치환된 LaFeO_(3)의 환원반응성에 대한 연구

전현표,이상범 배재대학교 자연과학연구소 2004 自然科學論文集 Vol.15 No.1

LaFeO_(3) 복합산화물과 부분 치환한 LaFeO_(3) 복합산화물을 Citrate와 Cyanide 공침법으로 합성하여 공기중에서 850℃로 24시간동안 열처리해 제조방법에 의한 영향을 비교하였다. XRD와 IR의 결과에 의하면, 합성된 산화물은 Orthorhombic의 Perovskite구조를 나타냈으나 B자리에 0.5mol의 Cu가 치환된 복합산화물은 단일상을 얻지 못하였다. 또한, 이들 산화물의 환원반응은 치환하지 않은 LaFeO_(3.17) 복합산화물은 2단계 반응인 반면에 치환한 복합산화물은 3단계 반응으로 Dopant에 의한 새로운 환원단계가 존재함을 알았다. LaFeO_(3) and substituted LaFeO_(3) mixed oxides were prepared by Citrate and Cyanide method in air 850℃/24h. These oxides of orthorhombic perovskite were characterized by XRD and IR, but substituted LaFeO_(3) with 0.5mol Cu at B site was not obtained single phase. Also, reduction reaction of un-substituted LaFeO_(3.17) were two steps but each site substituted oxides were three steps reactions. These means that new reduction step of each site substituted oxides were atributed to dopant.

한국형 우울장애 약물치료 알고리듬 (Ⅳ) : 우울장애의 아형 및 부작용에 따른 항우울제의 선택과 여성우울장애에서의 치료전략

전현태,이상열,김원,민경준,박원명,서정석,석정호,송해철,전덕인,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : In 2002, the Korean Medication Algorithm Project for Major depressive Disorder (KMAP-MD) was published, but there has been a need for a guideline about detailed issues of depressive disorder. We revised KMAP-MDD andreestablished Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) in 2006. Methods : A questionnaire had been developed by the executive committee for KMAP-DD. The review committee consisted of 101 experienced psychiatrists. From the total of 22 questions in the questionnaire, 7 questions were evaluated for these subjects . We classified the expert opinions to 3 categories according to its confidence interval; first, second and third line. Results : SSRI and venlafaxine were the first line antidepressants (AD) for atypical and melancholic depression. For dysthymic disorder and minor depressive disorder, SSRI was recommended as the first line medications. Only AD medications was a preferred initial strategy for treating premenstrual dysphoric disorder, mild to moderate and severe non-psychotic postpartum depression. In severe psychotic postpartum depression, combination therapy of AD and atypical antipsychotics was the treatment of choice. SSRI was preferred when considering sedation, anticholinergic and cardiovascular adverse effects. Also, experts recommended mirtazapine against gastrointestinal adverse effects and bupropion in avoiding sexual dysfunction. Conclusion : These results suggest that clinicians have to consider both clinical situations and drug adverse effects in the choice of antidepressant medications.

Al-Cu-Mg合金의 時效析出에 미치는 豫備時效의 影響

趙顯麒,洪俊杓,全在英 경북대학교 공과대학 1983 工大硏究誌 Vol.12 No.-

The influences of preageing on age-precipitation in Al-2.02t% Cu-1.1wt% Mg alloy have been investigated by means of measurements of hardness, tensile strength and electrical resistivity and transmission electron microscopy. The results obtained are summarized as follows. The two-step aged alloy is more age-hardenable than the onestep aged alloy in early stage of ageing. It is because of the formation and growth of solute atom cluster and GPB zones. The maximum hardness and strength of the alloy aged 200℃ is obtained by preaged at 100℃. It is because of fine and dense distribution of S'metastable phase. The hardness and strength are remarkably decreased with sufficient ageing time after preageing at room temperature and 170℃. It is because of the formation and coarsening of S'metastable phase by the preageing.

일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성

주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-

Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.

한국형 우울장애 약물치료 알고리듬 2006 (Ⅲ) : 정신병적 양상을 동반한 주요우울삽화

김원,박원명,서정석,민경준,석정호,전덕인,전현태,이상열,송해철,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Since the publication of Korean Medication Algorithm Project for Major DepressiveDisorder (KMAP-MD) in 2002, there has been a substantial need for a revision due to rapid progress in the pharmacological management of depressive disorder. We revised KMAP-MD 2002 and developed the Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) 2006. Methods : We developed a questionniare for surveying the opinion of experts on pharmacotherapy of depressive disorder. The questionnaire consisted of 4 parts ; 1) treatment of non-psychotic depressive disorder, 2) treatment of psychotic de-pressive disorder, 3) treatment according to clinical subtypes and drugs choice considering adverse effects, and 4) treatment of depressive disorder in women. The questionnaire was completed by the review committee consisting of 101 experienced Korean psychiatrists. It is composed of 22 questions, and each question includes 54 sub-items. We classified the expert opinionto 3 categories (the first-line, the second-line, or the third-line) by χ²-test. Results : For depressive disorder with psychotic features, most reviewers prefer the combination of antidepressant and atypical antipsychotics. Electroconvulsive therapy and the combination of antidepressant and typical antipsychotics were the second-line treatment. Among antidepressants, venlafaxine was the most preferred, and SSRI and mirtazapine followed. Among atypical antipsychotics, quetiapine, risperidone and olanzapine were the most preferred, in this order. In patients who have no response to the first-line treatment, many reviewers recommended switching to another antidepressant or adding another atypical antipsychotics Conclusion : For severe depressive disorder with psychotic features, the combination of antidepressant and atypical antipsy-chotics was preferred for the first-line treatment. These results suggest that the medication strategies of depressive disorder are rapidly changing and reflects the recent studies and clinical experiences.

한국형 우울장애 약물치료 알고리듬 2006 (Ⅰ)

서정석,민경준,김원,석정호,박원명,송해철,이상열,전덕인,전현태,홍진표,한국형 우울장애 약물치료 알고리듬 2006 연구그룹 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : Since the publication of Korean Medication Algorithm Project for Major depressive Disorder (KMAP-MD) in 2002, there has been a substantial need for a revision due to rapid progress in the pharmacological management for depressive disorder. We revised KMAP-MD to Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) in 2006. This paper is one of the following 4 papers consisting of Korean pharmacological algorithm for depressive disorder. Methods : The questionnaire consisted of 4 parts ; initial treatment of 1) non-psychotic depressive disorder, 2) psychotic depressive disorder, 3) treatment strategy for clinical subtypes and drug choice considering adverse effects, and 4) treatment for depressive disorder in women. It was composed of 22 questions, and each question had 54 sub-items. The questionnaire was completed by the review committee consisting of 101 experienced Korean psychiatrists. We classified the expert opinion to 3 categories (the first-line, the second-line, or the third-line). Results : For non-psychotic major depression, regardless ofthe severity of an episode, the antidepressant (AD) monotherapy was the optimal first-line treatment. SSRI, venlafaxine, and mirtazapine were the 1st-line AD. In case of a partial or no response to initial strategy, adding another AD was recommended. For psychotic major depression, combination of an AD and an atypical antipsychotic (AAP) was the treatment of choice. Among AAPs, quetiapine, rispendone, olanzapine were preferred. For non-responder to initial strategy, the next step was adding or changing AD before changing AAP. For women with premenstrual dysphoric syndrome or postpartum depression without psychotic features, AD monotherapty was a preferred strategy while for psychotic postpartum depression, combination of AD and AAP was recommended. Experts recommended various ADs according to adverse effect. Conclusion : These results suggest that the medication strategies for depressive disorder are rapidly changing and reflect the recent studies and clinical experiences.

Effect of Partially Purified Lipid from the Mussel Mytilus coruscus on Apoptosis in Cancer Cells

( You Jin Jeon ),( Jae Hyun Jeong ),( Yong Tae Kim ),( Seung Jae Lee ),( Eun Kyung Kim ),( Pyo Jam Park ),( Byong Tae Jeon ),( Sang Ho Moon ),( Chang Bum Ahn ),( Hyun Kang ),( Yon Suk Kim ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.1

Anticancer effects of the mussel (Mytilus coruscus) cultivated in Korea were determined. Lipid extracts of Mytilus coruscus were prepared using extractions in several organic solvents: methanol, chloroform, hexane, methanol:chloroform=1:1, and chloroform:hexane=1:1. Anticancer activities of the extracts were evaluated using apoptosis assays analyzed by flow cytometry. The hexane extract exhibited the highest anticancer activity. This extract was further separated and purified using thin layer chromatography, through which lipid compounds were isolated, and their components were analyzed; the major fatty acids were eiocosadienoic acid (EA, C20:2), eicosapentaenoic acid (EPA, C20:5), and docosahexaenoic acid (DHA, C22:6), and these components were higher than those of the mussels cultivated in New Zealand and Italy. The partially purified lipid compounds exhibited an anticancer effect in several cancer cell lines. These results indicate that lipid extract of M. coruscus effectively inhibits in vitro tumor growth by inducing apoptosis of cancer cells.

Differential Induction of PepTLP Expression via Complex Regulatory System against Fungal Infection, Wound, and Jasmonic Acid Treatment during Pre-and Post-Ripening of Nonclimacteric Pepper Fruit

Jeon, Woong-Bae,Kim, Kwang-Sang,Lee, Hyun-Hwa,Cheong, Soo-Jin,Cho, Song-Mi,Kim, Sun-Min,Pyo, Byoung-Sik,Kim, Ynung-Soon,Oh, Boung-Jun The Korean Society of Plant Pathology 2004 Plant Pathology Journal Vol.20 No.4

Ripe fruit of pepper (Capsicum annuum) showed resistance to Colletotrichum gloeoporioides, but unripe fruit was susceptible. We previously isolated the PepTLP gene that induced in both unripe and ripe fruit by fungal infection and wound, and only in ripe fruit by jasmonic acid (JA) treatment. To examine further regulation of PepTLP, the action of specific agonist and antagonists of known signaling effector on the .PepTLP expression by fungal infection, wound, and JA was investigated. A similar dephosphorylation event negatively activated all the PepTLP expression in the ripe fruit by fungal infection, wound, and JA. The induction of PepTLP expression by wound is differentially regulated via phosphorylation and dephosphorylation step during pre- and post-ripening, respectively. In addition, the induction of PepTLP expression in the ripe fruit by wound and JA is differentially regulated via dephosphorylation and phosphorylation step, respectively. Only both wound and JA treatment has synergistic effect on the PepTLP expression in the unripe fruit. Both SA and JA treatments on the unripe fruit, and both wound or JA and SA on the ripe fruit could not do any effect on the expression of PepTLP. These results suggest that the induction of PepTLP expression is differentially regulated via complex regulatory system against fungal infection, wound, and JA treatment during pre- and post-ripening of pepper fruit.

Effects of growth stage and position within the beam in the structure and chemical composition of sika deer (Cervus nippon) antlers

Jeon, Byong Tae,Kim, Kyoung Hoon,Cheong, Sun Hee,Kang, Sung Ki,Park, Pyo Jam,Kim, Dong Hyun,Jung, Ho Sung,Park, Jae Hyun,Thomas, David G.,Moon, Sang Ho CSIRO Publishing 2012 Animal production science Vol.52 No.1

<P> The purpose of the present study was to investigate the changes in structural and chemical properties of sika deer antler at different stages of its growth in order to improve scientific assessment of antler’s quality. Eighteen antler samples, harvested on 40, 50 and 60 days after casting were collected from randomly selected deer farms, and the structural properties of antlers were examined. The chemical composition of each antler was determined in the upper, middle and basal section. Our results showed that the crude protein, crude fat (ether extract), uronic acid and sialic acid increased markedly from the base to the upper section, but the ash was higher in the basal section. Collagen content increased significantly from the upper to the basal section in all groups. The structural factors, including length and girth were positively or negatively correlated with the chemical composition such as glycosaminoglycans, ether extract-fat, ash, uronic acid, sialic acid, total sugar and collagen content. These findings may provide useful basic information and identify biomarkers for the association between structural properties and chemical composition during antler growth period, which should facilitate efficient production of high quality antlers for food consumption and as pharmaceutical agents. </P>

Evaluation of Contaminant Concentrations in Wet and Dry Seasons during Pump-and-Treat Pilot Tests

Jeon, Woo-Hyun,Lee, Jin-Yong,Kwon, Hyung-Pyo,Jun, Seong-Chun,Cheon, Jeong-Yong Korean Society of Soil and Groundwater Environment 2013 지하수토양환경 Vol.18 No.6

This study was performed to examine use of the pump-and-treat method for remediation of TCE, CF and CT in groundwater contaminated by DNAPL. The Woosan industrial complex is located in Wonju, about 120 km east of Seoul, Korea. Two pumping wells (KDPW7 and KDPW8) and five monitoring wells (KDMW7, KDMW8, KDMW9, KDMW10, and SKW2) were installed for the test. An asphalt laboratory is a main source of the extensive subsurface contamination at this site. To evaluate change in the concentrations of TCE, CF, and CT in groundwater in the study area, three rounds of pump-and-treat pilot tests were performed (6 July to 6 August, 22 August to 6 September, and 19 September to 2 December in 2011). The groundwater levels and the concentrations of TCE, CF, and CT exhibited negative correlations in the wet season but positive correlations in the dry season, which suggests that the TCE concentrations were mainly controlled by dilution through rainfall during the wet season and by residual TCE, CF, and CT in the unsaturated zone during the dry season. These possibilities should be considered in the full-scale remediation plan.