제1요수 불완전 하반신 마비 환자에서의 기능적 전기자극에 의한 훈련 증례보고

최현주,이수영,김종문,강선화,정순열,강곤,정진상 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Functional electrical stimulation(FES) is known to increase muscle bulk and strength and prevent muscle atrophy in complete paraplegic patients. And other benefits include peripheral adaptations which improve muscle endurance, girth, and appearance, as well as central circulatory adaptation which enhances aerobic(cardiopulmonary) capacity. Good candidates for FES include spinal cord injured patients who have clinically complete upper motor neuron lesion between T4-T12. But we experienced incomplete L1 paraplegic patient who has improved maximal knee extension power, endurance, circumference and cross-sectional area of the thigh and the shank after FES-induced exercise for 44 weeks. So we recommend more trial of the FES-induced exercise to not only complete but also incomplete lumbar paraplegic patients.

대용섬유자원으로써 어저귀를 이용한 한지제조 (제2보) : 인피 및 목질부 섬유를 이용한 한지 제조 Manufacturing of The Hanjis Made from Bast Fiber and woody core fibers

정선화,조남석,최태호 한국목재공학회 2004 목재공학 Vol.32 No.1

생장속도가 빨라서 단위면적당 Biomass의 생산량이 많은 어저귀(Indian mallow, Abutilon avicennae G.)를 원료로 하여 펄프화하였으며, 제조한 한지의 물리적·기계적·현미경적 특성에 관하여 비교 검토하였다. 제조한 한지의 특성을 살펴보면 광학적, 강도적 현미경적인 특성에서 설포메틸 펄프화법이 우수한 결과를 나타냈고, 장섬유인 인피부 펄프에 대한 단섬유인 목질부 펄프의 혼입량 증가에 따른 변화에 있어 지질(밀도, 백색도, 불투명도, 지합)의 변화는 점차 증가했으나, 강도는 감소하는 경향을 나타냈다. This study was carried out to investigate the sheet properties of Indian mallow Hanji, made by different pulping methods, such as alkali and sulfomethylated pulpings, and different stock compositions, various mixing ratios of bast fiber and woody core fibers. Indian mallow hanjis made from the sulfomethylated pulps had higher brightness and sheet strength than the alkali pulps. It was found that the brightness of sulfomethylated pulp was enough high without an extra-bleaching. In the mechanical properties of Indian mallow hanjis mixed with bast fiber and woody core stalk pulps, the sheet strength were decreased as wood core pulps contents were increased. The sheet formation were increased as the increase of woody core pulps contents, while the sheet strength decreased Although the sulfomethylated pulping resulted in higher pulp yield, no morphological differences of fiber surfaces were shown as compared to the different pulping methods.

질소분압에 따른 TaNx coating층의 미세조직 연구

김선화,최용락 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.3 No.3

TaNx film were fabricated for this research by the reactive magnetron sputtering process. In order to improve TCR, it was investigated the transformation of coated TaNx film. The variables were the N₂/Ar fraction and the thermal heat-treatment. The electrical resistance and the TCR of specimen were measured. It was observed the microstructure change under thermal heat-treatment by XRD experiment. Also the morphology of TaNx film was observed by SEM. As a result, TCR was stabilized when N₂/Ar fraction were 0.166 to 0.25. The phases of as-coated TaNx film were Ta, TaN, β-Ta and amorphous. The new phases, Ta₄N and Ta₃N?? were formed after thermal heat-treatment. As the ratio of nitrogen gas was increased, the morphology of the layer was changed to a discontinuous island particle. These results were consistent with results of electrical resistance change.

대용섬유자원으로써 어저귀를 이용한 한지제조(제1보) : 어저귀의 건물 생산량 및 펄프화 특성 Productivity and Pulping Characteristics of Indian Mallow

정선화,조남석,최태호 한국목재공학회 2002 목재공학 Vol.30 No.2

본 실험은 산림자원의 감소 예방과 지구의 환경보존을 위해서 생장이 빠르고 펄프원자재로 활용할 수 있는 비목재 섬유작물을 도입하는 것을 목적으로 하고 있다. 또한 부족한 한지의 원료인 닥나무를 수입하고 있는 실정에서, 국내에서 자생하고 있는 비목재섬유로 한지를 제조함으로써 수입대체 및 원가절감 등 일석이조의 효과를 거둘 수 있다. 이에 불량한 환경조건에서도 생육이 왕성한 어저귀(Abutilon avicennae G.)를 재배하여 그간의 진보된 펄프 제조기술을 적용하여 새로운 제지용 원료로 개발함으로써 부족한 원자재는 물론이거니와 국내 부존자원 이용의 극대화를 꾀하고자 실시하였다. 또한 폐기처리되는 농산물의 이용극대화를 꾀하기 위해 전목펄프화를 실시하였다. 그 결과 어저귀는 생장속도가 빠르고 수확기가 짧으며 집약적 재배 및 관리가 가능하여 단위면적당 최대의 수확량을 올릴 수 있었다. 어저귀 인피부의 섬유장은 2.4㎜로써 목재섬유 중 소나무와, 비목재섬유 중 케나프와 매우 유사한 결과를 보여주었고, 화학성분의 분석결과 어저귀 섬유는 추출성분의 함량이 높고 리그닌이 적은 것이 특징적으로 나타났다. 펄프화와 관련하여 인피부는 150℃에서 48∼57%, 전간부는 170℃에서 43∼51%의 높은 수율을 나타냈고, 설포메틸 펄프화법의 수율이 더 높게 나타났다. 펄프의 탈리그닌율도 두가지 펄프화법 모두 90% 이상의 높은 탈리그닌율을 나타내었다. Indian mallow is characterized by the rapid growth and high harvest of the fibrous materials. This study was carried out to investigate the sheet properties of Hanji using Indian mallow, made by different pulping methods, such as alkali and sulfomethylated pulpings and different stock compositions, various mixing ratios of bast fiber, woody core and whole stalk fibers. The results from this study were summarized as follows. The length and width of the bast fibers were 1.40∼4.30㎜(av. 2.35㎜) and 9.2∼26.4㎛(av. 18.3㎛), respectively. The cell wall thickness was 4.0∼11.5㎛(av. 7.7㎛). Runkel ratio, flexibility coefficient and fiber length/fiber width ratio were 1.38, 0.42 and 128 respectively. Bast fiber and whole stalk were cooked by alkali and sulfomethylated methods. Sulfomethylated pulping resulted in superior pulp in terms of yield and quality as compared with those of alkali pulping. The pulp yields of bast fiber was higher than those of whole stalk.

Inhibitory Effect of Cordycepin on Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

Cordycepin separated from Cordyceps militaris is a major physiologic active component in Cordyceps militaris. The platelet aggregation is stimulated by Ca^(2+), which is either mobilized from intracellular endoplasmic reticulum or transported from extracellular space. cGMP antagonizes the actions of Ca^(2+). Based on these facts, we have investigated the effects of cordycepin on the mobilization of Ca^(2+) and the production of cGMP on collagen (10 ㎍/ml)-induced human platelet aggregation. Cordycepin potently stimulated the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. Cordycepin (500 μM) inhibited also the collagen-induced human platelet aggregation in the presence both 1 mM and 2 mM of CaCl_(2). These are in accord with the results that cordycepin inhibited the Ca^(2+)-influx on collagen-induced human platelet aggregation. These results suggest that cordycepin decrease the intracellular Ca^(2+) concentration to inhibit collagen-induced human platelet aggregation. Besides, cordycepin increased the level of cGMP on collagen-induced human platelet aggregation. This result is related with the decrease of intracellular Ca^(2+) concentration, because cGMP inhibits the mobilization of Ca^(2+). In addition, cordycepin inhibited the human platelet aggregation induced by LY-83583, inhibitor of guanylate cyclase. This result suggested that cordycepin inhibit the platelet aggregation by stimulating the activity of guanylate cyclase. In conclusion, we demonstrated that cordycepin might have the antiplatelet function by inhibiting Ca^(2+)-mobilization via the stimulation of the production of cGMP.

Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.

강우시 유입하천이 화성호에 미치는 기여도 파악

이상은 ( Sang Eun Lee ),안태웅 ( Tae Woong Ahn ),최이송 ( I Song Choi ),최선화 ( Seon Hwa Choi ),오종민 ( Jong Min Oh ) 한국물환경학회 ( 구 한국수질보전학회 ) 2010 공동 추계학술발표회 Vol.2010 No.-

Genomic Sequence Variability of the Prion Gene (PRNP) in Korean Cattle

Choi, Sang-Haeng,Chae, Sung-Hwa,Choi, Han-Ho,Kim, Jeong-Seon,Kang, Bo-Ra,Yeo, Jung-Sou,Choi, Inho,Lee, Yong-Seok,Choy, Yun-Ho,Park, Hong-Seog Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.5

In this study, we have investigated sequence variants in the PRNP gene of 20 individuals belonging to the Korean cattle, and have analyzed and compared genetic features between varieties of other cattle breeds. Of the 73 sequence variants identified in Korean cattle, 27 were identified for the first time in this study, whereas 46 of these polymorphisms had previously been isolated. We discovered a 2.6 kb SNP hot spot region localized on the putative promoter region of the PRNP gene. Furthermore, the copy numbers of the octapeptide repeat (24 bp indel) which is detected on the coding sequence (CDS) of the PRNP exhibited a completely homozygous 6/6 genotype which is dominant in other cattle breeds. We also characterized a new 19 bp/10 bp allele located on the putative promoter region of the PRNP gene, which represented 0.71 in allele frequency. To the best of our knowledge, this report is the first to address polymorphisms of the PRNP gene structure in Korean cattle in which BSE has yet to be discovered. Therefore, our findings may prove useful with regard to our current understanding of allelic diversity in bovine species, and may also provide new insights into the genetic factors associated with susceptibility or resistance to BSE.

Degradation of Prochloraz by Rice Bakanae Disease Pathogen Fusarium fujikuroi with Differing Sensitivity a Possible Explanation for Resistance Mechanism

( Seon Hwa Kim ),( Myung Ryeol Park ),( Young Cheol Kim ),( Se Weon Lee ),( Byung Ryeol Choi ),( Si Woo Lee ),( In Seon Kim ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.4

The fungicide prochloraz was subjected to degradation by the pathogen causing rice Bakanae disease, Fusarium fujikuroi, in order to gain an insight into the mechanisms of sensitivity and resistance to the fungicide. Growth-inhibiting assays of pathogens conducted on potato dextrose agar (PDA) plates by a paper-disc agar-diffusion method. Significant growth inhibition of the sensitive strain CF106 was observed at the recommended treatment level of prochloraz, whereas negligible growth inhibition of the resistant strain CF245 was observed at the same treatment level. The strain CF245 was shown to be able to grow on PDA with 500 mg/L of the fungicide, which is significantly higher than its recommended treatment level. Growth-inhibiting assays of pathogens were also conducted in potato dextrose broth (PDB) medium supplemented with prochloraz at different concentrations, measuring their biomass weights over the incubation period. Significant growth inhibition was observed in the strain CF106 at a level of 0.5 mg/L, but negligible growth inhibition was observed in the strain CF245 at the same treatment level with the strain CF106. The strain CF245 could grow in PDB supplemented with 1.0 mg/L of prochloraz. The degradation of prochloraz by the two strains was evaluated by gas liquid chromatography and mass spectrometry analyses. The strain CF245 completely degraded 1.0 mg/L of prochloraz in 5 days after incubation, whereas no degradation of prochloraz was observed by the strain CF106 at the same treatment level. Liquid chromatography Q-TOF MS detected N-(2-(2,4,6-trichlorophenoxy)ethyl)propan-1-amine as a major degradation product of prochloraz by the strain CF245. These results indicated that the degradation of prochloraz may account for the reduced sensitivity of the strain CF245 to prochloraz.

LiI-Doped Sulfide Solid Electrolyte: Enabling a High-Capacity Slurry-Cast Electrode by Low-Temperature Post-Sintering for Practical All-Solid-State Lithium Batteries

Choi, Seon-Joo,Choi, Sun-Hwa,Bui, Anh Dinh,Lee, You-Jin,Lee, Sang-Min,Shin, Heon-Cheol,Ha, Yoon-Cheol American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.37

<P>All-solid-state lithium batteries (ASSLBs) based on sulfide solid electrolytes (SEs) have received great attention because of the high ionic conductivity of the SEs, intrinsic thermal safety, and higher energy density achievable with a Li metal anode. However, studies on practical slurry-cast composite electrodes show an extremely limited battery performance than the binder-free pelletized electrodes because of the poor interfacial robustness between the active materials and SEs by the presence of a polymeric binder. Here, we employ a low-temperature post-sintering process for the slurry-cast composite electrodes in order to overcome the binder-induced detrimental effects on the electrochemical performance. The LiI-doped Li<SUB>3</SUB>PS<SUB>4</SUB> SEs are chosen because the addition of iodine not only improves the Li-ion conductivity and Li metal compatibility but also lowers the glass-transition and crystallization temperatures. Low-temperature post-sintering of composite cathodes consisting of a LiNi<SUB>0.6</SUB>Co<SUB>0.2</SUB>Mn<SUB>0.2</SUB>O<SUB>2</SUB>-active material, LiI-doped Li<SUB>3</SUB>PS<SUB>4</SUB> SE, polymeric binder, and conducting agent shows a significantly improved electrochemical performance as compared to a conventional slurry-cast electrode containing pre-annealed SEs. Detailed analyses by electrochemical impedance spectroscopy and galvanostatic intermittent titration technique confirm that post-sintering effectively reduces the interfacial resistance and enhances the chemomechanical robustness at solid-solid interfaces, which enables the development of practical slurry-cast ASSLBs with sulfide SEs.</P> [FIG OMISSION]</BR>