case was reported in the Philippines on January 30th, with its first local transmission documented on March 7.4
Resveratrol Promotes Self-digestion to Put Cancer to Sleep
Alessandra Ferraresi,Ciro Isidoro,Suyanee Thongchot 대한암예방학회 2024 Journal of cancer prevention Vol.29 No.1
Resveratrol, a natural polyphenol present in a variety of food stuff, has been shown to exert preventive and curative anticancer activity in several in vitro and in vivo models. Such chemopreventive/anticancer activity has been linked to biochemical and epigenetic modifications of multiple pathways involved in carcinogenesis and metastasization. In this commentary, we focus on the recent work done in our laboratory showing that resveratrol has potential to prevent and cure cancer by promoting epigenetic-mediated autophagy-dependent tumor dormancy, an effect associated with re-education of the cancer-associated fibroblasts and reduced production of inflammatory cytokines in the tumor microenvironment. The clinical translation of the current knowledge on resveratrol nticancer activity is also discussed.
Jorge E. Jiménez-Hornero,Inés Mª Santos Dueñas,Isidoro García-García 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
First-principles models of any process usually describe its complex underlying mechanisms using differentialand algebraic equations including several unknown parameters, whose values must be normallyestimated from experimental data. In this context, assessment of the influence of each parameter onmodel outputs, also known as sensitivity analysis, is an invaluable tool to, for example, simplify the structureof such model. In this work, variance-based Global Sensitivity Analysis (GSA) using Sobol’ main andtotal effects was carried out on a previously proposed acetification process first-principles model. Threeparameters (KSE, KIA and KSO) showed less influence than the remaining nine considering their statedvalue ranges; KSE presented no influence in all the analysed experimental conditions, value variation ofKIA exhibited a slightly greater effect on experiments with higher mean acetic acid concentrations andKSO showed the strongest impact by varying its value in all the experiments. According to these results,the model was simplified and its simulation compared with the initially proposed model and the experimentaldata. The analysis performed, by way of example, can be of crucial importance for any otherprocess.
Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
Rohini Gomathinayagam,Ji Hee Ha,Muralidharan Jayaraman,송용상,Ciro Isidoro,Danny N. Dhanasekaran 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.3
Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.
Usefulness of Pharmacogenetic Analysis in Psychiatric Clinical Practice: A Case Report
Manuel A. Franco-Martin,Francisco Sans,Belen García-Berrocal,Cristina Blanco,Carlos Llanes-Alvarez,María Isidoro-García 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3
There are many factors involved in the effectiveness and efficiency of psychiatric drug treatment. One of them is psychotropic drug metabolism, which takes place mostly in the liver through the P450 enzyme system. However, there are genotypic variants of this system’s enzymes that can directly affect both the efficacy and the onset of side effects of a given therapeutic regimen. These genotypic changes could partly explain the lack of efficacy of treatment in certain patients. We report the case of a patient diagnosed with bipolar type I disorder that presented multiple and frequent manic episodes in which the efficacy and tolerability of several pharmacological regimens with mood stabilizers and antipsychotics was scarce. The choice of medical treatment should be based on its efficacy and side effect profile. This decision can be made more accurately using the information provided by pharmacogenetic analysis. This case illustrates the importance of pharmacogenetic studies in clinical practice. The results of pharmacogenetic analysis helped to decide on a better treatment plan to achieve clinical improvement and reduce drug-induced adverse effects.
Giselle Maria Maciel,Luciana Porto de Souza Vandenberghe,Ricardo Cancio Fendrich,Bianca Eli Della Bianca,Charles Windson Isidoro Haminiuk,Carlos Ricardo Soccol 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.6
Xylanases are glycosidases mainly responsible for the hydrolysis of β-1,4 linkages in xylan. Xylanase was produced in this work by solid-state fermentation using agro industrial residues with Aspergillus niger strain, which was screened through qualitative and quantitative methods. Extraction processes with different solvents were evaluated. Solvent volume, time, and agitation speed (shaker) were optimized using statistical designs. Drying studies of the solid fermented material were also conducted in a laboratory oven where the following conditions were applied: 42oC and 50oC for 20 h and 80oC for 1 h; 50oC and 75oC for 6 and 3 h, respectively. Best extraction conditions were 37 mL of solvent composed by NaCl solution (0.9%) with Tween 80 (0.1%) in 3 g of cultured material with agitation at 133 rpm in shaker for 4 min. Highest xylanase activity was 2,327 IU/gdm. The drying at 42oC for 20 h provided a better maintenance of xylanase activity (58% of xylanase activity). Xylanases are glycosidases mainly responsible for the hydrolysis of β-1,4 linkages in xylan. Xylanase was produced in this work by solid-state fermentation using agro industrial residues with Aspergillus niger strain, which was screened through qualitative and quantitative methods. Extraction processes with different solvents were evaluated. Solvent volume, time, and agitation speed (shaker) were optimized using statistical designs. Drying studies of the solid fermented material were also conducted in a laboratory oven where the following conditions were applied: 42oC and 50oC for 20 h and 80oC for 1 h; 50oC and 75oC for 6 and 3 h, respectively. Best extraction conditions were 37 mL of solvent composed by NaCl solution (0.9%) with Tween 80 (0.1%) in 3 g of cultured material with agitation at 133 rpm in shaker for 4 min. Highest xylanase activity was 2,327 IU/gdm. The drying at 42oC for 20 h provided a better maintenance of xylanase activity (58% of xylanase activity).