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( Sung Min Kim ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Min Seok Hur ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Psoriasis is an inflammatory disease, characterized by erythematous papules or plaques with white scale. Risk of cardiovascular diseases is elevated in patients with psoriasis, and systemic treatments of psoriasis may lower cardiovascular events. Objectives: This study was aimed to assess the association between the rates of cardiovascular diseases and systemic treatments of psoriasis. Methods: This nationwide population-based cohort study analyzed the data of patients with psoriasis using National Health Insurance Service Database. The database was collected from 2006 to 2018 in Korea and a total of 1,201,778 patients with psoriasis over 20 years old were included. In this study, the patients who have never received systemic therapy were defined as mild. The patients were classified as moderate to severe, if they had received any systemic treatments such as methotrexate, cyclosporine, acitretin, phototherapy, or biologics. Results: Overall cumulative incidences for major adverse cardiovascular events (MACEs) were 7.00, 3.17, 2.37, 0.83, and 3.61 for cyclosporine, methotrexate, phototherapy, biologics, and mild group, respectively. Conclusion: The therapeutic modalities in psoriasis were related to cardiovascular outcomes in this study. Methotrexate, phototherapy, and biologics tend to lower the rate of cardiovascular events. The randomized trials are needed to evaluate the effectiveness of systemic antipsoriatic treatments and cardiovascular safety.
( Sang Yoon Jeon ),( Ji Hyun Choe ),( Sang Eun Lee ),( Jae Hong Park ),( Si Ra Bang ),( Yong Han Kim ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.4
Surgical excision was performed on a 30-years old woman with a painful mass on her left thigh. The pathologic findings on the mass indicated fibromatosis. After the operation, she complained of allodynia and spontaneous pain at the operation site and ipsilateral lower leg. We treated her based on postoperative femoral neuropathy, but symptom was aggravated. We found a large liposarcoma in her left iliopsoas muscle which compressed the lumbar plexus. In conclusion, the cause of pain was lumbar plexopathy related to a mass in the left iliopsoas muscle. Prompt diagnosis of acute neuropathic pain after an operation is important and management must be based on exact causes.
( Sang Woong Youn ),( Bo Ri Kim ),( Joo Heung Lee ),( Hae Jun Song ),( Yong Beom Choe ),( Ji Ho Choi ),( Nack In Kim ),( Kwang Joong Kim ),( Jai Il Youn ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Background: The development of therapies for psoriasis has led to the need for a new strategy to the treatment of patients with moderate-to-severe psoriasis. New consensus guidelines for psoriasis treatment have been developed in some countries, some of which have introduced treatment goals to determine the timing of therapeutic regimens for psoriasis. Objective: To investigate the opinions held by Korean dermatologists who specialize in psoriasis about treatment goals, and to compare these with the European consensus. Methods: Korean dermatologists who specialize in psoriasis were asked 11 questions about defining the treatment goals for psoriasis. The questionnaire included questions about the factors used to classify the severity of psoriasis, defining the induction and maintenance phases of psoriasis treatment, defining treatment responses during the induction phase, and defining treatment responses during the maintenance phase. Results: The Korean consensus showed responses that were almost similar to the European consensus, even without using the Delphi technique, which uses repeated rounds of questions to reach a consensus. Only one response that related to psoriasis severity in the context of the quality of patients` lives differed from the European consensus. Conclusion: The concept of using treatment goals in the treatment of moderate-to-severe psoriasis can be applied to Korean psoriasis patients. Since a tool for assessing the quality of patients` lives is not commonly used in Korea, the development of a simple, rapidly completed, and region-specific health-related quality of life assessment tool would enable treatment goals to be used in routine clinical practice. (Ann Dermatol 27(2) 184∼189, 2015)
( Yong Beom Choe ),( Chul Jong Park ),( Dae Young Yu ),( Youngdoe Kim ),( Hyun Jeong Ju ),( Sang Woong Youn ),( Joo-Heung Lee ),( Byung Soo Kim ),( Seong Jun Seo ),( Seok-Kweon Yun ),( Joonsoo Park ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.1
Background: Psoriasis and psoriatic arthritis (PsA) are included in the group of immune-mediated inflammatory diseases (IMIDs) caused by systemic inflammation; however, indicators for monitoring inflammatory activity in patients with psoriasis, such as the Psoriasis Area and Severity Index (PASI), are limited. Objective: To determine whether the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire can be used to monitor disease activity in patients with psoriasis. Methods: This was a multicenter, noninterventional, cross-sectional study. Demographic factors and PASI and PASE scores were collected to investigate associations between each. Results: PASE data were available for 1,255 patients, of whom 498 (39.7%) had a score of ≥37. Compared with the group with PASE score <37, the group with score ≥37 had a higher proportion of women (34.9% vs. 48.8%, p<0.0001), older mean age at diagnosis (36.4 vs. 41.7 years, p<0.0001), more severe disease activity using PASI and body surface area measures (p=0.0021 and p=0.0008, respectively), and higher mean body mass index (23.7 vs. 24.1, p=0.0411). In a multiple linear regression model, PASE score was positively associated with cutaneous disease activity (p<0.0001). Conclusion: After risk-adjustment, PASE was positively associated with PASI, which suggests that PASE can be sensitive to disease activity. Since psoriasis is regarded as one of the IMIDs, PASE may be utilized as a tool not only to screen PsA but also to monitor disease activity. (Ann Dermatol 31(1) 29∼36, 2019)
Choe, Chang-Yong,Kim, Jung-Gon,Cho, Sang-Rae,Son, Dong-Soo,Kim, Young-Keun,Balasubramanian, S,Choe, Sang-Yong,Rho, Gyu-Jin Blackwell Verlag GmbH 2006 Reproduction in domestic animals Vol.41 No.1
<P>Contents</P><P>The success of AI technology is based on both semen quality and freezing process. In order to establish the semen freezing techniques in Korean native bucks, factors affecting the success were evaluated in the present study. Semen collected by electro-ejaculation from bucks during four distinct seasons was evaluated for semen volume and pH, sperm motility and survivability. The semen volume, concentration and total cell were higher in spring, summer and less in winter. Yet, there were no seasonal differences in the proportional data of live sperm, motility score and pH of semen among seasons. The percentage of live sperm after thawing was found to increase with increased concentration of lactose in Tris-Egg yolk-glycerol (TY-G), being highest in TY-G supplemented with 180 m<SMALL>M</SMALL> lactose (TYL180-G), but did not differ between TY-G and TYL120-G. Sperm motility was enhanced by employing 2.0 h equilibration time with rapid freezing method. In conclusion, semen could be frozen with high success rates for further use of AI in breeding techniques and to preserve the Korean native bucks.</P>
Choe, Ju-Hui,Kim, Hack-Youn,Choi, Yun-Sang,Han, Doo-Jeong,Choi, Ji-Hun,Kim, Yong-Jae,Kim, Cheon-Jei Korean Society for Food Science of Animal Resource 2011 한국축산식품학회지 Vol.31 No.6
This study was conducted to evaluate the antioxidant effects of pumpkin leaf extracted using a 50% ethanol on ground pork during storage. The pumpkin leaf extracts were added at concentrations of 0.05 (PE-0.05), 0.1 (PE-0.1), and 0.2% (PE-0.2) to ground pork, and 0.05% of ascorbic acid (As-0.05) was added as a control. Each sample was collected after 1, 4, 7, and 10 d of storage and the pH, total viable counts (TVC), conjugated dienes (CD), free fatty acids (FFA), and thiobarbituric reaction substance (TBARS) values were measured. The pH of the pork samples decreased until day 7, and then increased thereafter, except for the control and PE-0.05 sample. Lower CIE $a^*$ values were observed for pork samples containing PE relative to As-0.05 at increasing storage time (p<0.05). The addition of PE decreased the TVC, CD, FFA and TBARS values levels in the ground pork when compared to the control during 10 d of storage. These results indicate that PE can produce notable effects on meat products, such as inhibiting lipid oxidation and discoloration.
Choe, Jeong-Dong,Yeo, Kyoung-Hwan,Ahn, Young-Joon,Lee, Jong-Jin,Lee, Se-Hoon,Choi, Byung-Yong,Sung, Suk-Kang,Cho, Eun-Suk,Lee, Choong-Ho,Kim, Dong-Won,Chung, Il-Sub,Park, Dong-Gun,Ryu, Byung-Il The Institute of Electronics and Information Engin 2006 Journal of semiconductor technology and science Vol.6 No.2
We propose a damascene gate FinFET with Si nanocrystals implemented on bulk silicon wafer for low voltage flash memory device. The use of optimized SRON (Silicon-Rich Oxynitride) process allows a high degree of control of the Si excess in the oxide. The FinFET with Si nanocrystals shows high program/erase (P/E) speed, large $V_{TH}$ shifts over 2.5V at 12V/$10{\mu}s$ for program and -12V/1ms for erase, good retention time, and acceptable endurance characteristics. Si nanocrystal memory with damascene gate FinFET is a solution of gate stack and voltage scaling for future generations of flash memory device. Index Terms-FinFET, Si-nanocrystal, SRON(Si-Rich Oxynitride), flash memory device.