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자궁경부암 선별검진을 위한 세포진 검사와 인유두종바이러스 검사의 임상적 유용성
안태규,이경,김동원,한세준 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.4
목적 : 자궁경부 세포진 검사와 HPV DNA (Hybrid capture 1) 검사의 임상적 유용성을 알아보고자 본 연구를 시행하였다. 연구 방법 : 1995년 12월 1일부터 1998년 3월 31일까지 조선대학교병원 산부인과 외래를 방문한 1028명의 환자중 질확대경을 통한 조직검사 및 수술을 시행한 후 조직 검사를 시행하여 결과 비교가 가능한 환자 305명을 대상으로 본 연구를 시행하였다. 결과 : 1. 세포진 검사의 민감도는 63.0%, 특이도는 88.1%, 양성 예측율은 89.7%, 음성 예 측율은 59.3%이었다. 2. HPV DNA 검사의 민감도는 51.9%, 특이도는 85.3%, 양성 예측율은 85.2%, 음성 예측율은 52.1%이었다. 3. HPV DNA검사와 세포진 검사를 병행하였을 경우 민감도는 76.9%, 특이도는 76.9%, 위양성률은 23.1%, 위음성률은 23.1%이다. 결론 : 본 연구에서 자궁경부암 선별 검사로서 형태학적 검사인 세포진 검사와 생물학적 검사인 HPV DNA 검사를 동시에 사용하면 서로의 단점을 보완하여 향후 적절한 선별검진의 간격을 결정하는 등 자궁경부암 조기 진단에 매우 유용하게 사용할 수 있을 것으로 생각된다. Objective : The purpose of this study was to find out the efficacy of cytology and HPV DNA test (Hybrid capture I) in early diagnosis of cervical cancer. Methods :This study included 1028 patients who visited the Department of Obstetrics and Gynecology, Cho-sun University Hospital From December 1, 1995 to March 31, 1998. And we chose 305 samples who underwent biopsies among taking the cytology and HPV DNA test. All women simultaneously underwent an exo- and endo-cervical smear. Results : 1. The sensitivity and specificity of cytology were 63.0% and 88.1%, respectively. 2. The positive predictive value and negative predictive value of cytology were 89.7% and 59.3%, respectively. 3. The sensitivity and specificity of HPV DNA test were 51.9% and 85.3%, respectively. 4. The positive predictive value and negative predictive value of HPV DNA test were 85.2% and 52.1%, respectively. 5. When HPV DNA test and Papanicloaou smear were combined, the sensitivity and specificity were 76.9% and 76.9%, respectively. However, the specificity of the combined test with HPV DNA test and Papanicloaou smear was lower than Papanicloaou smear alone. Conclusion : The sensitivity of cervical cytology was markedly improved by combination with HPV DNA test. So, the combined test could improve the high false negativity of cervical cytology, if the effectiveness is confirmed by mass screening study.
A New Yield Criterion for Fiber-Reinforced Composite Materials
이규세 선문대학교 2000 공학계열 논총 Vol.3 No.-
A new yield criterion for fiber-reinforced composite material is developed, which is simple and efficient to be implemented into an incremental elastic-plastic constitutive model. The constitutive model is for a predictive analysis procedure for composites, to represent progressively nonlinear material behavior of composite materials until a material failure is predicted. An anisotropic initial yield criterion is established that includes the effects of different yield strengths in each material direction, and between tension and compression. Anisotropic work-hardening model and subsequent yield surface are developed to describe material behavior beyond the initial yield. The current model is implemented into a computer code, which is Predictive Analysis for Composite Structures (PACS). The accuracy and efficiency of the yield criterion are verified by solving a number of various fiber-reinforced composite laminates with and without geometric discontinuity. The comparisons of the numerical results to the experimental and other numerical results available in the literature indicate the validity and efficiency of the developed model.
이규세 선문대학교 1998 공과대학논문집 Vol.1 No.1
시멘트 콘크리트 포장은 대형 차량 하중에 대한 지지력이 좋고 수명이 길며, 시공 후에 잦은 유지 보수가 필요치 않다는 측면에서 국내 고속도로에는 1980년대 도입된 이후부터 그 사용이 급격히 증가하였으며, 앞으로 건설되는 대규모 고속도로들도 콘크리트 포장으로 시공할 가능성은 증가하고 있다. 이에 본 연구 는 균열에 의한 Punch-Out 파괴에 따른 콘크리트 포장의 수명을 규명하기 위하여 이론적 연구를 수행하여 1/4로 상사한 시험체를 제작하고 정적하중 재하실험을 실시하였다. The use of cement concrete pavement in the roadway system has increased since its first application in 1980's in Korea by virtue of its good durability and excellent load-resisting capacity. In this study, eight 1/4 reduced specimens were tested to investigate the fatigue life expectancy of. continuously reinforced concrete pavements(CRCP). First, a static test was performed to define the static failure load.
Yi, Gyu-Sei 한국복합신소재구조학회 2014 복합신소재구조학회논문집 Vol.5 No.4
A progressive failure analysis procedure for composite laminates is developed in here and in the companion paper. An anisotropic plastic constitutive model for fiber-reinforced composite material, is developed, which is simple and efficient to be implemented into computer program for a predictive analysis procedure of composites. In current development of the constitutive model, an incremental elastic-plastic constitutive model is adopted to represent progressively the nonlinear material behavior of composite materials until a material failure is predicted. An anisotropic initial yield criterion is established that includes the effects of different yield strengths in each material direction, and between tension and compression. Anisotropic work-hardening model and subsequent yield surface are developed to describe material behavior beyond the initial yield under the general loading condition. The current model is implemented into a computer code, which is Predictive Analysis for Composite Structures (PACS), and is presented in the companion paper. The accuracy and efficiency of the anisotropic plastic constitutive model are verified by solving a number of various fiber-reinforced composite laminates with and without geometric discontinuity. The comparisons of the numerical results to the experimental and other numerical results available in the literature indicate the validity and efficiency of the developed model.