The Effect of Building Characteristics and Psychological Variables to Occupants' IEQ Satisfaction in Office Buildings

Heejin Han,Chungyoon Chun,Yoorim Choi,John Goins,Hui Zhang,Edward Arens 한국생활환경학회 2013 한국생활환경학회지 Vol.20 No.6

The purpose of this study is to find building and psychological variables which affect occupants" IEQ (Indoor environment quality) satisfaction in office buildings. The results showed that (1) occupants" IEQ satisfaction increased with behavior adjustability, satisfaction with interior design, and level of ensuring privacy. (2) Occupants" satisfaction with each physical condition (thermal, noise, lighting, indoor air quality) decreased when building scale is too large. Building scale also had a significant effect on behavior adjustability. (3) The linear relationship between all psychological variables and IEQ satisfaction was proved. (4) As IEQ satisfaction (thermal, noise, lighting, indoor air quality) increased, overall workspace satisfaction did also increase. Especially, among four IEQ satisfactions, noise satisfaction was the most effective factor on overall workspace satisfaction.

Immediate bimaxillary full-arch reconstruction using an industrial outsourced digitally guided workflow – a feasibility demonstration

Adam S.C. Siu,James K.F. Chow,Edward Hui,Mei M. Chong,Michel Dard 대한치과이식임플란트학회 2021 The Korean Academy of Implant Dentistry Vol.40 No.4

Bimaxillary immediate full-arch restorations can be prosthodontically, surgically, and esthetically demanding. State-of-the-art computer- assisted guided surgery can significantly improve the predictability and reliability of such procedures while reducing the chair time for the patient. This case report demonstrates how such procedures can be applied using an industrially outsourced service to assist implant planning and treatment preparation. A 63-year-old partially edentulous female with a failing dentition presented at our clinic. After medical assessment and the patient s request to avoid any edentulous episodes during treatment, a digitally guided bimaxillary full-arch reconstruction with an immediate restoration was performed within one session. The surgical and restorative procedures were performed as planned, allowing an immediate provisional restoration. The comparison of the planned and actual implant positions indicated slight inaccuracies between these positions. These deviations did not affect the immediate provisionalization, functionality, or esthetics of the immediate or final prosthetic rehabilitation. Fully digitally guided workflows represent a valuable tool for the efficient and reliable immediate transition from a failing dentition to a fixed reconstruction. The application of an outsourced and assisted digital planning service allows immediate access to digitally guided surgery and can improve efficiency. Deviations between planned and actual implant positions were most likely related to the rotational degrees of freedom around the teeth used for guide retention.

Development of the ASHRAE Global Thermal Comfort Database II

Fö,ldvá,ry Lič,ina, Veronika,Cheung, Toby,Zhang, Hui,de Dear, Richard,Parkinson, Thomas,Arens, Edward,Chun, Chungyoon,Schiavon, Stefano,Luo, Maohui,Brager, Gail,Li, Peixian,Kaam, Soazig Elsevier 2018 Building and environment Vol.142 No.-

<P><B>Abstract</B></P> <P>Recognizing the value of open-source research databases in advancing the art and science of HVAC, in 2014 the ASHRAE Global Thermal Comfort Database II project was launched under the leadership of University of California at Berkeley's Center for the Built Environment and The University of Sydney's Indoor Environmental Quality (IEQ) Laboratory. The exercise began with a systematic collection and harmonization of raw data from the last two decades of thermal comfort field studies around the world. The ASHRAE Global Thermal Comfort Database II (Comfort Database), now an online, open-source database, includes approximately 81,846 complete sets of objective indoor climatic observations with accompanying “<I>right-here-right-now</I>” subjective evaluations by the building occupants who were exposed to them. The database is intended to support diverse inquiries about thermal comfort in field settings. A simple web-based interface to the database enables filtering on multiple criteria, including building typology, occupancy type, subjects' demographic variables, subjective thermal comfort states, indoor thermal environmental criteria, calculated comfort indices, environmental control criteria and outdoor meteorological information. Furthermore, a web-based interactive thermal comfort visualization tool has been developed that allows end-users to quickly and interactively explore the data.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The scope, development, contents, and accessibility of the Comfort Database is documented. </LI> <LI> The Comfort Database II includes approximately 76,000 complete sets of thermal comfort data. </LI> <LI> The Comfort Database provides access to the collected raw data. </LI> <LI> Web-based interactive visualization tool was developed that allows end-users to interactively explore the data. </LI> </UL> </P>

Accelerating Magnetic Resonance Fingerprinting Using Hybrid Deep Learning and Iterative Reconstruction

Peng Cao,Di Cui,Yanzhen Ming,Varut Vardhanabhuti,Elaine Lee,Edward Hui 대한자기공명의과학회 2021 Investigative Magnetic Resonance Imaging Vol.25 No.4

Purpose: To accelerate magnetic resonance fingerprinting (MRF) by developing a flexible deep learning reconstruction method. Materials and Methods: Synthetic data were used to train a deep learning model. The trained model was then applied to MRF for different organs and diseases. Iterative reconstruction was performed outside the deep learning model, allowing a changeable encoding matrix, i.e., with flexibility of choice for image resolution, radiofrequency coil, k-space trajectory, and undersampling mask. In vivo experiments were performed on normal brain and prostate cancer volunteers to demonstrate the model performance and generalizability. Results: In 400-dynamics brain MRF, direct nonuniform Fourier transform caused a slight increase of random fluctuations on the T2 map. These fluctuations were reduced with the proposed method. In prostate MRF, the proposed method suppressed fluctuations on both T1 and T2 maps. Conclusion: The deep learning and iterative MRF reconstruction method described in this study was flexible with different acquisition settings such as radiofrequency coils. It is generalizable for different in vivo applications.

Association between High Diffusion-Weighted Imaging-Derived Functional Tumor Burden of Peritoneal Carcinomatosis and Overall Survival in Patients with Advanced Ovarian Carcinoma

An He,Perucho Jose AU,Chiu Keith WH,Hui Edward S,Chu Mandy MY,Ngu Siew Fei,Ngan Hextan YS,Lee Elaine YP 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.5

Objective: To investigate the association between functional tumor burden of peritoneal carcinomatosis (PC) derived from diffusion-weighted imaging (DWI) and overall survival in patients with advanced ovarian carcinoma (OC). Materials and Methods: This prospective study was approved by the local research ethics committee, and informed consent was obtained. Fifty patients (mean age ± standard deviation, 57 ± 12 years) with stage III–IV OC scheduled for primary or interval debulking surgery (IDS) were recruited between June 2016 and December 2021. DWI (b values: 0, 400, and 800 s/mm2) was acquired with a 16-channel phased-array torso coil. The functional PC burden on DWI was derived based on K-means clustering to discard fat, air, and normal tissue. A score similar to the surgical peritoneal cancer index was assigned to each abdominopelvic region, with additional scores assigned to the involvement of critical sites, denoted as the functional peritoneal cancer index (fPCI). The apparent diffusion coefficient (ADC) of the largest lesion was calculated. Patients were dichotomized by immediate surgical outcome into high- and low-risk groups (with and without residual disease, respectively) with subsequent survival analysis using the Kaplan-Meier curve and log-rank test. Multivariable Cox proportional hazards regression was used to evaluate the association between DWI-derived results and overall survival. Results: Fifteen (30.0%) patients underwent primary debulking surgery, and 35 (70.0%) patients received neoadjuvant chemotherapy followed by IDS. Complete tumor debulking was achieved in 32 patients. Patients with residual disease after debulking surgery had reduced overall survival (p = 0.043). The fPCI/ADC was negatively associated with overall survival when accounted for clinicopathological information with a hazard ratio of 1.254 for high fPCI/ADC (95% confidence interval, 1.007–1.560; p = 0.043). Conclusion: A high DWI-derived functional tumor burden was associated with decreased overall survival in patients with advanced OC.

Accuracy of routine digitally guided immediate full-arch rehabilitations: an observational analysis of eight patients

James Kwok Fai Chow,Adam Shui Cheong Siu,Edward Hui,Raymond Lop Keung Chow,Michel Dard 대한치과이식임플란트학회 2021 The Korean Academy of Implant Dentistry Vol.40 No.4

Purpose: Guided surgery might significantly improve the efficacy and predictability of full-arch rehabilitations. This requires highly accurate implant placement. This retrospective statistical analysis of patient records aimed at identifying the factors affecting the implant placement accuracy of guided single and bimaxillary immediate full-arch rehabilitations. Materials and Methods: Patient, anatomy, procedure, and implant-related parameters that might influence the coronal, apical and angular deviation of the implants and anchoring pins were statistically analyzed using various statistical models: Mixed regression models were used to analyze differences within groups of single parameters individually. Statistically significant associations between placement accuracy and influencing factors after eliminating covariate factors were identified using multivariable mixed regression models. Results: Patient records of 8 partially edentulous patients treated by four different surgeons and involving 11 procedures, including 61 implants, were analyzed. Average coronal, apical, and angular deviations of (1.16±0.80) mm, (1.49±0.89) mm, and (4.06±2.17)° respectively were measured. From the mixed regression analysis, gender, jaw type, implant position, bone resection, and pinhole drill guide were found to have a statistically significant association with one or more accuracy parameters. As part of the multivariable regression analysis after elimination of covariate parameters, the coronal and apical offsets appeared to be influenced by the use of pinhole drill guides (P<0.001) and angular offsets by the surgeon (P=0.063), age (P=0.027), and implant position (P=0.014). Conclusions: Digital workflows allow for the successful full-arch rehabilitation of partially and fully edentulous patients. The implant placement accuracy might be improved by considering the identified procedure, anatomic, and patient-related factors.

Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) in Virally Suppressed Chronic Hepatitis B (CHB) Patients with Moderate or Severe Renal Impairment, or in End-Stage Renal Disease (ESRD) Patients on Hemodialysis (HD): Week 2

( Jeong Heo ),( Harry L.A. Janssen ),( Young-suk Lim ),( Edward J. Gane ),( Claire Fournier ),( Sang Hoon Ahn ),( Owen Tsang ),( Wan-long Chuang ),( Aric Josun Hui ),( Magdy Elkhashab ),( Chi-yi Chen 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: TAF, a novel tenofovir prodrug, has demonstrated noninferior efficacy to TDF with superior bone and renal safety in virally suppressed CHB patients with eGFR (by Cockcroft-Gault; eGFR_CG) ³50 mL/min when switched from TDF. The efficacy and safety of virally suppressed patients on TDF with renal impairment who were switched to TAF were evaluated in this Phase 2 study. Methods: CHB patients with renal impairment taking TDF for ³48 weeks and virally suppressed for ³6 months with HBV DNA <20 IU/mL at screening were enrolled into 2 cohorts: 1) moderate-severe renal impairment (eGFR_CG 15 to <60mL/min) and 2) ESRD (eGFR_CG <15 mL/min) patients on chronic HD. All patients were switched to TAF 25 mg QD for 96 weeks. Co-primary endpoints were proportion with HBV DNA <20 IU/mL and graded adverse events (AEs)/lab abnormalities at Week 24. Results: 93 patients (Mod-severe impairment 78; ESRD 15) were enrolled from 26 sites in 8 countries. Median age was 65 years, 74% male, 77% Asian, 83% HBeAg-negative, up to 60% had low BMD at hip and/or spine, and 60% and 24% had a history of HTN and/or diabetes, respectively. Key efficacy/safety results at Week 24 are summarized in the Table. All patients on treatment at Week 24 maintained HBV DNA <20 IU/mL and a high proportion had normal ALT levels. Relative to baseline levels, switching to TAF from TDF resulted in increases in hip/spine BMD, decreases in bone turnover markers, as well as increases in eGFR_CG and decreases in renal tubular markers. TAF was well tolerated with few having Grade 3 or 4 AEs (8%) and no discontinuations due to AEs. Conclusions: In renally-impaired CHB patients, including ESRD patients on HD, viral suppression was well maintained and the bone and renal safety were improved 24 weeks after switching from TDF to TAF.