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Fabrication of Silicon-Vacancy Color Centers in Nanodiamonds by using Si-Ion Implantation
Hyeongkwon Kim,Hyeyeon Kim,Jaeyong Lee,Weon Cheol Lim,John A. Eliades,Joonkon Kim,Jonghan Song,석재권 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.73 No.5
Si ions 2.3 MeV are implanted into nanodiamonds (NDs) at doses of 11012 11015 ions/cm2. The ion implantation not only creates silicon-vacancy (SiV) color centers but also reduces the size of the NDs from 50 nm to 10 nm. As the Si dose is increased up to 1 1013 ions/cm2, the luminescence from the nitrogen-vacancy (NV) color centers in the ND initially increases. At higher dose rates, the luminescence from the NV color centers decreases. Due to the differences in the minimum ND size required for stable luminescence, the zero phonon line (ZPL) of the SiV color center appears after the luminescence from the NV center decreases dramatically. The ZPLs from both centers become almost negligible after Si ions have been implanted at doses higher than 5 1014 ions/cm2. These observations are explained by the reduced size of the NDs and the number of implanted Si ions, which is estimated based on SRIM simulations.
Disfluency Characteristics of School-Age Children with High-Functioning Autism Spectrum Disorders
Heeyoung Park(박희영),Hyeyeon Park(박혜연),Dongran Won(원동란),Haewon Kim(김혜원),Seungha Song(송승하),Hyun Sub Sim(심현섭) 한국언어청각임상학회 2018 Communication Sciences and Disorders Vol.23 No.2
Objectives: The purpose of this study was to investigate characteristics of speech disfluency in school-age children with high-functioning autism spectrum disorders (HF-ASD), children who stutter (CWS), and control children on reading, story retelling, and picture description tasks. Methods: Seven HF-ASD, 6 CWS, and 8 control children participated in this study. All participants ranged in age from 6 to 8 years and were matched for age and vocabulary ability. Speech samples were collected from three speaking tasks, and disfluency characteristics were identified and classified as stuttering-like disfluencies (SLD) or other disfluencies (OD). Results: Three groups did not differ in OD frequencies across the three speaking tasks. There was no significant difference between the HF-ASD and CWS groups in total disfluencies (TD) on the picture description task with SLD on the story retelling and picture description tasks. In the HF-ASD group, TD frequency in story retelling and OD frequency in story retelling and picture description were significantly higher compared to their reading performance; SLD frequency did not change significantly across tasks. In SLD subtypes, there was no significant difference in single-syllable repetition, part-word repetition and prolongation frequencies between the HF-ASD and CWS groups, but the CWS group produced more blocks than the HF-ASD group. Conclusion: These results demonstrate that, similar to children who stutter, school-age children with HF-ASD are disfluent in their verbal production except for reading. This finding suggests that the disfluent speech characteristics of HF-ASD children should be considered in evaluation and intervention. 배경 및 목적: 본 연구는 읽기, 이야기 다시말하기, 그림 설명하기의 세 가지 발화과제에서 학령기 고기능 자폐스펙트럼장애 아동들(HF-ASD)의 비유창성을 평가하고 과제에 따른 비유창성 특성이 말더듬 아동 및 일반아동들과 어떠한 차이를 보이는지 살펴보고자 하였다. 방법: 초등학교 저학년(만 6-8세) HF-ASD 아동 7명과 언어와 생활연령을 일치시킨 말더듬 아동 6명, 일반아동 8명을 연구대상으로 세 가지 발화과제에서 집단 간 또는 과제 간 총비유창성(TD)과 정상적 비유창성(OD), 비정상적 비유창성(SLD)에 유의한 차이가 있는지 알아보았다. 결과: 집단 간 비교에서 HF-ASD 아동들의 OD 빈도는 세 가지 과제 모두에서 말더듬 아동 및 일반아동들과 유의한 차이가 없었다. HF-ASD 아동들의 TD 빈도는 그림 설명하기 과제에서, SLD 빈도는 그림 설명하기와 이야기 다시말하기 과제에서 말더듬 아동만큼 높게 나타났다. 집단 내 비교에서 HF-ASD 아동들의 TD 빈도는 읽기보다 이야기 다시말하기 과제에서, OD 빈도는 읽기보다 이야기 다시말하기와 그림 설명하기 과제에서 유의하게 증가하였으나, SLD 빈도는 과제별로 유의한 차이를 보이지 않았다. 또한, HF-ASD 아동들은 SLD의 하위유형 중 일음절낱말반복과 낱말부분반복, 연장 빈도에서 말더듬 아동들과 유의한 차이가 없었으나 막힘 빈도에서 말더듬 아동들이 HF-ASD 아동들보다 유의하게 높게 나타났다. 논의 및 결론: 본 연구의 결과들은 HF-ASD 아동들이 읽기를 제외한 발화상황에서 말더듬 아동들만큼 비유창하다는 사실을 뒷받침해준다. HF-ASD 아동들의 언어적 문제뿐 아니라 구어 산출에서의 비유창성을 개선하기 위한 평가와 중재가 고려되어야 하겠다.
( Ji-su Yang ),( Hae-won Lee ),( Hyeyeon Song ),( Ji-hyoung Ha ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.1
Identifying the extracellular metabolites of microorganisms in fresh vegetables is industrially useful for assessing the quality of processed foods. Pectobacterium carotovorum subsp. carotovorum (PCC) is a plant pathogenic bacterium that causes soft rot disease in cabbages. This microbial species in plant tissues can emit specific volatile molecules with odors that are characteristic of the host cell tissues and PCC species. In this study, we used headspace solid-phase microextraction followed by gas chromatography coupled with mass spectrometry (HS-SPME-GC-MS) to identify volatile compounds (VCs) in PCC-inoculated cabbage at different storage temperatures. HS-SPME-GC-MS allowed for recognition of extracellular metabolites in PCC-infected cabbages by identifying specific volatile metabolic markers. We identified 4-ethyl-5-methylthiazole and 3-butenyl isothiocyanate as markers of fresh cabbages, whereas 2,3-butanediol and ethyl acetate were identified as markers of soft rot in PCC-infected cabbages. These analytical results demonstrate a suitable approach for establishing non-destructive plant pathogen-diagnosis techniques as alternatives to standard methods, within the framework of developing rapid and efficient analytical techniques for monitoring plant-borne bacterial pathogens. Moreover, our techniques could have promising applications in managing the freshness and quality control of cabbages.
알츠하이머 치매 환자에서의 추체외로 증상과 영역별 인지기능의 연관성
최준배(Junbae Choi),명우재(Woojae Myung),송지혜(Jihye Song),김상하(Sang Ha Kim),윤혜연(Hyeyeon Yoon),강효신(Hyo Shin Kang),나덕렬(Duk L. Na),김성윤(Seong Yoon Kim),이재홍(Jae-Hong Lee),한설희(Seol-Heui Han),최성혜(Seong Hye Choi),김상윤 대한노인정신의학회 2013 노인정신의학 Vol.17 No.1
Objectives:We aimed to investigate the prevalence of Extrapyramidal signs (EPS) and the associations between EPS and cognitive subdomains in patients with Alzheimer disease (AD). Methods:We recruited 1,324 patients with AD from the Clinical Research of Dementia of South Korea (CREDOS), a hospital based cohort study with fifty-six participating hospitals. We estimated cognitive subdomain using the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D). Dementia severity was measured by Clinical Dementia Rating Sum of Boxes (CDR- SB) and Korean version of Mini-Mental Status Examination (K-MMSE). The EPS group was defined by the presence of at least one EPS based on a focused neurologic examination. Results:The prevalence of patients with EPS was 11%. These had higher CDR-SB scores than non-EPS group. After controlling for demographic, radiological, and dementia severity (CDR-SB) factors, EPS group showed lower cognitive ability in the subdomains for visuospatial and frontal-executive function than non-EPS group. The patients with EPS were showed significantly higher scores in the subdomain for memory function. Conclusion:The presence of EPSs in patients with AD was associated with lower visuospatial, frontal-executive function and higher memory function.