Research on Laser Thread Form Bending of Stainless Steel Tube

Fuqiang Li,Shourong Liu,Aiping Shi,Qiulu Chu,Qiang Shi,Yuxiang Li 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.6

Compared to traditional bending methods, laser bending can yield products with better shapes and higher quality using the simpler equipment. In this paper, the mechanism of Laser-assisted tube bending is elaborated, and then the influence of processing parameters (including laser power, scanning speed, spot diameter, and scanning times) on the bending angle is studied with both the finite element method and experiments. The bending angle increases with an increase of laser power and spot diameter and with a decrease in the scanning speed. Three-dimensional (3D) thread form bending can be achieved by planning the optimal route, scanning parameters, and the number of laser scans. In contrast to the desired thread diameter of 20 mm and thread pitch of 180 mm, the resulting thread of the stainless steel tube is close to the target shape with errors of 3% for thread diameter and 2.5% for thread pitch, which are both in an acceptable range and thus verify the validity of the parameters selection and route planning method.

PC-SAN: Pretraining-Based Contextual Self-Attention Model for Topic Essay Generation

( Fuqiang Lin ),( Xingkong Ma ),( Yaofeng Chen ),( Jiajun Zhou ),( Bo Liu ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.8

Automatic topic essay generation (TEG) is a controllable text generation task that aims to generate informative, diverse, and topic-consistent essays based on multiple topics. To make the generated essays of high quality, a reasonable method should consider both diversity and topic-consistency. Another essential issue is the intrinsic link of the topics, which contributes to making the essays closely surround the semantics of provided topics. However, it remains challenging for TEG to fill the semantic gap between source topic words and target output, and a more powerful model is needed to capture the semantics of given topics. To this end, we propose a pretraining-based contextual self-attention (PC-SAN) model that is built upon the seq2seq framework. For the encoder of our model, we employ a dynamic weight sum of layers from BERT to fully utilize the semantics of topics, which is of great help to fill the gap and improve the quality of the generated essays. In the decoding phase, we also transform the target-side contextual history information into the query layers to alleviate the lack of context in typical self-attention networks (SANs). Experimental results on large-scale paragraph-level Chinese corpora verify that our model is capable of generating diverse, topic-consistent text and essentially makes improvements as compare to strong baselines. Furthermore, extensive analysis validates the effectiveness of contextual embeddings from BERT and contextual history information in SANs.

Multi-source Network-coded D2D Cooperative Content Distribution Systems

Weijun Xing,Fuqiang Liu,Chao Wang,Ming Xiao,Ping Wang 한국통신학회 2018 Journal of communications and networks Vol.20 No.1

In this paper, we investigate the information transmissionin a typical 5G device-to-device (D2D) communication applicationscenario, i.e., a content distribution system with a numberof information sources intending to broadcast their messages tomultiple destinations in the vicinity. Due to the dynamic natureof wireless signal propagation links, it is hard to guarantee a satisfactoryperformance by direct source-destination transmissions,especially when the system is operating in a reuse-mode. Relays canbe introduced to the system to solve this problem. However, adoptingthe conventional repetition coding at relays inefficiently utilizesthe available resources, for the considered multi-source scenario. Therefore, we investigate applying a class of finite-field networkcodes at the relays, when potentially three types of relays are deployedto assist the information distribution process. We proposedthe algorithms to derive the system outage probability and analyzethe trade-off between energy efficiency and spectral efficiency. Ouranalytical and numerical results clearly demonstrate the potentialof exploiting network-coded cooperative communications in future5G D2D systems.

polymer-permeating grain boundary method for highly efficient perovskite solar cell

이호준,( Li Fuqiang ),( Liu Fengwu ),( Li Ying ),( Zhang Anqi ),( Du Xiangrui ),( Semo Son ),( Sangwook Wu ),( Sung Heum Park ) 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.-

Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia

Gong Lei,Odilov Bekzod,Han Feng,Liu Fuqiang,Sun Yujing,Zhang Ningxin,Zuo Xiaolin,Yang Jiaojiao,Wang Shouyu,Hou Xinguo,Ren Jianmin 한국유전학회 2022 Genes & Genomics Vol.44 No.6

Background: Cleidocranial dysplasia (CCD) is a rare genetic disorder affecting bone and cartilage development. Clinical features of CCD comprise short stature, delayed ossification of craniofacial structures with numerous Wormian bones, underdeveloped or aplastic clavicles and multiple dental anomalies. Several studies have revealed that CCD development is strongly linked with different mutations in runt-related transcription factor 2 (RUNX2) gene. Objective: Identification and functional characterization of RUNX2 mutation associated with CCD. Methods: We performed genetic testing of a patient with CCD using whole exome sequencing and found a novel RUNX2 frameshift mutation: c.1550delT in a sporadic case. We also compared the functional activity of the mutant and wild-type RUNX2 through immunofluorescence microscopy and osteocalcin promoter luciferase assay. Results: We found a novel RUNX2 frameshift mutation, c.1550delT (p.Trp518Glyfs*60). Both mutant RUNX2 and wild-type RUNX2 protein were similarly confined in the nuclei. The novel mutation caused abrogative transactivation activity of RUNX2 on osteocalcin promoter. Conclusions: We explored a novel RUNX2 deletion/frameshift mutation in a sporadic CCD patient. This finding suggests that the VWRPY domain may play a key role in RUNX2 transactivation ability.

Numerical study of effect of membrane properties on long-cycle performance of vanadium redox flow batteries

Wei, Zi,Siddique, N.A.,Liu, Dong,Sakri, Shambhavi,Liu, Fuqiang Techno-Press 2016 Advances in energy research Vol.4 No.4

Fundamental understanding of vanadium ion transport and the detrimental effects of cross-contamination on vanadium redox flow battery (VRFB) performance is critical for developing low-cost, robust, and highly selective proton-conducting membranes for VRFBs. The objective of this work is to examine the effect of conductivity and diffusivity, two key membrane parameters, on long-cycle performance of a VRFB at different operating conditions using a transient 2D multi-component model. This single-channel model combines the transport of vanadium ions, chemical reactions between permeated ions, and electrochemical reactions. It has been discovered that membrane selecting criterion for long cycles depends critically on current density and operating voltage range of the cell. The conducted simulation work is also designed to study the synergistic effects of the membrane properties on dynamics of VRFBs as well as to provide general guidelines for future membrane material development.

Tumor Targeting and pH-Responsive Polyelectrolyte Complex Nanoparticles Based on Hyaluronic Acid-Paclitaxel Conjugates and Chitosan for Oral Delivery of Paclitaxel

Jiao Li,Pingsheng Huang,Longlong Chang,Xingwen Long,Anjie Dong,Jinjian Liu,Liping Chu,Fuqiang Hu,Jianfeng Liu,Liandong Deng 한국고분자학회 2013 Macromolecular Research Vol.21 No.12

A new platform of paclitaxel (PTX) for application as an oral delivery system was developed, by combining the pH sensitivity of polyelectrolyte complex nanoparticles (CNPs) and the active targeting of hyaluronic acid (HA). Chitosan/hyaluronic acid-paclitaxel (CS/HA-PTX) CNPs were prepared by coating the CS onto the HA-PTX nanoparticles (NPs), and characterized by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), transmission electron microscopy (TEM) and high-performance liquid chromatography (HPLC). HA-PTX conjugates could self-assemble into NPs in aqueous solution with an average size of 100±5 nm, and the PTX content of HA-PTX conjugates was 10.6 wt%. The CS/HA-PTX CNPs had a smaller size and higher PTX content when the ratio of positive charge to negative charge was 2:1. The in vitro release of PTX from CNPs was pH-responsive,suggesting that the CS shell could prevent the breakage of the ester bond in HA-PTX NPs in acidic pH conditions. HA-PTX NPs exhibited higher cellular uptake than free PTX against HepG2 cells via receptor-mediated endocytosis. PTX could accumulate remarkably into tumor sites after oral administration of CNPs. These results indicate that the CNP drug delivery system has great potential for applications in the oral administration of hydrophobic drugs.

ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages

Fu Qiang,Shen Na,Fang Tao,Zhang Hewei,Di Yanbo,Liu Xuan,Du Chao,Guo Jianshuang 한국유전학회 2024 Genes & Genomics Vol.46 No.3

Background ACT001 is an anti-inflammatory agent that has been widely investigated for its role in tumors, intracranial diseases, and fibrotic diseases, but its effect on acute lung injury is less known. Objective The purpose of this study was to investigate the effect and mechanism of ACT001 on regulating inflammation and pyroptosis in lipopolysaccharide (LPS)-induced alveolar macrophages. Methods NR8383 alveolar macrophages treated with LPS were used to replicate the proinflammatory macrophage phenotype observed during acute lung injury. After ACT001 treatment, we measured the secretion and expression levels of critical inflammatory cytokines, the rate of pyroptosis, and the expression of NLRP3 inflammasome-associated proteins and pyroptosis-associated proteins. In addition, we assessed the role of the PPAR-γ/NF-κB signaling pathways and further validated the results with a PPAR-γ inhibitor. Results Our findings confirmed that ACT001 reduced the expression and release of inflammatory factors, attenuated cell pyroptosis, and downregulated the expression of NLRP3, ASC, caspase-1 p20, and GSDMD-N. These effects may be achieved by activating PPAR-γ expression and then inhibiting the NF-κB signaling pathway. When macrophages were treated with the PPAR-γ inhibitor, the protective effects of ACT001 were reversed. Conclusion ACT001 significantly ameliorated inflammation and pyroptosis via the PPAR-γ/NF-κB signaling pathways in LPS-induced NR8383 alveolar macrophages. Background ACT001 is an anti-inflammatory agent that has been widely investigated for its role in tumors, intracranial diseases, and fibrotic diseases, but its effect on acute lung injury is less known. Objective The purpose of this study was to investigate the effect and mechanism of ACT001 on regulating inflammation and pyroptosis in lipopolysaccharide (LPS)-induced alveolar macrophages. Methods NR8383 alveolar macrophages treated with LPS were used to replicate the proinflammatory macrophage phenotype observed during acute lung injury. After ACT001 treatment, we measured the secretion and expression levels of critical inflammatory cytokines, the rate of pyroptosis, and the expression of NLRP3 inflammasome-associated proteins and pyroptosis-associated proteins. In addition, we assessed the role of the PPAR-γ/NF-κB signaling pathways and further validated the results with a PPAR-γ inhibitor. Results Our findings confirmed that ACT001 reduced the expression and release of inflammatory factors, attenuated cell pyroptosis, and downregulated the expression of NLRP3, ASC, caspase-1 p20, and GSDMD-N. These effects may be achieved by activating PPAR-γ expression and then inhibiting the NF-κB signaling pathway. When macrophages were treated with the PPAR-γ inhibitor, the protective effects of ACT001 were reversed. Conclusion ACT001 significantly ameliorated inflammation and pyroptosis via the PPAR-γ/NF-κB signaling pathways in LPS-induced NR8383 alveolar macrophages.