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Ghazanfari, Adibehalsadat,Marasini, Shanti,Miao, Xu,Park, Ji Ae,Jung, Ki-Hye,Ahmad, Mohammad Yaseen,Yue, Huan,Ho, Son Long,Liu, Shuwen,Jang, Yeong Ji,Chae, Kwon Seok,Chang, Yongmin,Lee, Gang Ho Elsevier 2019 Colloids and surfaces. A, Physicochemical and engi Vol.576 No.-
<P><B>Abstract</B></P> <P>Ultrasmall heavy metal oxide nanoparticles are potential candidate materials for X-ray computed tomography (CT) contrast agents because they possess high X-ray attenuation powers owing to high X-ray attenuation coefficients of heavy metal atoms and high density of heavy metal atoms per nanoparticle. In this study, five kinds of polyacrylic acid (PAA)-coated ultrasmall heavy metal oxide (Bi<SUB>2</SUB>O<SUB>3</SUB>, Yb<SUB>2</SUB>O<SUB>3</SUB>, NaTaO<SUB>3</SUB>, Dy<SUB>2</SUB>O<SUB>3</SUB>, and Gd<SUB>2</SUB>O<SUB>3</SUB>) nanoparticles were synthesized and their X-ray attenuation properties were investigated. The estimated average particle diameters were 2.3 ± 0.1, 1.7 ± 0.1, 1.5 ± 0.1, 1.8 ± 0.1, and 1.9 ± 0.1 nm for PAA-coated ultrasmall Bi<SUB>2</SUB>O<SUB>3,</SUB> Yb<SUB>2</SUB>O<SUB>3</SUB>, NaTaO<SUB>3</SUB>, Dy<SUB>2</SUB>O<SUB>3</SUB>, and Gd<SUB>2</SUB>O<SUB>3</SUB> nanoparticles, respectively. All of the nanoparticle suspension samples exhibited a high colloidal stability, a high biocompatibility, and X-ray attenuation powers which were stronger than that of a commercial iodine contrast agent Ultravist<SUP>®</SUP> at the same atomic concentration and much stronger, at the same number density. The effectiveness of the nanoparticle suspension samples as CT contrast agents was demonstrated by acquiring in vivo CT images by using one of the samples (i.e., PAA-coated ultrasmall Bi<SUB>2</SUB>O<SUB>3</SUB> nanoparticles). After intravenous injection into the mouse tail vein, positive contrast enhancements in various organs were observed.</P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Adibehalsadat Ghazanfari,Shanti Marasini,Tirusew Tegafaw,Son Long Ho,Xu Miao,Mohammad Yaseen Ahmad,Huan Yue,이강호,박지애,정기혜,장용민,오인택,채권석 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.3
Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in com- puted tomography (CT). In this study, ultrasmall Yb2O3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the rst time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2:1 0:1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravistr) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb2O3 nanoparticles for use as a powerful CT contrast agent.
Molybdenum isotopes separation using squared-off optimized cascades
Aghaie Mahdi,Ghazanfari Valiyollah 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9
Recently molybdenum alloys have been introduced as accident tolerating materials for cladding of fuel rods. Molybdenum element has seven stable isotopes with different neutron absorption cross section used in various fields, including nuclear physics and radioisotope production. This study presents separation approaches for all intermediate isotopes of molybdenum element by squared-off cascades using a newly developed numerical code with Salp Swarm Algorithm (SSA) optimization algorithm. The parameters of cascade including feed flow rate, feed entry stage, cascade cut, input feed flow rate to gas centrifuges (GCs), and cut of the first stage are optimized to maximize both isotope recovery and cascade capacity. The squared off and squared cascades are studied, and the efficiencies are compared. The results obtained from the optimization showed that for the selected squared off cascade, Mo94 in four separation steps, Mo95 in five steps, Mo96 in six steps, Mo97 in seven steps, and Mo98 in two steps are separated to the desired concentrations. The highest recovery factor is obtained 63% for Mo94 separation and lowest recovery factor is found 45% for Mo95
Abbas Bahador,Jamshid Hadjati,Niloofar Hassannejad,Hadi Ghazanfari,Mohammadreza Maracy,Sirous Jafari,Maryam Nourizadeh,Amirhooshang Nejadeh 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.3
Objectives: Brucellosis remains one of the most common zoonotic diseases worldwide. In humans, brucellosis can be a serious, debilitating, and sometimes chronic disease. Different mechanisms can be postulated as to the basis for the induction of the chronic status of infectious diseases that T regulatory cells are one of the most important related mechanisms. The current study was designed to determine whether percentage of CD4+Treg cells and their CD25high and FoxP3high subpopulations in peripheral blood are changed in human brucellosis samples in comparison to a control group. Methods: In total, 68 brucellosis patients (acute form: n Z 43, chronic form: nZ25) and 36 healthy volunteers entered our study. After isolating of peripheral blood mononuclear cells, heparinized venous blood samples were obtained from both patients and healthy donors, CD4, CD25, and FoxP3 molecules were evaluated by two- and three-color flow cytometric methods. Results: The results revealed a new finding in relation to Treg cells and human brucellosis. The numbers of CD4+Treg cells and their CD25high and FoxP3high subsets increase significantly in the peripheral blood of acute and chronic forms of brucellosis samples compared with healthy groups, with this increase being greater in the chronic group. Conclusion: There seems to be a correlation between increase of CD4+Treg cells and their subsets and the disease progress from healthy state to acute and chronic brucellosis.
Shanti Marasini,Huan Yue,Son Long Ho,차현실,박지애,Ki-Hye Jung,Adibehalsadat Ghazanfari,Mohammad Yaseen Ahmad,Shuwen Liu,채권석,장용민,이강호 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.8
Until now, there have been limited studies on T2 magnetic resonance imaging (MRI) contrast agents (CAs) using paramagnetic nanoparticles (NPs). In this study, ultrafine dysprosium oxide (Dy2O3) NPs were synthesized as a T2 MRI CA. To obtain high biocompatibility and colloidal stability in aqueous medium for in vivo applications, they were grafted with polyacrylic acid. They displayed paramagnetism with an appreciable magnetization value at 300?K and consequently, an appreciable transverse water proton spin relaxivity (r2) value which increased as the applied MR field increased. Their potential as a T2 MRI CA was proved by taking in vivo T2 MR images in mice.
Mohammad Yaseen Ahmad,차현실,오인택,Tirusew Tegafaw,XUMIAO,Son Long Ho,Shanti Marasini,Adibehalsadat Ghazanfari,Huan Yue,채권석,장용민,이강호 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.4
We prepared gadolinium oxide (Gd2O3) nanoparticles (GNPs) coated with a trans‐activator of transcription (TAT) peptide with cell‐penetrating ability (i.e., TAT‐GNPs) through one‐pot process. We characterized the particle diameter, surface‐coating structure, water proton relaxivities, and in vitro cellular toxicities of the TAT‐GNPs. We measured in vivo T1 magnetic resonance images (MRI) in a model nude mouse with liver cancer prior and posterior to intravenous administration. The average particle diameter of the GNPs was 1.5 nm. The sample solution exhibited a longitudinal water proton relaxivity (r1) of 18.2/s/mM (r2/r1 = 1.6, r2 = transverse water proton relaxivity), which is four to five times higher than those of commercial Gd‐chelates. The in vivo T1 MRI exhibited positively (or T1) enhanced contrasts in the mouse liver cancer after intravenous administration, demonstrating that the TAT‐GNPs acted as an enhanced cancer‐imaging agent similar to the cancer‐targeting agent in T1 MRI.
Fateh, Abolfazl,Aghasadeghi, Mohammad Reza,Keyvani, Hossein,Mollaie, Hamid Reza,Yari, Shamsi,Tasbiti, Ali Reza Hadizade,Ghazanfari, Morteza,Monavari, Seyed Hamid Reza Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: A recent genome-wide association study (GWAS) on patients with chronic hepatitis C (CHC) treated with peginterferon and ribavirin (pegIFN-${\alpha}$/RBV) identified a single nucleotide polymorphism (SNP) on chromosome 19 (rs12979860) which was strongly associated with a sustained virological response (SVR). The aim of this study was twofold: to study the relationship between IL28B rs12979860 and sustained virological response (SVR) to pegIFN-${\alpha}$/RVB therapy among CHC patients and to detect the rs12979860 polymorphism by high resolution melting curve (HRM) assay as a simple, fast, sensitive, and inexpensive method. Materials and Methods: The study examined outcomes in 100 patients with chronic hepatitis C in 2 provinces of Iran from December 2011 to June 2013. Two methods were applied to detect IL28B polymorphisms: PCR-sequencing as a gold standard method and HRM as a simple, fast, sensitive, and inexpensive method. Results: The frequencies of IL28B rs12979860 CC, CT, and TT alleles in chronic hepatitis C genotype 1a patients were 10% (10/100), 35% (35/100), and 6% (6/100) and in genotype 3a were 13% (13/100), 31% (31/100), and 5% (5/100), respectively. In genotype 3a infected patients, rs12979860 (CC and CT alleles) and in genotype 1a infected patients (CC allele) were significantly associated with a sustained virological response (SVR). The SVR rates for CC, CT and TT (IL28B rs12979860) were 18%, 34% and 4%, respectively. Multiple logistic regression analysis identified two independent factors that were significantly associated with SVR: IL-28B genotype (rs 12979860 CC vs TT and CT; odds ratio [ORs], 7.86 and 4.084, respectively), and HCV subtype 1a (OR, 7.46). In the present study, an association between SVR rates and IL28B polymorphisms was observed. Conclusions: The HRM assay described herein is rapid, inexpensive, sensitive and accurate for detecting rs12979860 alleles in CHC patients. This method can be readily adopted by any molecular diagnostic laboratory with HRM capability and will be clinically beneficial in predicting treatment response in HCV genotype 1 and 3 infected patients. In addition, it was demonstrated that CC and CT alleles in HCV-3a and the CC allele in HCV-1a were significantly associated with response to pegIFN-${\alpha}$/RBV treatment. The present results may help identify subjects for whom the therapy might be successful.
Tegafaw, Tirusew,Oh, In Taek,Cha, Hyunsil,Yue, Huan,Miao, Xu,Ho, Son Long,Ahmad, Mohammad Yaseen,Marasini, Shanti,Ghazanfari, Adibehalsadat,Kim, Hee-Kyung,Chae, Kwon Seok,Chang, Yongmin,Lee, Gang Ho Elsevier 2018 The Journal of physics and chemistry of solids Vol.120 No.-
<P><B>Abstract</B></P> <P>In this study, amorphous carbon nanoparticles (CNPs) with an average diameter of 2.2 nm were synthesized by reducing dextrose (C<SUB>6</SUB>H<SUB>12</SUB>O<SUB>6</SUB>) with sodium hydroxide in an aqueous medium. The amorphous CNPs formed stable colloidal suspensions in water owing to the presence of hydrophilic functional groups on the nanoparticle surfaces. The amorphous CNPs exhibited ultraviolet (UV)-visible absorption (λ<SUB>abs</SUB>) at 267 nm and emission (λ<SUB>em</SUB>) at 453 nm under UV irradiation; thus, the colloidal suspension appeared sky-blue in color under UV irradiation. The amorphous CNPs were paramagnetic with weak magnetization at room temperature and exhibited small longitudinal (r<SUB>1</SUB>) and transverse (r<SUB>2</SUB>) water proton relaxivities of 0.036 and 0.068 s<SUP>−1</SUP>mM<SUP>−1</SUP>, respectively. The amorphous CNPs exhibited no cellular toxicity up to the measured carbon concentration of 500 μM and presented fluorescence microscopy images on a micrometer scale, thus demonstrating their utility in fluorescence bio-imaging applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The amorphous CNPs with an average diameter of 2.2 nm were synthesized in an aqueous medium. </LI> <LI> The CNPs were non-toxic and formed stable colloidal suspensions in water. </LI> <LI> The CNPs were paramagnetic and exhibited weak magnetization at room temperature. </LI> <LI> The CNPs exhibited small water proton relaxivities. </LI> <LI> Fluorescence microscopy demonstrated the utility of the CNPs in fluorescence bio-imaging applications. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>