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        Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

        Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

        Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

      • KCI등재

        대전문학사 서술의 현황과 전망

        김화선(Kim, Hwa??Seon) 한국비평문학회 2013 批評文學 Vol.- No.50

        본 논문은 지역문학의 정체성을 사유하고 한국문학사 속에서 대전문학이 갖는 의미를 고민하는 작업의 일환으로 대전문학사가 형성되는 그 기원의 지점을 탐색하고 있다. 이를 위해 기존의 지역문학 논의가 놓치고 있는 지역 문학사 기술과 관련된 다양한 담론들의 양상을 꼼꼼하게 점검하면서 해방공간을 중심으로 상이한 로컬 역사들이 서로 만나면서 충돌하고 있는 상황을 구체적으로 살펴보고 있다. 문학사는 엄격한 실증이 기초가 되어야 함에도 불구하고 그간의 대전문학사는 자료 수집의 곤란함이 야기한 실질적인 어려움과 연구자들의 실증적인 태도의 부재 등 여러 가지 이유로 인해 오류를 반복하고 재생산해왔다. 이 글은 지금까지 논의된 대전문학사 서술의 오류를 구체적 자료를 통해 점검하고 문학사 서술이 기억에 의존할 때 왜곡될 수밖에 없는 양상을 분석하여 다음의 결과를 도출하였다. 우선 대전문학사 서술에 있어 「향토」, 「동백」과 관련된 오류가 존재하고 있음을 확인하였다. 또한 기억과 망각이 맞물린 해방공간의 대전문학장이 이데올로기적 투쟁으로 얼룩져 좌익 성향의 잡지인 「현대」와 「신성」이 문학사에서 배제되어 왔음을 알 수 있었다. 「향토」?「동백」-「호서문학」으로 이어지는 순수문학의 흐름이 주된 경향으로 자리 잡은 기존의 대전문학사 서술에서 참여파 진보문인들의 목소리는 침묵당해 왔던 것이다. 대전문학사 서술의 오류를 지적하고, 해방기 진보적인 성향의 「현대」와 「신성」을 제외하고 만들어진 대전문학의 기원과 정체에 문제제기를 함으로써 소외되고 망각된 지역문학의 흐름을 복원해야 하는 필요성을 제시하고 있다는 점에서 본 논문의 의의를 찾을 수 있다. This paper aims to analyze the origin of the history of the local literature in Daejeon, especially focused on the liberation period for agonizing the meaning of Daejeon literature under the history of Korean literature. This paper examines diverse discourses about situations of the history of the local literature and different conditions of local history. Though the history of literature is based in the actual proof materials, the history of Daejeon literature has reproduced many errors because of troubles of data collection and non-positive attitudes of researchers. The results of this thesis are listed below. First, this paper found out description"s mistakes of the history of Daejeon literature specially in Hyangto(향토) and Dongback(동백). And the field of Daejeon literature on the liberation period was stained with an ideological conflict, therefore Hyundae(현대) and Sinsung(신성) which were left-wing literary magazines was totally excluded in the history of the local literature in Daejeon. Then the flow of history of Daejeon literature has become a tendency of pure literature in Hyangto(향토)-Dongback(동백)-Hosemunhak(호서문학). This paper has a literary significant meanings for finding errors in the history of Daejeon literature and raising the issue of identity and origin of it.

      • 저강도 펄스형 초음파를 이용한 개의 슬개골 탈구 치료 효과

        조성진,김남수,김화영,김선균,이성호,김병수 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

        The effect of low-intensity ultrasonography on dislocation of the patella and fracture healing is controversial, and current management of that does not generally involve the use of ultrasound therapy. Nine patients with dislocation of the patella were treated with low-intensity ultrasonography(l5 mW/㎠, 1∼3.3 MHz) per 10-15 min/days, with an interval of 3 days during the last 3 weeks, at Family Animal Hospital(in Kunsan city). Ultrasound therapy may be beneficial to dislocation of the patella and healing. This finding is of considerable importance in that treatment with a low-intensity pulsed ultrasound signal may reduce healing time and could yield substantial cost savings and decreases in disability associated with delayed healing of dislocation of the patella.

      • 자기조절 학습 수준과 웹에서의 학습자-자료 상호작용과의 관계 연구

        김현배,이선화 부산교육대학교 교육대학원 2000 논문집 Vol.2 No.-

        The purpose of this study is to examine the relation of level of self-regulated learning and learner-content interaction in Web-based instruction. Analysis on the difference of learner-content interaction result shows significant statistical differences between the level of self-regulated learning of amount of references, that of relevant references and achievement. This study shows that the levels of self-regulated learning in Web-based instruction are primary variables on learner-content interaction. Especially, the higher level self-regulated learning group shows more activities in learner-content interaction while the lower level self-regulated learning group shows less. So the Web-based instruction can provide the higher level self-regulated learning group with better environment. And, according to the fact that the higher self-regulated learning students have, the more students activate learner-content interaction, it suggest that teachers would design and present teaching-learning environment for students to use actively self-regulated learning.

      • Procast를 이용한 AISI 316합금의 주조방안 연구

        김기선,김선화 순천향대학교 부설 산업기술연구소 2003 순천향 산업기술연구소논문집 Vol.9 No.1

        In order to improve the casting process of a steel casting, the casting design method of AISI 316 alloy was investigated using a Procast. The design for a casting and a gate system were performed by solidworks. The analysis of solid fraction, solidification time, shrinkage and pore for AISI 316 models have been done with a Procast. As a result of solidification time, steep thermal gradient was observed where the thickness of casting change. The probability of macrocrack formation increased at casted area between large head feeders because of large cooling rate difference. Shrinkage was predicted around head feeders with medium thermal gradient. It were very important to increase the molten pressure and to maintain a gate with smooth curvature in order to get a good flow. The larger head feeder was, the less directional solidification was. Head feeder, especially it's volume and location, gave an strong influence on the casting defects.

      • 일부 응급구조과 학생과 간호과 학생의 안락사에 대한 태도조사 연구

        김미선,박미화,황선영 한국응급구조학회 2002 한국응급구조학회지 Vol.6 No.1

        This descriptive study was conducted to identify the attitude toward euthanasia of EMT and nursing students and to compare their attitude before and after clinical practice. The convenience sample was comprised of 40 first grade and 40 second grade EMT students attended at G college in G-city, and 40 first grade and 40 third grade nursing students attended at C college in C-province. The variable was tested with an euthanasia attitude scale developed by Kim Ae Kyoung(2001). The valid responses were obtained and analyzed by using SPSS PC+ from November 25 to December 6.2002. The results showed that most of the respondents agreed to have positive attitude toward euthanasia in terms of client's right and client's quality of life. Also, they thought that euthanasia should be legalized and the right to die with dignity should be guaranteed. The EMT respondents having a clinical experience showed significantly higher score than respondents having no experience in the subarea of medical ethics and nursing respondents who had a clinical practice showed significantly higher score than others no experience in the subarea of quality of life. But, the other sub-areas had no significant difference between the respondents before and after clinical practice.

      • 질소분압에 따른 TaNx coating층의 미세조직 연구

        김선화,최용락 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.3 No.3

        TaNx film were fabricated for this research by the reactive magnetron sputtering process. In order to improve TCR, it was investigated the transformation of coated TaNx film. The variables were the N₂/Ar fraction and the thermal heat-treatment. The electrical resistance and the TCR of specimen were measured. It was observed the microstructure change under thermal heat-treatment by XRD experiment. Also the morphology of TaNx film was observed by SEM. As a result, TCR was stabilized when N₂/Ar fraction were 0.166 to 0.25. The phases of as-coated TaNx film were Ta, TaN, β-Ta and amorphous. The new phases, Ta₄N and Ta₃N?? were formed after thermal heat-treatment. As the ratio of nitrogen gas was increased, the morphology of the layer was changed to a discontinuous island particle. These results were consistent with results of electrical resistance change.

      • 팔라디움 촉매하에서 산염화물과 유기주석의 커플링 반응

        김두화,박정환,한도수,허선아,김성현,조성동 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1

        The reaction of Asymmetrical organotins with acid chlorides in the presence of Benzylbis (triphenylphosphine) palladium(Ⅱ) chloride gave good yields of ketones in chloroform.

      • 급랭응고한 Mg-Zn-Ca-Si계 합금의 열안정성에 관한 연구

        김태봉,김선화 순천향대학교 부설 산업기술연구소 2000 순천향 산업기술연구소논문집 Vol.6 No.1

        Melt spinning process was used to prepare the rapidly solidified ribbons of Mg-6Zn-5Ca(wt%) alloys with 1, 2 wt% Si. In present work, SEM, EDS, XRD, and microhardness test were performed to investigate the characteristics of the ribbons. The microhardness of the ribbons according to Si content decreased slowly since the content of MgCaSi precipitates in air side of ribbons increased. The Mg-6Zn-5Ca-1Si melt-spin ribbon heat-treated at 150 ℃ and 1hr showed the maximum microhardness and then its microhardness decreased slowly above 150 ℃.For the ribbon of alloy with 2 wt% Si, its hardness increased up to 200℃ and then decreased rapidly. As the content of Si and the heat-treatment temperature increased, the content of MgCaSi formed initially in air side increased. The present result showed that the addition of Si to Mg-6Zn-5Ca alloys decreased the microhardness of the ribbons and did not improve them mechanically even after aging.

      • 급랭응고된 Al-Fe계 합금의 열안정성에 관한 연구

        김선화 순천향대학교 1992 논문집 Vol.15 No.3

        The main purpose of this paper was to investigate the change of rapidly solidified microstructures and dispersoid behavior according to heat-treatment in Al-Fe-V-Si and Al-Fe- Cr-Y alloys. The rapidly solidified microstructure of the Al-Fe-V-Si alloy was microdendritic structure at wheel contact area and cell structure at air contact area. Subcell structure was observed in the Al-Fe-Cr-Y alloy. instead of tangled dislocation. (111) preferred orientation was formed at both alloys The main role of the other elements seems to alter the rapidly solidified microstructure and the kinetics of precipitataion in the aluminum alloys. Decomposition of the Al-Fe-V-Si alloy occurred at about 350℃. This alloy exhibited excellent thermal stability at elevated temperature. Thermal stability of the Al-Fe-Cr-Y alloy was less than that of the Al-Fe-Cr-Y alloy.

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