Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats

Changchun Yu,Yuan Lin,Yong-jian Xiong,Da-peng Chen,Yanli Li,Bin Xu,Zeyao Tang,Chunling Jiang,Li Wang 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.1

Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal inflammation and cooccurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is used to treat digestive disorders. The present study was designed to characterize the effects of atractylodin on amelioration of both jejunal inflammation and the co-occurring dysmotility in both constipation-prominent (CP) and diarrheaprominent (DP) rats. The results indicated that atractylodin reduced proinflammatory cytokines TNF-α, IL-1β, and IL-6 in the plasma and inhibited the expression of inflammatory mediators iNOS and NF-kappa B in jejunal segments in both CP and DP rats. The results indicated that atractylodin exerted stimulatory effects and inhibitory effects on the contractility of jejunal segments isolated from CP and DP rats respectively, showing a contractile-state-dependent regulation. Atractylodininduced contractile-state-dependent regulation was also observed by using rat jejunal segments in low and high contractile states respectively (5 pairs of low/ high contractile states). Atractylodin up-regulated the decreased phosphorylation of 20 kDa myosin light chain, protein contents of myosin light chain kinase (MLCK), and MLCK mRNA expression in jejunal segments of CP rats and down-regulated those increased parameters in DP rats. Taken together, atractylodin alleviated rat jejunal inflammation and exerted contractile-state-dependent regulation on the contractility of jejunal segments isolated from CP and DP rats respectively, suggesting the potential clinical implication for ameliorating intestinal inflammation and co-occurring dysmotility.

Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats

Yu, Changchun,Xiong, Yongjian,Chen, Dapeng,Li, Yanli,Xu, Bin,Lin, Yuan,Tang, Zeyao,Jiang, Chunling,Wang, Li The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.1

Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal inflammation and co-occurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is used to treat digestive disorders. The present study was designed to characterize the effects of atractylodin on amelioration of both jejunal inflammation and the co-occurring dysmotility in both constipation-prominent (CP) and diarrhea-prominent (DP) rats. The results indicated that atractylodin reduced proinflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$, and IL-6 in the plasma and inhibited the expression of inflammatory mediators iNOS and NF-kappa B in jejunal segments in both CP and DP rats. The results indicated that atractylodin exerted stimulatory effects and inhibitory effects on the contractility of jejunal segments isolated from CP and DP rats respectively, showing a contractile-state-dependent regulation. Atractylodin-induced contractile-state-dependent regulation was also observed by using rat jejunal segments in low and high contractile states respectively (5 pairs of low/high contractile states). Atractylodin up-regulated the decreased phosphorylation of 20 kDa myosin light chain, protein contents of myosin light chain kinase (MLCK), and MLCK mRNA expression in jejunal segments of CP rats and down-regulated those increased parameters in DP rats. Taken together, atractylodin alleviated rat jejunal inflammation and exerted contractile-state-dependent regulation on the contractility of jejunal segments isolated from CP and DP rats respectively, suggesting the potential clinical implication for ameliorating intestinal inflammation and co-occurring dysmotility.

Design of a ROM-Less Direct Digital Frequency Synthesizer on FPGA

Zhanpeng Jiang,Rui Xu,Hai Huang,Changchun Dong 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.5

DDFS (Direct Digital Frequency Synthesizer) is a new technique of frequency synthesizes which introduces the advanced digital processing theory into frequency synthesis. A direct digital frequency synthesizer is composed of a phase accumulator, an adder, an ROM for wave pattern saving, a D/A converter and a LPF (low pass filter). With the rapid development of VLSI, the speed of algorithm is required increasingly higher. This paper proposes a new frequency synthesizer by improving the structure of data storage which ensures the accuracy and speed. Rotation method was used to resolve the expected angle into many small rotation angles and sting wave symmetry principle was used to resolve the string wave. From point to area, the values in one quadrant were calculated and sampled and then the data was saved in ROM. Under the control of frequency, the data in ROM was read and then transferred to the D/A converter chip and the following low pass filter to achieve frequency synthesize. This algorithm could reduce the usage of ROM to increase the calculation efficiency.

An Optimization of CORDIC Algorithm and FPGA Implementation

Rui Xu,Zhanpeng Jiang,Hai Huang,Changchun Dong 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.6

ASIC and FPGA ASIC and FPGA are considered to be the ideal platform for special fast calculations because of the hardware structure, and how to achieve computational algorithm by is the hotpot of research. The CORDIC (Coordinate Rotational Digital Computer) can break the basis functions down to operations of shift and addition or subtraction, which can be used to lay the foundation for the realization of complex logic. But the functions selected by traditional CODIC for angle encoding are too complex, which will lead to some problems, such as too much of area consumption and large delay. In this paper, an optimization of CORDIC algorithm are proposed, which reduce the consumption of Adders and comparators, decrease the complexity and delay of the algorithm implement in hardware. The proposed algorithms are modeled in Verilog Hardware Description Language and implemented with FPGA. The simulation results show that the functions of sine and cosine are realized successfully, and the proposed algorithm not only improves the computation speed but also reduces the system hardware resources.

Investigation on the Airflow Fields of New Melt-blown Dies with Rectangular Jets

Yudong Wang,Fang Jiang,Wan’e Ning,Sheng Xie,Changchun Jiang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.10

In order to reduce the fiber diameter and the energy consumption in the melt-blowing process, three new slot dies(slot die with air accelerator, slot die with stabilizers and slot die with extensions) are designed. The airflow fields of thesedies have been numerically calculated and experimentally verified. The results reveal that the slot die with stabilizers and slotdie with extensions have higher average stagnation temperatures, average air pressure and average turbulent kinetic energythan those of the common slot die. Compared with the common slot die, the slot die with air accelerator could increase theaverage stagnation temperature on the spinning line, however, its average pressure is reduced and the average turbulentkinetic energy is locally increased. By comprehensively comparing the average stagnation temperature, average air pressureand average turbulent kinetic energy on the spinning lines of these slot dies, the new slot die with stabilizers is the mostconducive to the attenuation of the melt-blowing fibers and the reduction of energy consumption. The research in this workcan have strong guiding significance for the optimization of die structure and the attenuation of melt-blowing fibers.

Tensile Behaviors of Laser-Discrete-Quenched Substrate/Nickel Coating of Electroplated Grinding Wheel

Cong Mao,Yujie Zhong,Yongle Hu,Weidong Tang,Z. M. Bi,Zhaohong Lei,Changchun Jiang,Aimin Tang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.5

Electroplated grinding wheel has significant advantages, such as longer service life, higher removal rate, reduction of preparation work, reapplication of the wheel bub. Then it is an efficient, green and eco-friendly abrasive tool. In order to reveal the mechanism that the service life of the electroplated grinding wheel is increased by pre-quenched substrate, the tensile behavior and interfacial stresses of the laser-discrete-quenched substrate/nickel coating were studied through tensile experiment and simulation. The results show that random initial cracks appear in the nickel coating over the unquenched zone before the tensile experiment. There is an inter-diffusion region at the interface of steel substrate and nickel coating; in comparison with the unquenched zone, the size of the inter-diffusion region in the laser-quenched zone was decreased significantly (e.g., 1.2 μm in comparison with 2.6 μm). In tensile testing, the coating over the pre-quenched specimen remains bonded with the substrate firmly even the fracture occurs. In contrast, the damages in the forms of blistering, stripping and exfoliating occurred in the coating over the unquenched specimen. When a fracture occurs, there is a significant difference of the ultimate strains of quenched and unquenched zones; the ultimate strain of quenched zone is 0.0714, while that of the unquenched zone is 0.1667. At the bonding interface, the pre-quenched specimen ensured the overall shear stress and the maximum normal stress, which are lower than those of unquenched specimen. The initial cracks in pre-quenched specimen propagate during stretching, the effect of the absorbed strain energy reduces strain mismatch between the substrate and coating at the interface, and this improves the bonding strength at the interface of the laser-discrete-quenched specimen significantly.