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Two cases of phymatous rosacea successfully treated by surgical and non-surgical treatment
( Ha Neul Oh ),( Tae Jun Park ),( Bo Young Kim ),( Chang Min Kim ),( Il-hwan Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
In addition to a primary feature of rosacea, phymatous rosacea may include skin thickening, irregular surface nodularities, and patulous follicles. There are several therapeutic options for phymatous rosacea, including isotretinoin, antibiotics and surgical treatments. However, Phymatous rosacea can be disfiguring and difficult to treat. Case 1. A 79-year-old man patient presented with erythematous large nodular masses on the nose. Under the impression of phymatous rosacea in the advanced stage, because the patient complained about breathing discomfort and cosmetic problems, surgical treatment was considered. Electrocautery was performed to correct the deformity of the nose. Two months later, the lesion was obviously decreased and the results were satisfactory both functionally and cosmetically. Case 2. A 27-year-old man patient, with a history of aplastic anemia, presented with pricky erythematous plaque on the nose. Under the impression of phymatous rosacea in the early stage, treatment was initiated with isotretinoin 20 mg daily. There was a slight improvement at the beginning of the treatment and the lesion was definitely improved from 9 months after the treatment. Currently, the lesion is under the same treatment protocol without any side effects. We herein report on two cases of successfully treated phymatous rosacea, emphasizing the importance of choosing the appropriate treatment modality.
Effects of microstructure and intergranular glassy phases on thermal conductivity of silicon nitride
Kim, Jin-Myung,Ko, Sin-Il,Kim, Ha-Neul,Ko, Jae-Woong,Lee, Jae-Wook,Kim, Hai-Doo,Park, Young-Jo Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.7
<P><B>Abstract</B></P> <P>In this study, the binary sintering additives Y<SUB>2</SUB>O<SUB>3</SUB>-Sc<SUB>2</SUB>O<SUB>3</SUB>, were first applied to the Si<SUB>3</SUB>N<SUB>4</SUB> system to investigate their effects on microstructure and thermal conductivity. The microstructure and thermal conductivity of both sintered silicon nitride (SSN) and sintered reaction-bonded silicon nitride (SRBSN) were found to be significantly dependent on the additive composition. Among various combinations of Y<SUB>2</SUB>O<SUB>3</SUB> and Sc<SUB>2</SUB>O<SUB>3</SUB>, 1mol% Y<SUB>2</SUB>O<SUB>3</SUB>−3mol% Sc<SUB>2</SUB>O<SUB>3</SUB> prominently enhanced thermal conductivity, and the enhancement could not be attributed to any difference in microstructure or lattice defects. TEM observation revealed that this composition was more liable to devitrify the glassy phase with a lower degree of stress accumulation, and to possibly produce a grain boundary that was cleaner or with a higher order of atomic arrangement. A microstructure model for thermal conductivity was proposed which took the thermal resistance of the grain boundaries into account. The grain boundary state exerted a remarkable influence on the thermal conductivity of fine microstructures, and the experimentally measured thermal conductivity values were consistent with those given by the proposed model.</P>
Kim, Ju Eun,Shrestha, Abinash Chandra,Kim, Hyo Shin,Ham, Ha Neul,Kim, Jun Hyeong,Kim, Yeong Jee,Noh, Yun Jeong,Kim, Su Jin,Kim, Dae Keun,Jo, Hyung Kwon,Kim, Dae Sung,Moon, Kwang Hyun,Lee, Jeong Ho,Jeo Hindawi 2019 Evidence-based Complementary and Alternative Medic Vol.2019 No.-
<P>Alzheimer's disease (AD) is linked to an extensive neuron loss via accumulation of amyloid-beta (A<I>β</I>) as senile plaques associated with reactive astrocytes and microglial activation in the brain. The objective of this study was to assess the therapeutic effect of WS-5 ethanol extract in vitro and in vivo against A<I>β</I>-induced AD in mice and to identify the extract's active constituents. In the present study, WS-5 exerted a significant inhibitory effect on acetylcholinesterase (AChE). Analysis by transmission electron microscopy (TEM) revealed that WS-5 prevented A<I>β</I> oligomerization via inhibition of A<I>β</I><SUB>1-42</SUB> aggregation. Evaluation of antioxidant activities using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) demonstrated that WS-5 possessed a high antioxidant activity, which was confirmed by measuring the total antioxidant status (TAS). Furthermore, the anti-inflammatory properties of WS-5 were examined using lipopolysaccharide-stimulated BV-2 microglial cells. WS-5 significantly inhibited the lipopolysaccharide–induced production of nitric oxide and two proinflammatory cytokines, TNF-<I>α</I> and IL-6. The memory impairment in mice with A<I>β</I>-induced AD was studied using the Morris water maze and passive avoidance test. Immunohistochemistry was performed to monitor pathological changes in the hippocampus and cortex region of the mouse brain. The animal study showed that WS-5 (250 mg/kg) treatment improved learning and suppressed memory impairment as well as reduced A<I>β</I> plaque accumulation in A<I>β</I>-induced AD. HPLC analysis identified the extract's active compounds that exert anti-AChE activity. In summary, our findings suggest that WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.</P>
Crystal structure and functional characterization of SF216 from <i>Shigella flexneri</i>
Kim, Ha-Neul,Seok, Seung-Hyeon,Lee, Yoo-Sup,Won, Hyung-Sik,Seo, Min-Duk Wiley (John WileySons) 2017 FEBS letters Vol.591 No.21
<P>Shigella flexneri is a Gram-negative anaerobic bacterium that causes highly infectious bacterial dysentery in humans. Here, we solved the crystal structure of SF216, a hypothetical protein from the S.flexneri 5a strain M90T, at 1.7 angstrom resolution. The crystal structure of SF216 represents a homotrimer stabilized by intersubunit interactions and ion-mediated electrostatic interactions. Each subunit consists of three beta-strands and five alpha-helices with the beta-beta-beta-alpha-alpha-alpha-alpha-alpha topology. Based on the structural information, we also demonstrate that SF216 shows weak ribonuclease activity by a fluorescence quenching assay. Furthermore, we identify potential druggable pockets (putative hot spots) on the surface of the SF216 structure by computational mapping.</P>
The catalytic role of additive components for the nitridation of silicon/additive mixture
KIM, Ha-Neul,PARK, Young-Jo,KIM, Jin-Myung,LEE, Jae-Wook,KO, Jae-Woong,KIM, Hai-Doo,LEE, Seung-Jun,BAEK, Seung-Su,SEO, Il-Sung Ceramic Society of Japan 2016 JOURNAL OF THE CERAMIC SOCIETY OF JAPAN - Vol.124 No.3
<P>The nitriding behavior of silicon/additives mixture with varied composition was investigated by focusing on the catalytic effect of sintering additives (Y2O3 and Al2O3) and diluents (Si3N4). While sintering additives have originally been mixed to form a liquid phase to promote both densification and grain growth during post-sintering, it was revealed that the addition of Y2O3 enhances the nitriding reaction by eliminating the SiO2 and Si3N4 layer on the surface of silicon particles. Further, a synergistic effect resulting in an increased nitridation was verified by concurrent addition of sintering additives and diluents. The contribution of each component of the compact to the promoted nitriding reaction was elucidated in quasi in-situ manner by the combination of phase analysis and thermogravimetric analysis. (C) 2016 The Ceramic Society of Japan. All rights reserved.</P>
CT Findings of Azygos Venous System: Congenital Variants and Acquired Structural Changes
Ha Neul Kim,Youkyung Lee,Su Jin Hong,Ji Hun Kang,Ji-hoon Jung 대한영상의학회 2024 대한영상의학회지 Vol.85 No.1
The azygos venous system is a crucial conduit of the posterior thorax and potentially vital collateral pathway. However, it is often overlooked clinically and radiologically. This pictorial essay reviews the normal azygos venous anatomy and CT findings of congenital variations and structural changes associated with acquired pathologies.
Kim Ha-Neul,Kim Mi-Ju,Park Young-Jo,Ko Jae-Woong 한국세라믹학회 2021 한국세라믹학회지 Vol.58 No.1
The eff ect of rare-earth oxides on the characteristics of porous sintered reaction-bonded silicon nitride (SRBSN) was investigated. Three types of raw Si powder mixtures containing diff erent rare-earth oxide (La 2 O 3 , Er 2 O 3 , and Yb 2 O 3 ) were prepared and nitrided in the form of compacts. The nitriding profi les of the respective raw powder mixtures with elevating temperature indicated that Yb 2 O 3 clearly promoted the nitridation of Si compacts at low temperature compared with other rare-earth oxides, and the β-Si 3 N 4 ratio after completion of the nitriding reaction was diff erent at which temperature the major nitridation occurred. Yb 2 O 3 was found to be the most eff ective additive to achieve a strong porous SRBSN, having the fl exural strength of 441 MPa. The reason why Yb 2 O 3 promotes the nitridation reaction and has excellent mechanical properties after post-sintering is that oxygen was removed during the nitriding reaction, which was supported by the analysis of oxygen content via the laser-induced breakdown spectroscopy.