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Jeong Hyunjin,Hong Eun-Hye,Ahn Jae-Hee,Cho Jaewon,Jeong Jae-Hyeon,Kim Chae-Won,Yoon Byung-Il,Koo Ja Hyun,Park Yun-Yong,Yang Yoon Mee,Iwawaki Takao,Bruce A. Vallance,Chang Sun-Young,Ko Hyun-Jeong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic reticulum-resident protein disulfide reductase that mediates the cleavage and degradation of misfolded proteins. Although ERdj5 expression is significantly higher in the colonic tissues of patients with inflammatory bowel disease than in healthy controls, its role in inflammatory bowel disease has not yet been reported. In the current study, we used ERdj5-knockout mice to investigate the potential roles of ERdj5 in inflammatory bowel disease. ERdj5 deficiency causes severe inflammation in mouse colitis models and weakens gut barrier function by increasing NF-κB-mediated inflammation. ERdj5 may not be indispensable for goblet cell function under steady-state conditions, but its deficiency induces goblet cell apoptosis under inflammatory conditions. Treatment of ERdj5-knockout mice with the chemical chaperone ursodeoxycholic acid ameliorated severe colitis by reducing endoplasmic reticulum stress. These findings highlight the important role of ERdj5 in preserving goblet cell viability and function by resolving endoplasmic reticulum stress.
Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis
Seunghee Jun(Seunghee Jun),Hyunjin Park(Hyunjin Park),Ui-Jeong Kim(Ui-Jeong Kim),Eun Jeong Choi(Eun Jeong Choi),Hye Ah Lee(Hye Ah Lee),Bomi Park(Bomi Park),Soon Young Lee(Soon Young Lee),Sun Ha Jee(Su 한국역학회 2023 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.
The SAMI Galaxy Survey: Kinematic Alignments of Early-type Galaxies in A119 and A168
Jeong, Hyunjin,Kim, Suk,Owers, Matt S.,Joo, Seok-Joo,Kim, Hak-Sub,Lee, Woong,Lee, Youngdae,Sande, Jesse van de,Lee, Jaehyun,Yi, Sukyoung K.,Croom, Scott M.,Bryant, Julia J.,Rey, Soo-Chang,Brough, Sara American Astronomical Society 2019 The Astrophysical journal Vol.875 No.1
Jeong, Hyunjin,Yi, Sukyoung K.,Bureau, Martin,Davies, Roger L.,Falcó,n-Barroso, Jesú,s,van de Ven, Glenn,Peletier, Reynier F.,Bacon, Roland,Cappellari, Michele,de Zeeuw, Tim,Emsellem, Eric Blackwell Publishing Ltd 2009 Monthly notices of the Royal Astronomical Society Vol.398 No.4
<P>ABSTRACT</P><P>We present <I>Galaxy Evolution Explorer</I> far-ultraviolet (FUV) and near-ultraviolet (NUV) imaging of 34 nearby early-type galaxies from the SAURON representative sample of 48 E/S0 galaxies, all of which have ground-based optical imaging from the MDM Observatory. The surface brightness profiles of nine galaxies (≈26 per cent) show regions with blue UV−optical colours suggesting RSF. Five of these (≈15 per cent) show blue integrated UV–optical colours that set them aside in the NUV integrated colour–magnitude relation. These are objects with either exceptionally intense and localized NUV fluxes or blue UV−optical colours throughout. They also have other properties confirming they have had RSF, in particular Hβ absorption higher than expected for a quiescent population and a higher CO detection rate. This suggests that residual star formation is more common in early-type galaxies than we are used to believe. NUV blue galaxies are generally drawn from the lower stellar velocity dispersion (σ<SUB>e</SUB> < 200 km s<SUP>−1</SUP>) and thus lower dynamical mass part of the sample. We have also constructed the first UV Fundamental Planes and show that NUV blue galaxies bias the slopes and increase the scatters. If they are eliminated, the fits get closer to expectations from the virial theorem. Although our analysis is based on a limited sample, it seems that a dominant fraction of the tilt and scatter of the UV Fundamental Planes is due to the presence of young stars in preferentially low-mass early-type galaxies. Interestingly, the UV–optical radial colour profiles reveal a variety of behaviours, with many galaxies showing signs of RSF, a central UV-upturn phenomenon, smooth but large-scale age and metallicity gradients and in many cases a combination of these. In addition, FUV−NUV and FUV−<I>V</I> colours even bluer than those normally associated with UV-upturn galaxies are observed at the centre of some quiescent galaxies. Four out of the five UV-upturn galaxies are slow rotators. These objects should thus pose interesting challenges to stellar evolutionary models of the UV upturn.</P>