Anti-glioma Effect and Safety of Docetaxel-loaded Nanoemulsion

Huil Gaoe,Xinguo Jiang,Zhiqing Pang,Shuaiqi Pan,Shijie Cao,Zhi Yang,Chen Chen 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.2

Docetaxel, an inhibitor of microtubule depolymerization, has been used for many malignancies. Due to its toxicity and the non-selective distribution of its commercial formulation, Taxotere®, new formulations with less toxicity and tumor targeting need to be explored. For its safety and ease of factory scale production, nanoemulsion, was selected to encapsulate docetaxel. The particle size of docetaxel loaded nanoemulsion (DNE) was 72.3 nm, the average zeta potential was −6.38 mV, the encapsulation efficiency was 93.1% and the drug loading capacity was 2.87%. Although DNE presented similar antiproliferation effects on both U87 cells and bEnd.3 cells, its in vivo toxicity was significantly lower than Taxotere®. In vivo fluorescent imaging suggested nanoemulsions loaded with a fluorescent probe could distribute to the brain and accumulate at the glioma site. The pharmacological experiments also confirmed that the DNE could target glioma sites and prolong the median survival time of mice with gliomas. In conclusion, DNE is a new, less toxic, drug formulation that is effective for brain glioma therapy.

A New Cassane-type Diterpene and Other Constituents from Caesalpinia minax

Huiling Liu,Guoxu Ma,Jingquan Yuan,Xiaoming Tan,Qingxia Zheng,Zhaocui Sun,Junshan Yang,Xudong Xu 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.5

A New Cassane-type Diterpene and Other Constituents from Caesalpinia minax

Liu, Huiling,Ma, Guoxu,Yuan, Jingquan,Tan, Xiaoming,Zheng, Qingxia,Sun, Zhaocui,Yang, Junshan,Xu, Xudong Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5

Effect of Laser Power on Hybrid Laser-Gas Metal Arc Welding (GMAW) of a 6061 Aluminum Alloy

Zhou Huiling,Fu Fanglian,Dai Zhixin,Qiao Yanxin,Chen Jian,Yang Lanlan,Liu Wen 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.11

The effect of laser power on the geometrical characteristics, microstructure and micro-hardness of the welding joints for 6061 aluminum alloy after hybrid laser-gas metal arc welding (GMAW) was investigated. The results showed that the welding joints from "Bottom" to "Top" were mainly composed of planar crystals, columnar crystals, and equiaxed dendrites. With increasing laser power, the weld depth and width and the grain size increased. When the laser power reached 5 kW, pores could be found in the weld pool region. Micro-hardness measurements showed that the application of higher laser power hardly changed the hardness of the welding joint.

Research on the Distribution and Self-Similarity Characteristic of End-To-End Network Delay

Min Liu,Yanru Xue,Yang Zhao,Huiling Guo 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.3

As an important indicator of evaluating network performance, network delay can reflect the transmission performance of the current path and also the service level provided by the opposite terminal host. In the paper, analysis is first conducted on the composition of network delay; besides, through Ping measuring method, Ping measuring network delay experiment is conducted on different destination hosts of local area network (LAN) and wide area network (WAN). Besides, the distribution features of network delay as time changes is analyzed, while the influence of data package (in terms of the size) on network delay will be explored in the paper. After the process, the definition, along with the distinguishing method of the self-similarity process is introduced, and self-similarity distinguishing is rendered on network delay through the variance-time plot. According to analysis result, network delay is featured by strong nonlinearity and self-similarity. Compared with LAN, WAN is endowed with higher long-range dependency.

Effects of Cloud Microphysical Latent Heat on a Heavy Rainstorm in Beijing

Chunwei Guo,Hui Xiao,Huiling Yang,Liang Zhai,Xiangchen Kong 한국기상학회 2019 Asia-Pacific Journal of Atmospheric Sciences Vol.55 No.3

The latent heat produced by cloud microphysical processes can greatly affect the thermal and dynamic structure of the atmosphere, as well as the development and evolution of clouds and precipitation. In this study, to examine the consequences of different kinds of latent heat produced by microphysical processes, four sensitivity tests were conducted based on the control simulation results of a heavy rainstorm occurred in Beijing on 21 July 2012 using theWeather Research and Forecasting Model (WRF).Without the latent heat absorption of evaporation, the convective cloud system developed stronger, and the accumulated precipitation amount increased.Without the latent heat release of deposition, the transit time of the surface front was delayed; in addition, the convective cloud system developed weakly. The accumulated conversion amounts of microphysical processes and the accumulated rainfall amount in the deposition adiabatic test were far less than those in the other tests.Without the latent heat of melting and freezing, the convective cloud system did not change substantially, and there was only a minor effect on precipitation. Hydrometeor production exhibited some changes related to precipitation in the five tests. The latent heat produced by the convective system varied substantially in the five tests with a change in the latent heat budget.

Deep electrical structure and dynamic mechanism of the Yinchuan Graben on the western margin of the Ordos Block

Gang Min,Bingxi Yin,Jinchao Chen,Yong Yang,Huiling Yuan,Yan Wang 한국지질과학협의회 2022 Geosciences Journal Vol.26 No.1

The Yinchuan Graben (YG) is situated in the transitional area between the Tibetan Plateau, Ordos Block (OB) and Alxa Block (AB). The dynamic mechanism of the YG is controversial because of its unique tectonic environment. This study used a broadband magnetotelluric profile constrained by high-density point spacing to reliably obtain the deep electrical structure across the Helanshan Orogenic Belt and YG and to discuss the dynamic mechanism of the YG. The main research results are as follows. 1) Our profile and previous seismic profiles show a low-resistivity and low-velocity body in the deep YG, which extends upward and cuts through the bottom boundary of the upper crust, and all results indicate that this body may be the result of partial melting due to upwelling mantle material. 2) Our profile also shows a high-resistivity anomaly in the middle–lower crust of the Helanshan orogenic belt, which can be interpreted as intrusive rocks formed by the emplacement of partially melted materials. 3) The Helanshan east piedmont fault dips eastward and intersects with the Yellow River fault at the depth of 20 km, and the typical structure of the intersection may be the seismogenic structure of the Pingluo Ms8.0 earthquake. 4) The evolution of the YG may have been controlled by various dynamic mechanisms, and the initial formation of the YG may have resulted from the upwelling mantle material beneath the northern OB; the evolution of the YG since 10 Ma may also have been affected by lateral mantle flow from the Tibetan Plateau to the gap between the OB and AB.

PMIC용 고신뢰성 eFuse OTP 메모리 설계

양혜령,최인화,장지혜,김려연,하판봉,김영희,Yang, Huiling,Choi, In-Wha,Jang, Ji-Hye,Jin, Liyan,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.7

In this paper, a BCD process based high-reliability 24-bit dual-port eFuse OTP Memory for PMICs is designed. We propose a comparison circuit at program-verify-read mode to test that the program datum is correct by using a dynamic pseudo NMOS logic circuit. The comparison result of the program datum with its read datum is outputted to PFb (pass fail bar) pin. Thus, the normal operation of the designed OTP memory can be verified easily by checking the PFb pin. Also we propose a sensing margin test circuit with a variable pull-up load out of consideration for resistance variations of programmed eFuse at program-verify-read mode. We design a 24-bit eFuse OTP memory which uses Magnachip's $0.35{\mu}m$ BCD process, and the layout size is $289.9{\mu}m{\times}163.65{\mu}m$ ($=0.0475mm^2$). 본 논문에서는 BCD 공정 기반으로 PMIC용 고신뢰성 24비트 듀얼 포트(dual port) eFuse OTP 메모리를 설계하였다. 제안된 dynamic pseudo NMOS 로직회로를 이용한 프로그램 데이터 비교회로는 program-verify-read 모드에서 프로그램 데이터와 read 데이터를 비교하여 PFb(pass fail bar) 핀으로 비교 결과를 출력한다. 그래서 한 개의 PFb 핀만 테스트하므로 eFuse OTP 메모리가 정상적으로 프로그램 되었는지를 확인할 수 있다. 그리고 program-verify-read 모드를 이용하여 프로그램된 eFuse 저항의 변동을 고려한 가변 풀-업 부하(variable pull-up load)를 갖는 센싱 마진 테스트 회로를 설계하였다. Magnachip $0.35{\mu}m$ BCD 공정을 이용하여 설계된 24비트 eFuse OTP 메모리의 레이아웃 면적은 $289.9{\mu}m{\times}163.65{\mu}m$($=0.0475mm^2$)이다.