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천골기형종(Sacral Teratoma)을 갖인 태아의 임신분만 경과 및 병리학적 고찰
홍순박 現代醫學社 1969 現代醫學 Vol.10 No.1
This is a case of benign, cystic, sacral teratoma found in a neonatal male infant. In this report the author described delivery course and obstetrical findings of the woman pregnant the ' fetus having sacral teratoma. Clinically, this case was diagnosed as twin pregnancy, malposition of fetus hydramniosis and between even with plane abdominal X-ray finding of the pregnant. Pathological examination revealed that the sacral mass of the infant was cystic and fluctuated, and contained many globular masses resembling the skin, intestinal tract, brain, lung, liver, spleen, bone marrow, and myxoma. It measured 15×14×13cm in three dimensions, and: was 320gm in weight. This tumor was attached to the outer surface of the sacrum and was not communicated with the meninges, of the spinal, cord. Microscopically, elements from three germ layers were present in the masses contained in the cystic space. A large portion-of the masses was madeup of tissues derived from the etodermal and mesodermal components. Endodermal component was the least prominent, but intestinal mucosa, islands of liver and lung parenchyma were remarkably well developed. The cystic space.
Bak, Min Ji,Truong, Van-Long,Ko, Se-Yeon,Nguyen, Xuan Ngan Giang,Jun, Mira,Hong, Soon-Gi,Lee, Jong-Won,Jeong, Woo-Sik The Korean Society of Ginseng 2016 Journal of Ginseng Research Vol.40 No.4
Background: The induction of cellular defensive genes such as phase II detoxifying and antioxidant enzymes is a highly effective strategy for protection against carcinogenesis as well as slowing cancer development. Transcription factor Nrf2 (nuclear factor E2-related factor 2) is responsible for activation of phase II enzymes induced by natural chemopreventive compounds. Methods: Red ginseng oil (RGO) was extracted using a supercritical $CO_2$ extraction system and chemical profile of RGO was investigated by GC/MS. Effects of RGO on regulation of the Nrf2/antioxidant response element (ARE) pathway were determined by ARE-luciferase assay, western blotting, and confocal microscopy. Results: The predominant components of RGO were 9,12-octadecadienoic acid (31.48%), bicyclo[10.1.0] tridec-1-ene (22.54%), and 22,23-dihydrostigmasterol (16.90%). RGO treatment significantly increased nuclear translocation of Nrf2 as well as ARE reporter gene activity, leading to upregulation of heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1. Phosphorylation of the upstream kinases such as apoptosis signal-regulating kinase (ASK)1, mitogen-activated protein kinase (MAPK) kinase (MKK)4/7, c-Jun N-terminal kinase (JNK), and p38 MAPK were enhanced by treatment with RGO. In addition, RGO-mediated Nrf2 expression and nuclear translocation was attenuated by JNK inhibitor SP600125 and p38 MAPK inhibitor SB202190. Conclusion: RGO could be used as a potential chemopreventive agent, possibly by induction of Nrf2/ARE-mediated phase II enzymes via ASK1-MKK4/7-JNK and p38 MAPK signaling pathways.
Bovine Serum Albumin이 家兎肝 Mitochondria의 Adenylate Kinase 活性度 및 酸化的燐酸化에 미치는 影響
洪淳搏 現代醫學社 1969 現代醫學 Vol.10 No.1
It has been known that the enzyme myokinase, or adenylate kinase, which catalyzes the establishment of an equilibrium among the three nucleotides, adenosine triphosphate, aenosine diphosphate, and adenylic acid, is localized in the mitochondria. For the purpose of studying the effect of bovine serum albumin on the adenylate kinase activity and oxidative phosphorylation of rabbit liver mitochondria, the following experiments were undertaken: 1. Mitochondria were isolated from the rabbit liver with 0.25 M sucrose by the differential centrifugation technique of Schneider. 2. The method of paper chromatography and isotope exchange reaction between ^(14)C-AMP and ATP were used to determine the adenylate kinase activity of rabbit liver mitochondria after incubation of mitochondrial suspension with ^(14)G-AMP and ATP. These experiments have revealed the following results: 1. The adenylate kinase activity of liver mitochondria was activated by Mg^(++), this activation was augmented in the presence of bovine serum albumin. 2. The adenylate kinase activity of liver mitochondria was slightly activated by Ca^(++), this activation was inhibited by the addition of bovine serum albumin. 3. When the liver mitochondrial suspension including bovine serum albumin and Mg^(++) a, stored at 4℃ for 24 hours, its adenylate kinase activity was augmented markedly, however, in the stored Jiver mitochondrial suspension without bovine serum albumin, the inase activity was augmented to less extent. 4. Afeter heat treatment of liver mitochondria at 90℃ for 5 minutes, the andenylate kinase activity still survived. 5. In the liver raitochondrial suspension with bovine serum albumin, the adenylate kinase showed its maximum activity in a dilution 1 : 3 water, but in the suspension without bovine serum albumin the kinase showed its maximum acivity in a dilution 1 4 water. 6. The phosphorylation of liver mitochondria was inhibited by the addition of residual adenylate kinase, whereas oxygen consumption of liver mitochondria was not influenced by the residual adenylate kinase. Therefore, the oxidative phosphorylation of the liver mitochondria was reduced by the residual adenylate kinase. Bovine serum albumin protected the phosphorylation process of the liver mitochondria against residual adenylate kinase.
권순홍(Soon Hong Kwon),진병연(Byungyun Jin),박강박(Kang-Bak Park) 한국산업융합학회 2016 한국산업융합학회 논문집 Vol.19 No.4
There are many hoppers in the actual industrial plants such as grain hoppers in agricultural companies, surge hoppers in steel companies, and so on. In general, they are time-delay systems so that their level control is not easy. Thus, they have been manually controlled to avoid the overflow and empty out. In this paper, we proposed Fuzzy PID controller for level control of hopper systems. To show the effectiveness of the proposed scheme, some simulation results are given.
박효순(Park, Hyoo-Soon),이무식(Lee, Moo-Sik),나백주(Na, Bak-Ju),홍지영(Hong, Jee-Young),장민영(Jang, Min-Young) 한국산학기술학회 2010 한국산학기술학회 학술대회 Vol.- No.-
본 연구는 환자의 의료기관 선택기준에 관한 조사를 실시하는데 있다. 외래, 중 병원에서 검사한 사항을 CD로 담아 타 병원 진료 후 현 병원에 내원한 대상자와 본 병원에서 진료 후 CD를 가지고 타 병원으로 전원 하는 환자 및 보호자를 대상으로 2009년 10월 5일부터 10월 26일까지 본 연구에 동의하는 대상자 302명을 대상으로 하였다. 내원·전원 환자의 물리적 특성에서 주차시설, 주위시설, 의료진 서비스 품질에서는 간호사 친절도, 전문성, 설명, 의료 서비스 품질 특성에서는 의료기기 최신설비, 병원 평판에서는 의료인력ּ 의술, 주위 환경, 병원 외적 요인에서는 진료의 권유 항목이 유의하였다(p<0.05). 내원 시 병원 선택 변수 평균치 검정 결과 중 성별에서는 만족도, 연령별에서는 의료진 서비스품질, 거주지에서는 병원외적요인, 병원지역에서는 병원평판, 만족도, 진료기관에서는 병원평판, 만족도, 진료구분에서는 만족도에서 유의하였다(p<0.05). 전원 시 병원 선택 변수 평균치 검정결과 중 연령별에서는 의료진 서비스품질, 거주지에서는 병원외적요인, 병원지역에서는 병원평판, 만족도, 진료기관에서는 병원평판, 만족도, 진료구분에서는 만족도가 유의하였다(p<0.05). 본 연구에서는 내원·전원 환자는 물리적 환경, 의료서비스 품질, 병원 평판 등 을 병원 선택에 중요한 요인들로 지각 하고 있으며 간호사와 주위 사람들의 권유에 의하여 병원을 선택한다고 나타났다. 내원 환자는 의료진 서비스 품질, 병원 평판, 만족도에서 평균치가 높게 나타났다. 전원 환자는 물리적 환경, 의료진 서비스품질, 의료 서비스 품질, 병원 평판, 만족도에서 평균치가 높게 나타났다. 자료 분석은 SPSS 12.0 Window Program을 이용하였다.
임성현,박홍순,노승호,한상길,랑문정,윤여경 한국공업화학회 2003 공업화학 Vol.14 No.3
본 연구는 알킬 페놀류 8종(4-t-butyl phenol (BP), 4-n-pentyl phenol (PP), 4-n-hexyl phenol (HxP), 4-t-octyl phenol (t-OP), 4-n-heptyl phenol (HpP), b-nonyl phenol (b-NP). 4-n-octyl phenol (OP), 4-n-nonyl phenol (NP))을 액체 크로마토그래피(HPLC) 다이오드 배열 검출기(diode array detector, DAD)를 이용하여 동시분석하였다. 분리관은 역상 Cl8(250×4.6 mm), 이동상은 물과 메탄올을 사용하여 기울기 용리(gradient)하에서 알킬 페놀류의 알킬 길이에 따라 분리하였으며, 알킬 페놀류의 검량선을 도시한 결과 좋은 직선성이 보였다. 상기 분석법으로 국내 유통 중인 주방 세제류 내 알킬 패놀류를 분석한 결과 불검출 되었고, 이때 검출한계는 주입량(10 μL) 대비 1 pg이었다. 4-t-butyl phenol (BP), 4-n-pentyl phenol (PP), 4-n-hexyl phenol (HxP), 4-1-octyl phenol (t-OP), 4-n-heptyl phenol (HpP), b-nonyl phenol (b-NP), 4-n-octyl phenol (OP), and 4-n-nonyl phenol (NP) were simultaneously separated by a high performance liquid chromatography (HPLC) with UV diode array detector(230 nm, f60 nm, 280 nm) using an octadecylsilica column (Cl8, 250×4.6 mm) and water/methanol gradient solution. The calibration curves of alkyl phenols showed a good linear relationship, and the recoveries were over 95%. With the detection limit of 1pg for alkyl phenols with respect to the injected amount, alkyl phenols were not detected in tile dishwashing detergents that were available on the market.