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Sang-Hun Park,Kyung-Soon Park Sung-Am Cho 대한치과보철학회 2016 The Journal of Advanced Prosthodontics Vol.8 No.2
PURPOSE The purpose of this study was to compare the removal torques of a chemically modified SLActive implant and a blasted, laser-treated (BLT) implant, which were soaked in saline for 2 weeks after their surface modifications. The removal torques of the two implants were measured 4 weeks after their implantation into the bone defect area in rabbit tibias with concentrated growth factor (CGF) application. MATERIALS AND METHODS To make artificial bone defects in the cortical layers of both tibias, an 8-mm diameter trephine bur was used. Then, prepared CGF was applied to the bony defect of the left tibia, and the bony defect of the right tibia was left unfilled. Four weeks later, the surgical sites of 16 rabbits were re-exposed. For 8 rabbits, the SLActive implants (Straumann, Switzerland) were inserted in the left tibia, and the BLT implants (CSM implant, Daegu, Korea) were inserted in the right tibia. For other rabbits, the BLT implants were inserted in the left tibia, and the SLActive implants were inserted in the right. Four weeks afger the insertion, torque removal was measured from 4 rabbits exterminated via CO2 inhalation. RESULTS No significant difference was observed between removal torques of the BLT implant and the SLActive implant (P>.05). CONCLUSION It was found that BLT surface modification exhibited excellent osseointegration. In addition, CGF application did not affect the insertion and removal torque of the implants.
Sung-Am Cho,Kyung-Su Ha 대한치과이식임플란트학회 1999 The Korean Academy of Implant Dentistry Vol.18 No.1
티타늄의 열처리가 산화막의 형성을 증가하는 방향으로 영향을 주는 것으로 나타났다. 그러나 열처리를 한시편의 거칠기는 열처리를 하는 시간을 늘어나게 함에 따라 조도가 감소하는 양상을 나타내었으며, 티타늄이 매식된 골은 아무것도 매식하지 아니한 대조군의 골에 비해 티타늄의 유리를 나 타내었으나 이것이 골결합의 한 과정에서 나타난것인지 아니면 나사형임프란트의 매식과정에서 나타나 는 것인지는 알 수 없었다. 또한 티 타늄산화막의 두께와 이온의 누출의 연관관계는 앞으로 풀어야 할 숙제이 다.
The Effect of Surface Area of Implant on Bonding Strength between Implant and Bone
Cho,Sung-Am 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1
임프란트의 외표면적이 골과의 결합의 정도에 미치는 영향을 알아보기 위하여 10개의 grade Ⅱ 티타늄 임프란트를 사용하여 이를 직경 3미리와 5미리의 2개의 군으로 나누어 10마리의 토끼의 무릎뼈에 삽입하였다. 6주후에 동물들을 희생시키고 회전제거력을 Tohnichi 15-BTG-N Torque gauge Manometer로 측정하여 5㎜직경 그룹의 회전제거력이 3㎜직경 그룹의 회전제거력보다 큰 것을 확인하였다. (p=0.008) The effect of the surface area of implant on degree of osseointegration was investigated by putting the 10 grade-Ⅱ titanium screw implants into 10 isogenic rabbits tibia. Implants were divided in 2 groups into 3㎜ diameter and 5㎜ diameter. After 6 weeks, animals were sacrificed and removal torques were measured with Tonhnichi 15 BTG-N Torque Gauge Manometer. The results were as follows: The removal torques was higher in 5㎜ diameter group than the 3㎜ diameter group.(p=0.008)
On the effects of the characteristics of the titanium oxide to the osteoblast cell culture
Cho, Sung-Am The Korean Academy of Prosthodonitics 2000 대한치과보철학회지 Vol.38 No.3
Statement of problem. Confusion about the relationship of surface characteristics of implant to osteoblast cell attachment. Purpose. This study attempted to bone cell attachment to the implant surface which was modified by heat. Material and methods. Commercially pure titanium grade 2, $4{\times}4mm$ sheet 40 pieces were treated for 10 minutes with ultrasonic cleaner with methylethyl ketone, ethanol, deionized distilled water, and half of the specimen 20 pieces were heat treated in $980^{\circ}C$ for 15 minutes. All 40 specimens were autoclaves. Total 6 dishes were prepared, 3 dishes were for control group, and the other 3 dishes were for heat treatment. In fourth day, cell account was done. Conculsion. The change of surface characterization by heat treatment could affect the cell attachment in the early stage however, the change of surface characterization would not be prolonged.
( Sung Yong Han ),( Hyun Young Woo ),( Jeong Heo ),( Sang Gyu Park ),( Sung Ik Pyeon ),( Young Joo Park ),( Dong Uk Kim ),( Gwang Ha Kim ),( Hyung Hoi Kim ),( Geun Am Song ),( Mong Cho ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.3
Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical factors predicting sustained virological response 12 weeks (SVR12) after the end of SOF/RBV treatment. Methods: A total of 181 patients with HCV GT2 with/without cirrhosis were treated with SOF/RBV for 16/12 weeks. Rapid virological response (RVR) was defined as non-detectable HCV RNA at 4 weeks. Results: The RVR rate was 80.7% (146/181), the end of treatment response rate was 97.8% (177/181) and the SVR12 rate was 92.8% (168/181). Of eight patients with relapse, four did not achieve RVR. Three patients had a history of hepatocellular carcinoma (HCC). Multivariable analysis showed that RVR (p = 0.015) and no previous history of HCC (p = 0.007) were associated with SVR12. Factors significantly contributing to RVR included cirrhosis, creatinine concentration, and pre-treatment HCV RNA level. SVR12 rate was significantly higher in RVR (+) than RVR (-) patients (95.2% vs. 82.9%, p = 0.011) and also significantly higher in patients without than with a history of HCC (94.1% vs. 72.7%, p = 0.008). During treatment, 80/181 patients (44.2%) experienced mild to moderate adverse events, with 32 (17.7%) requiring RBV dose reductions due to anemia. Conclusions: SOF/RBV treatment was effective and tolerable in HCV GT2 patients. RVR and no previous history of HCC were positive predictors of SVR12.
On the effect of the characteristics of the titanium oxide to the osteoblast cell culture.
Cho, Sung-Am 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1
Statement of problem. Confusion about the relationship of surface characteristics of implant to osteoblast cell attachment. Purpose. This study attempted to bone cell attachment to the implant surface which was modified by heat. Material and methods. Commercially pure titanium grade 2,4×4㎜ sheet 40 pieces were treated for 10 minutes with ultrasonic cleaner with methylethyl ketone, ethanol, deionized distilled water, and half of the specimen 20 pieces were heat treated in 980℃ for 15 minutes. All 40 specimens were autoclaves. Total 6 dishes were prepared, 3 dishes were for control group, and the other 3 dishes were for heat treatment. In fourth day, cell account was done. Conculsion. The change of surface characterization by heat treatment could affect the cell attachment in the early stage however, the change of surface characterization would not be prolonged.
Cho, Sung-Am,Lee, Byung-Kil,Park, Sang-Hun,Ahn, Jae-Jin Informa UK Ltd. 2014 Platelets Vol.25 No.8
<P>Platelet-rich fibrin (PRF) is nowadays often used in various fields, but no removal torque studies have yet been done to evaluate the effects of the platelet-rich fibrin on the bone integration at the initial healing period. An experimental study have been performed in rabbits to evaluate whether the complete PRF clots can accelerate the bone integration of implants at the initial healing period after creating bone defects in tibias. The effec t of the complete PRF clots on bone integration was studied in two rabbit groups, 4-week group (group A) and 6-week group (group B) after preparing bony defects. Artificial bony defects were prepared in the tibias of rabbits. The complete PRF clots was applied to the defects in the experimental group, whereas the defects were unfilled in the control group. Four weeks later, machined implants were installed into the rabbit tibias (group A). Six weeks after installation, the removal torque from nine rabbits was measured to examine the bone healing effect of PRF. In another rabbits (group B), 6 weeks after preparing bony defects, installation was performed, and another 6 weeks after installation, the removal torque from nine rabbits was measured. The authors found a positive significant effect of the complete PRF clots on bone integration (higher bone density) in group A installed at 4 weeks after preparing bony defects (<I>p</I> = 0.008; <I>t</I>-test), but not in group B installed at 6 weeks after preparing bony defects (<I>p</I> = 0.677).</P>
Cho, Sung-Am,Park, Sang-Hun,Cho, Jin-Hyun The Korean Academy of Prosthodonitics 2014 The Journal of Advanced Prosthodontics Vol.6 No.6
PURPOSE. The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test. MATERIALS AND METHODS. A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; $200{\mu}g/rabbit$). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week. RESULTS. While no statistically significant difference was observed between the two groups (P=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-to-implant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant. CONCLUSION. We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.