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Guo Weiming,Jin Peng,Li Ruomei,Huang Lu,Liu Zhen,Li Hairui,Zhou Ting,Fang Bing,Xia Lunguo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The identification of predictive markers to determine the triggering phase prior to the onset of osteoporosis is essential to mitigate further irrevocable deterioration. To determine the early warning signs before osteoporosis, we used the dynamic network biomarker (DNB) approach to analyze time-series gene expression data in a zebrafish osteoporosis model, which revealed that cyclin-dependent kinase inhibitor 1 A (cdkn1a) is a core DNB. We found that cdkn1a negatively regulates osteogenesis, as evidenced by loss-of-function and gain-of-function studies. Specifically, CRISPR/Cas9-mediated cdkn1a knockout in zebrafish significantly altered skeletal development and increased bone mineralization, whereas inducible cdkn1a expression significantly contributed to osteoclast differentiation. We also found several mechanistic clues that cdkn1a participates in osteoclast differentiation by regulating its upstream signaling cascades. To summarize, in this study, we provided new insights into the dynamic nature of osteoporosis and identified cdkn1a as an early-warning signal of osteoporosis onset.
Weiming Cao,Benqi Guo 대한수학회 2004 대한수학회지 Vol.41 No.2
A preconditioning algorithm is developed in this paper for the iterative solution of the linear system of equations resulting from the p-version boundary element approximation of the three dimensional integral equation with hypersingular operators. The preconditioner is derived by first making the nodal and side basis functions locally orthogonal to the element internal bases, and then by decoupling the nodal and side bases from the internal bases. Its implementation consists of solving a global problem on the wirebasket and a series of local problems defined on a single element. Moreover, the condition number of the preconditioned system is shown to be of order O((1 + ln p)7). This technique can be applied to discretization with triangular elements and with general basis functions.
Weiming He,Yuguang Xu,Chaoyang Gong,Xiaozhen Liu,Yuqiang Wu,Xi Xie,Jiazhen Chen,Yi Yu,Zhiyong Guo,Qiang Sun 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.4
Purpose: The aim of this study was to quantify renal microcirculatory perfusion in braindead donors using contrast-enhanced ultrasonography (CEUS), and to establish an accurate, noninvasive, and convenient index for predicting delayed graft function (DGF) post-transplantation. Methods: In total, 90 brain-dead donor kidneys (training group, n=60; validation group, n=30) examined between August 2020 and November 2022 were recruited in this prospective study. CEUS was performed on the kidneys of brain-dead donors 24 hours before organ procurement and time-intensity curves were constructed. The main measures were arrival time, time to peak, and peak intensity of the kidney segmental arteries, cortex, and medulla. Recipients were divided into DGF and non-DGF groups according to early post-transplant graft function. The area under the receiver operating characteristic curve (AUC) was used to assess diagnostic performance. Results: The arrival time of the kidney segmental artery and cortex and the time interval between the time to peak of the segmental artery and cortex were identified as independent factors associated with DGF by multivariate stepwise regression analysis. A new index for the joint prediction model of three variables, the contrast-enhanced ultrasonography/Kidney Donor Profile index (CEUS-KDPI), was developed. CEUS-KDPI showed high accuracy for predicting DGF (training group: AUC, 0.91; sensitivity, 90.5%; specificity, 92.3%; validation group: AUC, 0.84; sensitivity, 75.0%; specificity, 92.3%). Conclusion: CEUS-KDPI accurately predicted DGF after kidney transplantation. CEUS may be a potential noninvasive tool for bedside examinations before organ procurement and may be used to predict early renal function after kidney transplants kidneys from donors after brain death.
( Zhen Guo ),( Xingchen Cai ),( Ruiqing Liu ),( Jianfeng Gong ),( Yi Li ),( Lei Cao ),( Weiming Zhu ) 대한장연구학회 2018 Intestinal Research Vol.16 No.2
Background/Aims: Resection of the diseased segment and suture of the victim segment is recommended for enteroenteric fistula in Crohn’s disease (CD). The main difficulty in this procedure remains reliable diagnosis of the victim segment, especially for fistulas found intraoperatively and inaccessible on endoscopic examination. We aimed to explore whether intraoperative inspection alone is reliable. Methods: Patients undergoing conservative surgery between 2011 and 2016 for enteroenteric fistulas complicating CD were identified from a prospectively maintained database. Patients were divided according to whether the victim segment was evaluated by preoperative endoscopy + intraoperative inspection (PI group) or by intraoperative inspection alone (I group). Outcomes were compared. Results: Of 65 patients eligible for the study, 37 were in in the PI group and 28 were in the I group. The baseline characteristics were similar between the groups, except for the rate of emergency surgery (0/37 in PI group vs. 5/28 in I group, P=0.012). Fistulas involved more small intestines (4/37 in PI group vs. 15/28 in I group, P< 0.001) and fewer sigmoid colons (17/37 in PI group vs. 4/28 in I group, P=0.008) in I group due to accessibility with endoscopy. No difference was found in postoperative complications, stoma rates, postoperative recurrence, or disease at the repair site between the 2 groups (P >0.05). Conclusions: For fistulas found intraoperatively and inaccessible on endoscopic examination, intraoperative inspection was a reliable guide when choosing between en bloc resection and a conservative procedure. (Intest Res 2018;16:282-287)
Yue Weiming,Zhang Shengxue,Li Chunlong,Jiang Tiancai,Liu Lubei,Wang Ruoxu,Huang Yulu,Tan Teng,Guo Hao,Zaplatin Evgeny,Xiong Pingran,Wu Andong,Wang Fengfeng,Zhang Shenghu,Huang Shichun,He Yuan,Yao Zeen 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.8
As a part of R&D work for the high intensity proton linac of China Accelerator Driven Sub-critical System project, a superconducting half-wave cavity with a frequency of 162.5 MHz and an optimal beta of 0.15 (HWR015) has been developed at Institute of Modern Physics (IMP), Chinese Academy of Sciences. In this paper, the design and test results will be described in detail. We introduced a new stiffening strategy for the HWR cavity, the simulation results show that the cavity has much lower frequency sensitivity coefficient (df/dp), Lorentz force detuning coefficient (KL), and can achieve more stable mechanical properties. The performance of the HWR cavity operated in cryostat will be also reported.
Design and Test Result of a Superconducting Double-Spoke Cavity
Tiancai Jiang,Yulu Huang,Shengxue Zhang,Lubei Liu,Pingran Xiong,Chunlong Li,Hao Guo,Weiming Yue,Shenghu Zhang,Yuan He 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.3
Superconducting multi-spoke cavities are outstanding alternative choice for acceleration of heavy ions inmedium velocity regimes. Based on the scheme of China ADS, several researches on the superconductingdouble-spoke cavities were done and two prototype cavities have been developed. In this paper, the RFdesign, the mechanical design and fabrication considerations of the bare cavity will be described indetail. After Buffered Chemical Polishing and High Pressure Rinsing, one of the prototype cavities wasinstalled into the Vertical Test Stand for high gradient RF testing at 4.2 K. The measurement results of thequality factor as a function of the accelerating field and the maximum surface field will be presented. Anaccelerating gradient of more than 15 MV/m is achieved during the test, with maximum surface electricfield of 58 MV/m, and maximum surface magnetic field of 117 mT