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문석우,Ivo D. Dinov,Alen Zamanyan,Ran Shi,Alex Genco,Sam Hobel,Paul M. Thompson,Arthur W. Toga,Alzheimer’s Disease Neuroimaging Initiative 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.1
ObjectiveaaThis article investigates subjects aged 55 to 65 from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database to broaden our understanding of early-onset (EO) cognitive impairment using neuroimaging and genetics biomarkers. MethodsaaNine of the subjects had EO-AD (Alzheimer’s disease) and 27 had EO-MCI (mild cognitive impairment). The 15 most important neuroimaging markers were extracted with the Global Shape Analysis (GSA) Pipeline workflow. The 20 most significant single nucleotide polymorphisms (SNPs) were chosen and were associated with specific neuroimaging biomarkers. ResultsaaWe identified associations between the neuroimaging phenotypes and genotypes for a total of 36 subjects. Our results for all the subjects taken together showed the most significant associations between rs7718456 and L_hippocampus (volume), and between rs7718456 and R_hippocampus (volume). For the 27 MCI subjects, we found the most significant associations between rs6446443 and R_superior_frontal_gyrus (volume), and between rs17029131 and L_Precuneus (volume). For the nine AD subjects, we found the most significant associations between rs16964473 and L_rectus gyrus (surface area), and between rs12972537 and L_rectus_gyrus (surface area). ConclusionaaWe observed significant correlations between the SNPs and the neuroimaging phenotypes in the 36 EO subjects in terms of neuroimaging genetics. However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.
EPIR effect of Cu2O films by electrochemical deposition
D.W. Shi,C.J. Luo,C.P. Yang,R. Yang,H.B. Xiao,K. Barner,V.V. Marchenkov 한국물리학회 2014 Current Applied Physics Vol.14 No.9
Cuprous oxide (Cu2O) films and Cu/Cu2O/Cu/FTO sandwich structures were prepared by electrochemical deposition on conductive FTO substrates with different pH value conditions but constant deposition potential. The phase composition, crystal structure and microstructure of the Cu2O films were characterized by XRD, SEM and EDS as well as by ElectricePulseeInducedeResistance (EPIR) perturbation. In particular, the switching effects of the Cu/Cu2O/Cu/FTO device are examined in this work. The result shows that the EPIR-effect is large for the Cu/Cu2O/Cu/FTO device at room temperature and strongly related to the pH value of the solution. In both acidic and neutral conditions, for example at pH ¼ 5, 6 and 7, the EPIR effect is significant and decreases with increasing pH value. It disappears when the pH value goes further into the alkaline regime, i.e. pH ¼ 8, 9 and 10. Space charge barriers at the interface of electrode and Cu2O are used to explain the IeV characteristic of the layer structure and the EPIR-effect.
Intrinsic rotation reversal, non-local transport, and turbulence transition in KSTAR L-mode plasmas
Shi, Y.J.,Kwon, J.M.,Diamond, P.H.,Ko, W.H.,Choi, M.J.,Ko, S.H.,Hahn, S.H.,Na, D.H.,Leem, J.E.,Lee, J.A.,Yang, S.M.,Lee, K.D.,Joung, M.,Jeong, J.H.,Yoo, J.W.,Lee, W.C.,Lee, J.H.,Bae, Y.S.,Lee, S.G.,Yo International Atomic Energy Agency 2017 Nuclear fusion Vol.57 No.6
<P>Experiments of electron cyclotron resonance heating (ECH) power scan in KSTAR tokamak clearly demonstrate that both the cutoff density for non-local heat transport (NLT) and the threshold density for intrinsic rotation reversal can be determined by the collisionality. We demonstrate that NLT can be affected by ECH, and the intrinsic rotation direction follows the changes of NLT. The cutoff density of NLT and threshold density for rotation reversal can be significantly increased by ECH. The poloidal flow of turbulence in core plasma is in the electron and the ion diamagnetic direction in ECH plasmas and high density OH plasma, respectively. The auto-power spectra of density fluctuation are almost the same in the outer region for both ECH and OH plasmas. On the other hand, the divergence in density fluctuation spectra at high frequency range between OH and ECH plasma is clearly observed in core region. The features of linear confinement and saturated confinement also appeared in ECH plasma, which is similar to the linear ohmic confinement (LOC) mode and saturate ohmic confinement (SOC) mode. All these observations in macroscopic parameters and micro fluctuations suggest a possible link between the macro phenomena and the structural changes in turbulence mode.</P>
Isostructural metal-insulator transition in VO<sub>2</sub>
Lee, D.,Chung, B.,Shi, Y.,Kim, G.-Y.,Campbell, N.,Xue, F.,Song, K.,Choi, S.-Y.,Podkaminer, J. P.,Kim, T. H.,Ryan, P. J.,Kim, J.-W.,Paudel, T. R.,Kang, J.-H.,Spinuzzi, J. W.,Tenne, D. A.,Tsymbal, E. Y. American Association for the Advancement of Scienc 2018 Science Vol.362 No.6418
<P><B>Separating structure and electrons in VO<SUB>2</SUB></B></P><P>Above 341 kelvin—not far from room temperature—bulk vanadium dioxide (VO<SUB>2</SUB>) is a metal. But as soon as the material is cooled below 341 kelvin, VO<SUB>2</SUB> turns into an insulator and, at the same time, changes its crystal structure from rutile to monoclinic. Lee <I>et al.</I> studied the peculiar behavior of a heterostructure consisting of a layer of VO<SUB>2</SUB> placed underneath a layer of the same material that has a bit less oxygen. In the VO<SUB>2</SUB> layer, the structural transition occurred at a higher temperature than the metal-insulator transition. In between those two temperatures, VO<SUB>2</SUB> was a metal with a monoclinic structure—a combination that does not occur in the absence of the adjoining oxygen-poor layer.</P><P><I>Science</I>, this issue p. 1037</P><P>The metal-insulator transition in correlated materials is usually coupled to a symmetry-lowering structural phase transition. This coupling not only complicates the understanding of the basic mechanism of this phenomenon but also limits the speed and endurance of prospective electronic devices. We demonstrate an isostructural, purely electronically driven metal-insulator transition in epitaxial heterostructures of an archetypal correlated material, vanadium dioxide. A combination of thin-film synthesis, structural and electrical characterizations, and theoretical modeling reveals that an interface interaction suppresses the electronic correlations without changing the crystal structure in this otherwise correlated insulator. This interaction stabilizes a nonequilibrium metallic phase and leads to an isostructural metal-insulator transition. This discovery will provide insights into phase transitions of correlated materials and may aid the design of device functionalities.</P>
Toroidal rotation profile structure in KSTAR L-mode plasmas with mixed heating by NBI and ECH
Shi, Y.J.,Ko, S.H.,Kwon, J.M.,Ko, W.H.,Diamond, P.H.,Yi, S.,Ida, K.,Lee, K.D.,Jeong, J.H.,Seo, S.H.,Hahn, S.H.,Yoon, S.W.,Bae, Y.S.,Terzolo, L.,Yun, G.S.,Bitter, M.,Hill, K. IOP 2016 Nuclear fusion Vol.56 No.1
<P>The structure of the toroidal rotation profile with mixed heating by neutral beam injection (NBI) and electron cyclotron resonance heating (ECH) has been investigated in KSTAR L-mode plasmas. ECH with varying resonance layer positions was used for heating a mix control. The experimental results show that ECH causes a counter-current rotation increment both for off-axis and on-axis ECH heating. For L-mode plasmas, off-axis ECH produces larger counter-current rotation than on-axis ECH. Analysis of ion heat and momentum transport for the ECH L-mode plasmas shows that the electron temperature gradient is the main reason for the degradation of ion heat confinement and also the main driving force for the non-diffusive momentum flux. As a possible mechanism for the counter-current intrinsic torque with ECH, the transition of the turbulence mode from ion temperature gradient (ITG) to the trapped electron mode (TEM) with the resulting sign change of turbulence driven residual stress is suggested. A linear gyro-kinetic analysis shows the ITG → TEM transition occurs in a localized region during ECH injection, and the trend of TEM excitation is consistent with the observed macroscopic trend of the toroidal rotation.</P>