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박충환(Chung-Hwan Park),박희동(Hee-Oong Park),이창균(Chang-Kyun Lee),임봉수(Bong-Su Lim) 대전대학교 환경문제연구소 2002 환경문제연구소 논문집 Vol.6 No.-
This study was carried out to evaluate performance of sewage treatment facility in rural area. Average effluent concentration was 7.6mg/l BOD, 10.3mg/l COD. 4.7mg/l SS, 19.140mg/l TN. and 1.631mg/l TP. within discharge quality standard. The removal efficiency rate of BOD. COD and SS was good as 89.8%. 78.5% and 90.1 %. respectively. But that of TN. TP was very low as 25.0% and 31.4% respectvely. Average sewage flow rate was investigated by about 1.1㎥/d per household. 398 I pcd. In rainfall period. the removal efficiency rate of BOD. TN and TP was very low as 15%. 22% and 28%. respectively because of inflow and infiltration into sewer. In flowing concentration of sewage was diluted as rain is inserted into sewer and submerged facility was not operated at normal condition. Therefore it is required that the sewer will have to repair and hydraulic design for facility will have to be check. So it is necessary to support systematical. administrative measures for responsible management.
발파공의 천공오차와 발파정확도의 상관성에 관한 현장조사 및 계층분석기법 연구
이덕환(Deok-Hwan Lee),최성웅(Sung-Oong Choi),김창오(Chang-Oh Kim) 한국암반공학회 2014 터널과지하공간 Vol.24 No.5
발파를 이용한 채광작업에 있어서 천공의 정확성은 발파의 효율성을 결정할 수 있는 중요한 요소 중의 하나이며, 따라서 천공오차의 발생 원인에 대한 분석과 천공오차의 발생 정도를 줄일 수 있는 대책 마련은 발파의 효율성 및 안전성 확보에서 매우 중요하다. 본 연구에서는 천공오차의 발생 원인을 제어가능 요인과 제어불가능 요인으로 나누어 분석하였으며 현장조사와 AHP 분석을 통하여 천공오차를 유발하는 요인들의 영향성을 살펴보았다. 또한 이들 간의 가중치 분석을 통해 천공오차를 낮출 수 있는 효과적인 대책을 제시하였다. Drilling accuracy is known to be one of the most important factors determining blasting efficiency in mining by blast operation. Therefore analysing the causes of drilling error and preparing a countermeasure for minimizing drilling error are very important for blasting efficiency and safety. In this study, causes of drilling error are analyzed with dividing them into controllable factors and uncontrollable factors, and relationship between each cause is also comprehended through field measurement and AHP analysis. Finally, effective measures to help lower the drilling error are proposed with the results from weighting analysis for each factor.
백서 심장 및 현장독성에 대한 Doxorubicin 과 Epirubicin 의 영향
박유환(You Hwan Park),정희상(Hoe Sang Jung),김완중(Wan Jung Kim),권희식(Hee Sik Kwon),김용태(Young Tae Kim),문철웅(Chul Oong Moon),박찬국(Chan Kook Park),이승일(Seung Il Lee),홍순표(Soon Pyo Hong) 대한내과학회 1991 대한내과학회지 Vol.41 No.3
N/A Doxorubicin is an antibiotic of the anthracycline group which has proven effective in treating a variety of malignant disorders. Its use in cancer chemotherapy has been limitd, however, because of the its cardiotoxic side effects. Attempts to reduce the cardiotoxicity of anthracycline antibotics include the synthesis of structural analogs, e.g., epirubicin, the coupling of active drugs to carriers, and the discovery of new types of anthracyclines. In this experiment, the toxicity of epirubicin was examined in various organs of rats for levels of malondialdehyde and activity of free radical scavengers (superoxide dismutase and catalase) and compared with the toxicity of doxorubicin. The following results were obtained: 1) Doxorubicin increased the quantity of malondiadehyde by 519% (p<0.01) in the heart, 45% (p<0.01) in the kideny, 35%(p<0.05) in the lung, and 41% (p<0.05) in the liver. Epirubicin increased the quantity of malondiadehyde by 10%(p<0.05) in the heart and 26%(p<0.01) in the kidney, but there was little change in the lung and liver. 2) Doxorubicin and Epirubicin decreased the activities of catalase in the heart by 11% and 17% but increased the it in the kidney by 27% and 19%, respectively (p<0.05). 3) Doxorubicin and Epirubicin increased the activities of SOD in the heart by 24% (p<0.01) and 199%(p<0.05) and in the kidney by 23%(p<0.01) and 34% (p<0.05) respectively. In conclusion, Epirubicin shows less toxicity in the heart than the kidney and has less cardiorenal toxicity in rats compared to Doxorubicin for same doses.
직접전단시험에서 절리면의 2차 거칠기가 거칠기 정량화 파라미터에 미치는 영향
이덕환(Deok-Hwan Lee),최성웅(Sung-Oong Choi) 한국암반공학회 2014 터널과지하공간 Vol.24 No.1
절리면의 전단강도를 결정하는 중요한 인자로 알려진 암반 절리면의 거칠기는 여러 가지 방법에 의해 연구되어 왔다. 하지만, 거칠기를 구성하는 요소인 1차 거칠기와 2차 거칠기를 분리하여 거칠기를 평가하려는 시도는 매우 제한적으로 수행되고 있다. 본 연구에서는 인장절리 시험편을 이용하여 직접전단시험을 통해 2차 거칠기 요소를 파괴하고 이를 거칠기 파라미터를 이용하여 정량화 하였다. 거칠기 파라미터는 수직응력과 측정간격이 증가할수록 감소하였으나, 1.5 MPa 이상의 수직응력에서는 일정한 경향을 나타내지 않았다. 또한 전단 반대방향의 거칠기 면적 감소율은 거칠기 파라미터가 증가할수록 감소하였다. Rock joint surface roughness, which is known to be one of the most important factors for defining shear strength of rock mass, has been researched in various methods. However, approaches to separate a roughness into two groups (primary and secondary) for evaluating the roughness have been rarely performed. In this study, elements of secondary roughness were eliminated through direct shear testing with tensile joint specimen and they were quantified with joint parameters. It is revealed that roughness parameters decrease with increasing the normal stress and sampling intervals, except for the case in which the normal stress is larger than 1.5 MPa. Also it is analyzed that ratio of area reduction in the opposite direction of shearing decreases with increasing the roughness parameter.
Moon Sub Choi,Jong kuk Lee,Joonho Richard Hwang,Hwan oong Lee 한국무역연구원 2014 貿易 硏究 Vol.10 No.6
By constructing a novel proprietary pharmaceutical database, we assessed whether the corporate transparency of Korean exchange-listed pharmaceutical companies affects event-study returns upon Korea Food and Drug Agency approvals of new drugs. The empirical findings are as follows: First, the evidence is that new drugs are priced in the announcement returns. Second, product innovation is appraised higher by the investors when the company is well-governed in terms of trading venue, R&D intensity, balance sheet variables, payout policy, valuation, and years of operation. Lastly, shareholders are wealthier with innovative new products promised by trustworthy managers.
Streptozotocin 유발성 당뇨백서에서 해당효소에 대한 Phlorizin의 효과
배학연,정회상,박유환,전용준,이승일,문철웅,양성훈,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
In glycolysis, the reactions catalyzed by hexokinase, Phosphofructokinase, and pyruvate kinase are lally irreversible; hence they would be expected to have regulatory as well as catalytic roles. They ilso adaptive in a number of physiological states, and although the molecular mechanisms controlling adaptations are largely unknown, dietary and hormonal stimuli serve as environmental factors lating enzyme levels in vivo. The present study was undertaken to examine the effects of phlorizin, a blocker of renal tubular ose reabsorption, on the activities of glucokinase, hexokinase, and pyruvate kinase in the liver and nrocytes of streptozotocin (STZ) diabetic rats. The levels of plasma glucose and insulin and the activities of glycolytic enzymes were measured onchird day after phlonzin treatment in normal and STZ diabetic rats and the results were as follows. 1. Plasma glucose levels were reduced by 14.35%(P<0.05) in normal rats and by 39.38% (p<0.01) in STZ diabetic rats. 2. Plasma insulin levels were reduced by 45.6% (P<0.05) in normal rats and by 58.2% (P<0.01) in STZ diabetic rats. 3. On the third day after phlorizin treatment, hepatic glucokinase and pyruvate kinase activities in normal rats were reduced by approximately 56% (P<0.01) and 43% (P<0.01) respectively, and erythrocyte hexokinase and pyruvate kinase activities were reduced by approximately 18% (P<0.05) and 22% (P<0.01) respectively, In STZ diabetic rat shepatic glucokinase and pyruvate kina activities were reduced by approximately 52% (P<0.01) and 22% (P<0.01) respectively, a erythrocyte hexokmase and pyruvate kinase activities were reduced by approximately 4% and 3 respectively. Thus the overall decreases of the levels of plasma glucose and insulin and the activity of glycoly enzymes were observed on the third day after phlorizin treatment in normal and STZ diabetic ra These alterations in the enzyme activity with phlorizin treatment were shown to be a result of reducinsulin levels, and the smaller decrease in enzyme actvity in STZ diabetic rats than in normal rats thought to be probably due to the reduced response to changes in insulin levels at near basal levels enzyme activity.