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The Predictive QSAR Model for hERG Inhibitors Using Bayesian and Random Forest Classification Method
Jun Hyoung Kim,Chong Hak Chae,Shin Myung Kang,Joo Yon Lee,Gil Nam Lee,Soon Hee Hwang,강남숙 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
In this study, we have developed a ligand-based in-silico prediction model to classify chemical structures into hERG blockers using Bayesian and random forest modeling methods. These models were built based on patch clamp experimental results. The findings presented in this work indicate that Laplacian-modified naïve Bayesian classification with diverse selection is useful for predicting hERG inhibitors when a large data set is not obtained.
Toxicokinetics of paraquat in Korean patients with acute poisoning
Hak-Jae Kim,Hyung-Ki Kim,Hwayoung Lee,Jun-Seok Bae,Jun-Tack Kown,Hyo-Wook Gil,Sae-Yong Hong 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentrationtime curve (AUC<sub>inf</sub>), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution (V<sub>d</sub>/F) were calculated. The maximum PQ concentration (C<sub>max</sub>) and the time to reach maximum PQ concentration (T<sub>max</sub>) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of 13.1±6.8 h. C<sub>max</sub> and AUC<sub>inf</sub> were 20.8±25.7 mg/l and 172.5±160.3 h·mg/ l, respectively. Apparent volume of distribution and apparent oral clearance were 50.9±61.3 l/kg and 173.4±111.2 l/h, respectively. There were a significant correlation (<i>r </i>=0.84; p<0.05) between the PQ amount ingested and C<sub>max</sub>. AUC<sub>inf </sub>also showed a significant correlation (<i>r </i>=0.83; p<0.05) with the PQ amount ingested. These correlations provide evidence that PQ has dose-linear toxicokinetic characteristics.
Oh, Jun-Hak,Yoo, Byung-Gil,Choi, In-Chul,Santella, Michael L.,Jang, Jae-il Cambridge University Press (Materials Research Soc 2011 Journal of materials research Vol.26 No.10
<▼1><B>Abstract</B><P/></▼1><▼2><P>In this work, we have systematically explored the influence of thermo-mechanical treatment on the precipitation behavior and its strengthening in Inconel 740, a relatively new Ni-based superalloy, using specimens on which different levels of stresses were applied at 700 °C. With increasing applied stress, fraction of gamma prime precipitates increased (without significant size change) and nanoindentation hardness was enhanced. The stress effects were discussed in terms of the free energy barrier for heterogeneous nucleation and the prevailing mechanisms of precipitation strengthening.</P></▼2>
노인의 건강수준에 따른 외적 이미지가 성공적 노화에 미치는 영향
유길준 ( Gil Jun You ),전상남 ( Sang Nam Jeon ),신학진 ( Hak Gene Shin ),황성완 ( Sung Wan Hwang ) 한국보건정보통계학회 (구 한국보건통계학회) 2011 보건정보통계학회지 Vol.36 No.2
Objectives: The purpose of this study was to find out how to affect of the elderly`s recognition and action on body image to successful aging between high level group of perceived health and low level group. Methods: The 297 survey samples were divided into high level group and low level group in terms of the perceived health. T-test was exploited to see the differences of extemal image and successful aging between two groups. Correlation and hierarchical regression were applied to see how the socio-economic and the external image influence the successful aging. Results: First, results showed the high level group of perceived health was significantly higher perception of self-other recognition, external image, appearance management and the elderly`s perception of successful aging than the low level group. Second, the high level group of perceived health showed the higher effect of socio-economic variables and the extemal image`s perception and management to the successful aging than the low level group. However, the low level group of perceived health perceived the external image and management was important to the successful aging. Conclusions: It is suggested to develop some programs and policies for improvement of external image and management in the context of successful aging.
Toxicokinetics of paraquat in Korean patients with acute poisoning
Kim, Hak-Jae,Kim, Hyung-Ki,Lee, Hwayoung,Bae, Jun-Seok,Kown, Jun-Tack,Gil, Hyo-Wook,Hong, Sae-Yong The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentration-time curve ($AUC_{inf}$), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution ($V_d/F$) were calculated. The maximum PQ concentration ($C_{max}$) and the time to reach maximum PQ concentration ($T_{max}$) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of $13.1{\pm}6.8h$. $C_{max}$ and $AUC_{inf}$ were $20.8{\pm}25.7mg/l$ and $172.5{\pm}160.3h{\cdot}mg/l$, respectively. Apparent volume of distribution and apparent oral clearance were $50.9{\pm}61.3l/kg$ and $173.4{\pm}111.2l/h$, respectively. There were a significant correlation (r=0.84; p<0.05) between the PQ amount ingested and $C_{max}$. $AUC_{inf}$ also showed a significant correlation (r=0.83; p<0.05) with the PQ amount ingested. These correlations provide evidence that PQ has dose-linear toxicokinetic characteristics.
The Predictive QSAR Model for hERG Inhibitors Using Bayesian and Random Forest Classification Method
Kim, Jun-Hyoung,Chae, Chong-Hak,Kang, Shin-Myung,Lee, Joo-Yon,Lee, Gil-Nam,Hwang, Soon-Hee,Kang, Nam-Sook Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
In this study, we have developed a ligand-based in-silico prediction model to classify chemical structures into hERG blockers using Bayesian and random forest modeling methods. These models were built based on patch clamp experimental results. The findings presented in this work indicate that Laplacian-modified naive Bayesian classification with diverse selection is useful for predicting hERG inhibitors when a large data set is not obtained.