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Virtual Metrology Modeling of Time-Dependent Spectroscopic Signals Using a Fused Lasso Algorithm
Chanhee Park(박찬희),Seoung Bum Kim(김성범),Jae Hong Yu(유재홍),Yong Joon Park(박영준),Su Gon Cho,Hyun Lee(이현),Baejin Lee(이배진),Younghoon Son(손영훈),Sangkil Lee(이상길),Chunsam Jun(전춘삼),Kyupil Lee(이규필) 대한산업공학회 2014 대한산업공학회 춘계학술대회논문집 Vol.2014 No.5
Reports on Manual Therapy in Chuncheon-si, Gangwon-do Province : A Retrospective Study
Chanhee Park,Moon pancheol 대한스포츠물리치료학회 2022 정형스포츠물리치료학회지 Vol.18 No.1
Purpose: This study aimed to investigate the differences and correlations between application of manual therapy to different body parts according to sex in Chuncheon-si, Gangwon-do, over the period of 3 years. Methods: The body parts were divided into pain regions (cervical, shoulder, elbow, wrist, lumbar, hip, knee, and ankle) of residents and office workers in the Chuncheon-si area. Data on the pain area were recorded from October 2019 to December 2020 at the neurosurgeon’s clinic and from January to December 2021 at the orthopedic surgeon’s office in Gangwon-do for 27 months and tabulated using an Excel format by the Chuncheon-si local council. Results: Cervical and lumbar were the most common pain areas where manual therapy was applied (>78%). Manual therapy was most frequently performed on Friday. Further, women received manual therapy more often than men. There were significant differences in pain between the wrist and knee regions (p<0.05). Conclusion: Our results provide promising clinical evidence that musculoskeletal pain significantly differs based on sex and body parts.
Virtual Metrology Modeling of Time-Dependent Spectroscopic Signals Using a Fused Lasso Algorithm
Chanhee Park(박찬희),Seoung Bum Kim(김성범),Jae Hong Yu(유재홍),Yong Joon Park(박영준),Su Gon Cho,Hyun Lee(이현),Baejin Lee(이배진),Younghoon Son(손영훈),Sangkil Lee(이상길),Chunsam Jun(전춘삼),Kyupil Lee(이규필) 한국경영과학회 2014 한국경영과학회 학술대회논문집 Vol.2014 No.5
Park, Chanhee,Lee, Soojin,Cho, Ik-Hyun,Lee, Hyun Kyoung,Kim, Donghoon,Choi, Se-Young,Oh, Seog Bae,Park, Kyungpyo,Kim, Joong Soo,Lee, Sung Joong Wiley Subscription Services, Inc., A Wiley Company 2006 GLIA Vol.53 No.3
<P>Viral infection is one of the leading causes of brain encephalitis and meningitis. Recently, it was reported that Toll-like receptor-3 (TLR3) induces a double-stranded RNA (dsRNA)-mediated inflammatory signal in the cells of the innate immune system, and studies suggested that dsRNA may induce inflammation in the central nervous system (CNS) by activating the CNS-resident glial cells. To explore further the connection between dsRNA and inflammation in the CNS, we have studied the effects of dsRNA stimulation in astrocytes. Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-α, IFN-β, and IP-10. Stimulation with poly(I:C) also induces the expression of these proinflammatory genes in primary astrocytes and in CRT-MG, a human astrocyte cell line. Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IκB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-κB (NF-κB), JNK, ERK, glycogen synthase kinase-3β (GSK-3β), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction. Interestingly, the inhibition of PI3 kinase suppressed the expression of IP-10, but upregulated the expression of IL-8, suggesting differential roles for PI3 kinase, depending on the target genes. These data suggest that the TLR3 expressed on astrocytes may initiate an inflammatory response upon viral infection in the CNS. © 2005 Wiley-Liss, Inc.</P>
Park, Changhoon,Seo, Hwi Won,Park, Su-Jin,Han, Kiwon,Chae, Chanhee Society for General Microbiology 2014 The Journal of general virology Vol.95 No.11
<P>The objective of this study was to compare the virulence and pathogenicity of a combination of concurrent infections of two genotypes of porcine circovirus type 2 (PCV2) and two genotypes of porcine reproductive and respiratory syndrome virus (PRRSV) in terms of PCV2 viraemia, and PCV2-associated lesions and antigens in co-infected pigs. Pigs with PCV2a (or 2b)/type 1 (or type 2) PRRSV had significantly (<I>P</I><0.05) higher mean clinical respiratory scores and lower average daily weight gain compared with pigs with PCV2a (or 2b). Co-infection induced significantly lower levels of anti-PCV2 and anti-PRRSV IgG antibodies than infection with one genotype alone, regardless of the genotype of the two viruses. Pigs with PCV2a (or 2b)/type 2 PRRSV had significantly (<I>P</I><0.05) higher levels of PCV2 viraemia, more severe PCV2-associated lesions, and more PCV2 DNA within the lesions compared with pigs with PCV2a (or 2b)/type 1 PRRSV. However, there was no significant difference in these parameters in pigs with PCV2a/type 2 PRRSV or PCV2b/type 2 PRRSV. The results of this study demonstrate significant differences in the virulence and pathogenicity of type 1 and type 2 PRRSV but no significant differences in the virulence and pathogenicity of PCV2a and PCV2b with respect to the production of PCV2-associated lesions.</P>