Dynamic analysis of indentation rolling resistance of steel cord rubber conveyor belt

Hong-yue Chen,Kun Zhang,Ming-bo Piao,Xin Wang,En-dong Li 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.9

To study the variation trend of the indentation rolling resistance of a rubber conveyor belt under different environmental temperatures, the sinusoidal compression displacement test was first carried out on the rubber matrix at six temperatures between -20 °C and 40 °C by a high and low temperature universal testing machine. Elastic modulus 1 E , 2 E and loss factor tanq of the rubber matrix were identified using the Fourier series. Then, the dynamic contact characteristics between the idling roller and conveyor belt were analyzed by the viscoelastic mechanics theory. Hence, the calculation equation of the indentation rolling resistance in the full thickness direction of the conveyor belt was deduced. Finally, a practical calculation and experimental verification of the indentation rolling resistance of the steel cord rubber conveyor belt at different temperatures were conducted. The results showed that the drop of the indentation rolling resistance of the conveyor belt was significant when the temperature was increased in the range of -20-10 °C. In the range of 10-40 °C, the influence of the increase of the ambient temperature on the indentation rolling resistance was relatively weak. Additionally, it is found that the contact force in the vertical direction and the idling roller diameter are important factors that affect the indentation rolling resistance of the conveyor belt. The influence of belt speed on the indentation rolling resistance is weak.

Absence of EZH2 Gene Mutation in Chronic Myeloid Leukemia Patients in Blast Crisis

Chen, Hao-Yue,Yao, Hong,Wu, Ling-Yu,Liu, Can-Jun,Zhu, Jian-Qin,Liu, Chun-Hua,Wang, Wei,Dong, Sha-Sha,Ping, Na-Na,Chen, Su-Ning,Sun, Miao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Static and dynamic characteristics of a novel moving magnet linear compressor

Hong-yue Chen,Zhangquan Lv,Xianyang Liu,Chen Chen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.1

Linear compressors are popular in the field of household refrigeration due to their high efficiency and excellent capacity modulation capability. In this study, we proposed a novel moving magnet linear compressor and investigated its static and dynamic characteristics. Static performance included static shaft force, force constant, and magnetic spring, which were examined via finite element analysis and verified by conducting specific thrust experiments. For dynamic characteristics, resonance frequency, piston stroke, and piston offset were calculated by considering the magnetic spring effect. Compared with the results that didn’t consider the magnetic spring effect, higher accuracy was achieved under various conditions. In addition, piston offset increased with discharge pressure, but it was insensitive to changes in piston stroke. The motor efficiency of the designed linear compressor prototype can reach 0.92 under no-load condition and 0.80 under a discharge pressure of 0.6 MPa with a stroke of 9 mm under air condition.

Clinical Study of Thalidomide Combined with Dexamethasone for the Treatment of Elderly Patients with Newly Diagnosed Multiple Myeloma

Chen, Hai-Fei,Li, Zheng-Yang,Tang, Jie-Qing,Shen, Hong-Shi,Cui, Qing-Ya,Ren, Yong-Ya,Qin, Long-Mei,Jin, Ling-Juan,Zhu, Jing-Jing,Wang, Jing,Ding, Jie,Wang, Ke-Yuan,Yu, Zi-Qiang,Wang, Zhao-Yue,Wu, Tian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: To investigate the relationship between the efficacy and safety of different doses of thalidomide (Thal) plus dexamethasone (Dex) as the initial therapy in elderly patients with newly diagnosed multiple myeloma (MM). Methods: Clinical data of 28 elderly patients with newly diagnosed MM who underwent the TD regimen as the initial therapy were analyzed retrospectively. The patients were divided into two groups according to the maximal sustained dose of Thal: lower dose (group A) and higher dose (group B). The overall response rate (ORR), progression free survival (PFS), overall survival (OS), and adverse events (AES) were compared between the two groups. Results: A total of 28 patients were followed up with a median of 18 months. The ORR was 60.1%. The median response time and PFS were 2.0 and 17.0 months, respectively. The mean sustained dose of Thal in group B was significantly higher than group A (292.9 mg v 180.4 mg, P=0.01). There was no significantly difference in ORR (57.1% v 64.3%, P=1.00) and PFS (9.63months v 17.66 months, P=0.73) between groups A and B. During the follow up, only five patients died (<40%) and, therefore, median OS values were not available. It is estimated, however, that the mean survival time in the two groups was 35.6 and 33.4 months (P>0.05), respectively. All of the patients tolerated the treatment well. The incidence of AES in patients with a grading above 3 in group B was significantly higher than in group A (P=0.033). Conclusions: The TD regimen results in a high response rate and manageable AES as the initial therapy in elderly patients with MM. TD should be considered as the front line regimen for the treatment of elderly patients with MM in areas with financial constraints. The clinical response can be achieved at a low dose Thal with minimal toxicity.

ER81-shRNA Inhibits Growth of Triple-negative Human Breast Cancer Cell Line MDA-MB-231 In Vivo and in Vitro

Chen, Yue,Zou, Hong,Yang, Li-Ying,Li, Yuan,Wang, Li,Hao, Yan,Yang, Ju-Lun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

The lack of effective treatment targets for triple-negative breast cancers make them unfitted for endocrine or HER2 targeted therapy, and their prognosis is poor. Transcription factor ER81, a downstream gene of the HER2, is highly expressed in breast cancer lines, breast atypical hyperplasia and primary breast cancers including triple-negative examples. However, whether and how ER81 affects breast cancer carcinogenesis have remained elusive. We here assessed influence on a triple-negative cell line. ER81-shRNA was employed to silence ER81 expression in the MDA-MB-231 cell line, and MTT, colony-forming assays, and flow cytometry were used to detect cell proliferation, colony-forming capability, cell cycle distribution, and cell apoptosis in vitro. MDA-MB-231 cells stably transfected with ER81-shRNA were inoculated into nude mice, and growth inhibition of the cells was observed in vivo. We found that ER81 mRNA and protein expression in MDA-MB-231 cells was noticeably reduced by ER81-shRNA, and that cell proliferation and clonality were decreased significantly. ER81-shRNA further increased cell apoptosis and the residence time in $G_0/G_1$ phase, while delaying tumor-formation and growth rate in nude mice. It is concluded that ER81 may play an important role in the progression of breast cancer and may be a potentially valuable target for therapy, especially for triple negative breast cancer.

Depression and APOEε4 Status in Individuals with Subjective Cognitive Decline: A Meta-Analysis

Yue-ping Huang,Ju-jun Xue,Chao Li,Xi Chen,Hong-juan Fu,Teng Fei,Peng-xiang Bi 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.9

Objective To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline(SCD) and its progression to objective cognitive decline. Methods After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to examine the role of APOEε4 and depression in SCD or its progression to mild cognitive impairment (MCI) or dementia. Results APOEε4 positivity was not different between SCD and normal individuals but was significantly higher in individuals with SCD plus than in normal individuals [odds ratio: 2.39 (95% CI: 1.87, 3.05); p<0.00001] and in SCD converters than in non-converters [odds ratio: 5.19 (95% CI: 2.36, 11.42); p<0.00001]. Depression was significantly higher in individuals with SCD [standardized mean difference: 0.63 (0.45, 0.82); p<0.00001] and SCD plus [standardized mean difference: 0.83 (0.43, 1.22); p<0.0001] than in normal individuals. However, depression was not different between SCD and MCI or between SCD converters and non-converters. Age of SCD converters was higher than non-converters [mean difference: 2.95 years (0.58, 5.31)]. Conclusion Whereas APOEε4 positivity was higher in SCD plus and SCD converters, depression was higher in SCD and SCD plus but was not different between SCD and MCI.

A Research on User Interest Model Using Ontology and VSM Extension

Yue-zhong Wu,Shu-hong Chen 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.7

The user interest model is the key technology for us to efficiently obtain personalized high quality resources in huge amounts of data. On the basis of traditional user interest model, combining with the concept of ontology, this paper comes up with a construction method based on ontology semantic tree and space vector method, and its eigenvalue is changing by using forgetting curve. The model describes a theme by using semantic concept tree, and it not only simply to describe the semantic relations between concepts, but also can reflect the user interest drift character. It is more accurate in characterization of user interest, and better reflects the change of user interest, and efficiently improves the quality of network document resource personalized services. Finally the experiment describes the update process of the proposed model by using an example, and illustrates that the proposed model is simple and practical.

Investigation of Microstructural Evolution and Electrical Properties for Ni-Sn Transient Liquid-Phase Sintering Bonding

Hong-Liang Feng,Ji-Hua Huang,Jian Yang,Shao-Kun Zhou,Rong Zhang,Yue Wang,Shu-Hai Chen 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.6

Ni/Ni-Sn/Ni sandwiched simulated package structures weresuccessfully bonded under low temperature and low pressure byNi-Sn transient liquid-phase sintering bonding. The results showthat, after isothermally holding for 240 min at 300 °C and 180 minat 340 °C, Sn was completely transformed into Ni3Sn4 intermetalliccompounds. When the Ni3Sn4 phases around Ni particles werepressed together, the porosity of the bonding layer increased, whichobviously differed from the normal sintering densification process. With further analysis of this phenomenon, it was found that largevolume shrinkage (14.94% at 340 °C) occurred when Ni reactedwith Sn to form Ni3Sn4, which caused void formation. Amechanistic model of the microstructural evolution in the bondinglayer was proposed. Meanwhile, the resistivity of the bonding layerwas measured and analyzed by using the four-probe method; themicrostructural evolution was well reflected by the resistivity ofthe bonding layer. The relationship between the resistivity andmicrostructure was also discussed in detail.

Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation

Chen Peng,Luo Xiaojun,Dai Guanqi,Jiang Yuchuan,Luo Yue,Peng Shuang,Wang Hao,Xie Penghui,Qu Chen,Lin Wenyu,Hong Jian,Ning Xue,Li Aimin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Dexmedetomidine (DEX) is an anesthetic that is widely used in the clinic, and it has been reported to exhibit paradoxical effects in the progression of multiple solid tumors. In this study, we sought to explore the mechanism by which DEX regulates hepatocellular carcinoma (HCC) progression underlying liver fibrosis. We determined the effects of DEX on tumor progression in an orthotopic HCC mouse model of fibrotic liver. A coculture system and a subcutaneous xenograft model involving coimplantation of mouse hepatoma cells (H22) and primary activated hepatic stellate cells (aHSCs) were used to study the effects of DEX on HCC progression. We found that in the preclinical mouse model of liver fibrosis, DEX treatment significantly shortened median survival time and promoted tumor growth, intrahepatic metastasis and pulmonary metastasis. The DEX receptor (ADRA2A) was mainly expressed in aHSCs but was barely detected in HCC cells. DEX dramatically reinforced HCC malignant behaviors in the presence of aHSCs in both the coculture system and the coimplantation mouse model, but DEX alone exerted no significant effects on the malignancy of HCC. Mechanistically, DEX induced IL-6 secretion from aHSCs and promoted HCC progression via STAT3 activation. Our findings provide evidence that the clinical application of DEX may cause undesirable side effects in HCC patients with liver fibrosis.

Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway

Guo, Hong-Yan,Xing, Yue,Sun, Yu-Qiao,Liu, Can,Xu, Qian,Shang, Fan-Fan,Zhang, Run-Hui,Jin, Xue-Jun,Chen, Fener,Lee, Jung Joon,Kang, Dongzhou,Shen, Qing-Kun,Quan, Zhe-Shan The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.6

Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by ¹H-NMR, ¹³C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC₅₀ < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC₅₀ > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.