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Park, Hyun-Hee,Lee, Kyu-Yong,Park, Dong Woo,Choi, Na-Young,Lee, Young Joo,Son, Jeong-Woo,Kim, Sangjae,Moon, Chanil,Kim, Hyun-Wook,Rhyu, Im Joo,Koh, Seong-Ho Elsevier 2018 Biomaterials Vol.155 No.-
<P><B>Abstract</B></P> <P> <I>In vivo</I> tracking of transplanted stem cells has been a central aim of stem cell therapy. Although many tracking systems have been introduced, no method has yet been validated for clinical applications. We developed a novel sophisticated peptide (GV1001) that mimics hTERT (human telomerase reverse transcriptase) and analysed its ability to track and protect stem cells after transplantation. Ferrocenecarboxylic acid-conjugated GV1001 (Fe-GV1001) efficiently penetrated stem cells with no adverse effects. Moreover, Fe-GV1001 improved the viability, proliferation, and migration of stem cells under hypoxia. After Fe-GV1001-labelled stem cells were transplanted into the brains of rats after stroke, the labelled cells were easily tracked by MRI. Our findings indicate that Fe-GV1001 can be used for the in vivo tracking of stem cells after transplantation into the brain and can improve the efficacy of stem cell therapy by sustaining and enhancing stem cell characteristics under disease conditions.</P>
Chanil Park,Seok-Woo Son,Jung-Hoon Kim 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.4
The nature of the vertical motion responsible for the summertime heavy rainfall events (HREs) in Korea is quantitatively examined. By compositing 318 HREs in June – September 1979 – 2018, it is found that the synoptic conditions of the HREs are typically characterized by a developing surface cyclone with a southwesterly low-level jet, and a well-defined upper-level jet streak and trough. This baroclinic environment allows for well-organized vertical motion over Korea at the east of the upper-level trough and the equatorward side of the upper-level jet entrance. The relative importance of dynamic and diabatic forcings in driving the vertical motion is quantified by solving the quasi-geostrophic omega equation. It turns out that the dynamic forcing, defined as Q-vector convergence, is comparable to the diabatic forcing in the developing stage of the HREs. The diabatic forcing, however, becomes more important in the mature stage as latent heating rapidly increases. The decomposition of Q-vector into the transverse (cross-isentropic) and shear wise (along-isentropic) components reveals that the dynamic uplift is largely caused by the shear wise Q-vector convergence which is closely related to the developing trough in the upper-to-middle troposphere on the west of the HREs. This result indicates that the HREs in Korea are organized by the baroclinic trough coupled to moist processes. The thermally-direct secondary circulation at the entrance region of the upper-level jet, which has been highlighted in the literature, plays a relatively minor role.
THE PROCESS OF FINANCIAL REFORMS IN CHINA
Park, Chanil 연세대학교 동서문제연구원 2004 Global economic review Vol.33 No.1
This study aims to show that financial reforms in China can be viewed as an endogenous adjustment process responding primarily to economic growth and changes in political constraints. The author's argument is thus against the mainstream view in which financial reforms are regarded as primary policy tools for the promotion of economic growth. Three factors are carefully examined for the explanation of the endogenous characteristics of financial reforms. First, this paper takes a close look at endogenous aspects of Chinese financial repression. The endogenous characters of financial repression explain why financial reforms in China follow an endogenous path. Second, recent developments of legal frameworks are found to have been institutional responses to macroeconomic imbalances, financial disorders, and increased demands for property right protection. Finally, this paper shows that the lack of market infrastructure and various political constraints have been major obstacles for China's capital market development.