급성 호흡곤란으로 내원한 성대기능이상 1례

함초롬,박경일,박혜연,황철웅,김종연,김태년,진재용,이성순 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Vocal cord dysfunction (VCD) is a respiratory disorder characterized by the abnormal adduction of the vocal cords upon inspiration, expiration, or both, leading to a diverse array of acute obstructive airway signs and symptoms (wheezing, chest tightness, shortness of breath, and cough). VCD frequently mimics or confounds asthma. Misdiagnosis as asthma has led to inappropriate treatment, most notably with high-dose corticosteroids. Mistaken for anaphylaxis or angioedema, VCD has led to intubation and tracheostomy. VCD should be suspected in patients who are treated aggressively for asthma but continue to experience dyspnea. The diagnosis of VCD is made from direct visualization of the vocal cords during an attack. Inspiratory, anterior vocal cord closure with a posterior glottic chink is seen. On pulmonary function testing, a pattern of "saw-toothing", or fluttering of the inspiratory limb, representing fluctuations in the abnormal cord motion is seen in VCD patient. Treatment includes discussion of the diagnosis with the patients, discontinuing unnecessary medications, using of a helium-oxygen mixture in acute attack. Speech therapy and psychotherapy are the mainstays of long-term treatment. Here in we report a case of VCD in company with asthma.

사설경호업체 종사자의 직무스트레스와 직무만족과의 관계

이상철,함주일,안길영 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this study was to identify the relationship between job stress and job satisfaction of employees in private body-guard company. In order to achieve this purpose, the instrument for data collection was a questionnaire in which consisted of questions regarding job stress and job satisfaction. The questionnaire's validity was evaluated by a panel of experts, and its reliability was evaluated by computing the Cronbach alpha values. Since the values ranged from .664 to .816, the questionnaire was deemed to be highly reliable. 220 subjects was selected from several private body-guard companies in Seoul, 2003. Among these selected subjects, 200(90%) responded, and data analyses consisted of employing descriptive statistics, one-way ANOVA, standard multiple regression using SPSS/PC version 10.0. The following results were obtained: First, job stress factors differ statistically and partially according to socio-demographic variables of employees in private body-guard company. Second, job satisfaction factors differ statistically and partially according to socio-demographic variables of employees in private body-guard company. Third, job stress statistically and significantly influenced job satisfaction.

형질세포치은염에 대한 증례보고

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

After authors experienced patients with plasma cell gingivitis, who had visited Department of Periodontics of Dental Hospital of Dnakook University from 1984 to 1990, authors selected 13 cases which were very similar with plasma cell gingivitis on clinical and histopathological aspect, and then re-examined these 13 cases about following standards, sudden onset of the lesion, no favorable result on medicinal and surgical treatment, dense infiltration of plasma cell, eosinophils in the Hematoxylin-Eosin stain, mast cells in Toluidine-Blue stain. Authors concluded that 4 cases are exactly consistent with plasma cell gingivitis. Authors studied these 4 cases about clinical and histopathological feature, and reviewed the past case report and literature. The following results were elicited. 1. Clinical sign and symptom has generalized feature in oral cavity, but when the disease occurs at the lips, the lower lips shows more severe manifestation. And the disease have a predilection for female but do not have prediliection for any age. 2. The most characteristic feature of the plasma cell gingivitis is dense plasma cell infiltration in light microscope, and other characteristic microscopic features are as followings; microvesicles in the epithelial layer, proliferation of epithelium, proliferation of papillary layer in connective tissue, dilatation of capillaries and occasional infiltration of eosinophils and mast cells. 3. Plasma cell gingivitis is specific immunological reaction that plasma cells chiefly react with certain allergen but this immunological reaction is limited on few population.

Garre씨 골수염의 증례보고

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Authors experienced Garre's osteomyelitis that showed 24 years male patient who visited the Dental Hospital of College of Dentistry of Dankook University because of right facial asymmetry from recurred swelling in right mandibular angle area. Because we thought that this case was rare, we examined the clinical, radiological, histopathological features, and discussed the etiologic factors and the pathogenesis of Garre's osteomyelitis through a review of literature. The results were as followings. 1. In clinical features, 24 years male patient showed right facial asymmetry from recurred swelling in right mandibular angle area. 2. In radiographic features, slight periosteal bone formation in right mandibular angle area was found. 3. In histopathologic features, parallel trabecular orientation that occurred perpendicular to the cortex was associated with medullary trabecular in the back ground of hemorragic loose connective tissue with lymphocytes and plasma cells. Many lamellated trabecular lined by active osteoblast cells were found. In other area, empty lacunae in trabecular were observed. 4. We considered the etiologic focus to be a low grade infection from prolonged infection right 1st mandibular molar.

방사선조사후 타액선 조직세포변화에 따른 타액분비의 감소에 관한 실험적 연구

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

After single fraction of 2, 5, 10 Gy irradiation on submandibular gland of 32 male rats, weighting 150 gm, respectively, these animal were sacrificed after 1, 7, 15 hours, 1, 3, 7, 14 days after irradiation. And excised submandibular gland were fixed in Bouin's solution for 2 hours. Paraffin sections were stained with H & E, and PAS for change of salivary gland tissue in order to get regeneration of salivary gland tissue cells and saliva secretion after irradiation. The results were following. 1. In PAS statining after 3 days of 5 Gy irradiation, decreased mucine serction of serous cells were seen, and after 7 dyas of 10 Gy irradiation, decreased mucine secretion of mucous cells were seen. Increased saliva secretion except mucous cells after 14 days was seen, but no resecretion of salivary gland tissue cells was observed in 10 Gy irradiation. 2. After 3 days of 2 Gy irradiation, 1 day of 5 Gy, and 15 yours of 10 Gy, degeneration of serous cells was seen and regeneration of these cells was seen after 14 days except 10 Gy irradiation.

임신성 종양 및 화농성 육아종에 대한 임상 및 병리조직학적 연구

李建馥,咸日成,金東民 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Pregnancy tumor is frequent disease entity in pregnant women and also pyogenic granuloma is very frequent disease entity in oral cavity, but at presnet day, the etiology and behavior of these disease is not clear. Therefore authors studied pregnancy tumor and pyogenic granuloma which have been experienced in Department of Periodontics of Dental Infirmary of Dankook University, and present preganacy tumor 8 cases and pyogenic granuloma 12 cases. Authors elicit the following results. 1. Pyogenic granuloma has a prediction for age, second decades to fifth decades of life and frequently occurs as twice as in female. 2. Pregnancy tumor more frequently occurs at the mixilla than mandibule and more frequently occurs at the anterior teeth area. On the contrary pyogenic granuloma has a prediction for mandible and molar area. Clinical sign and symptom shows swelling and hemorrhage on mild stimulation in both disease. 3. Pregnancy tumor and pyogenic granuloma may be occurred by specific reaction about nonspecific inflammation from local irritation. 4. The cause of non-complete regression of pregnancy tumor and pyogenic granuloma after parturition and subside of inflammation may be considered fibromatous change of these lesion.

폐경기여성에서 시청각 교육이 호르몬대체요법의 시행과 골다공증관련 생활습관의 변화에 미치는 효과

정태흠,전태희,김문찬,김영일,전대준,양승오,함수연,고병균,김성률 大韓家庭醫學會 2000 Korean Journal of Family Medicine Vol.21 No.11

일부 인쇄회로기판 납땜근로자들의 눈, 호흡기, 피부의 증상에 대한 조사연구

유재영,우극현,김진석,함정오,최태성,하봉구,정상재,박신구,김일룡 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 이 연구는 납점작업자를 대상으로 납점작업으로 유발될 가능성이 높은 눈, 호흡기, 피부 등의 증상호소율 및 노출강도에 따른 관련성을 파악하기위해 수행되었다. 방법 : 연구참가자 146명중 연구목적에 적합한 20명을 제외한 126명을 대상으로 '눈이 가렵고 충혈됨', '코가 가렵거나 파가움', '재채기', '콧물'. '코막힘' , '목이 따끔거림' , '목에 무언가가 걸려있는것 같음' , '갑자기 연속적인 기침을 함' , '운동 시에 다른 사람에 비해 숨이 가쁨', '숨을 쉴 때 쌕쌕하는 소리가 남', '가래가 끓음', '손이나 안면에 가려움을 느낌' , '안면에 여드름이 날' '손이나 안면에 붉은 반점이 남' 등 14가지 증상에 대한 경험유무와 혈중연농도, 납점작업의 건강위험요인에 대한 지식상태 등을 조사하였다. 결과 : 조사된 14가지의 증상 중, '갑자기 연속적인 기침을 함'이 하루 납점시간 4시간 이상인 군아서 4시간 미만인 군보다 유의하게 증상호소율이 높았으며, 다른 증상의 경우 하루 납땜시간에 따라 유의한 결과를 보이지 않았다. 납땜작업의 건강위험요인에 대한 질문에 12.8 %가 플럭스에 의한 건강위험을 지적하였다. 전체 대상자의 평균 혈중연농도는6.05 rg/dL였으며, 히고치는 15.50 rg/dL이었다.결론 : 납땜작업자에게 호흡기 증상의 위험이 높을 가능성이 있으며, 납땜작업의 건강위험에 대한추가적인 연구와 납점작업자들을 대상으로 납점작업에 의해 유발될 수 있는 건강장해에 대한 적극적인교육 및 홍보활동을 필요로 한다. Objectives : This study was conducted to evaluate the prevalence of ocular, respiratory and skin symptoms among solderers and to investigate the relationship between symptom prevalence and exposure intensity. Methods : We analyzed 126 eligible participants out of a population of 146 male solder-ers who completed the symptom questionnaires. Fourteen symptoms including 'itchy and red eyes', 'itchy or prickly nose', 'sneezing', 'rhinorrhea', 'blocked nose', 'prickly throat', 'foreign body sensation in throat', 'sudden bouts of coughing', 'exertional breathlessness', 'wheezing', 'sputum production', 'itchy face or hands', 'acneiform erup-tions on the face' and 'red spots on the face or hands' were contained. Blood lead levels of all the 126 participants were tested and the participants' own assessments of the health risk of soldering were collected. Results : Of the 14 investigated symptoms, 'sudden bouts of coughing' was significantly more prevalent in solderers who worked 4 hours or more a day than those who worked less than 4 hours a day, as for the other symptoms, there were no significant differences in the prevalences related to daily soldering hours. 2.8% of the solderers considered the risk of flux exposure to be serious. The mean blood lead bevel was 6.05 μg/dL (maximum 15.50 μg/dL). Conclusions : Soldering may increase the risk of respiratory symptoms. Further invert tigations on the hazards of soldering processes are warranted and solderers should be educarted on these hazards.

오골계 증탕액 급여가 흰쥐의 혈중 호르몬, Cytokine 및 특이항체에 미치는 영향

채현석,안종남,유영모,함준상,이종문,윤상기,최양일,Chae Hyun-Seok,Ahn Chong-Nam,Yoo Young-Mo,Ham Jun-Sang,Lee Jong-Moon,Yoon Sang-Ki,Choi Yang-Il 한국축산식품학회 2004 한국축산식품학회지 Vol.24 No.3

본 연구는 흰쥐(S.D, ♂)에 각 처리에 따라 기초사료로 시판사료(T$_1$)를 무제한 급여하면서 시험사료로 한약 증탕액 (T$_2$), 오골계 증탕액(T$_3$), 오골계 교잡종 육에 Flavourzyme을 0.1%첨가하여 가수 분해시킨 후 한약제와 혼합하여 증탕시킨 증탕액(T$_4$)을 35일간 경구 투여한 후 흰쥐의 혈청에 대한 glucose및 hormones과 면역학적 변화에 미치는 영향을 조사 한 결과는 다음과 같았다. 비만하였을 때나 과도한 스트레스를 받았을 때 insulin 함량이 증가한다고 하였으나 효소 처리 오골계 교잡종 증탕액을 급여한 처리구에서 체중 증가가 일반사료를 급여한 처리구에 비해 유의적으로(p<0.05) 증가하였어도 insulin 함량이 일반사료 급여구보다 증가하지 않은 것으로 나타나 바람직한 생리현상을 나타냈다. Aldosterone은 스테로이드 계통의 호르몬으로 물의 생리적 밸런스와 혈압조절에 관여하는데 일반사료 급여구에 비해 한약 증탕액, 오골계 증탕액,효소 처리 오골계 증탕액 급여 구에서 낮은 함량을 나타내 고농도 단백 식이의 급여에도 불구하고 aldosterone수치의 저하로 혈압 저하의 효과를 나타 낸 것은 한약을 첨가시켜 고압으로 처리시킨 증탕액의 효과와 가수분해 효소에 의한 소화가 용이하도록 처리한 결과로 사료된다 Cortisol은 스트레스 측정에 감도가 높은 호르몬으로 알려져 있는데 일반사료급여구가 0.67 nmol/L인 반면 증탕액을 급여한 구에서는 0.40∼0.49 nmol/L으로 cortisol 농도가 감소하는 경향을 나타냈는데 이는 aldosterone에서와 같이 한약제와 동물성 단백질을 섭취함에 따른 효과로 사료된다. 흰쥐에 증탕액 급여가 면역반응에 미치는 영향에서 IL-4, IFN-v 및 anti-BSA IgG의 역가는 일반사료를 급여한 처리구에 비해 오골계 증탕액 및 효소 처리 오골계 교잡종 증탕액 급여구에서 spleen과 serum두에서 증가하는 경향을 나타내었는데 앞에서 언급했던 바와 같이 한약(십전대보탕)의 효과와 소화시키기 쉬운 고농도의 단백질 가수분해 물질의 다량 섭취에 의해 면역 활성이 증가되었을 것으로 사료된다. This study was conducted to investigate feeding effects of the high pressure boiled extracts (HPBE) of the Ogol chicken with herbs on glucose, hormones and immunological response (cytokine, specific antibody) of serum in the rat which fed either with normal feed (T$_1$), normal feed + herb HPBE (T$_2$), normal feed + Ogol chicken HPBE (T$_3$), normal feed + mixture of cross-bred Ogol chicken HPBE (T$_4$) hydrolyzed with Flavourzyme 0.1% for 35 days. During experimental period, there was a weak trend to have a higher glucose content for the T$_4$ group with 102.27${\pm}$5.95 mg/dL, but it was not significantly higher than other treatments. For insulin level, T$_1$ group showed numerically a slightly higher level with 6.79${\pm}$4.64 ${\mu}$IU/mL, but the difference was not significant in statistic term due likely to a large variation in comparison with other treatments. The treatments did not significantly alter testosterone level in rat plasma with 1.09, 1.46, 0.98, 1.13 ng/mL in T$_1$, T$_2$, T$_3$ and T$_4$, respectively. T$_4$ treatment increased the aldosterone level to a significantly (p<0.05) higher level (273.33 ng/dL) than other treatments. The extract treated rat showed a tendency in the cortisol level of lower levels than the control group, particularly, it was significantly (p<0.05) lower in T$_3$ group than other groups. T$_3$ and T$_4$ groups showed higher levels for interlukin-4 (IL-4) and anti-BSA IgG in immune cells and plasma. T$_2$, T$_3$ and T$_4$ treatments showed a slightly higher levels in v-interferon (INF-r) than the control, with a greater effect for T4 treatments. These results suggested that HPBE of the cross-bred Ogol chicken hydrolyzed with Flavourzyme increased immunological activity and decreased the concentration of cortisol and aldosterone hormones.

J2.5dPathway: A 2.5D Visualization Tool to Display Selected Nodes in Biological Pathways, in Parallel Planes

Ham, Sung-Il,Song, Eun-Ha,Yang, San-Duk,Thong, Chin-Ting,Rhie, Arang,Galbadrakh, Bulgan,Lee, Kyung-Eun,Park, Hyun-Seok,Lee, San-Ho Korea Genome Organization 2009 Genomics & informatics Vol.7 No.3

The characteristics of metabolic pathways make them particularly amenable to layered graph drawing methods. This paper presents a visual Java-based tool for drawing and annotating biological pathways in two- and a-half dimensions (2.5D) as an alternative to three-dimensional (3D) visualizations. Such visualization allows user to display different groups of clustered nodes, in different parallel planes, and to see a detailed view of a group of objects in focus and its place in the context of the whole system. This tool is an extended version of J2dPathway.