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Roh, Tae Hoon,Park, Hun Ho,Kang, Seok-Gu,Moon, Ju Hyung,Kim, Eui Hyun,Hong, Chang-Ki,Ahn, Sung Soo,Choi, Hye Jin,Cho, Jaeho,Kim, Se Hoon,Lee, Seung Koo,Kim, Dong Seok,Kim, Sun Ho,Suh, Chang-Ok,Lee, Ky Williams & Wilkins Co 2017 Medicine Vol.96 No.27
<P><B>Abstract</B></P><P>The present study analyzed outcomes of surgery followed by concomitant chemoradiotherapy (CCRT) with temozolomide (TMZ) in patients with newly diagnosed glioblastoma (GBM) at a single institution. Outcomes were retrospectively reviewed in 252 consecutive patients with newly diagnosed GBM who underwent surgery followed by CCRT with TMZ at the authors’ institution between 2005 and 2013. At initial operation, 126 (50.0%), 55 (21.8%), 45 (17.9%), and 26 (10.3%) patients underwent gross total resection (GTR), subtotal resection, partial resection (PR), and biopsy, respectively. Their median overall survival (OS) was 20.8 months (95% confidence interval [CI] 17.7–23.9 months) and their median progression-free survival was 12.7 months (95% CI 11.2–14.2 months). The O<SUP>6</SUP>-methylguanine-DNA methyltransferase (MGMT) promoter was methylated in 78 (34.1%) of the 229 patients assayed, and an isocitrate dehydrogenase 1 mutation was detected in 7 (6.6%) of the 106 patients analyzed. Univariate analyses showed that patient age, involvement of eloquent areas, involvement of the subventricular zone, presence of leptomeningeal seeding, Karnofsky Performance Status, extent of resection (EOR), MGMT promoter methylation, and presence of an oligodendroglioma component were prognostic of OS. Multivariate analysis showed that age, involvement of eloquent areas, presence of leptomeningeal seeding, EOR, and MGMT promoter methylation were significantly predictive of survival. OS in patients with GBM who undergo surgery followed by CCRT with TMZ is enhanced by complete resection. Other factors significantly prognostic of OS include that age, involvement of eloquent areas, presence of leptomeningeal seeding, and MGMT promoter methylation.</P>
EBV Associated Lymphomatoid Granulomatosis in 18-Year-Old Male: A Case Report
Eun Sun Jung,Eun Young Bae,Eui Jeong Roh,Eun Hee Chung,Sun Kyoung You,Jin Man Kim,Minji Kim,Yeon Jung Lim 대한소아혈액종양학회 2022 Clinical Pediatric Hematology-Oncology Vol.29 No.2
Lymphomatoid granulomatosis (LYG) is an Epstein-Barr virus (EBV)-associated lym-phoproliferative disease. It is considered a rare entity in pediatric patients. An ado-lescent male with lobar consolidation suspected of having pneumonia was resistant to antibiotics and had persistently abnormal radiographs with chest pain. The patient was diagnosed with pulmonary LYG through video-assisted thoracoscopic surgery (VATS) lung biopsy. He received eight cycles of rituximab, vincristine, cyclo-phosphamide, and prednisolone (R-CVP) but had progressive disease. As the patient developed hypogammaglobulinemia after eight courses of rituximab, he received in-travenous gamma globulin (IVIG) at regular interval. With immune augmentation ef-fect of IVIG and immune modulation treatment with prednisolone, the patient has shown no aggravation of the lung lesions. Considering its rarity, high mortality, and frequent relapses, diagnostic methods investigating the radiologic abnormalities can help in early treatment initiation.
Functional characterization of Clonorchis sinensis choline transporter
원정연,Johnsy Mary Louis,Eui Sun Roh,차석호,한진희 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.4
Clonorchis sinensis is commonly found in East Asian countries. Clonorchiasis is prevalent in these countries and can lead to various clinical symptoms. In this study, we used overlap extension polymerase chain reaction (PCR) and the Xenopus laevis oocyte expression system to isolate a cDNA encoding the choline transporter of C. sinensis (CsChT). We subsequently characterized recombinant CsChT. Expression of CsChT in X. laevis oocytes enabled efficient transport of radiolabeled choline, with no detectable uptake of arginine, α-ketoglutarate, p-aminohippurate, taurocholate, and estrone sulfate. Influx and efflux experiments showed that CsChT-mediated choline uptake was time- and sodium-dependent, with no exchange properties. Concentration-dependent analyses of revealed saturable kinetics consistent with the Michaelis–Menten equation, while nonlinear regression analyses revealed a Km value of 8.3 μM and a Vmax of 61.0 pmol/oocyte/h. These findings contribute to widen our understanding of CsChT transport properties and the cascade of choline metabolisms within C. sinensis.
Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma
Yoon, Seon-Jin,Shim, Jin-Kyoung,Chang, Jong Hee,Moon, Ju Hyung,Roh, Tae-Hoon,Sung, Kyoung Su,Lee, Ji-Hyun,Kim, Eui-Hyun,Kim, Sun Ho,Hong, Yong-Kil,Lee, Su-Jae,Huh, Yong-Min,Kang, Seok-Gu Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-
<P>The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determined. This study analyzed samples from 82 patients with pGBM who had undergone tumor removal, pathological diagnosis, and isolation of tMSLC from April 2009 to October 2014. Survival, extent of resection, molecular markers, and tMSLC culture results were statistically evaluated. Median overall survival was 18.6 months, 15.0 months in tMSLC-positive patients and 29.5 months in tMSLC-negative patients (<I>P</I> = 0.014). Multivariate cox regression model showed isolation of tMSLC (OR = 2.5, 95% CI = 1.1~5.6, <I>P</I> = 0.021) showed poor outcome while larger extent of resection (OR = 0.5, 95% CI = 0.2~0.8, <I>P</I> = 0.011) has association with better outcome. The presence of tMSLCs isolated from the specimen of pGBM is associated with the survival of patient.</P>
Moon, Ju Hyung,Kim, Se Hoon,Shim, Jin-Kyoung,Roh, Tae-Hoon,Sung, Kyoung Su,Lee, Ji-Hyun,Park, Junseong,Choi, Junjeong,Kim, Eui-Hyun,Kim, Sun Ho,Kang, Seok-Gu,Chang, Jong Hee NATIONAL HELLENIC RESEARCH FOUNDATION 2016 ONCOLOGY REPORTS Vol.36 No.2
<P>During 5-aminolevulinic acid (ALA)-guided glioblastoma multiforme (GBM) surgery, we encountered fluorescence in ventricular walls that lacked enhancement on magnetic resonance (MR) images and were free of macroscopic invasion of tumor cells. However, the meaning of ventricular wall fluorescence during 5-ALA-guided surgery is still unknown. The aim of this study was to investigate the relationship between intraoperative 5-ALA fluorescence and histopathological findings of ventricular walls free of enhancement on MR images. Nineteen patients with newly diagnosed GBM located near the lateral ventricle underwent 5-ALA fluorescence-guided surgery. During the surgery, the ventricle wall was opened and investigated with the aid of a surgical microscope equipped with optical filters to examine 5-ALA fluorescence of the ventricular wall. Twenty-five ventricular wall tissues that were apparently free of tumor involvement by MR imaging and macroscopic observation were obtained during surgery. Among the 19 cases with brightly fluorescing tumor masses, 11 patients (57.9%) exhibited 5-ALA-induced fluorescence in the ventricular wall. Of the 25 ventricular wall samples, 11 exhibited 5-ALA-induced fluorescence; upon pathologic examination, tumors were present in 5 samples (45.5%), but the remaining 6 (54.5%) were free of tumor cells. A pathologic examination revealed no tumor cells in the 14 samples that lacked 5-ALA-induced fluorescence. Our data suggest the possibility that glioma cells exhibiting 5-ALA fluorescence are present in the ventricle wall, despite no signs of tumor involvement in MR images. Further investigation of non -tumor cells from tissues with 5-ALA fluorescence is needed to understand the nature of this unexpected ventricular wall fluorescence.</P>