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Haeng Seop Shin,Jeong Joo Park,Chaeshin Chu,송현제,Kyung Soon Cho,Joo Shil Lee,Sung Soon Kim,Mee Kyung Kee 대한의학회 2007 Journal of Korean medical science Vol.22 No.6
To determine the characteristics of seroprevalence of herpes simplex virus type 2 (HSV-2) infection among Korean people, a cross-sectional study was conducted on three groups in 2004. The three groups consisted of the general public who visited public health centers, commercial sex workers (CSWs), and human immunodeficiency virus (HIV)-infected persons. Among the general public, HSV-2 seroprevalence rates for age under the 20s, in the 20s, 30s, 40s and the above 22.6%, 32.7% and 32.3%, respectively, which showed rapid increase of the rate in the 30s (p<0.0001). In case of the above of 19 yr old, women (28.0%) was higher than men (21.7%) (p<0.0001). The rate of CSWs (81.6%) was about 10 times higher than that of general women. In case of HIV-infected men (47.6%), the figure was about 2-3 times higher than that of general men. The low rate in the teens and the 20s proved that it is essential to develop sexually transmitted infections (STIs) prevention programs of education and publicity for them as a precaution measure. This study is the first major study of its kind on HSV-2 and would provide basic data for prevention of STIs including information about target groups subject to vaccination program.
I-Chan Shin,Sang-Woo Jung,Haeng-Seop Song,Jin-Soo Byun,Jung-Ho Park National Institute of Ecology 2023 국립생태원회보(PNIE) Vol.4 No.3
This study aimed to identify the initial migratory macroinvertebrate species in two newly created mountain wetlands. To analyze the initial immigration species of macroinvertebrates, two experimental sites and two control sites were selected after habitat creation and investigated thrice from spring to fall. Benthic macroinvertebrates were collected quantitatively from each site using a Surber sampler and Modified D-frame deep net. After restoration at the two experimental sites, the number of macroinvertebrate species and individuals gradually increased from spring to fall and continued to increase over time with the development of waterside vegetation and habitat stabilization at the experimental sites. The species initially introduced to mountain wetlands after their creation were Ephemera strigata, Ephemera orientalis, Chironomidae sp., and Aquaris paludum. Subsequently, predators such as Davidius lunatus, Sieboldius albardae, Oyamia nigribasis, and Sialis longidens were introduced. Additionally, as a differentiating physicochemical factor between the two habitats, current velocity, which determines the distribution characteristics of benthic macroinvertebrates, and water temperature, which impacts the growth of organisms, showed a relatively stronger influence.
지식확산에 의한 감염병 실험실의 자율적 생물안전관리 학습조직 설계 및 실행
신행섭,유민수,Shin, Haeng-Seop,Yu, Minsu 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.2
Objectives: A learning organization was designed and implemented on the basis of the selection criteria and essential elements of knowledge translation theory. Methods: The learning organization was designed on the basis of biosafety harmonization criteria and risk management strategy and was implemented as the learning organization for biosafety management by the National Institute of Health, Korea Centers for Disease Control & Prevention. The effect of knowledge translation in the research institutions by evidence-based policy was verified. Results: The result of applying the knowledge translation theory involving all stakeholders showed a positive reaction in establishing and implementing biosafety management strategy and embodied risk assessment criteria and evoked sympathy with the necessity of learning and using of expert knowledge about risk assessment and risk management. All stakeholders initiated voluntarily action toward new human-network construction and communication between similar organizations. The learning organization's capability expanded the base of knowledge translation. Conclusion: These results showed that a learning organization could enhance the autonomous safety management system by diffusion of knowledge translation.
Lee, Tae Hee,Cha, Sun-Shin,Lee, Chang-Seop,Rhee, Joon Haeng,Chung, Kyung Min American Society for Microbiology 2014 Infection and immunity Vol.82 No.11
<P><I>Vibrio vulnificus</I> causes rapidly progressing septicemia with an extremely high mortality rate (≥50%), even with aggressive antibiotic treatment. The bacteria secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins, which are involved in the pathogenesis of Gram-negative <I>Vibrio</I> species. Recently, we reported that immunization with the C-terminal region of <I>V. vulnificus</I> RtxA1/MARTX<SUB>Vv</SUB>, RtxA1-C, elicits a protective immune response against <I>V. vulnificus</I> through a poorly defined mechanism. In this study, we generated a panel of new monoclonal antibodies (MAbs) against <I>V. vulnificus</I> RtxA1-C and investigated their protective efficacies and mechanisms in a mouse model of infection. Prophylactic administration of seven MAbs strongly protected mice against lethal <I>V. vulnificus</I> infection (more than 90% survival). Moreover, three of these MAbs (21RA, 24RA, and 47RA) demonstrated marked efficacy as postexposure therapy. Notably, 21RA was therapeutically effective against lethal <I>V. vulnificus</I> infection by a variety of routes. Using Fab fragments and a neutropenic mouse model, we showed that 21RA and 24RA mediate protection from <I>V. vulnificus</I> infection through an Fc-independent and/or neutrophil-independent pathway. In contrast, 47RA-mediated protection was dependent on its Fc region and was reduced to 50% in neutropenic mice compared with 21RA-mediated and 24RA-mediated protection. Bacteriological study indicated that 21RA appears to enhance the clearance of <I>V. vulnificus</I> from the blood. Overall, these studies suggest that humoral immunity controls <I>V. vulnificus</I> infection through at least two different mechanisms. Furthermore, our panel of MAbs could provide attractive candidates for the further development of immunoprophylaxis/therapeutics and other therapies against <I>V. vulnificus</I> that target the MARTX toxin.</P>
$bla_{SHV-2a}$와 $bla_{SHV-12}$ 항균제 내성 유전자의 분자적 진화 및 확산에 IS26 Mobile Element의 개입
김정민,신행섭,조동택,Kim, Jung-Min,Shin, Haeng-Seop,Cho, Dong-Taek 대한미생물학회 2000 大韓微生物學會誌 Vol.35 No.3
A clinical isolate of Klebsiella pneumoniae K7746 produced the extended-spectrum ${\beta}$-lactamase (ESBL) SHV-12. A 6.6 kb BamHI fragment containing the $bla_{SHV-12}$ gene of K7746 strain was cloned into pCRScriptCAM vector resulting in the recombinant plasmid p7746-Cl. The restriction map of 3.6 kb inserted DNA and sequences immediately surrounding $bla_{SHV-12}$ of p7746-C1 were homologous to plasmid pMPA2a carrying $bla_{SHV-2a}$. In addition, both $bla_{SHV-12}$ and $bla_{SHV-2a}$ were expressed from a common hybrid promoter made of the -35 region derived from the left inverted repeat of IS26 and the -10 region from the $bla_{SHV}$ promoter itself. The results indicate that $bla_{SHV-12}$ and $bla_{SHV-2a}$ may have evolved from a common ancestor in the sequential order of $bla_{SHV-2a}$ first, followed by $bla_{SHV-12}$. Furthermore, by the PCR mapping method using primers corresponding to the IS26 and $bla_{SHV}$, the association between IS26 and $bla_{SHV}$ was studied in 12 clinical isolates carrying $bla_{SHV-2a}$, 27 clinical isolates carrying $bla_{SHV-12}$, and 5 reference strains carrying $bla_{SHV-1}$ to $bla_{SHV-5}$. All 39 strains carrying $bla_{SHV-2a}$ or $bla_{SHV-12}$ were positive by the PCR, providing confirmative evidence that IS26 has been involved in the evolution and dissemination of $bla_{SHV-2a}$ and $bla_{SHV-12}$. But 5 reference strains carrying $bla_{SHV-1}$ to $bla_{SHV-5}$ were negative by the PCR. Therefore, we concluded that the molecular evolutionary pathway of $bla_{SHV-2a}$ and $bla_{SHV-12}$ may be different from that of other $bla_{SHV-ESBL}$, e.g., $bla_{SHV-2}$, $bla_{SHV-3}$, $bla_{SHV-4}$, and $bla_{SHV-5}$.