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Lee, Esther J.,Huh, Beom Kang,Kim, Se Na,Lee, Jae Yeon,Park, Chun Gwon,Mikos, Antonios G.,Choy, Young Bin Elsevier 2017 Progress in materials science Vol.89 No.-
<P><B>Abstract</B></P> <P>The plentiful assortment of natural and synthetic materials can be leveraged to accommodate diverse wound types, as well as different stages of the healing process. An ideal material is envisioned to promote tissue repair with minimal inconvenience for patients. Traditional materials employed in the clinical setting often invoke secondary complications, such as infection, pain, foreign body reaction, and chronic inflammation. This review surveys the repertoire of surgical sutures, wound dressings, surgical glues, orthopedic fixation devices and bone fillers with drug eluting capabilities. It highlights the various techniques developed to effectively incorporate drugs into the selected material or blend of materials for both soft and hard tissue repair. The mechanical and chemical attributes of the resultant materials are also discussed, along with their biological outcomes <I>in vitro</I> and/or <I>in vivo</I>. Perspectives and challenges regarding future research endeavors are also delineated for next-generation wound repair materials.</P>
Yu, Youngseok,Koh, Yoobin Esther,Lim, Hojoon,Jeong, Beomgyun,Isegawa, Kazuhisa,Kim, Daehyun,Ueda, Kohei,Kondoh, Hiroshi,Mase, Kazuhiko,Crumlin, Ethan J,Ross Jr, Philip N,Gallet, Jean-Jacques,Bournel, Institute of Physics 2017 Journal of Physics, Condensed Matter Vol.29 No.46
<P>The study of CO oxidation on Pt(1 1 0) surface is revisited using ambient pressure x-ray photoemission spectroscopy. When the surface temperature reaches the activation temperature for CO oxidation under elevated pressure conditions, both the <I>α</I>-phase of PtO<SUB>2</SUB> oxide and chemisorbed oxygen are formed simultaneously on the surface. Due to the exothermic nature of CO oxidation, the temperature of the Pt surface increases as CO oxidation takes place. As the CO/O<SUB>2</SUB> ratio increases, the production of CO<SUB>2</SUB> increases continuously and the surface temperature also increases. Interestingly, within the diffusion limited regions, the amount of surface oxide changes little while the chemisorbed oxygen is reduced.</P>
이상진,Alex Mammen,Esther J. Kim,김소연,박윤주,박미라,한형수,배용철,로넷,문제일 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.5
The vomeronasal organ (VNO) is a sensory organ that influences social and/or reproductive behavior and, in many cases, the survival of an organism. The VNO is believed to mediate responses to pheromones; however, many mechanisms of signal transduction in the VNO remain elusive. Here, we examined the expression of proteins involved in signal transduction that are found in the main olfactory system in the VNO. The localization of many signaling molecules in the VNO is quite different from those in the main olfactory system, suggesting differences in signal transduction mechanisms between these two chemosensory organs. Various signaling molecules are expressed in distinct areas of VNO sensory epithelium. Interestingly, we found the expressions of groups of these signaling molecules in glandular tissues adjacent to VNO, supporting the physiological significance of these glandular tissues. Our finding of high expression of signaling proteins in glandular tissues suggests that neurohumoral factors influence glandular tissues to modulate signaling cascades that in turn alter the responses of the VNO to hormonal status.
Lee, Sang Jin,Mammen, Alex,Kim, Esther J,Kim, So Yeun,Park, Yun Ju,Park, Mira,Han, Hyung Soo,Bae, Yong-Chul,Ronnett, Gabriele V,Moon, Cheil Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.5
<P>The vomeronasal organ (VNO) is a sensory organ that influences social and/or reproductive behavior and, in many cases, the survival of an organism. The VNO is believed to mediate responses to pheromones; however, many mechanisms of signal transduction in the VNO remain elusive. Here, we examined the expression of proteins involved in signal transduction that are found in the main olfactory system in the VNO. The localization of many signaling molecules in the VNO is quite different from those in the main olfactory system, suggesting differences in signal transduction mechanisms between these two chemosensory organs. Various signaling molecules are expressed in distinct areas of VNO sensory epithelium. Interestingly, we found the expressions of groups of these signaling molecules in glandular tissues adjacent to VNO, supporting the physiological significance of these glandular tissues. Our finding of high expression of signaling proteins in glandular tissues suggests that neurohumoral factors influence glandular tissues to modulate signaling cascades that in turn alter the responses of the VNO to hormonal status.</P>
Moon, Cheil,Liu, Bridget Q.,Kim, So Yeun,Kim, Esther J.,Park, Yun Ju,Yoo, Joo-Yeon,Han, Hyung Soo,Bae, Yong Chul,Ronnett, Gabriele V. Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.5
<P>Leukemia inhibitory factor (LIF), a neuropoietic cytokine, has been implicated in the control of neuronal development. We previously reported that LIF plays a critical role in regulating the terminal differentiation of olfactory sensory neurons (OSNs). Here, we demonstrate that LIF plays a complementary role in supporting the survival of immature OSNs. Mature OSNs express LIF, which may be elaborated in a paracrine manner to influence adjacent neurons. LIF null mice display more apoptotic immature neurons than do their wild-type littermates. LIF treatment of dissociated OSNs in vitro significantly reduces the apoptosis of immature OSNs. Double immunocytochemical analysis indicates that the survival of immature OSNs is dependent on the presence of LIF. LIF activates the phosphoinositide 3-kinase (PI3K) pathways and induces the expression of the antiapoptotic molecule Bcl-2 in OSNs, whereas inhibition of the PI3K pathway blocks LIF-dependent OSN survival and Bcl-2 induction. Thus, LIF plays a central role in maintaining the size and integrity of the population of immature neurons within the olfactory epithelium; this population is critical to the rapid recovery of olfactory function after injury. LIF may play a similar role elsewhere in the CNS and thus be important for manipulation of stem cell populations for therapeutic interventions. © 2008 Wiley-Liss, Inc.</P>
Lee, Seung-Yong,Housel, Lisa M.,Huang, Jianping,Wu, Lijun,Takeuchi, Esther S.,Marschilok, Amy C.,Takeuchi, Kenneth J.,Kim, Miyoung,Zhu, Yimei Elsevier Sequoia 2019 Journal of Power Sources Vol. No.
<P><B>Abstract</B></P> <P>Alpha-MnO<SUB>2</SUB> is an attractive cathode candidate for sodium-ion batteries attributed to its unique one-dimensional 2 × 2 tunnels for facile sodium-ion diffusion, in addition to its incomparable cost advantage. In particular, α-MnO<SUB>2</SUB> shows superior rate capability with silver stabilizing ions at the center of tunnels that improve electrical conductivity. In this work, we directly compare structural transformation of silver-containing α-MnO<SUB>2</SUB> nanorods (Ag<SUB>1.22</SUB>Mn<SUB>8</SUB>O<SUB>16-x</SUB> or L-Ag-HOL and Ag<SUB>1.66</SUB>Mn<SUB>8</SUB>O<SUB>16-y</SUB> or H–Ag-HOL), containing higher and lower concentrations of oxygen vacancies respectively, by transmission electron microscopy (TEM). The elaborate comparative and statistical TEM studies eliminate concerns regarding generalization errors and facilitate rational structural development of nanorods with improved functionality. It is found that sodium ions favorably diffuse through the area where oxygen vacancies are concentrated, and the samples with more silver ions and fewer oxygen vacancies (H–Ag-HOL) show more significant structural deformation with more inhomogeneous sodiation. The difference in functional electrochemistry coupled with the observed difference in inter- and intra-nanorod inhomogeneous structural evolution emphasizes the significance of the uniform electrical conductivity of the electrode. This work helps to improve the α-MnO<SUB>2</SUB> electrode material for sodium-ion batteries as well as suggesting the importance of delicate statistical approaches for TEM investigations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> H–Ag-HOL shows severe inter- and intra-nanorod inhomogeneous sodiation. </LI> <LI> H–Ag-HOL undergoes conversion reaction at earlier levels of sodiation L-Ag-HOL. </LI> <LI> Inhomogeneity of sodiation gradually increases with higher sodiation levels. </LI> <LI> Variance of TEM-EELS data emphasizes the importance of statistical TEM approach. </LI> </UL> </P>